Synthesis and antimycobacterial evaluation of pyrazinamide derivatives with benzylamino substitution.

[1]  V. Buchta,et al.  Antimicrobial activity of sulfonamides containing 5-chloro-2-hydroxybenzaldehyde and 5-chloro-2-hydroxybenzoic acid scaffold. , 2012, European journal of medicinal chemistry.

[2]  J. Jampílek,et al.  Synthesis and antimycobacterial evaluation of N-substituted 3-aminopyrazine-2,5-dicarbonitriles. , 2012, Bioorganic & medicinal chemistry letters.

[3]  Ying Zhang,et al.  Pyrazinamide Inhibits Trans-Translation in Mycobacterium tuberculosis , 2011, Science.

[4]  W. Jacobs,et al.  Pyrazinamide, but not pyrazinoic acid, is a competitive inhibitor of NADPH binding to Mycobacterium tuberculosis fatty acid synthase I. , 2011, Bioorganic & medicinal chemistry letters.

[5]  P. Jílek,et al.  Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides. , 2011, Bioorganic & medicinal chemistry.

[6]  P. Wangikar,et al.  Studies on toxicity of antitubercular drugs namely isoniazid, rifampicin, and pyrazinamide in an in vitro model of HepG2 cell line , 2011, Medicinal Chemistry Research.

[7]  W. Peters,et al.  Isoniazid and its toxic metabolite hydrazine induce in vitro pyrazinamide toxicity. , 2008, International journal of antimicrobial agents.

[8]  A. J. van der Ven,et al.  Antituberculosis drug‐induced hepatotoxicity: Concise up‐to‐date review , 2008, Journal of gastroenterology and hepatology.

[9]  V. Buchta,et al.  Synthesis, Antimycobacterial and Antifungal Evaluation of 3‐Arylaminopyrazine‐2,5‐dicarbonitriles , 2008, Archiv der Pharmazie.

[10]  W. Jacobs,et al.  Inhibition of Isolated Mycobacterium tuberculosis Fatty Acid Synthase I by Pyrazinamide Analogs , 2007, Antimicrobial Agents and Chemotherapy.

[11]  C. Leung,et al.  Antituberculosis drugs and hepatotoxicity , 2006, American journal of respiratory and critical care medicine.

[12]  C. Vilchèze,et al.  Pyrazinoic Acid and Its n-Propyl Ester Inhibit Fatty Acid Synthase Type I in Replicating Tubercle Bacilli , 2006, Antimicrobial Agents and Chemotherapy.

[13]  D. Šatínský,et al.  Novel Regioselective Preparation of 5-Chloropyrazine-2-Carbonitrile from Pyrazine-2-Carboxamide and Coupling Study of Substituted Phenylsulfanylpyrazine- 2-Carboxylic Acid Derivatives , 2005 .

[14]  Clifton E. Barry,et al.  Effects of Pyrazinamide on Fatty Acid Synthesis by Whole Mycobacterial Cells and Purified Fatty Acid Synthase I , 2002, Journal of bacteriology.

[15]  William R. Jacobs,et al.  Pyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosis , 2000, Nature Medicine.

[16]  V. Buchta,et al.  SYNTHESIS AND ANTITUBERCULOTIC ACTIVITY OF SOME SUBSTITUTED 3-ARYLAMINO-5-CYANO-2-PYRAZINECARBOXAMIDES , 1995 .

[17]  A. Lyčka,et al.  Synthesis and 1H and 13C NMR spectra of sulfur derivatives of pyrazine derived from amidation product of 2-chloropyrazine and 6-chloro-2-pyrazinecarbonitrile. Tuberculostatic activity , 1990 .