Genetic evaluation of suspected cases of transient HIV-1 infection of infants.

Detection of human immunodeficiency virus-type 1 (HIV-1) on only one or a few occasions in infants born to infected mothers has been interpreted to indicate that infection may be transient rather than persistent. Forty-two cases of suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants and one mother were reanalyzed. HIV-1 env sequences were not found in specimens from 20; in specimens from 6, somatic genetic analysis revealed that specimens were mistakenly attributed to an infant; and in specimens from 17, phylogenetic analysis failed to demonstrate the expected linkage between the infant's and the mother's virus. These findings argue that transient HIV-1 infection, if it exists, will only rarely be satisfactorily documented.

[1]  E. G. Shpaer,et al.  Genetic relationships determined by a DNA heteroduplex mobility assay: analysis of HIV-1 env genes. , 1993, Science.

[2]  I. Chen,et al.  Clearance of HIV infection in a perinatally infected infant , 1995, The New England journal of medicine.

[3]  E. Holmes,et al.  Molecular investigation of human immunodeficiency virus (HIV) infection in a patient of an HIV-infected surgeon. , 1993, The Journal of infectious diseases.

[4]  M. Kalish,et al.  Early detection of perinatal human immunodeficiency virus (HIV) type 1 infection using HIV RNA amplification and detection. New York City Perinatal HIV Transmission Collaborative Study. , 1997, The Journal of infectious diseases.

[5]  E. Lederer,et al.  Heat-inactivated Sendai virus can enter multiple MHC class I processing pathways and generate cytotoxic T lymphocyte responses in vivo. , 1995, Journal of immunology.

[6]  L. Mofenson,et al.  Zidovudine for the reduction of perinatal human immunodeficiency virus transmission: pediatric AIDS Clinical Trials Group Protocol 076--results and treatment recommendations. , 1995, The Pediatric infectious disease journal.

[7]  R. Koup,et al.  Transient HIV infection in infants. , 1996, The New England journal of medicine.

[8]  E. Abrams,et al.  Repeatedly positive human immunodeficiency virus type 1 DNA polymerase chain reaction in human immunodeficiency virus-exposed seroreverting infants. , 1995, The Pediatric infectious disease journal.

[9]  Richard A Koup,et al.  Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection , 1996, Cell.

[10]  C. Macken,et al.  Maternal HIV-1 viral load and vertical transmission of infection: The Ariel Project for the prevention of HIV transmission from mother to infant , 1997, Nature Medicine.

[11]  L. Moretta,et al.  Occurrence of human immunodeficiency virus type 1 (HIV-1)-specific cytolytic T cell activity in apparently uninfected children born to HIV-1-infected mothers. , 1994, The Journal of infectious diseases.

[12]  J. Skurnick,et al.  PCR analysis of HIV-seronegative, heterosexual partners of HIV-infected individuals. , 1995, Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association.

[13]  C. Giaquinto,et al.  Detection of virus in vertically exposed HIV-antibody-negative children , 1996, The Lancet.

[14]  G. Learn,et al.  Mother-to-infant transmission of human immunodeficiency virus type 1 involving five envelope sequence subtypes , 1997, Journal of virology.