The receptor tyrosine kinase Ror2 is involved in non‐canonical Wnt5a/JNK signalling pathway

Background: Ror2 is an orphan receptor, belonging to the Ror family of receptor tyrosine kinases. Although Ror2 has been shown to play crucial roles in developmental morphogenesis, the precise signalling events that Ror2 mediates remain elusive. Since Ror2 possesses an extracellular cysteine‐rich domain (CRD) that resembles the Wnt‐binding sites of the Frizzled (Fz) proteins, it is conceivable that Ror2 interacts with members of the Wnt family.

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