Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo
暂无分享,去创建一个
M. Almeida | M. Saarma | Y. Cordeiro | D. Foguel | H. Huttunen | K. Luk | T. Outeiro | F. Palhano | A. Domanskyi | M. Airavaara | L. Shvachiy | Xu Yan | A. Eesmaa | P. Chmielarz | A. Panhelainen | Katrina Albert | M. Voutilainen | D. Raymundo | G. R. Araujo | Aastha Singh | Kelvin C. Luk
[1] Cora R. von Collenberg,et al. CDNF rescues motor neurons in three animal models of ALS by targeting ER stress , 2020, bioRxiv.
[2] H. Lashuel. Do Lewy bodies contain alpha-synuclein fibrils? and Does it matter? A brief history and critical analysis of recent reports , 2020, Neurobiology of Disease.
[3] Shirin Doroudgar,et al. Mesencephalic astrocyte–derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart , 2020, The Journal of Biological Chemistry.
[4] P. Alam,et al. α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities , 2019, Journal of neurochemistry.
[5] M. Saarma,et al. CDNF Protein Therapy in Parkinson’s Disease , 2019, Cell transplantation.
[6] M. Saarma,et al. Characterization of CDNF-Secreting ARPE-19 Cell Clones for Encapsulated Cell Therapy , 2019, Cell transplantation.
[7] D. Ron,et al. MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP , 2019, Nature Communications.
[8] P. Zamorano,et al. CDNF induces the adaptive unfolded protein response and attenuates endoplasmic reticulum stress-induced cell death. , 2018, Biochimica et biophysica acta. Molecular cell research.
[9] B. Harvey,et al. KDEL Receptors Are Differentially Regulated to Maintain the ER Proteome under Calcium Deficiency. , 2018, Cell reports.
[10] Xiao-Jing Wang,et al. Cerebral Dopamine Neurotrophic Factor (CDNF) Has Neuroprotective Effects against Cerebral Ischemia That May Occur through the Endoplasmic Reticulum Stress Pathway , 2018, International journal of molecular sciences.
[11] R. Takahashi,et al. Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve , 2018, Molecular Neurodegeneration.
[12] Olli-Pekka Smolander,et al. Poststroke delivery of MANF promotes functional recovery in rats , 2018, Science Advances.
[13] T. P. Davis,et al. Serum albumin impedes the amyloid aggregation and hemolysis of human islet amyloid polypeptide and alpha synuclein. , 2018, Biochimica et biophysica acta. Biomembranes.
[14] K. Khodosevich,et al. MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke , 2017, Molecular therapy : the journal of the American Society of Gene Therapy.
[15] A. West,et al. α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration , 2017, Neurobiology of Disease.
[16] Xander M R van Wijk,et al. Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type , 2017, Scientific Reports.
[17] V. Lee,et al. Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies , 2017, The Journal of Biological Chemistry.
[18] H. Braak,et al. Neuropathological Staging of Brain Pathology in Sporadic Parkinson’s disease: Separating the Wheat from the Chaff , 2017, Journal of Parkinson's disease.
[19] M. Saarma,et al. Evidence for an Additive Neurorestorative Effect of Simultaneously Administered CDNF and GDNF in Hemiparkinsonian Rats: Implications for Different Mechanism of Action , 2017, eNeuro.
[20] M. Saarma,et al. Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra , 2017, eNeuro.
[21] R. Román,et al. Enhancing heterologous protein expression and secretion in HEK293 cells by means of combination of CMV promoter and IFNα2 signal peptide. , 2016, Journal of biotechnology.
[22] T. Outeiro,et al. Structure, function and toxicity of alpha‐synuclein: the Bermuda triangle in synucleinopathies , 2016, Journal of neurochemistry.
[23] Ho Chul Kang,et al. Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3 , 2016, Science.
[24] John Q Trojanowski,et al. Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease , 2016, The Journal of experimental medicine.
[25] H. Jasper,et al. Immune modulation by MANF promotes tissue repair and regenerative success in the retina , 2016, Science.
[26] Elliott W. Dirr,et al. Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration , 2015, Neurobiology of Disease.
[27] Takeo Kato,et al. Sensitive western blotting for detection of endogenous Ser129-phosphorylated α-synuclein in intracellular and extracellular spaces , 2015, Scientific Reports.
[28] M. Almeida,et al. The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role against α-Synuclein Oligomers* , 2015, The Journal of Biological Chemistry.
[29] C. Meyers,et al. The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (α-syn) toxicity to rat nigral neurons , 2015, Neurobiology of Aging.
[30] Vivek K Unni,et al. Progressive aggregation of alpha-synuclein and selective degeneration of Lewy inclusion-bearing neurons in a mouse model of parkinsonism , 2015, Cell reports.
[31] H. Huttunen,et al. Prolyl Oligopeptidase Enhances α-Synuclein Dimerization via Direct Protein-Protein Interaction* , 2015, The Journal of Biological Chemistry.
[32] G. Braus,et al. Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation , 2014, PLoS genetics.
[33] K. Luk,et al. Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates , 2014, Nature Protocols.
[34] C. Hetz,et al. Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1 , 2014, Proceedings of the National Academy of Sciences.
[35] L. Lannfelt,et al. Monoclonal antibodies selective for α‐synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α‐synuclein transgenic mice with the disease‐causing A30P mutation , 2013, Journal of neurochemistry.
[36] E. Masliah,et al. A Blood-Brain Barrier (BBB) Disrupter Is Also a Potent α-Synuclein (α-syn) Aggregation Inhibitor , 2013, The Journal of Biological Chemistry.
[37] J. Trojanowski,et al. Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice , 2012, Science.
[38] Ronald Melki,et al. Neuron‐to‐neuron transmission of α‐synuclein fibrils through axonal transport , 2012, Annals of neurology.
[39] Johannes E. Schindelin,et al. Fiji: an open-source platform for biological-image analysis , 2012, Nature Methods.
[40] J. Trojanowski,et al. Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice , 2012, The Journal of experimental medicine.
[41] J. Troncoso,et al. Accumulation of Toxic α-Synuclein Oligomer within Endoplasmic Reticulum Occurs in α-Synucleinopathy In Vivo , 2012, The Journal of Neuroscience.
[42] P. Spano,et al. Redistribution of DAT/α-Synuclein Complexes Visualized by “In Situ” Proximity Ligation Assay in Transgenic Mice Modelling Early Parkinson's Disease , 2011, PloS one.
[43] C. Rivera,et al. Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons , 2011, Neural plasticity.
[44] Fred H. Gage,et al. In vivo demonstration that α-synuclein oligomers are toxic , 2011, Proceedings of the National Academy of Sciences.
[45] Brian Spencer,et al. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein , 2009, Proceedings of the National Academy of Sciences.
[46] Polina Golland,et al. Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning , 2009, Proceedings of the National Academy of Sciences.
[47] Polina Golland,et al. CellProfiler Analyst: data exploration and analysis software for complex image-based screens , 2008, BMC Bioinformatics.
[48] R. Hauser,et al. Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease , 2008, Nature Medicine.
[49] Elisabet Englund,et al. Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation , 2008, Nature Medicine.
[50] Armin Giese,et al. Different Species of α-Synuclein Oligomers Induce Calcium Influx and Seeding , 2007, The Journal of Neuroscience.
[51] M. Saarma,et al. Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo , 2007, Nature.
[52] S. Michnick,et al. A highly sensitive protein-protein interaction assay based on Gaussia luciferase , 2006, Nature Methods.
[53] Anne E Carpenter,et al. CellProfiler: image analysis software for identifying and quantifying cell phenotypes , 2006, Genome Biology.
[54] R. Barbour,et al. Phosphorylation of Ser-129 Is the Dominant Pathological Modification of α-Synuclein in Familial and Sporadic Lewy Body Disease* , 2006, Journal of Biological Chemistry.
[55] Ivano Bertini,et al. Protonless NMR experiments for sequence-specific assignment of backbone nuclei in unfolded proteins. , 2006, Journal of the American Chemical Society.
[56] C. Dobson,et al. Heat Shock Protein 70 Inhibits α-Synuclein Fibril Formation via Preferential Binding to Prefibrillar Species* , 2005, Journal of Biological Chemistry.
[57] Takeshi Iwatsubo,et al. Aggresomes Formed by α-Synuclein and Synphilin-1 Are Cytoprotective* , 2004, Journal of Biological Chemistry.
[58] W. Dauer,et al. Parkinson's Disease Mechanisms and Models , 2003, Neuron.
[59] H. Braak,et al. Staging of brain pathology related to sporadic Parkinson’s disease , 2003, Neurobiology of Aging.
[60] S. Vanhatalo,et al. Neurturin is a neurotrophic factor for penile parasympathetic neurons in adult rat. , 2000, Journal of neurobiology.
[61] M. L. Schmidt,et al. α-Synuclein in Lewy bodies , 1997, Nature.
[62] A. Lees,et al. Ageing and Parkinson's disease: substantia nigra regional selectivity. , 1991, Brain : a journal of neurology.
[63] W. Gibb,et al. THE SIGNIFICANCE OF THE LEWY BODY IN THE DIAGNOSIS OF IDIOPATHIC PARKINSON'S DISEASE , 1989, Neuropathology and applied neurobiology.
[64] S. Munro,et al. A C-terminal signal prevents secretion of luminal ER proteins , 1987, Cell.