Controlled attenuation parameter is correlated with actual hepatic fat content in patients with non‐alcoholic fatty liver disease with none‐to‐mild obesity and liver fibrosis

Aim: Non‐invasive steatosis‐quantifying methods are required for non‐alcoholic fatty liver disease (NAFLD) patients in order to monitor disease severity and assess therapeutic efficacy. Controlled attenuation parameter (CAP) evaluated with vibration‐controlled transient elastography can predict the presence of steatosis, but its application to absolute hepatic fat quantitation remains unclear. The aim of this st\udy was to examine whether CAP is correlated with real hepatic fat content in NAFLD patients.

[1]  Z. Goodman,et al.  Epidemiology and natural history of non-alcoholic fatty liver disease. , 2016, Metabolism: clinical and experimental.

[2]  Q. Pan,et al.  Impact of skin capsular distance on the performance of controlled attenuation parameter in patients with chronic liver disease , 2015, Liver international : official journal of the International Association for the Study of the Liver.

[3]  F. Gonzalez,et al.  Steatogenesis in adult-onset type II citrullinemia is associated with down-regulation of PPARα. , 2015, Biochimica et biophysica acta.

[4]  K. Yoshioka,et al.  Measurement of liver stiffness as a non‐invasive method for diagnosis of non‐alcoholic fatty liver disease , 2015, Hepatology research : the official journal of the Japan Society of Hepatology.

[5]  Katsutoshi Tokushige,et al.  Diagnosis and classification of non‐alcoholic fatty liver disease and non‐alcoholic steatohepatitis: Current concepts and remaining challenges , 2015, Hepatology research : the official journal of the Japan Society of Hepatology.

[6]  A. Dhawan,et al.  Noninvasive biomarkers in non-alcoholic fatty liver disease: current status and a glimpse of the future. , 2014, World journal of gastroenterology.

[7]  Nik Raihan Nik Mustapha,et al.  Controlled attenuation parameter for the detection and quantification of hepatic steatosis in nonalcoholic fatty liver disease , 2014, Journal of gastroenterology and hepatology.

[8]  H. Cao,et al.  Controlled attenuation parameter for non-invasive assessment of hepatic steatosis in Chinese patients. , 2014, World journal of gastroenterology.

[9]  Yoshito Itoh,et al.  Limitations of liver biopsy and non-invasive diagnostic tests for the diagnosis of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. , 2014, World journal of gastroenterology.

[10]  S. Ahn,et al.  Controlled attenuation parameter (CAP) for detection of hepatic steatosis in patients with chronic liver diseases: a prospective study of a native Korean population , 2014, Liver international : official journal of the International Association for the Study of the Liver.

[11]  M. Yoneda Utility of controlled attenuation parameter measurement for assessing liver steatosis in Japanese patients with chronic liver diseases , 2013, Hepatology research : the official journal of the Japan Society of Hepatology.

[12]  A. Pollett,et al.  Controlled Attenuation Parameter (CAP): a noninvasive method for the detection of hepatic steatosis based on transient elastography , 2012, Liver international : official journal of the International Association for the Study of the Liver.

[13]  J. Vergniol,et al.  Non‐invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography , 2012, Liver international : official journal of the International Association for the Study of the Liver.

[14]  Jonathan C. Cohen,et al.  Human Fatty Liver Disease: Old Questions and New Insights , 2011, Science.

[15]  T. Aoyama,et al.  Clinical characteristics of de novo nonalcoholic fatty liver disease following pancreaticoduodenectomy , 2011, Journal of Gastroenterology.

[16]  O. Cummings,et al.  Generalizability of the Nonalcoholic Steatohepatitis Clinical Research Network Histologic Scoring System for Nonalcoholic Fatty Liver Disease , 2011, Journal of clinical gastroenterology.

[17]  Tomoko Nishizawa,et al.  Down-regulation of Srebp-1c Is Associated with the Development of Burned-out Nash Running Title: Down-regulation of Srebp-1c with Nafld Progression , 2022 .

[18]  M. Kadoya,et al.  Accurate and simple method for quantification of hepatic fat content using magnetic resonance imaging: a prospective study in biopsy-proven nonalcoholic fatty liver disease , 2010, Journal of Gastroenterology.

[19]  T. Aoyama,et al.  Serum Fragmented Cytokeratin 18 Levels Reflect the Histologic Activity Score of Nonalcoholic Fatty Liver Disease More Accurately Than Serum Alanine Aminotransferase Levels , 2010, Journal of clinical gastroenterology.

[20]  T. Saheki,et al.  Citrin deficiency as a cause of chronic liver disorder mimicking non-alcoholic fatty liver disease. , 2008, Journal of hepatology.

[21]  T. Aoyama,et al.  Development from simple steatosis to liver cirrhosis and hepatocellular carcinoma: a 27-year follow-up case , 2008, Clinical journal of gastroenterology.

[22]  Laurent Castera,et al.  Non-invasive evaluation of liver fibrosis using transient elastography. , 2008, Journal of hepatology.

[23]  V. de Lédinghen,et al.  Prevalence and factors associated with failure of liver stiffness measurement using FibroScan in a prospective study of 2114 examinations , 2006, European journal of gastroenterology & hepatology.

[24]  P. Giral,et al.  Sampling variability of liver biopsy in nonalcoholic fatty liver disease. , 2005, Gastroenterology.

[25]  O. Cummings,et al.  Design and validation of a histological scoring system for nonalcoholic fatty liver disease , 2005, Hepatology.

[26]  F. Brunello,et al.  Reliability of transient elastography for the detection of fibrosis in non-alcoholic fatty liver disease and chronic viral hepatitis. , 2011, Journal of hepatology.

[27]  E. Oda New criteria for 'obesity disease' in Japan. , 2006, Circulation journal : official journal of the Japanese Circulation Society.

[28]  Eiji Oda,et al.  New criteria for 'obesity disease' in Japan. , 2002, Circulation journal : official journal of the Japanese Circulation Society.