Blockage of a miR-21/EGFR regulatory feedback loop augments anti-EGFR therapy in glioblastomas.

[1]  S. Ogawa,et al.  miR-34a functions as a tumor suppressor modulating EGFR in glioblastoma multiforme , 2013, Oncogene.

[2]  J. Cheng,et al.  MicroRNA‐21 Expression is regulated by β‐catenin/STAT3 Pathway and Promotes Glioma Cell Invasion by Direct Targeting RECK , 2012, CNS neuroscience & therapeutics.

[3]  L. Xiaoyun,et al.  MicroRNA-21 is involved in osteosarcoma cell invasion and migration , 2011, Medical oncology.

[4]  J. Michálek,et al.  MiR‐195, miR‐196b, miR‐181c, miR‐21 expression levels and O‐6‐methylguanine‐DNA methyltransferase methylation status are associated with clinical outcome in glioblastoma patients , 2011, Cancer science.

[5]  T. Beißbarth,et al.  Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy. , 2011, Carcinogenesis.

[6]  T. MacDonald,et al.  Treatment of high-grade glioma in children and adolescents. , 2011, Neuro-oncology.

[7]  S. Kesari,et al.  A small-molecule IAP inhibitor overcomes resistance to cytotoxic therapies in malignant gliomas in vitro and in vivo. , 2011, Neuro-oncology.

[8]  Aileen McHarg,et al.  PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity , 2011, Molecular Cancer Therapeutics.

[9]  S. Subramaniam,et al.  MicroRNA-21 targets peroxisome proliferators-activated receptor-α in an autoregulatory loop to modulate flow-induced endothelial inflammation , 2011, Proceedings of the National Academy of Sciences.

[10]  A. Gaur,et al.  Downregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo. , 2011, Neuro-oncology.

[11]  D. Nam,et al.  Frizzled 4 regulates stemness and invasiveness of migrating glioma cells established by serial intracranial transplantation. , 2011, Cancer research.

[12]  Y. Shu,et al.  MiR-21 overexpression in human primary squamous cell lung carcinoma is associated with poor patient prognosis , 2011, Journal of Cancer Research and Clinical Oncology.

[13]  Dongsup Kim,et al.  Expression profiles of miRNAs in human embryonic stem cells during hepatocyte differentiation , 2011, Hepatology research : the official journal of the Japan Society of Hepatology.

[14]  Thomas Tuschl,et al.  miRNAs in human cancer , 2011, The Journal of pathology.

[15]  T. Jiang,et al.  Interruption of β-catenin suppresses the EGFR pathway by blocking multiple oncogenic targets in human glioma cells , 2010, Brain Research.

[16]  K. Kelnar,et al.  Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34. , 2010, Cancer research.

[17]  G. Calin,et al.  Targeting MicroRNAs With Small Molecules: From Dream to Reality , 2010, Clinical pharmacology and therapeutics.

[18]  Mei Mei,et al.  Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status , 2010, Laboratory Investigation.

[19]  M. Verheij,et al.  Novel therapeutics in combination with radiotherapy to improve cancer treatment: rationale, mechanisms of action and clinical perspective. , 2010, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

[20]  H. Lenz,et al.  EGFR Signaling and Drug Discovery , 2010, Oncology.

[21]  S. Gabriel,et al.  Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. , 2010, Cancer cell.

[22]  Julia Schüler,et al.  The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs , 2009, Nature Cell Biology.

[23]  H. Hollema,et al.  Expression of Epidermal Growth Factor Receptor (EGFR) and Activated EGFR Predict Poor Response to (Chemo)radiation and Survival in Cervical Cancer , 2009, Clinical Cancer Research.

[24]  E. Aboagye,et al.  Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-3/7 specific [18F]-labeled isatin sulfonamide , 2009, Proceedings of the National Academy of Sciences.

[25]  G. Bebb,et al.  Nimotuzumab: a novel anti-EGFR monoclonal antibody that retains anti-EGFR activity while minimizing skin toxicity , 2009, Expert opinion on biological therapy.

[26]  J. D. de Groot,et al.  Mediators of Glioblastoma Resistance and Invasion during Antivascular Endothelial Growth Factor Therapy , 2009, Clinical Cancer Research.

[27]  Z. Werb,et al.  Netting neutrophils in autoimmune small-vessel vasculitis , 2009, Nature Medicine.

[28]  A. Klekner,et al.  Analysis of EGFR Gene Amplification, Protein Over-expression and Tyrosine Kinase Domain Mutation in Recurrent Glioblastoma , 2009, Pathology & Oncology Research.

[29]  I. Fichtner,et al.  Radiosensitisation of U87MG brain tumours by anti-epidermal growth factor receptor monoclonal antibodies , 2009, British Journal of Cancer.

[30]  Erwin G. Van Meir,et al.  Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity. , 2009, Cancer research.

[31]  Susan M. Chang,et al.  Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[32]  T. Wurdinger,et al.  MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators , 2008, Molecular and Cellular Biology.

[33]  M. Korpal,et al.  The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional Repressors ZEB1 and ZEB2* , 2008, Journal of Biological Chemistry.

[34]  Yunqing Li,et al.  microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma. , 2008, Cancer research.

[35]  H. Hsieh,et al.  Sphingosine 1‐phosphate induces EGFR expression via Akt/NF‐κB and ERK/AP‐1 pathways in rat vascular smooth muscle cells , 2008 .

[36]  A. Lage,et al.  Treatment of high-grade glioma patients with the humanized anti-epidermal growth factor receptor (EGFR) antibody h-R3: Report from a phase I/II trial , 2006, Cancer biology & therapy.

[37]  K. Kosik,et al.  MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. , 2005, Cancer research.

[38]  M. Berger,et al.  Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib. , 2005, Journal of the National Cancer Institute.

[39]  T. Chou,et al.  Mutation in the Tyrosine Kinase Domain of Epidermal Growth Factor Receptor Is a Predictive and Prognostic Factor for Gefitinib Treatment in Patients with Non–Small Cell Lung Cancer , 2005, Clinical Cancer Research.

[40]  Lu Wang,et al.  MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2. , 2011, Cancer research.

[41]  C. Leisser,et al.  Wingless (Wnt)-3A induces trophoblast migration and matrix metalloproteinase-2 secretion through canonical Wnt signaling and protein kinase B/AKT activation. , 2010, Endocrinology.

[42]  G. Pazour.  Immunoprecipitation to examine protein complexes. , 2009, Methods in cell biology.