Gene therapy effectiveness differs for neuronal survival and behavioral performance

[1]  R. Sapolsky,et al.  Limitations in the neuroprotective potential of gene therapy with Bcl-2 , 2000, Brain Research.

[2]  J. McLaughlin,et al.  Calbindin D28K Gene Transfer via Herpes Simplex Virus Amplicon Vector Decreases Hippocampal Damage In Vivo Following Neurotoxic Insults , 1999, Journal of neurochemistry.

[3]  G. Robertson,et al.  Attenuation of Ischemia-Induced Cellular and Behavioral Deficits by X Chromosome-Linked Inhibitor of Apoptosis Protein Overexpression in the Rat Hippocampus , 1999, The Journal of Neuroscience.

[4]  S. Sensi,et al.  Rapid Ca2+ Entry through Ca2+-Permeable AMPA/Kainate Channels Triggers Marked Intracellular Ca2+Rises and Consequent Oxygen Radical Production , 1998, The Journal of Neuroscience.

[5]  R. Sapolsky,et al.  Gene Transfer of Calbindin D28k cDNA via Herpes Simplex Virus Amplicon Vector Decreases Cytoplasmic Calcium Ion Response and Enhances Neuronal Survival Following Glutamatergic Challenge but Not Following Cyanide , 1998, Journal of neurochemistry.

[6]  M. Schachner,et al.  Molecular mechanisms that underlie structural and functional changes atthe postsynaptic membrane duringsynaptic plasticity , 1998, Progress in Neurobiology.

[7]  D. German,et al.  Calbindin-D28k buffers intracellular calcium and promotes resistance to degeneration in PC12 cells. , 1998, Brain research. Molecular brain research.

[8]  R. Sapolsky,et al.  Increased Expression of Calbindin D28k via Herpes Simplex Virus Amplicon Vector Decreases Calcium Ion Mobilization and Enhances Neuronal Survival After Hypoglycemic Challenge , 1997, Journal of neurochemistry.

[9]  G. Robertson,et al.  Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus , 1997, Nature Medicine.

[10]  R. Sapolsky,et al.  Herpes Simplex Viral Vectors Expressing Bcl-2 Are Neuroprotective When Delivered After a Stroke , 1997, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[11]  S. L. Fink,et al.  Defective Herpes Simplex Virus Vectors Expressing the Rat Brain Stress‐Inducible Heat Shock Protein 72 Protect Cultured Neurons from Severe Heat Shock , 1997, Journal of neurochemistry.

[12]  G. Isom,et al.  Cyanide‐Induced Apoptosis and Oxidative Stress in Differentiated PC12 Cells , 1996, Journal of neurochemistry.

[13]  R. Sapolsky,et al.  A Herpes Simplex Virus Vector Overexpressing the Glucose Transporter Gene Protects the Rat Dentate Gyrus from an Antimetabolite Toxin , 1996, Experimental Neurology.

[14]  R. Sapolsky,et al.  Herpes simplex virus vectors overexpressing the glucose transporter gene protect against seizure-induced neuron loss. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[15]  M. Mattson,et al.  Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium , 1995, Brain Research.

[16]  R. Sapolsky,et al.  Herpes simplex virus vector system: analysis of its in vivo and in vitro cytopathic effects , 1995, Journal of Neuroscience Methods.

[17]  J. Coyle,et al.  Oxidative stress, glutamate, and neurodegenerative disorders. , 1993, Science.

[18]  J. Coyle,et al.  Glutamate Neurotoxicity and the Inhibition of Protein Synthesis in the Hippocampal Slice , 1991, Journal of neurochemistry.

[19]  S. Christakos,et al.  Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegenerative diseases. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[20]  J. Krieglstein,et al.  Pharmacology of cerebral ischemia 1990 : with 78 tables , 1990 .

[21]  J. Krieglstein,et al.  Pharmacology of cerebral ischemia : proceedings of the International Symposium on Pharmacology of Cerebral Ischemia, held in Marburg (FRG) on 16-17 July 1986 , 1986 .

[22]  M. Mayer,et al.  Cellular mechanisms underlying excitotoxicity , 1987, Trends in Neurosciences.

[23]  L. Jarrard,et al.  Selective hippocampal lesions and behavior: effects of kainic acid lesions on performance of place and cue tasks. , 1983, Behavioral neuroscience.

[24]  L. Jarrard Selective hippocampal lesions and behavior , 1980 .

[25]  G. Padmanaban,et al.  Effect of some "strong" excitants of central neurones on the uptake of L-glutamate and L-aspartate by synaptosomes. , 1974, Biochemical and biophysical research communications.

[26]  A. Cowey,et al.  Effects of dorsal and ventral hippocampal lesions on spontaneous alternation, learned alternation and probability learning in rats. , 1973, Brain research.