Vaccine strains of Vibrio cholerae induce a differential array of proinflammatory mediators in an intestinal epithelial cell line

Resumen es: En este estudio se evaluo la expresion de varios mediadores inflamatorios en la linea celular HT29-18N2 en respuesta a la interaccion con cepas vacunales...

[1]  G. Díaz,et al.  Antigenicidad e inmunogenicidad de una cepa inactivada de Vibrio cholerae O1 El Tor Inaba , 2009 .

[2]  M. Waldor,et al.  Filamentous phages linked to virulence of Vibrio cholerae. , 2003, Current opinion in microbiology.

[3]  R. Fando,et al.  Differential Interleukin-8 Response of Intestinal Epithelial Cell Line to Reactogenic and Nonreactogenic Candidate Vaccine Strains of Vibrio cholerae , 2001, Infection and Immunity.

[4]  J. Mekalanos,et al.  Association of Protease Activity in Vibrio choleraeVaccine Strains with Decreases in Transcellular Epithelial Resistance of Polarized T84 Intestinal Epithelial Cells , 2000, Infection and Immunity.

[5]  D. Collins Cytokine and cytokine receptor expression as a biological indicator of immune activation: important considerations in the development of in vitro model systems. , 2000, Journal of immunological methods.

[6]  J. Smith,et al.  Enteroaggregative Escherichia coli expresses a novel flagellin that causes IL-8 release from intestinal epithelial cells. , 2000, The Journal of clinical investigation.

[7]  Anisia J. Silva,et al.  Preliminary Assessment of the Safety and Immunogenicity of a New CTXΦ-Negative, Hemagglutinin/Protease-Defective El Tor Strain as a Cholera Vaccine Candidate , 1999, Infection and Immunity.

[8]  L. Eckmann,et al.  The regulation and functional consequence of proinflammatory cytokine binding on human intestinal epithelial cells. , 1998, Journal of immunology.

[9]  Jung Mogg Kim,et al.  Enteroinvasive bacteria directly activate expression of iNOS and NO production in human colon epithelial cells. , 1998, American journal of physiology. Gastrointestinal and liver physiology.

[10]  J. Benitez,et al.  Adherence of Vibrio cholerae to cultured differentiated human intestinal cells: an in vitro colonization model , 1997, Infection and immunity.

[11]  J. M. Kim,et al.  Increased motility of Helicobacter pylori by methylcellulose could upregulate the expression of proinflammatory cytokines in human gastric epithelial cells. , 1997, Scandinavian journal of clinical and laboratory investigation.

[12]  M. Rao,et al.  Field trial of a locally produced, killed, oral cholera vaccine in Vietnam , 1997, The Lancet.

[13]  J. Benitez,et al.  Tagging a Vibrio cholerae El Tor candidate vaccine strain by disruption of its hemagglutinin/protease gene using a novel reporter enzyme: Clostridium thermocellum endoglucanase A. , 1996, Vaccine.

[14]  Matthew K. Waldor,et al.  Lysogenic Conversion by a Filamentous Phage Encoding Cholera Toxin , 1996, Science.

[15]  C. Tacket,et al.  New evidence for an inflammatory component in diarrhea caused by selected new, live attenuated cholera vaccines and by El Tor and Q139 Vibrio cholerae , 1996, Infection and immunity.

[16]  M. Waldor,et al.  Live cholera vaccines: perspectives on their construction and safety , 1995 .

[17]  T. Phillips,et al.  HT29-18N2 differentiation in a protein-free medium , 1995, In Vitro Cellular & Developmental Biology - Animal.

[18]  M. Waldor,et al.  Safety, immunogenicity, and efficacy of live attenuated Vibrio cholerae 0139 vaccine prototype , 1995, The Lancet.

[19]  J. Ezzell,et al.  Development of a live, oral, attenuated vaccine against El Tor cholera. , 1994, The Journal of infectious diseases.

[20]  M. Levine,et al.  Safety and immunogenicity of live oral cholera vaccine candidate CVD 110, a delta ctxA delta zot delta ace derivative of El Tor Ogawa Vibrio cholerae. , 1993, The Journal of infectious diseases.

[21]  J. Kaper,et al.  CVD110, an attenuated Vibrio cholerae O1 El Tor live oral vaccine strain , 1993, Infection and immunity.

[22]  C. Tacket,et al.  SAFETY, IMMUNOGENICITY, AND EFFICACY OF RECOMBINANT LIVE ORAL CHOLERA VACCINES, CVD 103 AND CVD 103-HgR , 1988, The Lancet.

[23]  M. Levine,et al.  Volunteer studies of deletion mutants of Vibrio cholerae O1 prepared by recombinant techniques , 1988, Infection and immunity.

[24]  D. Louvard,et al.  Absorptive and mucus-secreting subclones isolated from a multipotent intestinal cell line (HT-29) provide new models for cell polarity and terminal differentiation , 1987, The Journal of cell biology.

[25]  P. Chomczyński,et al.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. , 1987, Analytical biochemistry.

[26]  M. Levine,et al.  Recombinant nontoxinogenic Vibrio cholerae strains as attenuated cholera vaccine candidates , 1984, Nature.

[27]  P. D. Cam,et al.  Investigations into the safety and immunogenicity of a killed oral cholera vaccine developed in Viet Nam. , 2002, Bulletin of the World Health Organization.

[28]  M. Kagnoff,et al.  Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis. , 1997, The Journal of clinical investigation.

[29]  M. Kagnoff,et al.  Perspectives Series: Host/Pathogen Interactions , 1997 .

[30]  J. Benitez,et al.  Genetic manipulation of Vibrio cholerae for vaccine development: construction of live attenuated El Tor candidate vaccine strains. , 1996, Archives of medical research.

[31]  M. Levine,et al.  Construction of genetically marked Vibrio cholerae O1 vaccine strains , 1993 .