Fighting food temptations: The modulating effects of short-term cognitive reappraisal, suppression and up-regulation on mesocorticolimbic activity related to appetitive motivation

The premise of cognitive therapy is that one can overcome the irresistible temptation of highly palatable foods by actively restructuring the way one thinks about food. Testing this idea, participants in the present study were instructed to passively view foods, up-regulate food palatability thoughts, apply cognitive reappraisal (e.g., thinking about health consequences), or suppress food palatability thoughts and cravings. We examined whether these strategies affect self-reported food craving and mesocorticolimbic activity as assessed by functional magnetic resonance imaging. It was hypothesized that cognitive reappraisal would most effectively inhibit the mesocorticolimbic activity and associated food craving as compared to suppression. In addition, it was hypothesized that suppression would lead to more prefrontal cortex activity, reflecting the use of more control resources, as compared to cognitive reappraisal. Self-report results indicated that up-regulation increased food craving compared to the other two conditions, but that there was no difference in craving between the suppression and cognitive reappraisal strategy. Corroborating self-report results, the neuroimaging results showed that up-regulation increased activity in important regions of the mesocorticolimbic circuitry, including the ventral tegmental area, ventral striatum, operculum, posterior insular gyrus, medial orbitofrontal cortex and ventromedial prefrontal cortex. Contrary to our hypothesis, suppression more effectively decreased activity in the core of the mesocorticolimbic circuitry (i.e., ventral tegmental area and ventral striatum) compared to cognitive reappraisal. Overall, the results support the contention that appetitive motivation can be modulated by the application of short-term cognitive control strategies.

[1]  F. Smulders,et al.  Impulsivity in obese women , 2006, Appetite.

[2]  David A Seminowicz,et al.  The Anatomy of the Mesolimbic Reward System: A Link between Personality and the Placebo Analgesic Response , 2009, The Journal of Neuroscience.

[3]  E. Rolls,et al.  Abstract reward and punishment representations in the human orbitofrontal cortex , 2001, Nature Neuroscience.

[4]  P. Hannaford.  Are low-dose oral contraceptives safer and better? , 1995, American journal of obstetrics and gynecology.

[5]  A. Craig,et al.  How do you feel — now? The anterior insula and human awareness , 2009, Nature Reviews Neuroscience.

[6]  Kevin N. Ochsner,et al.  For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion , 2004, NeuroImage.

[7]  Jia Hu,et al.  The endocannabinoid system: A new pharmacological target for obesity treatment? , 2009, Neuroscience bulletin.

[8]  James J. Gross,et al.  Handbook of emotion regulation , 2007 .

[9]  Jean Logan,et al.  Brain dopamine and obesity , 2001, The Lancet.

[10]  J. Beck.  The Beck Diet Solution Weight Loss Workbook , 2007 .

[11]  Fabian Grabenhorst,et al.  How cognition modulates affective responses to taste and flavor: top-down influences on the orbitofrontal and pregenual cingulate cortices. , 2008, Cerebral cortex.

[12]  J. Michael Schurr,et al.  Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by Taq IA A 1 Allele , 2022 .

[13]  B. Appelhans,et al.  Neurobehavioral Inhibition of Reward‐driven Feeding: Implications for Dieting and Obesity , 2009, Obesity.

[14]  R. Baumeister,et al.  The Physiology of Willpower: Linking Blood Glucose to Self-Control , 2007, Personality and social psychology review : an official journal of the Society for Personality and Social Psychology, Inc.

[15]  J. Panksepp,et al.  Behavioral functions of the mesolimbic dopaminergic system: An affective neuroethological perspective , 2007, Brain Research Reviews.

[16]  Anatol C. Kreitzer,et al.  Physiology and pharmacology of striatal neurons. , 2009, Annual review of neuroscience.

[17]  T. Mexia,et al.  Author ' s personal copy , 2009 .

[18]  R. Carelli,et al.  The Nucleus Accumbens and Pavlovian Reward Learning , 2007, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[19]  R. Baumeister.  Ego Depletion and Self-Control Failure: An Energy Model of the Self's Executive Function , 2002 .

[20]  D. Wegner,et al.  Thought suppression. , 2000, Annual review of psychology.

[21]  O. John,et al.  Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. , 2003, Journal of personality and social psychology.

[22]  Caroline Reid,et al.  From motivation to behaviour: A model of reward sensitivity, overeating, and food preferences in the risk profile for obesity , 2007, Appetite.

[23]  J. Wardle,et al.  Cognitive control of eating. , 1988, Journal of psychosomatic research.

[24]  Donald B. Twieg,et al.  Widespread reward-system activation in obese women in response to pictures of high-calorie foods , 2008, NeuroImage.

[25]  A. Roebroeck,et al.  Behavioural Brain Research , 2015 .

[26]  Bertram Gawronski,et al.  And deplete us not into temptation: Automatic attitudes, dietary restraint, and self-regulatory resources as determinants of eating behavior , 2007 .

[27]  Nikos K. Logothetis,et al.  Nonmonotonic noise tuning of BOLD fMRI signal to natural images in the visual cortex of the anesthetized monkey , 2001, Current Biology.

[28]  J. Weber,et al.  Prefrontal–striatal pathway underlies cognitive regulation of craving , 2010, Proceedings of the National Academy of Sciences.

[29]  C. Carver,et al.  Behavioral inhibition, behavioral activation, and affective responses to impending reward and punishment: The BIS/BAS Scales , 1994 .

[30]  H. Hospers,et al.  Adding cognitive therapy to dietetic treatment is associated with less relapse in obesity. , 2009, Journal of psychosomatic research.

[31]  Hans-Christian Bauknecht,et al.  Differential activation of the dorsal striatum by high-calorie visual food stimuli in obese individuals , 2007, NeuroImage.

[32]  T. Hällström,et al.  A short-term cognitive group treatment program gives substantial weight reduction up to 18 months from the end of treatment. A randomized controlled trial , 2005, Eating and weight disorders : EWD.

[33]  R. Mattes,et al.  A Figurative Measure of Subjective Hunger Sensations , 1999, Appetite.

[34]  M. Spinella.  NORMATIVE DATA AND A SHORT FORM OF THE BARRATT IMPULSIVENESS SCALE , 2007, The International journal of neuroscience.

[35]  K. Berridge,et al.  The Neuroscience of Natural Rewards: Relevance to Addictive Drugs , 2002, The Journal of Neuroscience.

[36]  J. Driskell,et al.  Sex differences in dieting trends, eating habits, and nutrition beliefs of a group of midwestern college students. , 2006, Journal of the American Dietetic Association.

[37]  N. Volkow,et al.  Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulation , 2009, Proceedings of the National Academy of Sciences.

[38]  A. Astrup,et al.  Randomized Controlled Trials of the D1/D5 Antagonist Ecopipam for Weight Loss in Obese Subjects , 2007, Obesity.

[39]  T. Robbins,et al.  Effects of selective excitotoxic lesions of the nucleus accumbens core, anterior cingulate cortex, and central nucleus of the amygdala on autoshaping performance in rats. , 2002, Behavioral neuroscience.

[40]  J. Polivy,et al.  Distractibility in dieters and nondieters: an alternative view of "externality". , 1978, Journal of personality and social psychology.

[41]  Anne Roefs,et al.  Control yourself or just eat what you like? Weight gain over a year is predicted by an interactive effect of response inhibition and implicit preference for snack foods. , 2010, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[42]  H. Hospers,et al.  Early associations with palatable foods in overweight and obesity are not disinhibition related but restraint related. , 2009, Journal of behavior therapy and experimental psychiatry.

[43]  S. Moreno,et al.  Clinical Validation of the Trait and State Versions of the Food Craving Questionnaire , 2008, Assessment.

[44]  宁北芳,et al.  疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A , 2005 .

[45]  Brent L. Hughes,et al.  Prefrontal-Subcortical Pathways Mediating Successful Emotion Regulation , 2008, Neuron.

[46]  R. Wise,et al.  How can drug addiction help us understand obesity? , 2005, Nature Neuroscience.

[47]  Nancy Kanwisher,et al.  Divide and conquer: A defense of functional localizers , 2006, NeuroImage.

[48]  Yu-Shin Ding,et al.  Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: Possible contributing factors , 2008, NeuroImage.

[49]  J. Gross,et al.  The Neural Bases of Emotion Regulation: Reappraisal and Suppression of Negative Emotion , 2008, Biological Psychiatry.

[50]  K. Grill-Spector,et al.  fMR-adaptation: a tool for studying the functional properties of human cortical neurons. , 2001, Acta psychologica.

[51]  Nikolaus Weiskopf,et al.  Optimal EPI parameters for reduction of susceptibility-induced BOLD sensitivity losses: A whole-brain analysis at 3 T and 1.5 T , 2006, NeuroImage.

[52]  R. Wiers,et al.  Working memory capacity and self-regulatory behavior: toward an individual differences perspective on behavior determination by automatic versus controlled processes. , 2008, Journal of personality and social psychology.

[53]  P. Tobler,et al.  Functional imaging of the human dopaminergic midbrain , 2009, Trends in Neurosciences.

[54]  J. Driskell,et al.  Observed sex differences in fast-food consumption and nutrition self-assessments and beliefs of college students. , 2009, Nutrition research.

[55]  E. Rolls,et al.  Cognitive Modulation of Olfactory Processing , 2005, Neuron.

[56]  K. Truesdale,et al.  Modest changes in dietary intake across the menstrual cycle: implications for food intake research , 2006, British Journal of Nutrition.

[57]  T. Robbins,et al.  Neural systems of reinforcement for drug addiction: from actions to habits to compulsion , 2005, Nature Neuroscience.