Mechanisms of p53-mediated apoptosis
暂无分享,去创建一个
[1] G. Kroemer. [Mitochondrial control of apoptosis]. , 2001, Bulletin de l'Academie nationale de medecine.
[2] S. Nagata,et al. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD , 1998, Nature.
[3] G. Evan,et al. Induction of TNF‐sensitive cellular phenotype by c‐Myc involves p53 and impaired NF‐κB activation , 1997, The EMBO journal.
[4] C. Moyret-Lalle,et al. Resistance of MCF7 human breast carcinoma cells to TNF-induced cell death is associated with loss of p53 function , 1997, Oncogene.
[5] C. Deng,et al. Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways , 1997, Nature Genetics.
[6] M. V. Heiden,et al. Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria , 1997, Cell.
[7] E. Shaulian,et al. Induction of Mdm2 and enhancement of cell survival by bFGF , 1997, Oncogene.
[8] G. Evan,et al. Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis. , 1997, Science.
[9] David P. Lane,et al. Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo , 1997, Current Biology.
[10] I. Krantz,et al. KILLER/DR5 is a DNA damage–inducible p53–regulated death receptor gene , 1997, Nature Genetics.
[11] V. Reinke,et al. The p53 targets mdm2 and Fas are not required as mediators of apoptosis in vivo , 1997, Oncogene.
[12] K. Kinzler,et al. A model for p53-induced apoptosis , 1997, Nature.
[13] Bert Vogelstein,et al. Cell-cycle arrest versus cell death in cancer therapy , 1997, Nature Medicine.
[14] G. Prendergast,et al. The polyproline region of p53 is required to activate apoptosis but not growth arrest , 1997, Oncogene.
[15] Wenyi Wei,et al. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. , 1997, Science.
[16] K. Helin,et al. Induction of DNA synthesis and apoptosis are separable functions of E2F-1. , 1997, Genes & development.
[17] D. Israeli,et al. A novel p53‐inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis , 1997, The EMBO journal.
[18] John Calvin Reed. Double identity for proteins of the Bcl-2 family , 1997, Nature.
[19] B. Groner,et al. Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain , 1997, Nature Medicine.
[20] P. Cohen,et al. Radiation and stress-induced apoptosis: a role for Fas/Fas ligand interactions. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[21] J C Reed,et al. Channel formation by antiapoptotic protein Bcl-2. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[22] P. Cohen,et al. Insulin-like Growth Factor (IGF)-binding Protein-3 Induces Apoptosis and Mediates the Effects of Transforming Growth Factor-β1 on Programmed Cell Death through a p53- and IGF-independent Mechanism* , 1997, The Journal of Biological Chemistry.
[23] K. Vousden,et al. Perturbation of the p53 response by human papillomavirus type 16 E7 , 1997, Journal of virology.
[24] A. Levine,et al. A proline-rich motif in p53 is required for transactivation-independent growth arrest as induced by Gas1. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[25] S. Korsmeyer,et al. bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[26] A. Fornace,et al. Induction of BCL2 family member MCL1 as an early response to DNA damage , 1997, Oncogene.
[27] Dean P. Jones,et al. Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked , 1997, Science.
[28] D. Green,et al. The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis , 1997, Science.
[29] J C Reed,et al. Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype , 1997, Science.
[30] S. Korsmeyer,et al. Bax suppresses tumorigenesis and stimulates apoptosis in vivo , 1997, Nature.
[31] A. Levine. p53, the Cellular Gatekeeper for Growth and Division , 1997, Cell.
[32] S. Nagata,et al. Apoptosis by Death Factor , 1997, Cell.
[33] G. Evan,et al. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB , 1997, Nature.
[34] Andy J. Minn,et al. Bcl-xL forms an ion channel in synthetic lipid membranes , 1997, Nature.
[35] A. Levine,et al. Identification of a novel p53 functional domain that is necessary for efficient growth suppression. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[36] A. K. Merchant,et al. Expression of wild-type p53 stimulates an increase in both Bax and Bcl-xL protein content in HT29 cells. , 1996, Oncogene.
[37] A. Neri,et al. Restoration of the transcription activation function to mutant p53 in human cancer cells. , 1996, Oncogene.
[38] A. Levine,et al. Wild-type p53 negatively regulates the expression of a microtubule-associated protein. , 1996, Genes & development.
[39] P. O'Connor,et al. The apoptosis-associated gamma-ray response of BCL-X(L) depends on normal p53 function. , 1996, Oncogene.
[40] V. Ferrans,et al. Reactive oxygen species are downstream mediators of p53-dependent apoptosis. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[41] X. Chen,et al. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. , 1996, Genes & development.
[42] K. Vousden,et al. Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function , 1996, Molecular and cellular biology.
[43] J. Lotem,et al. Cellular oxidative stress and the control of apoptosis by wild-type p53, cytotoxic compounds, and cytokines. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[44] K. Kinzler,et al. Genetic determinants of p53-induced apoptosis and growth arrest. , 1996, Genes & development.
[45] Xiaodong Wang,et al. Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c , 1996, Cell.
[46] S. Lowe,et al. Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene‐mediated apoptosis. , 1996, The EMBO journal.
[47] R. Meadows,et al. X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death , 1996, Nature.
[48] M. Greenberg,et al. E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation , 1996, Cell.
[49] T. Jacks,et al. Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1 , 1996, Cell.
[50] C. Harris,et al. The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway. , 1996, Genes & development.
[51] C. Prives,et al. p53: puzzle and paradigm. , 1996, Genes & development.
[52] G. Peters,et al. Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer. , 1996, Advances in cancer research.
[53] C. Prives,et al. apoptosis . p 53-responsive genes cannot induce A mutant p 53 that discriminates between , 1996 .
[54] E. May,et al. Transcriptional activation plays a role in the induction of apoptosis by transiently transfected wild-type p53. , 1995, Oncogene.
[55] A. Strasser,et al. Bcl‐2 and Fas/APO‐1 regulate distinct pathways to lymphocyte apoptosis. , 1995, The EMBO journal.
[56] K. Kinzler,et al. p21 is necessary for the p53-mediated G1 arrest in human cancer cells. , 1995, Cancer research.
[57] S. Benchimol,et al. Cytokines inhibit p53-mediated apoptosis but not p53-mediated G1 arrest , 1995, Molecular and cellular biology.
[58] D. Lane,et al. Small peptides activate the latent sequence-specific DNA binding function of p53 , 1995, Cell.
[59] S. Velasco-Miguel,et al. Induction of the growth inhibitor IGF-binding protein 3 by p53 , 1995, Nature.
[60] James Brugarolas,et al. Radiation-induced cell cycle arrest compromised by p21 deficiency , 1995, Nature.
[61] S. Korsmeyer,et al. Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death , 1995, Science.
[62] A. Levine,et al. Essential role for p53-mediated transcription in E1A-induced apoptosis. , 1995, Genes & development.
[63] E. Shaulian,et al. Induction of apoptosis in HeLa cells by trans-activation-deficient p53. , 1995, Genes & development.
[64] Stephen J. Elledge,et al. Mice Lacking p21 CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control , 1995, Cell.
[65] A. Neri,et al. Microinjection of monoclonal antibody PAb421 into human SW480 colorectal carcinoma cells restores the transcription activation function to mutant p53. , 1995, Cancer research.
[66] Seamus J. Martin,et al. Protease activation during apoptosis: Death by a thousand cuts? , 1995, Cell.
[67] C. Prives,et al. Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases , 1995, Nature.
[68] J. Roth,et al. Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression , 1995, Molecular and cellular biology.
[69] A. Giordano,et al. Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: blocking p53-induced apoptosis unmasks G1 arrest. , 1995, Blood.
[70] M. Kastan,et al. Growth factor modulation of p53-mediated growth arrest versus apoptosis. , 1995, Genes & development.
[71] E. White,et al. Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein , 1995, Molecular and cellular biology.
[72] John Calvin Reed,et al. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene , 1995, Cell.
[73] Yunping Lin. Cytokines Inhibit p53-Mediated Apoptosis but Not p53-Mediated G 1 Arrest , 1995 .
[74] K. Vousden,et al. Transcriptional activation by p53 correlates with suppression of growth but not transformation , 1994, Cell.
[75] N. Hay,et al. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1. , 1994, Genes & development.
[76] W. Kaelin,et al. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[77] G. Wahl,et al. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. , 1994, Genes & development.
[78] H. Hermeking,et al. Mediation of c-Myc-induced apoptosis by p53. , 1994, Science.
[79] R. DePinho,et al. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens , 1994, Nature.
[80] S. Lowe,et al. p53-Dependent apoptosis suppresses tumor growth and progression in vivo , 1994, Cell.
[81] G. Hannon,et al. p21-containing cyclin kinases exist in both active and inactive states. , 1994, Genes & development.
[82] M. Karin,et al. p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes , 1994, Nature.
[83] E. May,et al. Induction of apoptosis by transiently transfected metabolically stable wt p53 in transformed cell lines. , 1994, Cell death and differentiation.
[84] G. Evan,et al. c‐Myc‐induced apoptosis in fibroblasts is inhibited by specific cytokines. , 1994, The EMBO journal.
[85] John Calvin Reed,et al. Identification of a p53-dependent negative response element in the bcl-2 gene. , 1994, Cancer research.
[86] Kathleen R. Cho,et al. p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[87] D. Albert,et al. Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53. , 1994, Genes & development.
[88] H. Pan,et al. Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development. , 1994, Genes & development.
[89] G. Demers,et al. Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[90] A. Levine,et al. p53 and E2F-1 cooperate to mediate apoptosis. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[91] E. White,et al. Bcl-2 blocks p53-dependent apoptosis , 1994, Molecular and cellular biology.
[92] K. Kinzler,et al. Sequence-specific transcriptional activation is essential for growth suppression by p53. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[93] D. Lane,et al. Regulation of the cryptic sequence-specific DNA-binding function of p53 by protein kinases. , 1994, Cold Spring Harbor symposia on quantitative biology.
[94] C. Turck,et al. Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit , 1993, Nature.
[95] T. Halazonetis,et al. Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants. , 1993, The EMBO journal.
[96] J. Trent,et al. WAF1, a potential mediator of p53 tumor suppression , 1993, Cell.
[97] S. Elledge,et al. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases , 1993, Cell.
[98] S. Nagata,et al. Effect of bcl-2 on Fas antigen-mediated cell death. , 1993, Journal of immunology.
[99] D. Lane,et al. Activation of the cryptic DNA binding function of mutant forms of p53. , 1993, Nucleic acids research.
[100] C. Purdie,et al. Thymocyte apoptosis induced by p53-dependent and independent pathways , 1993, Nature.
[101] Scott W. Lowe,et al. p53 is required for radiation-induced apoptosis in mouse thymocytes , 1993, Nature.
[102] S. Lowe,et al. Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis. , 1993, Genes & development.
[103] P. Shaw,et al. Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[104] A. Kimchi,et al. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6 , 1991, Nature.
[105] A. Levine,et al. p 53 and E 2 F-1 cooperate to mediate apoptosis , 2022 .