FACTORS INFLUENCING IN VITRO EMBRYO PRODUCTION

In vitro embryo production (IVP) is currently one of the most important biotechnologies in cattle breeding and husbandry. However, the efficiency of in vitro embryo production is still low with only 30-40% of oocytes developing into blastocysts, probably because, the in vitro environment cannot mimic in vivo environment and results in embryos that have altered morphology and gene expression. Several factors can influence the IVP efficiency and contribute to the existing differences between in vivo and in vitro produced embryos. There is also evidence showing that IVP can cause some disorders during gestation and in offspring. The aim of this review is to give a brief overview of some factors that influence in vitro embryo development in cattle.

[1]  A. Gutiérrez-Adán,et al.  Long-term effect of in vitro culture of mouse embryos with serum on mRNA expression of imprinting genes, development, and behavior. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[2]  P. Hansen Physiological and cellular adaptations of zebu cattle to thermal stress. , 2004, Animal reproduction science.

[3]  L. Díaz-Cueto,et al.  The influence of growth factors on the development of preimplantation mammalian embryos. , 2001, Archives of medical research.

[4]  H. Callesen,et al.  OOCYTE GROWTH, CAPACITATION AND FINAL MATURATION IN CATTLE , 1997 .

[5]  L. Camargo,et al.  Taurina no desenvolvimento de embriões bovinos fecundados in vitro , 2002 .

[6]  J. Piedrahita,et al.  Errors in development of fetuses and placentas from in vitro-produced bovine embryos. , 2006, Theriogenology.

[7]  D. Gardner,et al.  Changes in requirements and utilization of nutrients during mammalian preimplantation embryo development and their significance in embryo culture. , 1998, Theriogenology.

[8]  S. Walker,et al.  Preimplantation development of in vitro-matured and in vitro-fertilized ovine zygotes: comparison between coculture on oviduct epithelial cell monolayers and culture under low oxygen atmosphere. , 1994, Biology of reproduction.

[9]  I. Mjör In vivo versus in vitro. , 2004, Journal of the American Dental Association.

[10]  J. G. Thompson,et al.  In vitro culture and embryo metabolism of cattle and sheep embryos - a decade of achievement. , 2000, Animal reproduction science.

[11]  B. Bavister,et al.  Culture of preimplantation embryos: facts and artifacts. , 1995, Human reproduction update.

[12]  A. Kruif,et al.  Influence of oxygen tension on apoptosis and hatching in bovine embryos cultured in vitro. , 2003, Theriogenology.

[13]  D. Gardner,et al.  Cryo‐survival and development of bovine blastocysts are enhanced by culture with recombinant albumin and hyaluronan , 2003, Molecular reproduction and development.

[14]  I. Gordon,et al.  Laboratory Production of Cattle Embryos , 1994, Veterinary Research Communications.

[15]  P. Humblot,et al.  Practical measures to improve in vitro blastocyst production in the bovine. , 1998, Theriogenology.

[16]  Z. Roth,et al.  Improvement of quality of oocytes collected in the autumn by enhanced removal of impaired follicles from previously heat-stressed cows. , 2001, Reproduction.

[17]  J. Dietl,et al.  Comparison of two media for sequential culture after IVF and ICSI shows no differences in pregnancy rates: a randomized trial. , 2004, Medical science monitor : international medical journal of experimental and clinical research.

[18]  R. Schultz,et al.  The molecular foundations of the maternal to zygotic transition in the preimplantation embryo. , 2002, Human reproduction update.

[19]  K. Okuda,et al.  Effects of fetal calf serum in culture medium on development of bovine oocytes matured and fertilized in vitro. , 1994, Theriogenology.

[20]  P. Hansen,et al.  Effect of season and exposure to heat stress on oocyte competence in Holstein cows. , 2002, Journal of dairy science.

[21]  D. Gardner,et al.  Metabolism of glucose, pyruvate, and glutamine during the maturation of oocytes derived from pre‐pubertal and adult cows , 1999, Molecular reproduction and development.

[22]  D. Gardner Mammalian embryo culture in the absence of serum or somatic cell support , 1994, Cell biology international.

[23]  P. Bols,et al.  Control of oocyte maturation in cows--biological factors. , 1998, Theriogenology.

[24]  R. Randel,et al.  High environmental temperature and humidity decrease oocyte quality in Bos taurus but not in Bos indicus cows. , 1998, Theriogenology.

[25]  P. Holm,et al.  In vivo versus in vitro produced bovine ova: similarities and differences relevant for practical application. , 1998, Reproduction, nutrition, development.

[26]  R. Godke,et al.  Comparison of hybrid and purebred in vitro-derived cattle embryos during in vitro culture. , 2003, Animal reproduction science.

[27]  P. Hansen,et al.  Genetic divergence in cellular resistance to heat shock in cattle: differences between breeds developed in temperate versus hot climates in responses of preimplantation embryos, reproductive tract tissues and lymphocytes to increased culture temperatures. , 2003, Reproduction.

[28]  R. Krisher,et al.  Developmental competence and metabolism of bovine embryos cultured in semi-defined and defined culture media. , 1999, Biology of reproduction.

[29]  P. Mermillod,et al.  Prepubertal bovine oocyte: A negative model for studying oocyte developmental competence , 1996, Molecular reproduction and development.

[30]  A. Harvey,et al.  Oxygen-Regulated Gene Expression in Bovine Blastocysts1 , 2004, Biology of reproduction.

[31]  B. Brackett,et al.  Effects of culture system and protein supplementation on mRNA expression in pre-implantation bovine embryos. , 2001, Human reproduction.

[32]  J. Lussier,et al.  Growth rates of follicles in the ovary of the cow. , 1987, Journal of reproduction and fertility.

[33]  M. Bahçeci,et al.  Impact of oxygen concentration on embryonic development of mouse zygotes. , 2004, Reproductive biomedicine online.

[34]  D. Lechniak,et al.  The ploidy of in vitro matured bovine oocytes is related to the diameter. , 2002, Theriogenology.

[35]  P. Hansen,et al.  Factors affecting seasonal variation in 90-day nonreturn rate to first service in lactating Holstein cows in a hot climate. , 1999, Journal of dairy science.

[36]  I Wilmut,et al.  Large offspring syndrome in cattle and sheep. , 1998, Reviews of reproduction.

[37]  Hiroyoshi Hoshi,et al.  In vitro production of bovine embryos and their application for embryo transfer. , 2003, Theriogenology.

[38]  R. Webb,et al.  Relationship Between Low-Molecular-Weight Insulin-Like Growth Factor-Binding Proteins, Caspase-3 Activity, and Oocyte Quality1 , 2005, Biology of reproduction.

[39]  Data Retrieval Committee Annual Report-Year 2004 SIGNIFICANT INCREASES IN TRANSFERS OF BOTH IN VIVO DERIVED AND IN VITRO PRODUCED EMBRYOS IN CATTLE AND CONTRASTED TRENDS IN OTHER SPECIES IN 2004 , 2007 .

[40]  D. Gardner,et al.  Use of G1.2/G2.2 media for commercial bovine embryo culture: equivalent development and pregnancy rates compared to co-culture. , 2003, Theriogenology.

[41]  H. Niemann,et al.  Effects of oocyte quality, oxygen tension, embryo density, cumulus cells and energy substrates on cleavage and morula/blastocyst formation of bovine embryos. , 2000, Theriogenology.

[42]  D. Tortonese,et al.  Developmental Capacity In Vitro of Prepubertal Oocytes , 2001, Anatomia, histologia, embryologia.

[43]  A. Lauria,et al.  The effects of epidermal growth factor and insulin-like growth factor I on the metabolic activity, nuclear maturation and subsequent development of cattle oocytes in vitro. , 1998, Journal of reproduction and fertility.

[44]  J. G. Thompson,et al.  Comparison between in vivo-derived and in vitro-produced pre-elongation embryos from domestic ruminants. , 1997, Reproduction, fertility, and development.

[45]  W. Hwang,et al.  Promoting effect of amino acids added to a chemically defined medium on blastocyst formation and blastomere proliferation of bovine embryos cultured in vitro. , 2004, Animal reproduction science.

[46]  J. Viana,et al.  Developmental competence of oocytes from prepubertal Bos indicus crossbred cattle. , 2005, Animal reproduction science.

[47]  P. Hansen,et al.  Inheritance of resistance of bovine preimplantation embryos to heat shock: Relative importance of the maternal versus paternal contribution , 2002, Molecular reproduction and development.

[48]  K. Lu,et al.  Effects of heparin and sperm concentration on cleavage and blastocyst development rates of bovine oocytes inseminated with flow cytometrically-sorted sperm. , 2004, Theriogenology.

[49]  P. Hyttel,et al.  Bovine oocyte diameter in relation to maturational competence and transcriptional activity , 1995, Molecular reproduction and development.

[50]  J. Rutledge,et al.  Parturition following transfer of embryos produced in two media under two oxygen concentrations. , 2005, Animal reproduction science.

[51]  A C Simpson,et al.  Effect of oxygen concentration on in-vitro development of preimplantation sheep and cattle embryos. , 1990, Journal of reproduction and fertility.

[52]  J. Southgate,et al.  Regulation of apoptosis in the bovine blastocyst by insulin and the insulin‐like growth factor (IGF) superfamily , 2002, Molecular Reproduction and Development.

[53]  P. Bredbacka,et al.  Glucose controls sex-related growth rate differences of bovine embryos produced in vitro. , 1996, Journal of reproduction and fertility.

[54]  A. Gutiérrez-Adán,et al.  Bovine Embryo Culture in the Presence or Absence of Serum: Implications for Blastocyst Development, Cryotolerance, and Messenger RNA Expression1 , 2003, Biology of reproduction.

[55]  A. Peterson,et al.  Improving successful pregnancies after embryo transfer. , 2003, Theriogenology.

[56]  R. Boni,et al.  Potential use of ovum pick-up for embryo production and breeding in cattle. , 1994, Theriogenology.

[57]  H. Leese,et al.  Can embryo metabolism be used for selecting bovine embryos before transfer? , 1999, Reproduction, nutrition, development.

[58]  B. Bavister,et al.  In vitro-matured/in vitro-fertilized bovine oocytes can develop into morulae/blastocysts in chemically defined, protein-free culture media. , 1991, Biology of reproduction.

[59]  T. Nagai,et al.  Effects of oxygen tension on the development and quality of porcine in vitro fertilized embryos. , 2004, Theriogenology.

[60]  D. Gardner,et al.  Towards a single embryo transfer. , 2003, Reproductive biomedicine online.

[61]  A. de Kruif,et al.  From co-culture to defined medium: state of the art and practical considerations. , 2001, Reproduction in domestic animals = Zuchthygiene.

[62]  J. Rooke,et al.  Regulation of nutrient uptake and metabolism in pre-elongation ruminant embryos. , 2019, Reproduction (Cambridge, England) Supplement.

[63]  X. Yang,et al.  Higher survival rate of vitrified and thawed in vitro produced bovine blastocysts following culture in defined medium supplemented with beta-mercaptoethanol. , 2006, Animal reproduction science.

[64]  R. Foote,et al.  Effects of O2 concentrations and superoxide dismutase on the development of IVM/IVF bovine embryos in ksom with 2.5 mM hepes , 1995 .

[65]  A. Gutiérrez-Adán,et al.  Effect of the in vitro culture system on the kinetics of blastocyst development and sex ratio of bovine embryos. , 2001, Theriogenology.

[66]  H. A. Samad,et al.  In vitro production of bovine embryos , 2001 .

[67]  J. Rutledge,et al.  Cell allocation in bovine embryos cultured in two media under two oxygen concentrations , 2002, Zygote.

[68]  J. Miles,et al.  Effects of Embryo Culture on Angiogenesis and Morphometry of Bovine Placentas During Early Gestation1 , 2005, Biology of reproduction.

[69]  A. de Kruif,et al.  Effect of bovine herpesvirus‐1 or bovine viral diarrhea virus on development of in vitro‐produced bovine embryos , 1999, Molecular reproduction and development.

[70]  P. Lonergan,et al.  Effect of follicle size on bovine oocyte quality and developmental competence following maturation, fertilization, and culture in vitro , 1994, Molecular reproduction and development.

[71]  D. Ghosh,et al.  Recent developments in endocrinology and paracrinology of blastocyst implantation in the primate. , 1998, Human reproduction update.

[72]  D. Lechniak,et al.  Cytogenetic analysis of bovine parthenotes after spontaneous activation in vitro. , 1998, Theriogenology.

[73]  E. Gómez,et al.  Effects of glucose and protein sources on bovine embryo development in vitro. , 2000, Animal reproduction science.

[74]  H. Leese,et al.  Amino acid metabolism of preimplantation bovine embryos cultured with bovine serum albumin or polyvinyl alcohol. , 2004, Theriogenology.

[75]  T. Fair Follicular oocyte growth and acquisition of developmental competence. , 2003, Animal reproduction science.

[76]  K. Hardy,et al.  Growth factor expression and function in the human and mouse preimplantation embryo. , 2002, The Journal of endocrinology.

[77]  P. Holm,et al.  The effect of oxygen tension on porcine embryonic development is dependent on embryo type. , 2005, Theriogenology.

[78]  M. Lane,et al.  Mechanisms for managing cellular and homeostatic stress in vitro. , 2001, Theriogenology.

[79]  J. Aleksić,et al.  In vitro production of bovine embryos , 2003 .

[80]  D. Salamone,et al.  Biochemical and Developmental Evidence That Ooplasmic Maturation of Prepubertal Bovine Oocytes Is Compromised1 , 2001, Biology of reproduction.

[81]  M. L. Leibfried-Rutledge Factors determining competence of in vitro produced cattle embryos. , 1999, Theriogenology.

[82]  A. Massip,et al.  Cell Cycle Duration at the Time of Maternal Zygotic Transition for In Vitro Produced Bovine Embryos: Effect of Oxygen Tension and Transcription Inhibition1 , 2003, Biology of reproduction.

[83]  S. McGraw,et al.  Transcription Factor Expression Patterns in Bovine In Vitro-Derived Embryos Priorto Maternal-Zygotic Transition1 , 2004, Biology of reproduction.

[84]  J. Robinson,et al.  Development and de novo protein synthetic activity of bovine embryos produced in vitro in different culture systems. , 2001, Theriogenology.

[85]  T. Miyano Bringing up small oocytes to eggs in pigs and cows. , 2003, Theriogenology.

[86]  R. Foote,et al.  Development of bovine embryos in KSOM with added superoxide dismutase and taurine and with five and twenty percent O2. , 1995, Biology of reproduction.

[87]  L. Camargo,et al.  Efeito de concentração espermática e período de incubação oócitoespermatozóides na fecundação in vitro em bovinos da raça Gir , 2002 .

[88]  P. Quinn The development and impact of culture media for assisted reproductive technologies. , 2004, Fertility and sterility.

[89]  P. Holm,et al.  High bovine blastocyst development in a static in vitro production system using SOFaa medium supplemented with sodium citrate and myo-inositol with or without serum-proteins. , 1999, Theriogenology.

[90]  P. Hendriksen,et al.  Bovine follicular development and its effect on the in vitro competence of oocytes. , 2000, Theriogenology.

[91]  D. Stringfellow,et al.  Infectivity of bovine viral diarrhea virus associated with in vivo-derived bovine embryos. , 2004, Theriogenology.

[92]  B. Bavister,et al.  Effects of amino acids on development in vitro of cleavage-stage bovine embryos into blastocysts. , 1996, Reproduction, fertility, and development.

[93]  R. Scaramuzzi,et al.  Heat stress and seasonal effects on reproduction in the dairy cow--a review. , 2003, Theriogenology.

[94]  D. Armstrong Effects of maternal age on oocyte developmental competence. , 2001, Theriogenology.

[95]  S. Voelkel,et al.  Effect of gas atmosphere on the development of one-cell bovine embryos in two culture systems. , 1992, Theriogenology.

[96]  T. McEvoy Manipulation of domestic animal embryos and implications for development. , 2003, Reproduction in domestic animals = Zuchthygiene.

[97]  P. Lonergan,et al.  Effect of protein supplementation and presence of an antioxidant on the development of bovine zygotes in synthetic oviduct fluid medium under high or low oxygen tension. , 1999, Theriogenology.

[98]  R. Meidan,et al.  Impaired reproduction in heat-stressed cattle: basic and applied aspects. , 2000, Animal reproduction science.

[99]  H. Rodríguez-Martínez,et al.  Can we use in vitro fertilization tests to predict semen fertility? , 2000, Animal reproduction science.

[100]  P. Lonergan,et al.  Effect of culture system on the yield and quality of bovine blastocysts as assessed by survival after vitrification. , 2001, Theriogenology.

[101]  B Fischer,et al.  Oxygen tension in the oviduct and uterus of rhesus monkeys, hamsters and rabbits. , 1993, Journal of reproduction and fertility.

[102]  J. Renard,et al.  Evidence of oocyte donor cow effect over oocyte production and embryo development in vitro. , 2003, Reproduction.

[103]  B. Kemp,et al.  Environment of oocyte and embryo determines health of IVP offspring. , 2000, Theriogenology.

[104]  M. Goddard,et al.  Control of events during early cleavage of the mouse embryo: an analysis of the '2-cell block'. , 1983, Journal of embryology and experimental morphology.

[105]  R. Godke,et al.  Age and hormonal dependence of acquisition of oocyte competence for embryogenesis in prepubertal calves. , 1997, Biology of reproduction.

[106]  R. Roberts,et al.  Effects of D‐glucose concentration, D‐fructose, and inhibitors of enzymes of the pentose phosphate pathway on the development and sex ratio of bovine blastocysts , 2005, Molecular reproduction and development.

[107]  P. Lonergan,et al.  Effect of culture environment on gene expression and developmental characteristics in IVF-derived embryos. , 2006, Theriogenology.

[108]  D. Beebe,et al.  Microfluidic technology for assisted reproduction. , 2002, Theriogenology.

[109]  F. Dessy,et al.  Embryo production by ovum pick up in unstimulated calves before and after puberty. , 1999, Theriogenology.

[110]  A. Crosier,et al.  Influence of in vitro systems on embryo survival and fetal development in cattle. , 2001, Theriogenology.

[111]  N. Minami,et al.  Postnatal weight of calves derived from in vitro matured and in vitro fertilized embryos developed under various oxygen concentrations. , 2000, Reproduction, fertility, and development.

[112]  J. Rutledge,et al.  Estimates of heterosis for in vitro embryo production using reciprocal crosses in cattle. , 2000, Theriogenology.

[113]  H. Hoshi,et al.  Accumulation of cytoplasmic lipid droplets in bovine embryos and cryotolerance of embryos developed in different culture systems using serum‐free or serum‐containing media , 2002, Molecular reproduction and development.

[114]  B. Brackett,et al.  Influences of epidermal growth factor and insulin-like growth factor-I on bovine blastocyst development in vitro. , 2003, Animal reproduction science.