Understanding heterogeneity of human bone marrow plasma cell maturation and survival pathways by single-cell analyses

[1]  S. Lonial,et al.  Generation of human long-lived plasma cells by developmentally regulated epigenetic imprinting , 2021, Life Science Alliance.

[2]  I. Sanz,et al.  Plasma cell survival: The intrinsic drivers, migratory signals, and extrinsic regulators , 2021, Immunological reviews.

[3]  Dong Liu,et al.  NR4A1 enhances MKP7 expression to diminish JNK activation induced by ROS or ER-stress in pancreatic β cells for surviving , 2021, Cell death discovery.

[4]  C. Ribi,et al.  Restoration of NK Cell Cytotoxic Function With Elotuzumab and Daratumumab Promotes Elimination of Circulating Plasma Cells in Patients With SLE , 2021, Frontiers in Immunology.

[5]  David R Fooksman,et al.  Plasma cell dynamics in the bone marrow niche , 2021, Cell reports.

[6]  A. Saveliev,et al.  Efficient homing of antibody-secreting cells to the bone marrow requires RNA-binding protein ZFP36L1 , 2020, The Journal of experimental medicine.

[7]  Andreas Radbruch,et al.  Targeting CD38 with Daratumumab in Refractory Systemic Lupus Erythematosus. , 2020, The New England journal of medicine.

[8]  Enkelejda Miho,et al.  Maturation of the Human Immunoglobulin Heavy Chain Repertoire With Age , 2020, Frontiers in Immunology.

[9]  D. Green,et al.  The clearance of dead cells by efferocytosis , 2020, Nature Reviews Molecular Cell Biology.

[10]  Carole J Henry,et al.  Remembrance of Things Past: Long-Term B Cell Memory After Infection and Vaccination , 2019, Front. Immunol..

[11]  R. Scheuermann,et al.  Differential transcriptome and development of human peripheral plasma cell subsets. , 2019, JCI insight.

[12]  Paul J. Hoffman,et al.  Comprehensive Integration of Single-Cell Data , 2018, Cell.

[13]  H. Goldschmidt,et al.  Daratumumab plus Lenalidomide and Dexamethasone for Untreated Myeloma. , 2019, The New England journal of medicine.

[14]  P. Wilson,et al.  Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery , 2019, The Journal of Immunology.

[15]  Yvan Saeys,et al.  A comparison of single-cell trajectory inference methods , 2019, Nature Biotechnology.

[16]  A. Regev,et al.  Inflammatory regulatory network mediated by the joint action of NF-kB, STAT3, and AP-1 factors is involved in many human cancers , 2019, Proceedings of the National Academy of Sciences.

[17]  R. Satija,et al.  Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression , 2019, Genome Biology.

[18]  R. Kaufman,et al.  Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR , 2019, Nature Communications.

[19]  Lai Guan Ng,et al.  Dimensionality reduction for visualizing single-cell data using UMAP , 2018, Nature Biotechnology.

[20]  C. Hinze,et al.  Endocytosis in proliferating, quiescent and terminally differentiated cells , 2018, Journal of Cell Science.

[21]  Damian Szklarczyk,et al.  STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets , 2018, Nucleic Acids Res..

[22]  T. Hughes,et al.  The Human Transcription Factors , 2018, Cell.

[23]  G. Gibson,et al.  Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion , 2018, Nature Communications.

[24]  S. Kridel,et al.  CD38 Inhibits Prostate Cancer Metabolism and Proliferation by Reducing Cellular NAD+ Pools , 2018, Molecular Cancer Research.

[25]  M. Demaria,et al.  Hallmarks of Cellular Senescence. , 2018, Trends in cell biology.

[26]  Xuefeng Yin,et al.  Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus , 2018, Arthritis Research & Therapy.

[27]  Paul Hoffman,et al.  Integrating single-cell transcriptomic data across different conditions, technologies, and species , 2018, Nature Biotechnology.

[28]  M. Reth,et al.  Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells , 2018, Proceedings of the National Academy of Sciences.

[29]  Charlotte Soneson,et al.  Bias, robustness and scalability in single-cell differential expression analysis , 2018, Nature Methods.

[30]  E. Wagner,et al.  The AP-1 transcription factor JunB is essential for multiple myeloma cell proliferation and drug resistance in the bone marrow microenvironment , 2017, Leukemia.

[31]  P. Park,et al.  CD138 mediates selection of mature plasma cells by regulating their survival. , 2017, Blood.

[32]  Russell B. Fletcher,et al.  Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics , 2017, bioRxiv.

[33]  A. Letai,et al.  Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics. , 2017, Cancer cell.

[34]  S. Kleinstein,et al.  Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection , 2016, Nature Communications.

[35]  R. Aebersold,et al.  On the Dependency of Cellular Protein Levels on mRNA Abundance , 2016, Cell.

[36]  H. Kalbitzer,et al.  Orphan Nuclear Receptor NR4A1 Binds a Novel Protein Interaction Site on Anti-apoptotic B Cell Lymphoma Gene 2 Family Proteins* , 2016, The Journal of Biological Chemistry.

[37]  J. Mesirov,et al.  The Molecular Signatures Database Hallmark Gene Set Collection , 2015 .

[38]  W. Shi,et al.  Blimp-1 controls plasma cell function through regulation of immunoglobulin secretion and the unfolded protein response , 2015, Nature Immunology.

[39]  K. Toellner FOXP1 inhibits plasma cell differentiation. , 2015, Blood.

[40]  Steven H. Kleinstein,et al.  Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data , 2015, Bioinform..

[41]  Hao Wu,et al.  Long-Lived Plasma Cells Are Contained within the CD19(-)CD38(hi)CD138(+) Subset in Human Bone Marrow. , 2015, Immunity.

[42]  K. Hirano,et al.  Human CD43+ B cells are closely related not only to memory B cells phenotypically but also to plasmablasts developmentally in healthy individuals. , 2015, International immunology.

[43]  P. Linsley,et al.  MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data , 2015, Genome Biology.

[44]  Chen Xu,et al.  Identification of cell types from single-cell transcriptomes using a novel clustering method , 2015, Bioinform..

[45]  J. Youn,et al.  Early Growth Response-1 Plays a Non-redundant Role in the Differentiation of B Cells into Plasma Cells , 2015, Immune network.

[46]  Ivan V. Gregoretti,et al.  Diversity, cellular origin and autoreactivity of antibody-secreting cell expansions in acute Systemic Lupus Erythematosus , 2015, Nature Immunology.

[47]  Philip D. Hodgkin,et al.  The generation of antibody-secreting plasma cells , 2015, Nature Reviews Immunology.

[48]  Uri Hershberg,et al.  Lasting Antibody Responses Are Mediated by a Combination of Newly Formed and Established Bone Marrow Plasma Cells Drawn from Clonally Distinct Precursors , 2014, The Journal of Immunology.

[49]  M. Flajnik,et al.  Putting J Chain Back on the Map: How Might Its Expression Define Plasma Cell Development? , 2014, The Journal of Immunology.

[50]  K. Fairfax,et al.  The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice , 2014, Science Signaling.

[51]  W. Shi,et al.  The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity , 2014, The Journal of experimental medicine.

[52]  A. DeFranco,et al.  B Cell–Specific Loss of Lyn Kinase Leads to Autoimmunity , 2014, The Journal of Immunology.

[53]  John Calvin Reed,et al.  ER stress-induced cell death mechanisms. , 2013, Biochimica et biophysica acta.

[54]  D. Allman,et al.  What Is and What Should Always Have Been: Long-Lived Plasma Cells Induced by T Cell–Independent Antigens , 2013, The Journal of Immunology.

[55]  O. Elemento,et al.  Downregulation of FOXP1 is required during germinal center B-cell function. , 2013, Blood.

[56]  Stefan P. Glaser,et al.  Mcl-1 is essential for the survival of plasma cells , 2013, Nature Immunology.

[57]  Y. Choi,et al.  CD9 is a novel marker for plasma cell precursors in human germinal centers. , 2013, Biochemical and biophysical research communications.

[58]  David B. Darr,et al.  Monitoring Tumorigenesis and Senescence In Vivo with a p16 INK4a -Luciferase Model , 2013, Cell.

[59]  K. Lam,et al.  Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival , 2012, Proceedings of the National Academy of Sciences.

[60]  R. Ahmed,et al.  ZBTB32 Is an Early Repressor of the CIITA and MHC Class II Gene Expression during B Cell Differentiation to Plasma Cells , 2012, The Journal of Immunology.

[61]  Hui Liu,et al.  AnimalTFDB: a comprehensive animal transcription factor database , 2011, Nucleic Acids Res..

[62]  N. LeBrasseur,et al.  Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders , 2011, Nature.

[63]  S. Wittmer,et al.  IgM Production by Bone Marrow Plasmablasts Contributes to Long-Term Protection against Intracellular Bacterial Infection , 2011, The Journal of Immunology.

[64]  Xinbin Chen,et al.  Examination of the expanding pathways for the regulation of p21 expression and activity. , 2010, Cellular signalling.

[65]  M. Latterich,et al.  TOE1 interacts with p53 to modulate its transactivation potential , 2009, FEBS letters.

[66]  R. Geha,et al.  Transmembrane activator, calcium modulator, and cyclophilin ligand interactor drives plasma cell differentiation in LPS-activated B cells. , 2009, The Journal of allergy and clinical immunology.

[67]  J. Corbeil,et al.  The transcription factor Egr1 regulates the HIF‐1α gene during hypoxia , 2009, Molecular carcinogenesis.

[68]  M. Hahne,et al.  “APRIL hath put a spring of youth in everything”: Relevance of APRIL for survival , 2009, Journal of cellular physiology.

[69]  Virginia Pascual,et al.  A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus. , 2008, Immunity.

[70]  Gabriela Kania,et al.  B-MYB Is Essential for Normal Cell Cycle Progression and Chromosomal Stability of Embryonic Stem Cells , 2008, PloS one.

[71]  R. Geha,et al.  Cutting Edge: The Dependence of Plasma Cells and Independence of Memory B Cells on BAFF and APRIL1 , 2008, The Journal of Immunology.

[72]  O. Yoshie,et al.  1,25-Dihydroxyvitamin D3 Induces CCR10 Expression in Terminally Differentiating Human B Cells1 , 2008, The Journal of Immunology.

[73]  D. Jelinek,et al.  Regulated Expression of BAFF-Binding Receptors during Human B Cell Differentiation1 , 2007, The Journal of Immunology.

[74]  John Calvin Reed,et al.  Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma. , 2007, Blood.

[75]  W. Craigen,et al.  Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death , 2007, Nature Cell Biology.

[76]  Kenneth G. C. Smith,et al.  Competence and competition: the challenge of becoming a long-lived plasma cell , 2006, Nature Reviews Immunology.

[77]  T. Phan,et al.  Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation , 2006, The Journal of experimental medicine.

[78]  G. Jiménez-Gómez,et al.  Immunization-Induced Perturbation of Human Blood Plasma Cell Pool: Progressive Maturation, IL-6 Responsiveness, and High PRDI-BF1/BLIMP1 Expression Are Critical Distinctions between Antigen-Specific and Nonspecific Plasma Cells1 , 2006, The Journal of Immunology.

[79]  James M. Roberts,et al.  A New Description of Cellular Quiescence , 2006, PLoS biology.

[80]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[81]  A. Órfão,et al.  Aberrant expression of tetraspanin molecules in B-cell chronic lymphoproliferative disorders and its correlation with normal B-cell maturation , 2005, Leukemia.

[82]  J. Tschopp,et al.  Identification of proteoglycans as the APRIL-specific binding partners , 2005, The Journal of experimental medicine.

[83]  K. Calame,et al.  Regulation of plasma-cell development , 2005, Nature Reviews Immunology.

[84]  Yen-Ming Hsu,et al.  Selectivity of BAFF/BLyS and APRIL for binding to the TNF family receptors BAFFR/BR3 and BCMA. , 2005, Biochemistry.

[85]  Jhagvaral Hasbold,et al.  Plasma Cell Ontogeny Defined by Quantitative Changes in Blimp-1 Expression , 2004, The Journal of experimental medicine.

[86]  M. Zennaro,et al.  GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis. , 2004, Blood.

[87]  C. Berek,et al.  CD38 low IgG‐secreting cells are precursors of various CD38 high‐expressing plasma cell populations , 2004, Journal of leukocyte biology.

[88]  James G Krueger,et al.  Combining several ordinal measures in clinical studies , 2004, Statistics in medicine.

[89]  B. Harder,et al.  Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival. , 2004, Blood.

[90]  R. Bram,et al.  BCMA Is Essential for the Survival of Long-lived Bone Marrow Plasma Cells , 2004, The Journal of experimental medicine.

[91]  S. Lowe,et al.  Control of apoptosis by p53 , 2003, Oncogene.

[92]  J. Kearney,et al.  CD9 Is a Unique Marker for Marginal Zone B Cells, B1 Cells, and Plasma Cells in Mice1 , 2002, The Journal of Immunology.

[93]  J. Trowsdale,et al.  Genetic Control of MHC Class II Expression , 2002, Cell.

[94]  M. Nussenzweig,et al.  Role of antigen receptor affinity in T cell–independent antibody responses in vivo , 2002, Nature Immunology.

[95]  A. Campos-Caro,et al.  The heterogeneity shown by human plasma cells from tonsil, blood, and bone marrow reveals graded stages of increasing maturity, but local profiles of adhesion molecule expression. , 2002, Blood.

[96]  J. Bertoglio,et al.  Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing , 2001, Nature Cell Biology.

[97]  N. Copeland,et al.  Molecular cloning and functional characterization of murine Transmembrane Activator and CAML Interactor (TACI) with chromosomal localization in human and mouse , 2000, Mammalian Genome.

[98]  J. L. King,et al.  Evolutionary nucleotide replacements in DNA , 1979, Nature.

[99]  William M. Rand,et al.  Objective Criteria for the Evaluation of Clustering Methods , 1971 .

[100]  V. Giudicelli,et al.  IMGT(®) tools for the nucleotide analysis of immunoglobulin (IG) and T cell receptor (TR) V-(D)-J repertoires, polymorphisms, and IG mutations: IMGT/V-QUEST and IMGT/HighV-QUEST for NGS. , 2012, Methods in molecular biology.

[101]  T. Cotter,et al.  Key apoptosis regulating proteins are down-regulated during postnatal tissue development. , 2007, The International journal of developmental biology.

[102]  S. Nagata DNA degradation in development and programmed cell death. , 2005, Annual review of immunology.

[103]  Thomas L. Rothstein,et al.  The role of clonal selection and somatic mutation in autoimmunity , 1987, Nature.