Clinical applications of rhBMP-2 in maxillofacial surgery.

MATERIALS AND METHODS Examples of defects including mandibular continuity defects, preprosthetic atrophic alveolar ridge deficiencies, traumatic defects, and maxillary clefts were included. RESULTS All patients demonstrated osseous regeneration stimulated by rhBMP-2. CONCLUSION rhBMP-2 is successful in regenerating bone in a variety of maxillofacial defects. In the future, rhBMP-2 will play a significant role in the treatment of bone deficiencies.

[1]  H. Terai,et al.  A biodegradable delivery system for antibiotics and recombinant human bone morphogenetic protein‐2: A potential treatment for infected bone defects , 2006, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[2]  C. Kirker-Head,et al.  Bone formation in the goat maxillary sinus induced by absorbable collagen sponge implants impregnated with recombinant human bone morphogenetic protein-2. , 1996, The International journal of periodontics & restorative dentistry.

[3]  R. Marx,et al.  A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation. , 1997, The International journal of periodontics & restorative dentistry.

[4]  R. Nishimura,et al.  Long-term functional loading of dental implants in rhBMP-2 induced bone. A histologic study in the canine ridge augmentation model. , 2003, Clinical oral implants research.

[5]  G. Finerman,et al.  Resistant nonunions and partial or complete segmental defects of long bones. Treatment with implants of a composite of human bone morphogenetic protein (BMP) and autolyzed, antigen-extracted, allogeneic (AAA) bone. , 1992, Clinical orthopaedics and related research.

[6]  V. Rosen,et al.  Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage [published erratum appears in J Cell Biol 1995 Feb;128(4):following 713] , 1994, The Journal of cell biology.

[7]  P. Boyne,et al.  Human recombinant BMP-2 in osseous reconstruction of simulated cleft palate defects. , 1998, The British journal of oral & maxillofacial surgery.

[8]  Myron Nevins,et al.  De novo bone induction by recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillary sinus floor augmentation. , 2005, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[9]  A. Linde,et al.  Importance of delivery systems for growth-stimulatory factors in combination with osteopromotive membranes. An experimental study using rhBMP-2 in rat mandibular defects. , 1997, Journal of biomedical materials research.

[10]  P. Boyne,et al.  Application of Bone Morphogenetic Proteins in the Treatment of Clinical Oral and Maxillofacial Osseous Defects , 2001, The Journal of bone and joint surgery. American volume.