Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-κB
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[1] G A Rutter,et al. Regulation of mitochondrial metabolism by ER Ca2+ release: an intimate connection. , 2000, Trends in biochemical sciences.
[2] B van de Water,et al. Role of mitochondrial Ca2+ in the oxidative stress-induced dissipation of the mitochondrial membrane potential. Studies in isolated proximal tubular cells using the nephrotoxin 1,2-dichlorovinyl-L-cysteine. , 1994, The Journal of biological chemistry.
[3] R. Kaufman,et al. Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. , 1999, Genes & development.
[4] N. Kato,et al. Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[5] C. Rice,et al. Continuous human cell lines inducibly expressing hepatitis C virus structural and nonstructural proteins , 1998, Hepatology.
[6] G. Duverlie,et al. Expression of Hepatitis C Virus Proteins Interferes with the Antiviral Action of Interferon Independently of PKR-Mediated Control of Protein Synthesis , 2000, Journal of Virology.
[7] Ralf Bartenschlager,et al. Modulation of Hepatitis C Virus NS5A Hyperphosphorylation by Nonstructural Proteins NS3, NS4A, and NS4B , 1999, Journal of Virology.
[8] K. Shimotohno,et al. Production of two phosphoproteins from the NS5A region of the hepatitis C viral genome. , 1994, Biochemical and biophysical research communications.
[9] Y. Sun,et al. Free radicals, antioxidant enzymes, and carcinogenesis. , 1990, Free radical biology & medicine.
[10] A. Manning,et al. NF-κB as a primary regulator of the stress response , 1999, Oncogene.
[11] R. Bartenschlager,et al. Replication of the hepatitis C virus. , 2000, Bailliere's best practice & research. Clinical gastroenterology.
[12] Michael Karin,et al. Is NF‐κB the sensor of oxidative stress? , 1999 .
[13] M. Katze,et al. NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[14] Tao Yan,et al. Overexpression of Manganese Superoxide Dismutase Suppresses Tumor Necrosis Factor-induced Apoptosis and Activation of Nuclear Transcription Factor-κB and Activated Protein-1* , 1998, The Journal of Biological Chemistry.
[15] Sashwati Roy,et al. Involvement of intracellular Ca2+ in oxidant‐induced NF‐κB activation , 1996 .
[16] A. Nomoto,et al. Internal ribosome entry site within hepatitis C virus RNA , 1992, Journal of virology.
[17] R. Bartenschlager,et al. Mutations in Hepatitis C Virus RNAs Conferring Cell Culture Adaptation , 2001, Journal of Virology.
[18] J. Silver,et al. Replication of Subgenomic Hepatitis C Virus Rnas in a Hepatoma Cell Line , 1999 .
[19] Y. Shiratori,et al. Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator. , 1997, Journal of virology.
[20] H. Pahl,et al. Activation of NF‐κB by ER stress requires both Ca2+ and reactive oxygen intermediates as messengers , 1996, FEBS letters.
[21] R. Jove. Preface: STAT signaling , 2000, Oncogene.
[22] C. Rice,et al. Efficient initiation of HCV RNA replication in cell culture. , 2000, Science.
[23] C. Rice,et al. Overview of hepatitis C virus genome structure, polyprotein processing, and protein properties. , 2000, Current topics in microbiology and immunology.
[24] M. Lai. Cellular factors in the transcription and replication of viral RNA genomes: a parallel to DNA-dependent RNA transcription. , 1998, Virology.
[25] A. Nomoto,et al. Genetic analysis of internal ribosomal entry site on hepatitis C virus RNA: implication for involvement of the highly ordered structure and cell type-specific transacting factors. , 1997, Virology.
[26] Y. Liaw,et al. Activation of nuclear factor κB in hepatitis C virus infection: Implications for pathogenesis and hepatocarcinogenesis , 2000, Hepatology.
[27] J. Piette,et al. Crucial Role of the Amino-Terminal Tyrosine Residue 42 and the Carboxyl-Terminal PEST Domain of IκBα in NF-κB Activation by an Oxidative Stress1 , 2000, The Journal of Immunology.
[28] S. Lemon,et al. Internal ribosome entry site-mediated translation in hepatitis C virus replication. , 2000, Current topics in microbiology and immunology.
[29] R. Ray,et al. Hepatitis C Virus NS5A Physically Associates with p53 and Regulates p21/waf1 Gene Expression in a p53-Dependent Manner , 2001, Journal of Virology.
[30] Steve Olson. White House Enlists Science for Public Education Effort , 1997, Science.
[31] G. P. Studzinski. Apoptosis : a practical approach , 1999 .
[32] Michael G. Katze,et al. Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation , 1998, Molecular and Cellular Biology.
[33] G. De Sandre,et al. Severe impairment of antioxidant system in human hepatoma , 1986, Cancer.
[34] H. Hanafusa,et al. Unique signal transduction of Eyk: constitutive stimulation of the JAK‐STAT pathway by an oncogenic receptor‐type tyrosine kinase. , 1996, The EMBO journal.
[35] J. Butel,et al. Viral carcinogenesis: revelation of molecular mechanisms and etiology of human disease. , 2000, Carcinogenesis.
[36] A. Siddiqui,et al. Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism , 1993, Journal of virology.
[37] K. Meyer,et al. Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth. , 1999, The Journal of general virology.
[38] D. R. Taylor,et al. Hepatitis C virus RNA polymerase and NS5A complex with a SNARE-like protein. , 1999, Virology.
[39] Peter Lipp,et al. Calcium - a life and death signal , 1998, Nature.
[40] E. Wang,et al. Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[41] C. Rice,et al. Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinase , 1997, Journal of virology.
[42] C. Rice,et al. Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA. , 1997, Science.