Injection molded plastic lens for relay lens system and optical imaging probe

In this study, we designed, fabricated and characterized a plastic lens which can be used as an optical compartment of a relay lens system for a disposable endoscope or an imaging probe for optical-resolution photoacoustic microscopy (OR-PAM). Cost-effective injection molding using polycarbonate (PC) as a material was conducted for the mass production of the PC lens. The effects of important processing parameters, i.e. mold temperature, injection speed, packing pressure and packing time, on the transcription quality of the PC lenses were investigated quantitatively using the design of experiments based on the Taguchi method. Optical performances, i.e., focal length and birefringence, were evaluated to determine the optimal injection molding condition for the replication. The PC lenses facilitated the feasibility of developing a disposable length-adjustable endoscope comprising a relay lens system. The PC lens was also applied to an optical imaging probe in an OR-PAM for in vivo observation of mouse micro-vasculatures.

[1]  Rudolf Kingslake A New Bench for Testing Photographic Lenses , 1932 .

[2]  R. Morent,et al.  Progress in polymer science: Edited by A. D. Jenkins Pergamon Press, Oxford, 1971, 303 pp. £8.50 , 1972 .

[3]  A. Isayev Orientation development in the injection molding of amorphous polymers , 1983 .

[4]  B. Littenberg,et al.  Disposable, sheathed, flexible sigmoidoscopy: a prospective, multicenter, randomized trial. The Disposable Endoscope Study Group. , 1995, Gastrointestinal endoscopy.

[5]  R. Wimberger-Friedl The assessment of orientation, stress and density distributions in injection-molded amorphous polymers by optical techniques , 1995 .

[6]  A. J. Bur,et al.  In‐situ monitoring of product shrinkage during injection molding using an optical sensor , 1999 .

[7]  E. G. Hahn,et al.  Disposable-sheath, flexible gastroscope system versus standard gastroscopes: a prospective, randomized trial. , 1999, Gastrointestinal endoscopy.

[8]  J. Rizzo,et al.  A performance, safety and cost comparison of reusable and disposable endoscopic biopsy forceps: a prospective, randomized trial. , 2000, Gastrointestinal endoscopy.

[9]  T. Kwon,et al.  Modeling and numerical simulation of residual stresses and birefringence in injection molded center-gated disks , 2001 .

[10]  Xuehong Lu,et al.  A statistical experimental study of the injection molding of optical lenses , 2001 .

[11]  Victor L. Genberg,et al.  Stress birefringence modeling for lens design and photonics , 2002, International Optical Design Conference.

[12]  Jin-Woo Choi,et al.  Disposable smart lab on a chip for point-of-care clinical diagnostics , 2004, Proceedings of the IEEE.

[13]  Dong Sung Kim,et al.  Replication of microlens arrays by injection molding , 2004 .

[14]  Matthew D. Chidley,et al.  In vivo fiber-optic confocal reflectance microscope with an injection-molded plastic miniature objective lens. , 2005, Applied optics.

[15]  Dong Sung Kim,et al.  Disposable integrated microfluidic biochip for blood typing by plastic microinjection moulding. , 2006, Lab on a chip.

[16]  T. Kwon,et al.  A study of birefringence, residual stress and final shrinkage for precision injection molded parts , 2007 .

[17]  F. Kung,et al.  Optimizations of the Processing Parameters of High-Performance Engineering Plastic in Injection Molding , 2008 .

[18]  Dong Sung Kim,et al.  Experimental characterization of transcription properties of microchannel geometry fabricated by injection molding based on Taguchi method , 2008 .

[19]  Kuo-Ming Tsai,et al.  A study of the effects of process parameters for injection molding on surface quality of optical lenses , 2009 .

[20]  Jong Deok Kim,et al.  Replication and comparison of concave and convex microlens arrays of light guide plate for liquid crystal display in injection molding , 2010 .

[21]  Lihong V. Wang,et al.  In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths. , 2010, Chemical reviews.

[22]  Christian Hopmann,et al.  Analysis of lens manufacturing with injection molding , 2012 .

[23]  Jeehyun Kim,et al.  Objective-free optical-resolution photoacoustic microscopy , 2013, Journal of biomedical optics.

[24]  Dong Sung Kim,et al.  A centrifugal force-based serpentine micromixer (CSM) on a plastic lab-on-a-disk for biochemical assays , 2013 .

[25]  R. Spina,et al.  Analysis of polymer crystallization and residual stresses in injection molded parts , 2014 .