A sensitive glucose biosensor without using glucose test strips based on ZnO/SiO2/Si surface acoustic wave device

Abstract A sensitive glucose biosensor without using glucose test strips was fabricated based on a ZnO/SiO2/Si surface acoustic wave (SAW) device. The SAW devices were functionalized by immobilizing glucose oxidase onto a pH-sensitive polymer which was coated on the sensitive area of the SAW device. The sensitivity of the SAW glucose biosensor was 1.589 MHz/mM and the detection limit was lower than 6.29×10−4 mM, which was sensitive enough for glucose testing. The SAW glucose biosensor system showed good anti-interference to ascorbic acid, lactic acid and uric acid. The SAW glucose biosensor system kept a constant differential frequency for 10 h, demonstrating a good degree of reversibility and stability.

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