Metastatic Large Cell Neuroendocrine Carcinoma Combined with Gastric Adenocarcinoma

M.D.Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, KoreaA 67 year-old man was admitted due to findings that were suspicious for ma-lignancy on gastroscopy at a primary clinic. We also performed gastroscopy and this showed the presence of a 3 cm sized nodular elevated lesion at the angle of the stomach. A biopsy demonstrated the presence of adenocarcinoma of the stomach. A distal gastrectomy with D2 lymph node dissection was performed and the microscopic features of the resected specimen confirmed the diagnosis of ade-nocarcinoma of the stomach and also metastatic large cell neuroendocrine car-cinoma of lymph nodes of an unknown primary origin. Although double primary gastric adenocarcinoma and gastric neuroendocrine tumor with regional lymph node metastasis has been seldom reported, a double primary carcinoma of gastric adenocarcinoma and metastatic large cell neuroendocrine carcinoma of lymph nodes has seldom been reported. We report on this unusual case along with a review of the relevant medical literature.