Downregulation of cilia-localized Il-6R (cid:1) by 17 (cid:2) -estradiol in mouse and human fallopian tubes

H. Downregulation of cilia-localized Il-6R (cid:1) by 17 (cid:2) -estradiol in mouse and human fallopian tubes. Am J Physiol Cell Physiol 297: C140–C151, 2009. 2009; doi:10.1152/ajpcell.00047.2009.—The action of inter-leukin-6 (IL-6) impacts female reproduction. Although IL-6 was recently shown to inhibit cilia activity in human fallopian tubes in vitro, the molecular mechanisms underlying IL-6 signaling to tubal function remain elusive. Here, we investigate the cellular localization, regulation, and possible function of two IL-6 receptors (IL-6R (cid:1) and gp130) in mouse and human fallopian tubes in vivo. We show that IL-6R (cid:1) wild-type female days old for both used in in detection methods cel-

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