Dosage of Dyrk1a shifts cells within a p21-cyclin D1 signaling map to control the decision to enter the cell cycle.

[1]  W. Becker.  Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle control , 2012, Cell cycle.

[2]  Tobias Meyer,et al.  Supplemental Experimental Procedures A Two-Dimensional ERK-AKT Signaling Code for an NGF-Triggered Cell-Fate Decision , 2011 .

[3]  M. Washburn,et al.  DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. , 2011, Genes & development.

[4]  Matthew E. Ritchie,et al.  Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome , 2010, PloS one.

[5]  T. Meyer,et al.  The NADPH oxidases NOX4 and DUOX2 regulate cell cycle entry via a p53-dependent pathway , 2010, Oncogene.

[6]  Sabrina L Spencer,et al.  Non-genetic Cell-to-cell Variability and the Consequences for Pharmacology This Review Comes from a Themed Issue on Omics Edited the Distribution of Protein Abundance and Resulting Variability in Phenotype Measuring Cell-to-cell Variation , 2022 .

[7]  K. Chung,et al.  Function and regulation of Dyrk1A: towards understanding Down syndrome , 2009, Cellular and Molecular Life Sciences.

[8]  M. Blagosklonny,et al.  Growth stimulation leads to cellular senescence when the cell cycle is blocked , 2008, Cell cycle.

[9]  Atsushi Miyawaki,et al.  Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression , 2008, Cell.

[10]  R. Faragher,et al.  Cyclin D1 Overexpression Permits the Reproducible Detection of Senescent Human Vascular Smooth Muscle Cells , 2007, Annals of the New York Academy of Sciences.

[11]  A. Contestabile,et al.  Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with down syndrome and in Ts65Dn mice , 2007, Hippocampus.

[12]  M. Hirata,et al.  Involvement of GSK-3β and DYRK1B in Differentiation-inducing Factor-3-induced Phosphorylation of Cyclin D1 in HeLa Cells* , 2006, Journal of Biological Chemistry.

[13]  J. Skurnick,et al.  Proliferation dynamics in cultured skin fibroblasts from Down syndrome subjects. , 2005, Free Radical Biology & Medicine.

[14]  J. Massagué,et al.  G1 cell-cycle control and cancer , 2004, Nature.

[15]  Shengjun Ren,et al.  Cyclin C/Cdk3 Promotes Rb-Dependent G0 Exit , 2004, Cell.

[16]  J. Souček,et al.  Relationship between cyclin D1 and p21(Waf1/Cip1) during differentiation of human myeloid leukemia cell lines. , 2003, Leukemia research.

[17]  M. Pagano,et al.  Role of the SCFSkp2 Ubiquitin Ligase in the Degradation of p21Cip1 in S Phase* , 2003, Journal of Biological Chemistry.

[18]  Christopher J Marshall,et al.  Ras promotes p21Waf1/Cip1 protein stability via a cyclin D1‐imposed block in proteasome‐mediated degradation , 2003, The EMBO journal.

[19]  X. Estivill,et al.  Dyrk1A Haploinsufficiency Affects Viability and Causes Developmental Delay and Abnormal Brain Morphology in Mice , 2002, Molecular and Cellular Biology.

[20]  S. Rasmussen,et al.  Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study , 2002, The Lancet.

[21]  T. Blundell,et al.  Identification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1A. , 2001, The Biochemical journal.

[22]  X. Estivill,et al.  Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome. , 2001, Human molecular genetics.

[23]  David Valle,et al.  Human disease genes , 2001, Nature.

[24]  H. Hasle,et al.  Risks of leukaemia and solid tumours in individuals with Down's syndrome , 2000, The Lancet.

[25]  James M. Roberts,et al.  CDK inhibitors: positive and negative regulators of G1-phase progression. , 1999, Genes & development.

[26]  L. Hengst,et al.  Complete inhibition of Cdk/cyclin by one molecule of p21(Cip1). , 1998, Genes & development.

[27]  F. Zindy,et al.  Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. , 1997, Genes & development.

[28]  S. Lowe,et al.  Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a , 1997, Cell.

[29]  C. Sherr.  Cancer Cell Cycles , 1996, Science.

[30]  GZ Yan,et al.  NGF regulates the PC12 cell cycle machinery through specific inhibition of the Cdk kinases and induction of cyclin D1 , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[31]  J. Coyle.  Down Syndrome, Alzheimerʼs Disease, and the Trisomy 16 Mouse , 1989 .

[32]  D. Segal,et al.  Studies on Down's syndrome in tissue culture. I. Growth rates protein contents of fibroblast cultures , 1974, Journal of cellular physiology.

[33]  L. Becker,et al.  Growth and development of the brain in Down syndrome. , 1991, Progress in clinical and biological research.