Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells
暂无分享,去创建一个
Jiri Aubrecht | Andrew Williams | Carole L. Yauk | Leslie Recio | Daniel R. Hyduke | Albert J. Fornace | Carol D. Swartz | A. Fornace | D. Hyduke | I. Moffat | Andrew Williams | C. Yauk | J. Aubrecht | Heng-Hong Li | C. Swartz | L. Recio | Julie K. Buick | Heng‐Hong Li | Ivy Moffat
[1] Alan E. Hubbard,et al. Effect of Chemical Mutagens and Carcinogens on Gene Expression Profiles in Human TK6 Cells , 2012, PloS one.
[2] S. O. Mueller,et al. Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. , 2011, Toxicological sciences : an official journal of the Society of Toxicology.
[3] Peter Kasper,et al. Relevance and follow-up of positive results in in vitro genetic toxicity assays: an ILSI-HESI initiative. , 2007, Mutation research.
[4] Center for Food Safety and Applied Nutrition. , 1997, Nutrition reviews.
[5] T Sofuni,et al. ICH-harmonised guidances on genotoxicity testing of pharmaceuticals: evolution, reasoning and impact. , 1999, Mutation research.
[6] J. Kleinjans,et al. A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. , 2012, Carcinogenesis.
[7] A. Hubbard,et al. Correction: Effect of Chemical Mutagens and Carcinogens on Gene Expression Profiles in Human TK6 Cells , 2012, PLoS ONE.
[8] Shibing Deng,et al. Characterization and interlaboratory comparison of a gene expression signature for differentiating genotoxic mechanisms. , 2009, Toxicological sciences : an official journal of the Society of Toxicology.
[9] Jiri Aubrecht,et al. Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water , 2015, Critical reviews in toxicology.
[10] Rupert G. Miller. Simultaneous Statistical Inference , 1966 .
[11] Jason E. Stewart,et al. Minimum information about a microarray experiment (MIAME)—toward standards for microarray data , 2001, Nature Genetics.
[12] G. L. Kedderis,et al. Dose-response assessment of naphthalene-induced genotoxicity and glutathione detoxication in human TK6 lymphoblasts. , 2012, Toxicological sciences : an official journal of the Society of Toxicology.
[13] G. Warnes,et al. Differentiation of DNA reactive and non-reactive genotoxic mechanisms using gene expression profile analysis. , 2004, Mutation research.
[14] Michael L Bittner,et al. Stress-specific signatures: expression profiling of p53 wild-type and -null human cells , 2005, Oncogene.
[15] Raffaella Corvi,et al. Toxicogenomics applied to in vitro carcinogenicity testing with Balb/c 3T3 cells revealed a gene signature predictive of chemical carcinogens. , 2010, Toxicological sciences : an official journal of the Society of Toxicology.
[16] R. Tibshirani,et al. Diagnosis of multiple cancer types by shrunken centroids of gene expression , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[17] G. Churchill,et al. Statistical design and the analysis of gene expression microarray data. , 2007, Genetical research.
[18] D. Watson,et al. Relationships between genomic, cell cycle, and mutagenic responses of TK6 cells exposed to DNA damaging chemicals. , 2005, Mutation research.
[19] Jiri Aubrecht,et al. Development of a toxicogenomics signature for genotoxicity using a dose‐optimization and informatics strategy in human cells , 2015, Environmental and molecular mutagenesis.
[20] GUIDANCE DOCUMENT,et al. Guidance on Genotoxicity Testing and Data Interpretation for Pharmaceuticals Intended for Human Use , 2008 .
[21] H. Yamazaki,et al. Binding of diverse environmental chemicals with human cytochromes P450 2A13, 2A6, and 1B1 and enzyme inhibition. , 2013, Chemical research in toxicology.
[22] Marilyn J Aardema,et al. Identification of a gene expression profile that discriminates indirect-acting genotoxins from direct-acting genotoxins. , 2004, Mutation research.
[23] Jiri Aubrecht,et al. Voluntary exploratory data submissions to the US FDA and the EMA: experience and impact , 2010, Nature Reviews Drug Discovery.
[24] J. Kleinjans,et al. Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models. , 2013, Carcinogenesis.
[25] M. Hayashi,et al. Summary of major conclusions from the 5th IWGT, Basel, Switzerland, 17-19 August 2009. , 2011, Mutation research.
[26] Thorsten Dickhaus,et al. Simultaneous Statistical Inference , 2014, Springer Berlin Heidelberg.
[27] Perikles Simon,et al. Q-Gene: Processing Quantitative Real-time RT-PCR Data , 2003, Bioinform..