A unified account of cognitive impairments following frontal lobe damage: the role of working memory in complex, organized behavior.

A computer model is presented that performs 4 tasks sometimes impaired by frontal damage: motor sequencing, the Stroop task, the Wisconsin Card Sorting Test, and a context memory task. In each task, patterns of performance typical of frontal-damaged patients are shown to result from the same type of damage to the model, specifically, weakening of associations among elements in working memory. The simulation shows how a single underlying type of damage could result in impairments on a variety of seemingly distinct tasks. Furthermore, the hypothesized damage affects the processing components that carry out the task rather than a distinct central executive.

[1]  HighWire Press Philosophical Transactions of the Royal Society of London , 1781, The London Medical Journal.

[2]  W. Penfield,et al.  THE FRONTAL LOBE IN MAN: A CLINICAL STUDY OF MAXIMUM REMOVALS , 1935 .

[3]  C. Jacobsen,et al.  Studies of cerebral function in primates. I. The functions of the frontal association areas in monkeys. , 1936 .

[4]  Emil L. Post Formal Reductions of the General Combinatorial Decision Problem , 1943 .

[5]  D. A. Grant,et al.  A behavioral analysis of degree of reinforcement and ease of shifting to new responses in a Weigl-type card-sorting problem. , 1948, Journal of experimental psychology.

[6]  F. Plum Handbook of Physiology. , 1960 .

[7]  Karl H. Pribram,et al.  An experimental analysis of the behavioral disturbance produced by a left frontal arachnoidal endothelioma (meningioma) , 1964 .

[8]  J. M. Warren,et al.  THE FRONTAL GRANULAR CORTEX AND BEHAVIOR , 1964 .

[9]  A. Luria,et al.  TWO KINDS OF MOTOR PERSEVERATION IN MASSIVE INJURY OF THE FRONTAL LOBES. , 1965, Brain : a journal of neurology.

[10]  K. Pribram,et al.  Error recognition and utilization produced by injury to the frontal cortex in man. , 1970, Neuropsychologia.

[11]  E. Wilson The Insect Societies , 1974 .

[12]  John R. Anderson,et al.  RECOGNITION AND RETRIEVAL PROCESSES IN FREE RECALL , 1972 .

[13]  E. Perret The left frontal lobe of man and the suppression of habitual responses in verbal categorical behaviour. , 1974, Neuropsychologia.

[14]  G. Bower,et al.  A propositional theory of recognition memory , 1974, Memory & cognition.

[15]  E. Drewe,et al.  The effect of type and area of brain lesion on Wisconsin card sorting test performance. , 1974, Cortex; a journal devoted to the study of the nervous system and behavior.

[16]  H. Nelson A Modified Card Sorting Test Sensitive to Frontal Lobe Defects , 1976, Cortex.

[17]  G. Schwartz,et al.  Consciousness and Self-Regulation , 1976 .

[18]  D. Kimura,et al.  Acquisition of a motor skill after left-hemisphere damage. , 1977, Brain : a journal of neurology.

[19]  W. Kintsch,et al.  Memory and cognition , 1977 .

[20]  J. Webster,et al.  Frontal Lobe Lesions and Behavior* , 1981, Southern medical journal.

[21]  B. Milner,et al.  Performance of complex arm and facial movements after focal brain lesions , 1981, Neuropsychologia.

[22]  D. Kimura,et al.  Left-hemisphere control of oral and brachial movements and their relation to communication. , 1982, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[23]  L. Squire Comparisons between forms of amnesia: some deficits are unique to Korsakoff's syndrome. , 1982, Journal of experimental psychology. Learning, memory, and cognition.

[24]  T. Shallice Specific impairments of planning. , 1982, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[25]  B. Milner Some cognitive effects of frontal-lobe lesions in man. , 1982, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[26]  F. Lhermitte 'Utilization behaviour' and its relation to lesions of the frontal lobes. , 1983, Brain : a journal of neurology.

[27]  A. Kertesz Localization in neuropsychology , 1983 .

[28]  John R. Anderson The Architecture of Cognition , 1983 .

[29]  M. Albert,et al.  Varieties of perseveration , 1984, Neuropsychologia.

[30]  Daniel L. Schacter,et al.  Retrieval without Recollection: An Experimental Analysis of Source Amnesia , 1984 .

[31]  D. Stuss,et al.  Neuropsychological studies of the frontal lobes. , 1984, Psychological bulletin.

[32]  G. W. Jason Manual sequence learning after focal cortical lesions , 1985, Neuropsychologia.

[33]  M Freedman,et al.  Bilateral frontal lobe disease and selective delayed response deficits in humans. , 1986, Behavioral neuroscience.

[34]  E. Hunt,et al.  Unified Model of Attention and Problem Solving. , 1986 .

[35]  J. Duncan Disorganisation of behaviour after frontal lobe damage , 1986 .

[36]  Geoffrey E. Hinton,et al.  Schemata and Sequential Thought Processes in PDP Models , 1986 .

[37]  Donald A. Norman,et al.  Attention to Action , 1986 .

[38]  James L. McClelland,et al.  Parallel distributed processing: explorations in the microstructure of cognition, vol. 1: foundations , 1986 .

[39]  D. Schacter Memory, amnesia, and frontal lobe dysfunction , 1987, Psychobiology.

[40]  P. Langley,et al.  Production system models of learning and development , 1987 .

[41]  Andrew P. Smith,et al.  Memory impairment following ruptured aneurysm of the anterior communicating artery , 1988, Brain and Cognition.

[42]  A. Diamond,et al.  The performance of human infants on a measure of frontal cortex function, the delayed response task. , 1989, Developmental psychobiology.

[43]  J. Changeux,et al.  A Simple Model of Prefrontal Cortex Function in Delayed-Response Tasks , 1989, Journal of Cognitive Neuroscience.

[44]  Daniel S. Levine,et al.  Modeling some effects of frontal lobe damage--Novelty and perseveration , 1989, Neural Networks.

[45]  Arthur P. Shimamura,et al.  Source memory impairment in patients with frontal lobe lesions , 1989, Neuropsychologia.

[46]  M A Just,et al.  From the SelectedWorks of Marcel Adam Just 1990 What one intelligence test measures : A theoretical account of the processing in the Raven Progressive Matrices Test , 2016 .

[47]  Adèle,et al.  The Development and Neural Bases of Higher Cognitive Functions. A conference. May 20-24, 1989, Philadelphia, Pa. , 1990, Annals of the New York Academy of Sciences.

[48]  John R. Anderson The Adaptive Character of Thought , 1990 .

[49]  James L. McClelland,et al.  On the control of automatic processes: a parallel distributed processing account of the Stroop effect. , 1990, Psychological review.

[50]  Arthur P. Shimamura,et al.  Memory for the temporal order of events in patients with frontal lobe lesions and amnesic patients , 1990, Neuropsychologia.

[51]  H. Damasio,et al.  Wisconsin Card Sorting Test performance as a measure of frontal lobe damage. , 1991, Journal of clinical and experimental neuropsychology.

[52]  Colin M. Macleod Half a century of research on the Stroop effect: an integrative review. , 1991, Psychological bulletin.

[53]  T. Shallice,et al.  Deficits in strategy application following frontal lobe damage in man. , 1991, Brain : a journal of neurology.

[54]  J. Changeux,et al.  The Wisconsin Card Sorting Test: theoretical analysis and modeling in a neuronal network. , 1991, Cerebral cortex.

[55]  M. Just,et al.  From the SelectedWorks of Marcel Adam Just 1992 A capacity theory of comprehension : Individual differences in working memory , 2017 .

[56]  J. Cohen,et al.  Context, cortex, and dopamine: a connectionist approach to behavior and biology in schizophrenia. , 1992, Psychological review.

[57]  F. N. Dempster,et al.  The rise and fall of the inhibitory mechanism: Toward a unified theory of cognitive development and aging , 1992 .

[58]  J. Stroop Studies of interference in serial verbal reactions. , 1992 .

[59]  John R. Anderson,et al.  Rules of the Mind , 1993 .