The design of scaffolds for use in tissue engineering. Part I. Traditional factors.

In tissue engineering, a highly porous artificial extracellular matrix or scaffold is required to accommodate mammalian cells and guide their growth and tissue regeneration in three dimensions. However, existing three-dimensional scaffolds for tissue engineering proved less than ideal for actual applications, not only because they lack mechanical strength, but they also do not guarantee interconnected channels. In this paper, the authors analyze the factors necessary to enhance the design and manufacture of scaffolds for use in tissue engineering in terms of materials, structure, and mechanical properties and review the traditional scaffold fabrication methods. Advantages and limitations of these traditional methods are also discussed.

[1]  N. Meyers,et al.  H = W. , 1964, Proceedings of the National Academy of Sciences of the United States of America.

[2]  J. Klawitter,et al.  Application of porous ceramics for the attachment of load bearing internal orthopedic applications , 1971 .

[3]  J M Brady,et al.  Degradation rates of oral resorbable implants (polylactates and polyglycolates): rate modification with changes in PLA/PGA copolymer ratios. , 1977, Journal of biomedical materials research.

[4]  S. Gogolewski,et al.  Resorbable materials of poly(L‐lactide). II. Fibers spun from solutions of poly(L‐lactide) in good solvents , 1983 .

[5]  G. Boering,et al.  Resorbable materials of poly(L-lactide). VII. In vivo and in vitro degradation. , 1987, Biomaterials.

[6]  Michel Vert,et al.  Structure-property relationships in the case of the degradation of massive aliphatic poly-(α-hydroxy acids) in aqueous media , 1990 .

[7]  D E Ingber,et al.  Hepatocyte culture on biodegradable polymeric substrates , 1991, Biotechnology and bioengineering.

[8]  R Langer,et al.  Tissue engineering by cell transplantation using degradable polymer substrates. , 1991, Journal of biomechanical engineering.

[9]  M L Cooper,et al.  In vivo optimization of a living dermal substitute employing cultured human fibroblasts on a biodegradable polyglycolic acid or polyglactin mesh. , 1991, Biomaterials.

[10]  Larry L. Hench,et al.  Bioceramics: From Concept to Clinic , 1991 .

[11]  R Langer,et al.  Switching from differentiation to growth in hepatocytes: Control by extracellular matrix , 1992, Journal of cellular physiology.

[12]  Characterization of a human dermal replacement , 1993 .

[13]  D E Ingber,et al.  Preparation of poly(glycolic acid) bonded fiber structures for cell attachment and transplantation. , 1993, Journal of biomedical materials research.

[14]  H R Allcock,et al.  Design of synthetic polymeric structures for cell transplantation and tissue engineering. , 1993, Clinical materials.

[15]  S. Shalaby,et al.  Biomedical polymers : designed-to-degrade systems , 1994 .

[16]  Robert Langer,et al.  Preparation and characterization of poly(l-lactic acid) foams , 1994 .

[17]  Antonios G. Mikos,et al.  Pore Morphology Effects on the Fibrovascular Tissue Growth in Porous Polymer Substrates , 1994, Cell transplantation.

[18]  C. Colton,et al.  Implantable biohybrid artificial organs. , 1995, Cell transplantation.

[19]  J M Powers,et al.  Fabrication of biodegradable polymer scaffolds to engineer trabecular bone. , 1995, Journal of biomaterials science. Polymer edition.

[20]  J. Vacanti,et al.  Tissue Engineering of Tendon , 1995 .

[21]  J. Vacanti,et al.  Engineered Bone from Polyglycolic Acid Polymer Scaffold and Periosteum , 1995 .

[22]  K. James,et al.  New Biomaterials For Tissue Engineering , 1996 .

[23]  A. Mikos,et al.  The Importance of New Processing Techniques in Tissue Engineering , 1996, MRS bulletin.

[24]  Buddy D. Ratner,et al.  Biomaterials Science: An Introduction to Materials in Medicine , 1996 .

[25]  W M Miller,et al.  Tissue engineering, bioartificial organs, and cell therapies: II. , 1996, Biotechnology and bioengineering.

[26]  Jeffrey A. Hubbell,et al.  Lactide-based poly(ethylene glycol) polymer networks for scaffolds in tissue engineering. , 1996 .

[27]  R Langer,et al.  Novel approach to fabricate porous sponges of poly(D,L-lactic-co-glycolic acid) without the use of organic solvents. , 1996, Biomaterials.

[28]  M. Peshwa,et al.  Tissue engineering, bioartificial organs, and cell therapies: I. , 1996, Biotechnology and bioengineering.

[29]  K. Leong,et al.  Poly(L-lactic acid) foams with cell seeding and controlled-release capacity. , 1996, Journal of biomedical materials research.

[30]  M J Yaszemski,et al.  Bone formation by three-dimensional stromal osteoblast culture in biodegradable polymer scaffolds. , 1997, Journal of biomedical materials research.

[31]  Ted A. Bateman,et al.  Porous Materials for Bone Engineering , 1997 .

[32]  Robert Langer,et al.  Synthesis and Characterization of Photo-Cross-Linked Polymers Based on Poly(l-lactic acid-co-l-aspartic acid) , 1997 .

[33]  Synthetic Extracellular Matrices for Cell Transplantaton , 1997 .

[34]  C. Vacanti,et al.  Tissue Engineered Cartilage , 1997 .

[35]  J. Jansen,et al.  Tissue Engineering of Bone , 1997 .

[36]  Yilin Cao,et al.  Tissue Engineering Cartilage and Bone , 1997 .

[37]  J. Mayer,et al.  New Frontiers in Tissue Engineering: Tissue Engineered Heart Valves , 1997 .

[38]  V. Maquet,et al.  Design of Macroporous Biodegradable Polymer Scaffolds for Cell Transplantation , 1997 .

[39]  Joseph Kost,et al.  Handbook of Biodegradable Polymers , 1998 .

[40]  S. Woo,et al.  Ligament, tendon and fascia , 1998 .

[41]  J. English,et al.  Polyglycolide and polylactide , 1998 .

[42]  M. Sefton,et al.  Tissue engineering. , 1998, Journal of cutaneous medicine and surgery.

[43]  J. Davies,et al.  Three-dimensional matrices of calcium polyphosphates support bone growth in vitro and in vivo , 1998, Journal of materials science. Materials in medicine.

[44]  K E Healy,et al.  Engineering bone regeneration with bioabsorbable scaffolds with novel microarchitecture. , 1999, Tissue engineering.

[45]  A. Mikos,et al.  Growing new organs. , 1999, Scientific American.

[46]  Y. Shikinami,et al.  Bioresorbable devices made of forged composites of hydroxyapatite (HA) particles and poly-L-lactide (PLLA): Part I. Basic characteristics. , 1999, Biomaterials.

[47]  R. Reis,et al.  Dynamic mechanical properties of hydroxyapatite-reinforced and porous starch-based degradable biomaterials , 1999, Journal of materials science. Materials in medicine.

[48]  T. Park,et al.  Biodegradable polymeric microcellular foams by modified thermally induced phase separation method. , 1999, Biomaterials.

[49]  George John,et al.  Synthesis and Characterization of Photo-Cross-Linked Networks Based on l-Lactide/Serine Copolymers† , 1999 .

[50]  C. Patrick,et al.  In vivo evaluation of poly(L-lactic acid) porous conduits for peripheral nerve regeneration. , 1999, Biomaterials.

[51]  R Langer,et al.  Macroporous polymer foams by hydrocarbon templating. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[52]  A Ratcliffe,et al.  Tissue engineering of cartilage. , 2000, Methods in molecular biology.

[53]  K. Leong,et al.  The design of scaffolds for use in tissue engineering. Part II. Rapid prototyping techniques. , 2002, Tissue engineering.

[54]  G. B. Stark,et al.  Tissue engineering of bone , 2002, Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy.

[55]  Scott J. Hollister,et al.  Computational Design, Freeform Fabrication and Testing of Nylon-6 Tissue Engineering Scaffolds , 2002 .

[56]  Teruo Okano,et al.  Challenge to Tissue Engineering , 2003 .