Targeting of colloidal particles to the bone marrow.

Since intravenously administered colloidal particles are normally removed efficiently by the reticuloendothelial cells of the liver and spleen only a small fraction of these particles will reach the bone marrow. By coating model microspheres with a block co-polymer (poloxamer 407) it has been possible effectively to hinder the liver/spleen uptake and obtain a deposition of the microspheres primarily in the bone marrow. Such a carrier system will have application in radiodiagnosis and for treatment of various diseases in the bone marrow.

[1]  T. Saba.  Physiology and physiopathology of the reticuloendothelial system. , 1970, Archives of internal medicine.

[2]  S. Davis,et al.  The organ uptake of intravenously administered colloidal particles can be altered using a non‐ionic surfactant (Poloxamer 338) , 1984, FEBS letters.

[3]  Clive G. Wilson,et al.  Blood clearance and organ deposition of intravenously administered colloidal particles. The effects of particle size, nature and shape , 1982 .

[4]  F. Johnston,et al.  A Radiation-Induced Bonding of Iodine at the Surface of Uniform Polystyrene Particles , 1974 .

[5]  H. Hoshi,et al.  Uptake of carbon and polystyrene particles by the sinusoidal endothelium of rabbit bone marrow and liver and rat bone marrow, with special reference to multiparticle-pinocytosis. , 1984, Archivum histologicum Japonicum = Nihon soshikigaku kiroku.

[6]  H. Anger,et al.  THE EFFECT OF ERYTHROPOIETIC STIMULATION ON MARROW DISTRIBUTION IN MAN, RABBIT AND RAT AS SHOWN BY FE59 AND FE52. , 1964, Blood.

[7]  G. Gagne,et al.  A new formulation of Tc-99m minimicroaggregated albumin for marrow imaging: comparison with other colloids, In-111 and Fe-59. , 1982, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[8]  S. Davis,et al.  Effect of a selected suppression of the reticuloendothelial system on the distribution of model carrier particles. , 1986, Journal of pharmaceutical sciences.

[9]  B. Benacerraf,et al.  The clearance of antigen antibody complexes from the blood by the reticuloendothelial system. , 1959, Journal of immunology.

[10]  D. Rawlins,et al.  Adsorption characteristics of certain polyoxyethylene-polyoxypropylene block co-polymers on polystyrene latex , 1979 .

[11]  S. Davis,et al.  The effect of hydrophilic coatings on the uptake of colloidal particles by the liver and by peritoneal macrophages , 1986 .