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Given an alphabet size $m\in\mathbb{N}$ thought of as a constant, and $\vec{k} = (k_1,\ldots,k_m)$ whose entries sum of up $n$, the $\vec{k}$-multi-slice is the set of vectors $x\in [m]^n$ in which each symbol $i\in [m]$ appears precisely $k_i$ times. We show an invariance principle for low-degree functions over the multi-slice, to functions over the product space $([m]^n,\mu^n)$ in which $\mu(i) = k_i/n$. This answers a question raised by Filmus et al. As applications of the invariance principle, we show: 1. An analogue of the"dictatorship test implies computational hardness"paradigm for problems with perfect completeness, for a certain class of dictatorship tests. Our computational hardness is proved assuming a recent strengthening of the Unique-Games Conjecture, called the Rich $2$-to-$1$ Games Conjecture. Using this analogue, we show that assuming the Rich $2$-to-$1$ Games Conjecture, (a) there is an $r$-ary CSP $\mathcal{P}_r$ for which it is NP-hard to distinguish satisfiable instances of the CSP and instances that are at most $\frac{2r+1}{2^r} + o(1)$ satisfiable, and (b) hardness of distinguishing $3$-colorable graphs, and graphs that do not contain an independent set of size $o(1)$. 2. A reduction of the problem of studying expectations of products of functions on the multi-slice to studying expectations of products of functions on correlated, product spaces. In particular, we are able to deduce analogues of the Gaussian bounds from \cite{MosselGaussian} for the multi-slice. 3. In a companion paper, we show further applications of our invariance principle in extremal combinatorics, and more specifically to proving removal lemmas of a wide family of hypergraphs $H$ called $\zeta$-forests, which is a natural extension of the well-studied case of matchings.