Association between global biomarker of oxidative stress and quantitative ultrasound parameters in middle-aged and elderly adults: A cross-sectional study

Introduction With the population aging, osteoporosis has become a major public health concern. Elevated oxidative stress is a vital detrimental factor for bone health. Compared to common oxidative stress-related biomarkers, Fluorescent Oxidation Products (FlOPs) reflect the global levels of oxidation from proteins, lipids, and DNA. Nevertheless, whether plasma FlOP levels are related to bone health measured by Quantitative ultrasound (QUS) is unclear. Thus, the present study examined the association between FlOPs and QUS parameters in middle-aged and elderly adults. Methods This community-based cross-sectional study was conducted in Changchun, northeast China. Plasma FlOPs were determined by a fluorescent microplate reader at a wavelength of 320/420 nm (excitation/emission). QUS parameters [speed of sound (SOS) and broadband ultrasound attenuation (BUA)] of the calcaneus were assessed by an ultrasound bone densitometer. We used multivariable linear regression to examine the association between FlOPs and QUS parameters. Results A total of 491 subjects were included in this study. Their average age was 65.2 years (standard deviation [SD]: 9.7 years). FlOPs were inversely associated with SOS (β for an increase of logarithmic interquartile range = −10.64; P = 0.018). Higher FlOP levels were marginally associated with lower SOS in females (β for an increase of logarithmic interquartile range = −9.68, P = 0.066), but not in males (β for an increase of logarithmic interquartile range = −11.84, P = 0.131). No significant relationship between FlOPs and BUA was observed. Conclusions Plasma FlOP levels were inversely associated with SOS, but not with BUA in middle-aged and elderly adults.

[1]  Wenfei Zhu,et al.  Sociodemographic and behavioral influences on multimorbidity among adult residents of northeastern China , 2022, BMC Public Health.

[2]  R. Maggi,et al.  Sex Steroid Regulation of Oxidative Stress in Bone Cells: An In Vitro Study , 2021, International journal of environmental research and public health.

[3]  A. Vuong,et al.  Plasma Fluorescent Oxidation Products and Bone Mineral Density Among Male Veterans: A Cross-Sectional Study. , 2021, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.

[4]  Jeff S. Kimball,et al.  Oxidative Stress and Osteoporosis. , 2021, The Journal of bone and joint surgery. American volume.

[5]  Wassan Nori,et al.  Lower Serum Irisin Levels Are Associated with Increased Osteoporosis and Oxidative Stress in Postmenopausal. , 2021, Reports of biochemistry & molecular biology.

[6]  Fulong Zhao,et al.  Correlation of oxidative stress-related biomarkers with postmenopausal osteoporosis: a systematic review and meta-analysis , 2021, Archives of Osteoporosis.

[7]  2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2021. , 2020, Diabetes care.

[8]  Houyi Sun,et al.  ROS signaling cascades: dual regulations for osteoclast and osteoblast. , 2020, Acta biochimica et biophysica Sinica.

[9]  L. Qin,et al.  Bajitianwan attenuates D-galactose-induced memory impairment and bone loss through suppression of oxidative stress in aging rat model. , 2020, Journal of ethnopharmacology.

[10]  S. Kasper,et al.  Identification of Differential Patterns of Oxidative Biomarkers in Prostate Cancer Progression. , 2019, Clinical genitourinary cancer.

[11]  Chaekyun Kim,et al.  Reactive Oxygen Species in Osteoclast Differentiation and Possible Pharmaceutical Targets of ROS-Mediated Osteoclast Diseases , 2019, International journal of molecular sciences.

[12]  D. Goltzman,et al.  Longitudinal assessment of health-related quality of life in osteoporosis: data from the population-based Canadian Multicentre Osteoporosis Study , 2019, Osteoporosis International.

[13]  Wenjun Zhang,et al.  Upregulation of SIRT1 inhibits H2O2‑induced osteoblast apoptosis via FoxO1/β‑catenin pathway. , 2018, Molecular medicine reports.

[14]  P. Abete,et al.  Oxidative stress, aging, and diseases , 2018, Clinical interventions in aging.

[15]  Wenjun Zhang,et al.  Upregulation of SIRT 1 inhibits H 2 O 2 ‐ induced osteoblast apoptosis via FoxO 1 / β ‐ catenin pathway , 2018 .

[16]  Yining Sun,et al.  Impact of Age, Gender, and Body Composition on Bone Quality in an Adult Population From the Middle Areas of China. , 2018, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.

[17]  J. Fleet.  The role of vitamin D in the endocrinology controlling calcium homeostasis , 2017, Molecular and Cellular Endocrinology.

[18]  Didier Hans,et al.  Quantitative Ultrasound (QUS) in the Management of Osteoporosis and Assessment of Fracture Risk. , 2017, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.

[19]  F. Altieri,et al.  Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans , 2017, Oxidative medicine and cellular longevity.

[20]  M. Brandi,et al.  Oxidative stress in bone remodeling: role of antioxidants. , 2017, Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases.

[21]  T. Link,et al.  Bone Quality—Beyond Bone Mineral Density , 2016, Seminars in Musculoskeletal Radiology.

[22]  Yue Wang,et al.  Protein Phosphatase 2A Mediates Oxidative Stress Induced Apoptosis in Osteoblasts , 2015, Mediators of inflammation.

[23]  Zhao‐ming Zhong,et al.  Advanced Oxidation Protein Products as a Novel Marker of Oxidative Stress in Postmenopausal Osteoporosis , 2015, Medical science monitor : international medical journal of experimental and clinical research.

[24]  P. V. von Hurst,et al.  Factors Affecting 25-Hydroxyvitamin D Concentration in Response to Vitamin D Supplementation , 2015, Nutrients.

[25]  P. Garnero.  The Role of Collagen Organization on the Properties of Bone , 2015, Calcified Tissue International.

[26]  Jean X. Jiang,et al.  Reactive oxygen species and oxidative stress in osteoclastogenesis, skeletal aging and bone diseases , 2015, Journal of Bone and Mineral Metabolism.

[27]  A. Palmer,et al.  Projection of osteoporosis-related fractures and costs in China: 2010–2050 , 2015, Osteoporosis International.

[28]  J. González‐Macías,et al.  Serum uric acid is associated with quantitative ultrasound parameters in men: data from the Camargo cohort , 2015, Osteoporosis International.

[29]  D. Feskanich,et al.  Association Between Global Biomarkers of Oxidative Stress and Hip Fracture in Postmenopausal Women: A Prospective Study , 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[30]  A. Hofman,et al.  The association between plasma homocysteine levels and bone quality and bone mineral density parameters in older persons. , 2014, Bone.

[31]  S. Ima-Nirwana,et al.  Calcaneal Quantitative Ultrasound as a Determinant of Bone Health Status: What Properties of Bone Does It Reflect? , 2013, International journal of medical sciences.

[32]  K. Lee.  Correlations of linear and nonlinear ultrasound parameters with density and microarchitectural parameters in trabecular bone. , 2013, The Journal of the Acoustical Society of America.

[33]  Hans-Joachim Appell Coriolano,et al.  Bone Quality: The Determinants of Bone Strength and Fragility , 2013, Sports Medicine.

[34]  Won-Young Lee,et al.  Association of Oxidative Stress with Postmenopausal Osteoporosis and the Effects of Hydrogen Peroxide on Osteoclast Formation in Human Bone Marrow Cell Cultures , 2010, Calcified Tissue International.

[35]  Nicholas Harvey,et al.  Osteoporosis: impact on health and economics , 2010, Nature Reviews Rheumatology.

[36]  T. Link,et al.  Quantitative ultrasound in the assessment of skeletal status , 2009, European Radiology.

[37]  E. Rimm,et al.  Plasma fluorescent oxidation products as potential markers of oxidative stress for epidemiologic studies. , 2007, American journal of epidemiology.

[38]  J. Manson,et al.  Prospective Study of , 2007 .

[39]  E. Rimm,et al.  Stability of measurements of biomarkers of oxidative stress in blood over 36 hours. , 2004, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[40]  Hang Zheng,et al.  Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB. , 2004, Biochemical and biophysical research communications.

[41]  Daniel W. Jones,et al.  The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. , 2003, JAMA.

[42]  Zhou Bei‐Fan.  Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults: study on optimal cut‐off points of body mass index and waist circumference in Chinese adults , 2002 .

[43]  J Töyräs,et al.  Bone mineral density, ultrasound velocity, and broadband attenuation predict mechanical properties of trabecular bone differently. , 2002, Bone.

[44]  K. Michaëlsson,et al.  Association between oxidative stress and bone mineral density. , 2001, Biochemical and biophysical research communications.

[45]  Susan R. Johnson,et al.  Osteoporosis prevention, diagnosis, and therapy. , 2001, JAMA.

[46]  B E Ainsworth,et al.  Compendium of physical activities: an update of activity codes and MET intensities. , 2000, Medicine and science in sports and exercise.

[47]  H. Shimasaki.  Assay of fluorescent lipid peroxidation products. , 1994, Methods in enzymology.

[48]  E. Frankel,et al.  Lipid oxidation. , 1980, Progress in lipid research.