Musical structural determinants of emotional judgments in dementia of the Alzheimer type.

People with dementia of the Alzheimer type (DAT) may well be emotionally soothed by listening to music. However, very few systematic studies have been conducted to support the anecdotal evidence. DAT does damage certain cerebral structures that subsume emotional processing, and some studies have demonstrated deficits affecting emotional judgments of facial expression and prosody in DAT. Accordingly, this study addressed the question of whether DAT might leave musical emotional judgment intact. Twelve early DAT participants and 12 healthy elderly participants took part in this study. Emotional judgments were examined in relation to mode and tempo, two important structural properties that contribute to the happy-sad distinction in music. Their respective contributions were assessed in four different experimental conditions. The DAT participants' responses were similar to those of healthy elderly participants, showing spared ability to employ tempo and mode as cues for emotional interpretation. The DAT participants' performance was not correlated with their global cognitive functioning. These results constitute a preliminary empirical demonstration that, in early DAT, musical emotional judgments appear to be based on normal structural analysis of musical input.

[1]  I. Peretz,et al.  Mode and tempo relative contributions to “happy-sad” judgements in equitone melodies , 2003, Cognition & emotion.

[2]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[3]  A. A. Clair,et al.  Therapeutic Uses of Music with Older Adults , 1996 .

[4]  C. Hatton,et al.  Music interventions for people with dementia: a review of the literature , 2004, Aging & mental health.

[5]  A. Halpern,et al.  Implicit Memory for Music in Alzheimer's Disease , 2000 .

[6]  Raquel E Gur,et al.  Emotion-discrimination deficits in mild Alzheimer disease. , 2005, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[7]  Jacalyn Duffin,et al.  Music, memory, and Alzheimer's disease: is music recognition spared in dementia, and how can it be assessed? , 2005, Medical hypotheses.

[8]  K. Scherer,et al.  Handbook of affective sciences. , 2003 .

[9]  K. Hevner,et al.  The affective value of pitch and tempo in music. , 1937 .

[10]  Dc Washington.  Diagnostic and Statistical Manual of Mental Disorders, 4th Ed. , 1994 .

[11]  Nathalie Bier,et al.  New learning in dementia: Transfer and spontaneous use of learning in everyday life functioning. Two case studies , 2008, Neuropsychological rehabilitation.

[12]  S Tanada,et al.  The Amygdala and Alzheimer's Disease , 2003, Annals of the New York Academy of Sciences.

[13]  M. Duffy.  Handbook of counseling and psychotherapy with older adults. , 1999 .

[14]  I. Peretz,et al.  Music and emotion: perceptual determinants, immediacy, and isolation after brain damage , 1998, Cognition.

[15]  R. G. Crowder.  Perception of the major/minor distinction: I. Historical and theoretical foundations. , 1984 .

[16]  Naomi Yatomi,et al.  Influence of Deteriorating Ability of Emotional Comprehension on Interpersonal Behavior in Alzheimer-Type Dementia , 2001, Brain and Cognition.

[17]  E. Ross,et al.  Musical Skill in Dementia: A Violinist Presumed to Have Alzheimer’s Disease Learns to Play a New Song , 2003, Neurocase.

[18]  L. Gagnon,et al.  Hétérogénéité des déficits cognitifs dans la démence de type Alzheimer et prise en charge cognitive de la mémoire: particularités et enjeux méthodologiques , 2005, Canadian Journal on Aging / La Revue canadienne du vieillissement.

[19]  D. Orbelo,et al.  Impaired affective prosody in AD , 2001, Neurology.

[20]  Autopsy-proven Alzheimer disease in a patient with dementia who retained musical skill in life. , 1997, Archives of neurology.

[21]  L. Brosgole,et al.  Facial and auditory affect recognition in senile geriatrics, the normal elderly and young adults. , 1993, The International journal of neuroscience.

[22]  S. Koger,et al.  Music therapy for dementia symptoms. , 2000, The Cochrane database of systematic reviews.

[23]  M. Lamar,et al.  Prosody impairment and associated affective and behavioral disturbances in Alzheimer's disease , 1996, Neurology.

[24]  Andrea R. Halpern,et al.  Recognition of familiar and unfamiliar melodies in normal aging and Alzheimer’s disease , 1995, Memory & cognition.

[25]  F. Pasquier,et al.  Perception of Emotion on Faces in Frontotemporal Dementia and Alzheimer’s Disease: A Longitudinal Study , 2004, Dementia and Geriatric Cognitive Disorders.

[26]  J. Hodges,et al.  Is semantic memory consistently impaired early in the course of Alzheimer's disease? Neuroanatomical and diagnostic implications , 1995, Neuropsychologia.

[27]  R. Maddock,et al.  Impaired recognition of facial expressions of emotion in Alzheimer's disease. , 2002, The Journal of neuropsychiatry and clinical neurosciences.

[28]  H. Isono,et al.  Comprehension of Emotions: Comparison between Alzheimer Type and Vascular Type Dementias , 2000, Dementia and Geriatric Cognitive Disorders.

[29]  A. Kaszniak,et al.  Processing of emotional cues in patients with dementia of the Alzheimer's type. , 1989, The International journal of neuroscience.

[30]  F. Boller,et al.  Discrimination of facial identity and of emotions in Alzheimer's Disease , 1998, Journal of the Neurological Sciences.

[31]  I. Peretz,et al.  Implicit and Explicit Emotional Memory for Melodies in Alzheimer's Disease and Depression , 2003, Annals of the New York Academy of Sciences.

[32]  O. Spreen,et al.  Comprar A Compendium of Neuropsychological Tests - Administration, Norms, and Commentary | Esther Strauss | 9780195159578 | Oxford University Press , 2009 .

[33]  W. Beatty,et al.  Preserved musical skill in a severely demented patient , 1988 .

[34]  V. Bowden,et al.  The Journal of Neuropsychiatry and Clinical Neurosciences , 1992 .

[35]  F. Pasquier,et al.  Perception of emotion in frontotemporal dementia and Alzheimer disease. , 1999, Alzheimer disease and associated disorders.

[36]  A. Benton.  Contributions to Neuropsychological Assessment: A Clinical Manual , 1983 .

[37]  Hans Spinnler,et al.  Handbook of Clinical and Experimental Neuropsychology , 1999 .

[38]  P. Juslin,et al.  Emotional expression in music. , 2003 .

[39]  F. Craik,et al.  The Oxford handbook of memory , 2006 .

[40]  I. Peretz,et al.  A developmental study of the affective value of tempo and mode in music , 2001, Cognition.

[41]  R. Adolphs,et al.  Amygdala damage impairs emotion recognition from music , 2007, Neuropsychologia.

[42]  E. Grober,et al.  Preservation of musical memory in Alzheimer's disease. , 1989, Journal of neurology, neurosurgery, and psychiatry.

[43]  Janice E. Knoefel,et al.  Clinical neurology of aging , 1985 .

[44]  D. Orbelo,et al.  Piano playing in Alzheimer's disease: Longitudinal study of a single case , 1999 .

[45]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[46]  C. Murphy,et al.  Working memory for nonverbal auditory information in dementia of the Alzheimer type. , 1998, Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists.

[47]  Kate Hevner,et al.  The affective character of the major and minor mode in music , 1935 .

[48]  David Wechsler,et al.  Wechsler Memory scale. , 2005 .

[49]  R. Kneafsey.  The therapeutic use of music in a care of the elderly setting: a literature review. , 1997, Journal of clinical nursing.

[50]  I. Peretz.  Dissociation between recognition and emotional judgements for melodies , 1999 .