An increase in spinal dehydroepiandrosterone sulfate (DHEAS) enhances NMDA-induced pain via phosphorylation of the NR1 subunit in mice: Involvement of the sigma-1 receptor

[1]  Tangui Maurice,et al.  The pharmacology of sigma-1 receptors. , 2009, Pharmacology & therapeutics.

[2]  A. Beitz,et al.  Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma‐1 and GABAA receptors , 2009, British journal of pharmacology.

[3]  A. Beitz,et al.  Intrathecal Injection of the &sfgr;1 Receptor Antagonist BD1047 Blocks Both Mechanical Allodynia and Increases in Spinal NR1 Expression during the Induction Phase of Rodent Neuropathic Pain , 2008, Anesthesiology.

[4]  A. Beitz,et al.  Intrathecal Clonidine Suppresses Phosphorylation of the N-Methyl-D-Aspartate Receptor NR1 Subunit in Spinal Dorsal Horn Neurons of Rats with Neuropathic Pain , 2008, Anesthesia and analgesia.

[5]  A. Beitz,et al.  Activation of the spinal sigma‐1 receptor enhances NMDA‐induced pain via PKC‐ and PKA‐dependent phosphorylation of the NR1 subunit in mice , 2008, British journal of pharmacology.

[6]  J A Peters,et al.  Guide to Receptors and Channels (GRAC), 3rd edition , 2008, British journal of pharmacology.

[7]  A. Beitz,et al.  Intrathecal treatment with σ1 receptor antagonists reduces formalin‐induced phosphorylation of NMDA receptor subunit 1 and the second phase of formalin test in mice , 2006, British journal of pharmacology.

[8]  B. Meyerson,et al.  Spinal NMDA receptor phosphorylation correlates with the presence of neuropathic signs following peripheral nerve injury in the rat , 2006, Neuroscience Letters.

[9]  S. Czuczwar,et al.  Endogenous neuroprotective factors: neurosteroids. , 2006, Pharmacological reports : PR.

[10]  M. Sokabe,et al.  Chronic administration of dehydroepiandrosterone sulfate (DHEAS) primes for facilitated induction of long-term potentiation via sigma 1 (σ1) receptor: Optical imaging study in rat hippocampal slices , 2006, Neuropharmacology.

[11]  M. Pallarés,et al.  The intrahippocampal administration of the neurosteroid allopregnanolone blocks the audiogenic seizures induced by nicotine , 2005, Brain Research.

[12]  M. Pallarés,et al.  Intrahippocampal nicotine and neurosteroids effects on the anxiety-like behaviour in voluntary and chronic alcohol-drinking rats , 2005, Behavioural Brain Research.

[13]  K. Chung,et al.  Enhancement of NMDA receptor phosphorylation of the spinal dorsal horn and nucleus gracilis neurons in neuropathic rats , 2005, Pain.

[14]  C. Inturrisi.  The role of N-methyl-D-aspartate (NMDA) receptors in pain and morphine tolerance. , 2005, Minerva anestesiologica.

[15]  J. S. Dillon.  Dehydroepiandrosterone, dehydroepiandrosterone sulfate and related steroids: their role in inflammatory, allergic and immunological disorders. , 2005, Current drug targets. Inflammation and allergy.

[16]  D. Overstreet,et al.  The involvement of dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) in blocking the therapeutic effect of electroconvulsive shocks in an animal model of depression , 2005, European Neuropsychopharmacology.

[17]  B. Dubrovsky.  Steroids, neuroactive steroids and neurosteroids in psychopathology , 2005, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[18]  T. Maurice.  Neurosteroids and σ1 Receptors, Biochemical and Behavioral Relevance , 2004, Pharmacopsychiatry.

[19]  W. Banks,et al.  DHEAS improves learning and memory in aged SAMP8 mice but not in diabetic mice. , 2004, Life sciences.

[20]  T. Nabeshima,et al.  A neuroactive steroid, dehydroepiandrosterone sulfate, prevents the development of morphine dependence and tolerance via c-fos expression linked to the extracellular signal-regulated protein kinase , 2004, Behavioural Brain Research.

[21]  C. Woolf,et al.  Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC‐dependent site, serine‐896, in spinal cord dorsal horn neurons , 2004, The European journal of neuroscience.

[22]  W. Leowattana.  DHEAS as a new diagnostic tool. , 2004, Clinica chimica acta; international journal of clinical chemistry.

[23]  J. M. Torres,et al.  DHEA, PREG and Their Sulphate Derivatives on Plasma and Brain After CRH and ACTH Administration , 2003, Neurochemical Research.

[24]  Abraham Weizman,et al.  Clozapine decreases rat brain dehydroepiandrosterone and dehydroepiandrosterone sulfate levels , 2003, European Neuropsychopharmacology.

[25]  W. Willis,et al.  Role of protein kinase A in phosphorylation of NMDA receptor 1 subunits in dorsal horn and spinothalamic tract neurons after intradermal injection of capsaicin in rats , 2002, Neuroscience.

[26]  A. Beitz,et al.  The antinociceptive and anti-inflammatory effect of ethylacetate extracts from Bang-Poong (Radix ledebouriellae) on the Freund's adjuvant-induced arthritis in rats. , 2002, Journal of veterinary science.

[27]  Howard S. Smith,et al.  Alpha2 receptors and agonists in pain management , 2001, Current opinion in anaesthesiology.

[28]  H. Ueda,et al.  Metabotropic Neurosteroid/ς-Receptor Involved in Stimulation of Nociceptor Endings of Mice , 2001 .

[29]  W D Willis,et al.  Role of Neurotransmitters in Sensitization of Pain Responses , 2001, Annals of the New York Academy of Sciences.

[30]  M. Tsuda,et al.  Modulation of NMDA- and (+)TAN-67-induced nociception by GABA(B) receptors in the mouse spinal cord. , 2000, Life Science.

[31]  Abraham Weizman,et al.  Basal plasma dehydroepiandrosterone sulfate level: a possible predictor for response to electroconvulsive therapy in depressed psychotic inpatients , 2000, Biological Psychiatry.

[32]  W. Willis,et al.  Enhanced Phosphorylation of NMDA Receptor 1 Subunits in Spinal Cord Dorsal Horn and Spinothalamic Tract Neurons after Intradermal Injection of Capsaicin in Rats , 2000, The Journal of Neuroscience.

[33]  S. Mellon,et al.  Neurosteroids: Biosynthesis and Function of These Novel Neuromodulators , 2000, Frontiers in Neuroendocrinology.

[34]  D. Haage,et al.  Neurosteroid modulation of synaptic and GABA-evoked currents in neurons from the rat medial preoptic nucleus. , 1999, Journal of neurophysiology.

[35]  L. Sorkin,et al.  Acute pain mechanisms. , 1999, The Surgical clinics of North America.

[36]  M. Schmidt,et al.  Correlation of serum L-carnitine and dehydro-epiandrosterone sulphate levels with age and sex in healthy adults. , 1999, Age and ageing.

[37]  J. Wishart,et al.  Relationships between age, dehydro-epiandrosterone sulphate and plasma glucose in healthy men. , 1999, Age and ageing.

[38]  S. Yen,et al.  Dehydroepiandrosterone: biosynthesis and metabolism in the brain. , 1999, Endocrinology.

[39]  S. Sakoda,et al.  The effect of dehydroepiandrosterone sulfate administration to patients with multi-infarct dementia , 1999, Journal of the Neurological Sciences.

[40]  E. Baulieu,et al.  Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[41]  T. Minami,et al.  Involvement of Glutamate Receptors in Strychnine- and Bicuculline-induced Allodynia in Conscious Mice , 1996, Anesthesiology.

[42]  F. Stephenson,et al.  The GABAA receptors. , 1995, The Biochemical journal.

[43]  J. Besson,et al.  Chronic treatments with aspirin or acetaminophen reduce both the development of polyarthritis and Fos-like immunoreactivity in rat lumbar spinal cord , 1994, Pain.

[44]  D. Gruol,et al.  Dehydroepiandrosterone sulfate alters synaptic potentials in area CA1 of the hippocampal slice , 1994, Brain Research.

[45]  A. Todd,et al.  Light microscope study of the coexistence of GABA‐like and glycine‐like immunoreactivities in the spinal cord of the rat , 1990, The Journal of comparative neurology.

[46]  S. Grillner,et al.  Excitatory amino acids and synaptic transmission: the evidence for a physiological function. , 1990, Trends in pharmacological sciences.

[47]  A. Todd,et al.  GABA-like immunoreactivity in type I glomeruli of rat substantia gelatinosa , 1990, Brain Research.

[48]  G. Delander,et al.  Morphine (intracerebroventricular) activates spinal systems to inhibit behavior induced by putative pain neurotransmitters. , 1989, The Journal of pharmacology and experimental therapeutics.

[49]  G. Wilcox,et al.  Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists. , 1987, The Journal of pharmacology and experimental therapeutics.

[50]  J. Fiet,et al.  Simultaneous radioimmunoassay of progesterone, androst-4-enedione, pregnenolone, dehydroepiandrosterone and 17-hydroxyprogesterone in specific regions of human brain. , 1987, Journal of steroid biochemistry.

[51]  G. Wilcox,et al.  Phencyclidine selectively blocks a spinal action of N-methyl-d-aspartate in mice , 1986, Neuroscience Letters.

[52]  R. H. Evans,et al.  The behavioural effects of an N-methylaspartate receptor antagonist following application to the lumbar spinal cord of conscious rats , 1984, Neuropharmacology.

[53]  E. Baulieu,et al.  Characterization and measurement of dehydroepiandrosterone sulfate in rat brain. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[54]  G. Wilcox,et al.  Intrathecal morphine in mice: a new technique. , 1980, European journal of pharmacology.

[55]  J. E. Vaughn,et al.  GABAergic terminals are presynaptic to primary afferent terminals in the substantia gelatinosa of the rat spinal cord , 1978, Brain Research.

[56]  M. Roo,et al.  Fast nongenomic effects of steroids on synaptic transmission and role of endogenous neurosteroids in spinal pain pathways , 2007, Journal of Molecular Neuroscience.

[57]  T. Maurice,et al.  The sigma1 protein as a target for the non-genomic effects of neuro(active)steroids: molecular, physiological, and behavioral aspects. , 2006, Journal of pharmacological sciences.

[58]  Kenneth E McCarson,et al.  The role of GABA in the mediation and perception of pain. , 2006, Advances in pharmacology.

[59]  C. Rhoden,et al.  Effects of the chronic use of dehydroepiandrosterone (DHEA) on testicular weight and spermatogenesis: Experimental study in rats , 2004, International Urology and Nephrology.

[60]  E. Baulieu.  Neurosteroids: of the nervous system, by the nervous system, for the nervous system. , 1997, Recent progress in hormone research.

[61]  S. Heinemann,et al.  Cloned glutamate receptors. , 1994, Annual review of neuroscience.

[62]  E. Baulieu,et al.  Chronobiologic dynamics of delta 5-3 beta-hydroxysteroids and glucocorticoids in rat brain and plasma and human plasma. , 1987, Progress in clinical and biological research.