Rapid On-Site Cytologic Evaluation during Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for Diagnosing Lung Cancer: A Randomized Study

Background: Although rapid on-site cytologic evaluation (ROSE) is widely used during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), its role remains unclear. Objectives: The purpose of the present study was to evaluate the efficacy of ROSE during EBUS-TBNA in the diagnosis of lung cancer. Methods: One hundred and twenty patients highly suspected of having lung cancer who had hilar/mediastinal lymphadenopathy or a tumor adjacent to the central airway were enrolled in this study and randomized to undergo EBUS-TBNA with or without ROSE. Results: Twelve patients with visible endobronchial lesions were excluded in the analysis. Thus, a total of 108 patients (55 in the ROSE group, 53 in the non-ROSE group) were analyzed. Additional procedures including EBUS-TBNA for lesions other than the main target lesion and/or transbronchial biopsy in the same setting were performed in 11% of patients in the ROSE group and 57% in the non-ROSE group (p < 0.001). Mean puncture number was significantly lower in the ROSE group (2.2 vs. 3.1 punctures, p < 0.001), and mean bronchoscopy time was similar between both groups (22.3 vs. 22.1 min, p = 0.95). The sensitivity and accuracy for diagnosing lung cancer were 88 and 89% in the ROSE group, and 86 and 89% in the non-ROSE group, respectively. No complications were associated with the procedures. Conclusions: ROSE during EBUS-TBNA is associated with a significantly lower need for additional bronchoscopic procedures and puncture number.

[1]  N. Hayashi,et al.  A new needle for transfiberoptic bronchoscopic use. , 1979, Chest.

[2]  R. Davenport Rapid on-site evaluation of transbronchial aspirates. , 1990, Chest.

[3]  C. Mountain,et al.  Regional lymph node classification for lung cancer staging. , 1997, Chest.

[4]  H. Rubin,et al.  Utility of on-site cytopathology assessment for bronchoscopic evaluation of lung masses and adenopathy. , 2000, Chest.

[5]  Michael A. Brooks,et al.  Transbronchial needle aspiration in diagnosing and staging lung cancer: how many aspirates are needed? , 2002, American journal of respiratory and critical care medicine.

[6]  R. Chin On-site Cytopathologic Analysis of Bronchoscopic Needle Aspiration: Pro: On-site Analysis Is Indicated , 2003 .

[7]  W. Boyan On-site Cytopathologic Analysis of Bronchoscopic Needle Aspiration: Con: On-site Analysis Is Not Indicated , 2003 .

[8]  D. Baram,et al.  Impact of rapid on-site cytologic evaluation during transbronchial needle aspiration. , 2005, Chest.

[9]  S. Gasparini It Is Time for This ‘ROSE’ to Flower , 2005, Respiration.

[10]  M. Louw,et al.  Utility of Rapid On-Site Evaluation of Transbronchial Needle Aspirates , 2005, Respiration.

[11]  M. Oki,et al.  Real‐time endobronchial ultrasound‐guided transbronchial needle aspiration is useful for diagnosing sarcoidosis , 2007, Respirology.

[12]  Moon Soo Kim,et al.  Real-time endobronchial ultrasound-guided transbronchial needle aspiration in mediastinal staging of non-small cell lung cancer: how many aspirations per target lymph node station? , 2008, Chest.

[13]  B. Han,et al.  Endobronchial ultrasound-guided transbronchial needle aspiration for staging of lung cancer: a systematic review and meta-analysis. , 2009, European journal of cancer.

[14]  A. Fernández-Villar,et al.  Effectiveness and safety of endobronchial ultrasound–transbronchial needle aspiration: a systematic review , 2009, European Respiratory Journal.

[15]  Soo Hyun Lee,et al.  Endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of lung cancer. , 2010, Lung cancer.

[16]  L. Schwartz,et al.  Utility of on-site evaluation of endobronchial ultrasound-guided transbronchial needle aspiration specimens , 2011, CytoJournal.

[17]  A. Bondi,et al.  Rapid on-site evaluation of transbronchial aspirates in the diagnosis of hilar and mediastinal adenopathy: a randomized trial. , 2011, Chest.

[18]  D. Feller-Kopman,et al.  Diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration: results of the AQuIRE Bronchoscopy Registry. , 2011, Chest.

[19]  L. Yarmus,et al.  A Randomized Prospective Trial of the Utility of Rapid On-Site Evaluation of Transbronchial Needle Aspirate Specimens , 2011, Journal of bronchology & interventional pulmonology.

[20]  G. da Cunha Santos,et al.  A prospective controlled trial of endobronchial ultrasound-guided transbronchial needle aspiration compared with mediastinoscopy for mediastinal lymph node staging of lung cancer. , 2011, The Journal of thoracic and cardiovascular surgery.

[21]  W. Bulman,et al.  Acquisition and processing of endobronchial ultrasound-guided transbronchial needle aspiration specimens in the era of targeted lung cancer chemotherapy. , 2012, American journal of respiratory and critical care medicine.

[22]  M. Oki,et al.  Prospective study of endobronchial ultrasound-guided transbronchial needle aspiration of lymph nodes versus transbronchial lung biopsy of lung tissue for diagnosis of sarcoidosis. , 2012, The Journal of thoracic and cardiovascular surgery.

[23]  M. Oki,et al.  Transesophageal Bronchoscopic Ultrasound-Guided Fine Needle Aspiration for Diagnosis of Sarcoidosis , 2012, Respiration.