BISMARSEN (BISMUTH ARSPHENAMINE SULFONATE) FOR TREATMENT OF SYPHILIS: A REVIEW OF FOURTEEN YEARS' EXPERIENCE

Bismarsen (bismuth arsphenamine sulfonate), an arsphenamine-bismuth compound synthesized by Dr. G. W. Raiziss1in 1924, has been subjected to clinical investigation in the department of dermatology and syphilology of the University of Pennsylvania School of Medicine since 1925. It was first used in the treatment of syphilis by Stokes and Chambers,2who in 1927 reported on two years of observation of its effects. In 1931 Stokes, Miller and Beerman3reported a summary of three more years' experience with the use of the drug in clinical practice, the results of a reexamination of 94 of the original 204 patients and a summary of the literature up to that date. This study revealed that bismarsen is a relatively nontoxic and easily administered drug for the treatment of patients with syphilis. The incidence of local reactions was low (2 per cent of injections), and systemic reactions occurred after only 0.5

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[13]  J. Stokes,et al.  AN APPRAISAL OF THE NEWEST ARSPHENAMINE SYNTHETIC, BISMARSEN, IN THE TREATMENT FOR SYPHILIS: BASED ON SEVEN THOUSAND SIX HUNDRED AND SIXTY-SIX INJECTIONS IN THREE HUNDRED AND FORTY-ONE CASES DURING FIVE YEARS , 1931 .

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