Comment on "Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch"

The uracil base-excision repair pathway has been strongly implicated in the process of immunoglobulin (Ig) heavy chain class switch recombination (CSR) ([ 1 ][1]–[ 4 ][2]). This process likely involves deamination of cytosine residues of the Ig switch region by activation-induced cytidine

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