Lipid peroxidation in cell death.

[1]  M. Zaiss,et al.  The double-edged role of 12/15-lipoxygenase during inflammation and immunity. , 2017, Biochimica et biophysica acta. Molecular and cell biology of lipids.

[2]  M. Díaz,et al.  Editorial: Impact of Lipid Peroxidation on the Physiology and Pathophysiology of Cell Membranes , 2016, Front. Physiol..

[3]  B. Stockwell,et al.  A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis , 2016, ACS central science.

[4]  B. Stockwell,et al.  Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis , 2016, Proceedings of the National Academy of Sciences.

[5]  B. Stockwell,et al.  Ferroptosis: Death by Lipid Peroxidation. , 2016, Trends in cell biology.

[6]  Constantinos G. Neochoritis,et al.  Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties. , 2015, Journal of medicinal chemistry.

[7]  M. Heinonen,et al.  LC-MS investigations on interactions between isolated β-lactoglobulin peptides and lipid oxidation product malondialdehyde. , 2015, Food chemistry.

[8]  M. Shchepinov,et al.  Isotope-reinforced polyunsaturated fatty acids protect mitochondria from oxidative stress. , 2015, Free radical biology & medicine.

[9]  O. Werz,et al.  5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease. , 2015, Biochimica et biophysica acta.

[10]  A. Walch,et al.  Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice , 2014, Nature Cell Biology.

[11]  Antonio Ayala,et al.  Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal , 2014, Oxidative medicine and cellular longevity.

[12]  E. Niki.  Biomarkers of lipid peroxidation in clinical material. , 2014, Biochimica et biophysica acta.

[13]  Matthew E. Welsch,et al.  Regulation of Ferroptotic Cancer Cell Death by GPX4 , 2014, Cell.

[14]  E. Niki.  Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence. , 2014, Free radical biology & medicine.

[15]  Torbjörn Persson,et al.  Oxidative Stress in Alzheimer's Disease: Why Did Antioxidant Therapy Fail? , 2014, Oxidative medicine and cellular longevity.

[16]  D. Steinhilber,et al.  Recent advances in the search for novel 5-lipoxygenase inhibitors. , 2014, Basic & clinical pharmacology & toxicology.

[17]  A. Birukova,et al.  Thermodynamic and kinetic investigations of the release of oxidized phospholipids from lipid membranes and its effect on vascular integrity. , 2013, Chemistry and physics of lipids.

[18]  L. Huc,et al.  Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance , 2013, Cell Death and Differentiation.

[19]  M. Shchepinov,et al.  Insights into the role of oxidative stress in the pathology of Friedreich ataxia using peroxidation resistant polyunsaturated fatty acids , 2013, Redox biology.

[20]  C. Spickett.  The lipid peroxidation product 4-hydroxy-2-nonenal: Advances in chemistry and analysis☆ , 2013, Redox biology.

[21]  A. Boveris,et al.  Lipid Peroxidation: Chemical Mechanism, Biological Implications and Analytical Determination , 2012 .

[22]  C. Cantor,et al.  Small amounts of isotope-reinforced polyunsaturated fatty acids suppress lipid autoxidation. , 2012, Free radical biology & medicine.

[23]  S. Arlt,et al.  Effect of One-Year Vitamin C- and E-Supplementation on Cerebrospinal Fluid Oxidation Parameters and Clinical Course in Alzheimer’s Disease , 2012, Neurochemical Research.

[24]  C. Cotman,et al.  Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures. , 2012, Archives of neurology.

[25]  M. R. Lamprecht,et al.  Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death , 2012, Cell.

[26]  A. Landar,et al.  Cell signalling by reactive lipid species: new concepts and molecular mechanisms , 2012, The Biochemical journal.

[27]  R. G. Salomon,et al.  Fragmentation of a linoleate-derived γ-hydroperoxy-α,β-unsaturated epoxide to γ-hydroxy- and γ-oxo-alkenals involves a unique pseudo-symmetrical diepoxycarbinyl radical. , 2012, Free radical biology & medicine.

[28]  H. Yin,et al.  Free radical lipid peroxidation: mechanisms and analysis. , 2011, Chemical reviews.

[29]  A. Jadhav,et al.  Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. , 2011, Journal of medicinal chemistry.

[30]  Liang-Jun Yan,et al.  Chemical probes for analysis of carbonylated proteins: a review. , 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[31]  Garret A. FitzGerald,et al.  Prostaglandins and Inflammation , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[32]  A. Dobrian,et al.  Functional and pathological roles of the 12- and 15-lipoxygenases. , 2011, Progress in lipid research.

[33]  M. Citron,et al.  Alzheimer's disease: strategies for disease modification , 2010, Nature Reviews Drug Discovery.

[34]  R. Bazinet,et al.  Regulation of brain polyunsaturated fatty acid uptake and turnover. , 2008, Prostaglandins, leukotrienes, and essential fatty acids.

[35]  A. Brash,et al.  Routes to 4-Hydroxynonenal: Fundamental Issues in the Mechanisms of Lipid Peroxidation* , 2008, Journal of Biological Chemistry.

[36]  S. Sarna,et al.  Vitamin E and selenium supplementation in geriatric patients , 1985, Biological Trace Element Research.

[37]  Maya Shvartsman,et al.  Intracellular labile iron. , 2008, The international journal of biochemistry & cell biology.

[38]  Luca Monticelli,et al.  Effect of lipid peroxidation on the properties of lipid bilayers: a molecular dynamics study. , 2007, Biophysical journal.

[39]  D. Praticò,et al.  A role for 12/15 lipoxygenase in the amyloid β precursor protein metabolism , 2007 .

[40]  O. Werz,et al.  5-Lipoxygenase: regulation of expression and enzyme activity. , 2007, Trends in biochemical sciences.

[41]  S. Hazen,et al.  Conformation of an endogenous ligand in a membrane bilayer for the macrophage scavenger receptor CD36. , 2007, Biochemistry.

[42]  D. Praticò,et al.  A role for 12/15 lipoxygenase in the amyloid beta precursor protein metabolism. , 2007, Journal of neurochemistry.

[43]  A. Casini,et al.  Measurement of lipid peroxidation in vivo: A comparison of different procedures , 1987, Lipids.

[44]  A. Brash,et al.  Synthesis of dihydroperoxides of linoleic and linolenic acids and studies on their transformation to 4-hydroperoxynonenal , 2005, Lipids.

[45]  Nicoletta Pellegrini,et al.  A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. , 2005, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[46]  J. Trojanowski,et al.  12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress. , 2004, The American journal of pathology.

[47]  M. Peters-Golden,et al.  5-lipoxygenase and FLAP. , 2003, Prostaglandins, leukotrienes, and essential fatty acids.

[48]  J. Redondo,et al.  Cyclooxygenase-2: a therapeutic target in angiogenesis. , 2003, Trends in molecular medicine.

[49]  J. Yodoi,et al.  A Comparative Study on the Hydroperoxide and Thiol Specificity of the Glutathione Peroxidase Family and Selenoprotein P* , 2002, The Journal of Biological Chemistry.

[50]  R. DuBois,et al.  Cyclooxygenase-2: a therapeutic target. , 2002, Annual review of medicine.

[51]  A. Brash,et al.  Two Distinct Pathways of Formation of 4-Hydroxynonenal , 2001, The Journal of Biological Chemistry.

[52]  S. Aust,et al.  Measurement of Lipid Peroxidation , 1999, Current protocols in toxicology.

[53]  A. Visser,et al.  Oxidation of unsaturated phospholipids in membrane bilayer mixtures is accompanied by membrane fluidity changes. , 2000, Biochimica et biophysica acta.

[54]  R. Young.  Inhibitors of 5-lipoxygenase: a therapeutic potential yet to be fully realized? , 1999 .

[55]  Xudong Huang,et al.  The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. , 1999, Biochemistry.

[56]  R. G. Salomon,et al.  (Carboxyalkyl)pyrroles in human plasma and oxidized low-density lipoproteins. , 1997, Chemical research in toxicology.

[57]  A. Brash,et al.  Discovery of a second 15S-lipoxygenase in humans. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[58]  O. Rådmark.  Arachidonate 5-lipoxygenase. , 2002, Journal of lipid mediators and cell signalling.

[59]  William L. Smith,et al.  Fatty Acid Substrate Specificities of Human Prostaglandin-endoperoxide H Synthase-1 and −2 , 1995, The Journal of Biological Chemistry.

[60]  W. Glasgow,et al.  Investigation of the oxygenation of phospholipids by the porcine leukocyte and human platelet arachidonate 12-lipoxygenases. , 1993, European journal of biochemistry.

[61]  M. Percival,et al.  Investigation of the mechanism of non-turnover-dependent inactivation of purified human 5-lipoxygenase. Inactivation by H2O2 and inhibition by metal ions. , 1992, European journal of biochemistry.

[62]  P. Young,et al.  The discovery and development of zileuton: an orally active 5-lipoxygenase inhibitor. , 1992, International journal of immunopharmacology.

[63]  H. Esterbauer,et al.  Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. , 1991, Free radical biology & medicine.

[64]  F. Ursini,et al.  Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51). , 1988, Biochemical pharmacology.

[65]  J. Braughler,et al.  The involvement of iron in lipid peroxidation. Importance of ferric to ferrous ratios in initiation. , 1986, The Journal of biological chemistry.

[66]  C. Rouzer,et al.  Single protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activities. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[67]  D. Yang,et al.  Oxygenation of phosphatidylcholine by human polymorphonuclear leukocyte 15-lipoxygenase. , 1985, Biochemical and biophysical research communications.

[68]  K. Austen,et al.  Characterization and separation of the arachidonic acid 5-lipoxygenase and linoleic acid omega-6 lipoxygenase (arachidonic acid 15-lipoxygenase) of human polymorphonuclear leukocytes. , 1985, The Journal of biological chemistry.