Studying platinum sensitivity and resistance in high-grade serous ovarian cancer: Different models for different questions.
暂无分享,去创建一个
[1] V. Beral,et al. Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer , 2015, Nature Reviews Cancer.
[2] Joshua M. Korn,et al. High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response , 2015, Nature Medicine.
[3] A. Zee,et al. Biobanking of patient and patient-derived xenograft ovarian tumour tissue: efficient preservation with low and high fetal calf serum based methods , 2015, Scientific Reports.
[4] L. Woelber,et al. Beyond Bevacizumab: An Outlook to New Anti-Angiogenics for the Treatment of Ovarian Cancer , 2015, Front. Oncol..
[5] Katja Kaipio,et al. Identification of Prognostic Groups in High-Grade Serous Ovarian Cancer Treated with Platinum-Taxane Chemotherapy. , 2015, Cancer research.
[6] Jacobus Pfisterer,et al. Standard chemotherapy with or without bevacizumab for women with newly diagnosed ovarian cancer (ICON7): overall survival results of a phase 3 randomised trial , 2015, The Lancet. Oncology.
[7] Carlos Caldas,et al. Maintaining Tumor Heterogeneity in Patient-Derived Tumor Xenografts. , 2015, Cancer research.
[8] J. Reis-Filho,et al. Ovarian carcinoma patient derived xenografts reproduce their tumor of origin and preserve an oligoclonal structure , 2015, Oncotarget.
[9] G. Heinze,et al. Molecular characterization of 7 new established cell lines from high grade serous ovarian cancer. , 2015, Cancer letters.
[10] A. Difeo,et al. Critical role of Wnt/β-catenin signaling in driving epithelial ovarian cancer platinum resistance , 2015, Oncotarget.
[11] Gordon B Mills,et al. Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours , 2015, Nature Communications.
[12] Joshy George,et al. Whole–genome characterization of chemoresistant ovarian cancer , 2015, Nature.
[13] J. Doroshow,et al. Phase I Study of Single-Agent AZD1775 (MK-1775), a Wee1 Kinase Inhibitor, in Patients With Refractory Solid Tumors. , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[14] Robert Langer,et al. An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors , 2015, Science Translational Medicine.
[15] James M. Olson,et al. A technology platform to assess multiple cancer agents simultaneously within a patient’s tumor , 2015, Science Translational Medicine.
[16] F. Lin,et al. Cyclin-dependent kinase inhibitor dinaciclib potently synergizes with cisplatin in preclinical models of ovarian cancer , 2015, Oncotarget.
[17] G. Inghirami,et al. Stromal contribution to the colorectal cancer transcriptome , 2015, Nature Genetics.
[18] Benjamin G. Bitler,et al. Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers , 2015, Nature Medicine.
[19] Evis Sala,et al. Spatial and Temporal Heterogeneity in High-Grade Serous Ovarian Cancer: A Phylogenetic Analysis , 2015, PLoS medicine.
[20] C. Wijmenga,et al. Gene expression analysis identifies global gene dosage sensitivity in cancer , 2015, Nature Genetics.
[21] Thomas O. McDonald,et al. Wee-1 Kinase Inhibition Overcomes Cisplatin Resistance Associated with High-Risk TP53 Mutations in Head and Neck Cancer through Mitotic Arrest Followed by Senescence , 2014, Molecular Cancer Therapeutics.
[22] N. Schultz,et al. The performance of BRCA1 immunohistochemistry for detecting germline, somatic, and epigenetic BRCA1 loss in high-grade serous ovarian cancer. , 2014, Annals of oncology : official journal of the European Society for Medical Oncology.
[23] Sohrab P. Shah,et al. Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution , 2014, Nature.
[24] Marijn T. M. van Jaarsveld,et al. Lysophospholipids secreted by splenic macrophages induce chemotherapy resistance via interference with the DNA damage response , 2014, Nature Communications.
[25] Wei-Ting Hwang,et al. Effects of BRCA1- and BRCA2-Related Mutations on Ovarian and Breast Cancer Survival: A Meta-analysis , 2014, Clinical Cancer Research.
[26] D. Matei,et al. The Novel, Small-Molecule DNA Methylation Inhibitor SGI-110 as an Ovarian Cancer Chemosensitizer , 2014, Clinical Cancer Research.
[27] R. Kimmig,et al. ERCC1-positive circulating tumor cells in the blood of ovarian cancer patients as a predictive biomarker for platinum resistance. , 2014, Clinical chemistry.
[28] E. Goode,et al. Prognostic and therapeutic relevance of molecular subtypes in high-grade serous ovarian cancer. , 2014, Journal of the National Cancer Institute.
[29] Luca Magnani,et al. Poised epigenetic states and acquired drug resistance in cancer , 2014, Nature Reviews Cancer.
[30] Xiaoming Wang,et al. Epithelial ovarian cancer: A case report , 2014, Experimental and therapeutic medicine.
[31] James D. Brenton,et al. Ovarian Cancer Cell Line Panel (OCCP): Clinical Importance of In Vitro Morphological Subtypes , 2014, PloS one.
[32] Marcela Dávila López,et al. Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment decisions , 2014, Oncotarget.
[33] L. Franke,et al. ATR inhibition preferentially targets homologous recombination-deficient tumor cells , 2014, Oncogene.
[34] Zachary C. Dobbin,et al. Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer , 2014, Oncotarget.
[35] Adam A. Margolin,et al. Functional Kinomics Identifies Candidate Therapeutic Targets in Head and Neck Cancer , 2014, Clinical Cancer Research.
[36] E. Yang,et al. An ex vivo assay of XRT-induced Rad51 foci formation predicts response to PARP-inhibition in ovarian cancer. , 2014, Gynecologic oncology.
[37] J. Dou,et al. Observation of ovarian cancer stem cell behavior and investigation of potential mechanisms of drug resistance in three-dimensional cell culture. , 2014, Journal of bioscience and bioengineering.
[38] R. Zeillinger,et al. BRCA1 gene promoter methylation status in high-grade serous ovarian cancer patients--a study of the tumour Bank ovarian cancer (TOC) and ovarian cancer diagnosis consortium (OVCAD). , 2014, European journal of cancer.
[39] Prahlad T. Ram,et al. Hematogenous metastasis of ovarian cancer: rethinking mode of spread. , 2014, Cancer cell.
[40] Sridhar Ramaswamy,et al. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility , 2014, Science.
[41] D. Matei,et al. Epithelial ovarian cancer experimental models , 2014, Oncogene.
[42] N. Navin,et al. Clonal Evolution in Breast Cancer Revealed by Single Nucleus Genome Sequencing , 2014, Nature.
[43] D. Matei,et al. Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial. , 2014, The Lancet. Oncology.
[44] Mahmood Ayub,et al. Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer , 2014, Nature Medicine.
[45] L. Galluzzi,et al. Systems biology of cisplatin resistance: past, present and future , 2014, Cell Death and Disease.
[46] S. Fox,et al. Molecular correlates of platinum response in human high‐grade serous ovarian cancer patient‐derived xenografts , 2014, Molecular oncology.
[47] L. Meng,et al. The Role of BRCA Status on the Prognosis of Patients with Epithelial Ovarian Cancer: A Systematic Review of the Literature with a Meta-Analysis , 2014, PloS one.
[48] R. Stephens,et al. Pathway-Specific Engineered Mouse Allograft Models Functionally Recapitulate Human Serous Epithelial Ovarian Cancer , 2014, PloS one.
[49] M. Gore,et al. A randomised, phase II trial of the DNA-hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in combination with carboplatin vs carboplatin alone in patients with recurrent, partially platinum-sensitive ovarian cancer , 2014, British Journal of Cancer.
[50] Alfonso Valencia,et al. Integrated Next-Generation Sequencing and Avatar Mouse Models for Personalized Cancer Treatment , 2014, Clinical Cancer Research.
[51] N. Curtin,et al. The Use of Ovarian Cancer Cells from Patients Undergoing Surgery to Generate Primary Cultures Capable of Undergoing Functional Analysis , 2014, PloS one.
[52] E. Fuller,et al. Culture Models to Define Key Mediators of Cancer Matrix Remodeling , 2014, Front. Oncol..
[53] C. Annunziata,et al. Recent Technological Advances in Using Mouse Models to Study Ovarian Cancer , 2014, Front. Oncol..
[54] Clarence C Lee,et al. Genomic and transcriptomic plasticity in treatment-naïve ovarian cancer , 2014, Genome research.
[55] Manuel Hidalgo,et al. Patient-derived xenograft models: an emerging platform for translational cancer research. , 2014, Cancer discovery.
[56] Jinmin Zhao,et al. In vitro ovarian cancer model based on three-dimensional agarose hydrogel , 2014, Journal of tissue engineering.
[57] J. Sarkaria,et al. Tumorgrafts as In Vivo Surrogates for Women with Ovarian Cancer , 2014, Clinical Cancer Research.
[58] Mallika Singh,et al. Mouse tumour models to guide drug development and identify resistance mechanisms , 2014, The Journal of pathology.
[59] U. Matulonis,et al. Current Status and Evolution of Preclinical Drug Development Models of Epithelial Ovarian Cancer , 2013, Front. Oncol..
[60] C. Scott,et al. Patient-Derived Xenograft Models to Improve Targeted Therapy in Epithelial Ovarian Cancer Treatment , 2013, Front. Oncol..
[61] J. Jonkers,et al. Molecular Pathways Molecular Pathways : How Can BRCA-Mutated Tumors Become Resistant to PARP Inhibitors ? , 2014 .
[62] W. Barry,et al. Predictive value of circulating tumor cells (CTCs) in newly-diagnosed and recurrent ovarian cancer patients. , 2013, Gynecologic oncology.
[63] H. Hollema,et al. Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL , 2013, British Journal of Cancer.
[64] Alan Ashworth,et al. Mechanisms of resistance to therapies targeting BRCA-mutant cancers , 2013, Nature Medicine.
[65] A. Rafii,et al. Microenvironment mesenchymal cells protect ovarian cancer cell lines from apoptosis by inhibiting XIAP inactivation , 2013, Cell Death and Disease.
[66] Li Ding,et al. Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts. , 2013, Cell reports.
[67] S. Shah,et al. Type-Specific Cell Line Models for Type-Specific Ovarian Cancer Research , 2013, PloS one.
[68] Kwok-Kin Wong,et al. New cast for a new era: preclinical cancer drug development revisited. , 2013, The Journal of clinical investigation.
[69] G. Hannon,et al. Patient-derived tumor xenografts: transforming clinical samples into mouse models. , 2013, Cancer research.
[70] Ali Bashashati,et al. Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling , 2013, The Journal of pathology.
[71] R. Drapkin,et al. Modeling High-Grade Serous Carcinoma: How Converging Insights into Pathogenesis and Genetics are Driving Better Experimental Platforms , 2013, Front. Oncol..
[72] Peter Bouwman,et al. A high-throughput functional complementation assay for classification of BRCA1 missense variants. , 2013, Cancer discovery.
[73] C. Sander,et al. Evaluating cell lines as tumour models by comparison of genomic profiles , 2013, Nature Communications.
[74] D. Planchard,et al. Detection of circulating tumor cells harboring a unique ALK rearrangement in ALK-positive non-small-cell lung cancer. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[75] K. Flatten,et al. ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status. , 2013, Cancer research.
[76] D. Speicher,et al. Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition , 2013, Cell cycle.
[77] W. Bshara,et al. Origin of the vasculature supporting growth of primary patient tumor xenografts , 2013, Journal of Translational Medicine.
[78] N. Rosenfeld,et al. Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA , 2013, Nature.
[79] Lin Feng,et al. RIF1 Counteracts BRCA1-mediated End Resection during DNA Repair* , 2013, The Journal of Biological Chemistry.
[80] Kate Lawrenson,et al. A three-dimensional microenvironment alters protein expression and chemosensitivity of epithelial ovarian cancer cells in vitro , 2013, Laboratory Investigation.
[81] W. Sellers,et al. Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance , 2013, Nature.
[82] K. Cibulskis,et al. Prognostically relevant gene signatures of high-grade serous ovarian carcinoma. , 2012, The Journal of clinical investigation.
[83] B. Vanderhyden,et al. Technical challenges and limitations of current mouse models of ovarian cancer , 2012, Journal of Ovarian Research.
[84] P. Maxwell,et al. Clinicopathological features of homologous recombination-deficient epithelial ovarian cancers: sensitivity to PARP inhibitors, platinum, and survival. , 2012, Cancer research.
[85] Robert Brown,et al. Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling , 2012, Oncogene.
[86] Anne-Marie Mes-Masson,et al. Derivation and characterization of matched cell lines from primary and recurrent serous ovarian cancer , 2012, BMC Cancer.
[87] M. Yi,et al. Perturbation of Rb, p53, and Brca1 or Brca2 cooperate in inducing metastatic serous epithelial ovarian cancer. , 2012, Cancer research.
[88] M. Esteller,et al. Lurbinectedin (PM01183), a New DNA Minor Groove Binder, Inhibits Growth of Orthotopic Primary Graft of Cisplatin-Resistant Epithelial Ovarian Cancer , 2012, Clinical Cancer Research.
[89] J. Delord,et al. Implication of Tumor Microenvironment in Chemoresistance: Tumor-Associated Stromal Cells Protect Tumor Cells from Cell Death , 2012, International journal of molecular sciences.
[90] Michael M Gottesman,et al. Cisplatin Resistance: A Cellular Self-Defense Mechanism Resulting from Multiple Epigenetic and Genetic Changes , 2012, Pharmacological Reviews.
[91] C. Drake,et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. , 2012, The New England journal of medicine.
[92] D. Bowtell,et al. The changing view of high-grade serous ovarian cancer. , 2012, Cancer research.
[93] J. Malek,et al. Mesenchymal Cell Interaction with Ovarian Cancer Cells Triggers Pro-Metastatic Properties , 2012, PloS one.
[94] E. Voest,et al. The role of mesenchymal stem cells in anti-cancer drug resistance and tumour progression , 2012, British Journal of Cancer.
[95] D. Matei,et al. Epigenetic resensitization to platinum in ovarian cancer. , 2012, Cancer research.
[96] L. Galluzzi,et al. Molecular mechanisms of cisplatin resistance , 2012, Oncogene.
[97] Andrew L. Kung,et al. A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response , 2012, Nature.
[98] S. Ramaswamy,et al. Systematic identification of genomic markers of drug sensitivity in cancer cells , 2012, Nature.
[99] Adam A. Margolin,et al. The Cancer Cell Line Encyclopedia enables predictive modeling of anticancer drug sensitivity , 2012, Nature.
[100] C. Creighton,et al. High-grade serous ovarian cancer arises from fallopian tube in a mouse model , 2012, Proceedings of the National Academy of Sciences.
[101] V. A. Flørenes,et al. Predicting platinum resistance in primary advanced ovarian cancer patients with an in vitro resistance index , 2012, Cancer Chemotherapy and Pharmacology.
[102] P. Borst,et al. Drug resistance in the mouse cancer clinic. , 2012, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.
[103] Kylie L. Gorringe,et al. An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice. , 2012, The Journal of clinical investigation.
[104] Jay W. Wright,et al. BRCAness Profile of Sporadic Ovarian Cancer Predicts Disease Recurrence , 2012, PloS one.
[105] Peter Bouwman,et al. BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance. , 2011, Cancer cell.
[106] Davide Corà,et al. A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer. , 2011, Cancer discovery.
[107] J. Brenton,et al. Evolution of platinum resistance in high-grade serous ovarian cancer. , 2011, The Lancet. Oncology.
[108] G. Mills,et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth , 2011, Nature Medicine.
[109] T. Ludwig,et al. BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity , 2011, Science.
[110] A. Jazaeri,et al. Molecular requirements for transformation of fallopian tube epithelial cells into serous carcinoma. , 2011, Neoplasia.
[111] Kenneth P. Nephew,et al. Rethinking ovarian cancer: recommendations for improving outcomes , 2011, Nature Reviews Cancer.
[112] R. J. Kelleher,et al. Humanized Mouse Model of Ovarian Cancer Recapitulates Patient Solid Tumor Progression, Ascites Formation, and Metastasis , 2011, PloS one.
[113] B. Monk,et al. Circulating tumor cells predict progression free survival and overall survival in patients with relapsed/recurrent advanced ovarian cancer. , 2011, Gynecologic oncology.
[114] H. Mackay,et al. Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study. , 2011, The Lancet. Oncology.
[115] Georgia Sotiropoulou,et al. DNA methylation of tumor suppressor and metastasis suppressor genes in circulating tumor cells. , 2011, Clinical chemistry.
[116] Rochelle L. Garcia,et al. Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[117] Lewis C Cantley,et al. The APL paradigm and the "co-clinical trial" project. , 2011, Cancer discovery.
[118] M. Hidalgo,et al. A Pilot Clinical Study of Treatment Guided by Personalized Tumorgrafts in Patients with Advanced Cancer , 2011, Molecular Cancer Therapeutics.
[119] Benjamin J. Raphael,et al. Integrated Genomic Analyses of Ovarian Carcinoma , 2011, Nature.
[120] R. Drapkin,et al. Modeling high-grade serous ovarian carcinogenesis from the fallopian tube , 2011, Proceedings of the National Academy of Sciences.
[121] Richard A. Moore,et al. ARID1A mutations in endometriosis-associated ovarian carcinomas. , 2010, The New England journal of medicine.
[122] M. Gerlinger,et al. How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine , 2010, British Journal of Cancer.
[123] M. Pajic,et al. Tumor-initiating cells are not enriched in cisplatin-surviving BRCA1;p53-deficient mammary tumor cells in vivo , 2010, Cell cycle.
[124] D. Matei,et al. A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum‐resistant, epithelial ovarian cancer , 2010, Cancer.
[125] B. Karlan,et al. Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[126] R. Coleman,et al. Chemosensitivity testing with ChemoFx and overall survival in primary ovarian cancer. , 2010, American journal of obstetrics and gynecology.
[127] Thomas J. Hardcastle,et al. Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma , 2010, Oncogene.
[128] D. Adams,et al. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers , 2010, Nature Structural &Molecular Biology.
[129] Y. Drew,et al. Development of a Functional Assay for Homologous Recombination Status in Primary Cultures of Epithelial Ovarian Tumor and Correlation with Sensitivity to Poly(ADP-Ribose) Polymerase Inhibitors , 2010, Clinical Cancer Research.
[130] Ie-Ming Shih,et al. The Origin and Pathogenesis of Epithelial Ovarian Cancer: A Proposed Unifying Theory , 2010, The American journal of surgical pathology.
[131] B. Vanderhyden,et al. Conditional Inactivation of Brca1, p53 and Rb in Mouse Ovaries Results in the Development of Leiomyosarcomas , 2009, PloS one.
[132] A. Ashworth,et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. , 2009, The New England journal of medicine.
[133] Daniel Birnbaum,et al. Gene expression profiling and prediction of clinical outcome in ovarian cancer. , 2009, Critical reviews in oncology/hematology.
[134] Tsuyoshi Arai,et al. Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents , 2009, Molecular Cancer Therapeutics.
[135] J. Marto,et al. Primary ex-vivo cultures of human fallopian tube epithelium as a model for serous ovarian carcinogenesis , 2009, Oncogene.
[136] Brett L Carlson,et al. Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts. , 2009, Neuro-oncology.
[137] Hans W. Nijman,et al. Prognostic significance of tumor-infiltrating T-lymphocytes in primary and metastatic lesions of advanced stage ovarian cancer , 2008, Cancer Immunology, Immunotherapy.
[138] Hui-Yi Lin,et al. Effect of TRA-8 Anti-Death Receptor 5 Antibody in Combination With Chemotherapy in an Ex Vivo Human Ovarian Cancer Model , 2009, International Journal of Gynecologic Cancer.
[139] Joshy George,et al. Integrated Genome-Wide DNA Copy Number and Expression Analysis Identifies Distinct Mechanisms of Primary Chemoresistance in Ovarian Carcinomas , 2009, Clinical Cancer Research.
[140] H. Hollema,et al. Survival-Related Profile, Pathways, and Transcription Factors in Ovarian Cancer , 2009, PLoS medicine.
[141] F. Patel,et al. Utility of Gene Promoter Methylation in Prediction of Response to Platinum-Based Chemotherapy in Epithelial Ovarian Cancer (EOC) , 2009, Cancer investigation.
[142] R. Tothill,et al. Novel Molecular Subtypes of Serous and Endometrioid Ovarian Cancer Linked to Clinical Outcome , 2008, Clinical Cancer Research.
[143] A. Mes-Masson,et al. Characterization of three new serous epithelial ovarian cancer cell lines , 2008, BMC Cancer.
[144] M. Castiglione,et al. Epithelial ovarian carcinoma: ESMO clinical recommendations for diagnosis, treatment and follow-up. , 2008, Annals of oncology : official journal of the European Society for Medical Oncology.
[145] B. Karlan,et al. Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance. , 2008, Cancer research.
[146] J. Kigawa,et al. Mechanisms of chemoresistance and poor prognosis in ovarian clear cell carcinoma , 2008, Cancer science.
[147] F. Couch,et al. Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers , 2008, Nature.
[148] Jorge S. Reis-Filho,et al. Resistance to therapy caused by intragenic deletion in BRCA2 , 2008, Nature.
[149] Anil K Sood,et al. Early events in the pathogenesis of epithelial ovarian cancer. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[150] J. Jonkers,et al. Modeling therapy resistance in genetically engineered mouse cancer models. , 2008, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.
[151] Glenn Heller,et al. Circulating Tumor Cell Number and Prognosis in Progressive Castration-Resistant Prostate Cancer , 2007, Clinical Cancer Research.
[152] A. V. D. Van Der Zee,et al. Profiling studies in ovarian cancer: a review. , 2007, The oncologist.
[153] Jos Jonkers,et al. Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer , 2007, Proceedings of the National Academy of Sciences.
[154] W. Grizzle,et al. Efficacy of anti-death receptor 5 (DR5) antibody (TRA-8) against primary human ovarian carcinoma using a novel ex vivo tissue slice model. , 2007, Gynecologic oncology.
[155] Anil Potti,et al. An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[156] D. Xing,et al. A mouse model for the molecular characterization of brca1-associated ovarian carcinoma. , 2006, Cancer research.
[157] S. Pignata,et al. Activity of chemotherapy in mucinous epithelial ovarian cancer: a retrospective study. , 2005, Anticancer research.
[158] Thomas Helleday,et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase , 2005, Nature.
[159] Alan Ashworth,et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy , 2005, Nature.
[160] Alison Stopeck,et al. Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[161] R. Coleman,et al. Progression‐free interval in ovarian cancer and predictive value of an ex vivo chemoresponse assay , 2004, International Journal of Gynecologic Cancer.
[162] Marie Joseph,et al. Gene expression signature with independent prognostic significance in epithelial ovarian cancer. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[163] Robert Brown,et al. The epigenetics of ovarian cancer drug resistance and resensitization. , 2004, American journal of obstetrics and gynecology.
[164] A. Ashworth,et al. Hallmarks of 'BRCAness' in sporadic cancers , 2004, Nature Reviews Cancer.
[165] Robert Brown,et al. The Acquisition of hMLH1 Methylation in Plasma DNA after Chemotherapy Predicts Poor Survival for Ovarian Cancer Patients , 2004, Clinical Cancer Research.
[166] I. Shih,et al. Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis. , 2004, The American journal of pathology.
[167] A. Maier,et al. Clonogenic assay with established human tumour xenografts: correlation of in vitro to in vivo activity as a basis for anticancer drug discovery. , 2004, European journal of cancer.
[168] T. Bauknecht,et al. A randomized clinical trial of cisplatin/paclitaxel versus carboplatin/paclitaxel as first-line treatment of ovarian cancer. , 2003, Journal of the National Cancer Institute.
[169] Robert S Mannel,et al. Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group study. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[170] I. Shih,et al. Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma. , 2003, Journal of the National Cancer Institute.
[171] George Coukos,et al. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. , 2003, The New England journal of medicine.
[172] H. Ozçelik,et al. Epigenetic factors controlling the BRCA1 and BRCA2 genes in sporadic ovarian cancer. , 2002, Cancer research.
[173] E. Trimble,et al. Survival effect of maximal cytoreductive surgery for advanced ovarian carcinoma during the platinum era: a meta-analysis. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[174] H. Varmus,et al. Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. , 2002, Cancer cell.
[175] R. L. Baldwin,et al. BRCA1 promoter region hypermethylation in ovarian carcinoma: a population-based study. , 2000, Cancer research.
[176] T. Fojo,et al. Paclitaxel selects for mutant or pseudo-null p53 in drug resistance associated with tubulin mutations in human cancer , 2000, Oncogene.
[177] J. Herman,et al. Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. , 2000, Journal of the National Cancer Institute.
[178] P. Scheffer,et al. Development of a panel of 15 human ovarian cancer xenografts for drug screening and determination of the role of the glutathione detoxification system. , 2000, Gynecologic oncology.
[179] Chun-Fang Xu,et al. Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics , 1999, Oncogene.
[180] M. Piver,et al. Characterization of human ovarian carcinomas in a SCID mouse model. , 1999, Gynecologic oncology.
[181] A. Godwin,et al. High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[182] H. Fiebig,et al. The clonogenic assay with human tumor xenografts: evaluation, predictive value and application for drug screening. , 1990, Annals of oncology : official journal of the European Society for Medical Oncology.
[183] M. Gore,et al. Treatment of relapsed carcinoma of the ovary with cisplatin or carboplatin following initial treatment with these compounds. , 1990, Gynecologic oncology.
[184] J. Smyth,et al. Characterization and properties of nine human ovarian adenocarcinoma cell lines. , 1988, Cancer research.
[185] W. Kleine. Prognostic significance of growth characteristics of xenotransplanted ovarian carcinomas into nude mice. , 1986, Gynecologic oncology.
[186] C. Krumdieck,et al. A new instrument for the rapid preparation of tissue slices. , 1980, Analytical biochemistry.
[187] J.,et al. The New England Journal of Medicine. , 1961, Canadian Medical Association journal.
[188] M. Piccart,et al. An update on PARP inhibitors—moving to the adjuvant setting , 2015, Nature Reviews Clinical Oncology.
[189] Klaus Pantel,et al. Circulating tumor cells: liquid biopsy of cancer. , 2013, Clinical chemistry.
[190] E. Obermayr,et al. Molecular characterization of circulating tumor cells in patients with ovarian cancer improves their prognostic significance -- a study of the OVCAD consortium. , 2013, Gynecologic oncology.
[191] Shridar Ganesan,et al. Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. , 2013, Cancer discovery.
[192] A. Jemal,et al. Cancer statistics, 2012 , 2012, CA: a cancer journal for clinicians.
[193] R. Brentjens,et al. Adoptive T cell immunotherapy strategies for the treatment of patients with ovarian cancer. , 2010, Discovery medicine.
[194] Michael L Pearl,et al. Clinical significance of circulating tumor cells detected by an invasion assay in peripheral blood of patients with ovarian cancer. , 2009, Gynecologic oncology.
[195] D. Huntsman,et al. Establishment of subrenal capsule xenografts of primary human ovarian tumors in SCID mice: potential models. , 2005, Gynecologic oncology.
[196] Ook.,et al. CYCLOPHOSPHAMIDE AND CISPLATIN COMPARED WITH PACLITAXEL AND CISPLATIN IN PATIENTS WITH STAGE III AND STAGE IV OVARIAN CANCER , 2000 .
[197] F. Parazzini,et al. Response to second-line weekly cisplatin chemotherapy in ovarian cancer previously treated with a cisplatin- or carboplatin-based regimen. , 1994, European journal of cancer.