POSITRON EMISSION TOMOGRAPHY FOR IN-VIVO MEASUREMENT OF REGIONAL BLOOD FLOW, OXYGEN UTILISATION, AND BLOOD VOLUME IN PATIENTS WITH BREAST CARCINOMA

Regional blood flow, oxygen extraction ratio, and oxygen utilisation were measured in nine patients with breast carcinoma by means of the oxygen-15 steady-state inhalation technique and positron emission tomography. Regional blood volume was measured by means of tracer amounts of carbon-11-labelled carbon monoxide. The regional blood flow was consistently higher in non-necrotic tumour tissue than in surrounding normal breast tissue or contralateral normal breast. Oxygen utilisation was slightly higher in the tumour. The regional oxygen extraction ratio (ie, the fraction of oxygen extracted from the nutritional blood supply) was appreciably lower in the tumour than in normal breast tissue. These findings suggest that there is, at least on a macroscopic level, no supply-limited impairment of respiration in human breast cancer.

[1]  M E Phelps,et al.  ECAT: a new computerized tomographic imaging system for positron-emitting radiopharmaceuticals. , 1978, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[2]  T Jones,et al.  In vivo disturbance of the oxidative metabolism of glucose in human cerebral gliomas , 1983, Annals of neurology.

[3]  G. Slegers,et al.  Uptake of 13N-ammonia by human tumours as studied by positron emission tomography. , 1982, The British journal of radiology.

[4]  H. Bierman,et al.  Studies on the blood supply of tumors in man. IV. The increased oxygen content of venous blood draining neoplasms. , 1952, Journal of the National Cancer Institute.

[5]  T Jones,et al.  Serial observations on the pathophysiology of acute stroke. The transition from ischaemia to infarction as reflected in regional oxygen extraction. , 1983, Brain : a journal of neurology.

[6]  E. Hall,et al.  Radiobiology for the radiologist , 1973 .

[7]  Macbeth Ra,et al.  Oxygen consumption and anaerobic glycolysis of human malignant and normal tissue. , 1962 .

[8]  O. Warburg On respiratory impairment in cancer cells. , 1956, Science.

[9]  R. Frackowiak,et al.  Quantitative Measurement of Regional Cerebral Blood Flow and Oxygen Metabolism in Man Using 15O and Positron Emission Tomography: Theory, Procedure, and Normal Values , 1980, Journal of computer assisted tomography.

[10]  J. Eys,et al.  Molecular Interrelations of Nutrition and Cancer , 1982 .

[11]  S. G. Burgiss,et al.  Design and Performance Characteristics of a Positron Emission Computed Axial Tomograph--ECAT®-II , 1979, IEEE Transactions on Nuclear Science.

[12]  M. Ter-pogossian,et al.  The continuous inhalation of oxygen-15 for assessing regional oxygen extraction in the brain of man. , 1976, The British journal of radiology.

[13]  J. Shirlaw THE METABOLISM OF TUMOURS , 1931 .

[14]  A A Lammertsma,et al.  Correction for the Presence of Intravascular Oxygen-15 in the Steady-State Technique for Measuring Regional Oxygen Extraction Ratio in the Brain: 1. Description of the Method , 1983, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[15]  Peter J. Ell,et al.  Computed Emission Tomography , 1983 .

[16]  Terry Jones,et al.  Measurement of CBF and CMRO2 using the continuous inhalation of C15O2 and 15O2: Experimental validation using CO2 reactivity in the anaesthetised dog , 1981, Journal of the Neurological Sciences.