Simulation of airflow fields and microparticle deposition in realistic human lung airway models. Part II: Particle transport and deposition

Abstract In Part II, given the airflow fields discussed in Part I, microparticle deposition for a practical range of Stokes numbers, 0.025 ⩽ St ⩽ 0.102 , has been simulated and analyzed, comparing different temporal assumptions, inlet conditions and geometric configurations. The matching steady-state assumption with equivalent Reynolds and Stokes numbers achieves basically the same deposition fraction (DF) values as under transient inhalation conditions. When comparing parabolic vs. realistic inlet velocity profiles, total DF-values are higher for the parabolic inlet flow for all Stokes numbers. Geometric features, such as out-of-plane configurations and cartilaginous rings in the trachea, further change local deposited microparticle concentrations when compared with simple airway models. Furthermore, significant differences were recorded when comparing DFs in some branches of the present realistic model and the Weibel Type A model. For practical purposes, algebraic microparticle-deposition correlations, DF = DF ( Re , St ) , have been obtained for both the left and right upper lung airways. Based on current research results, the out-of-plane model with tracheal rings and realistic inlet condition is recommended for future work.

[1]  C. Kim,et al.  Assessment of regional deposition of inhaled particles in human lungs by serial bolus delivery method. , 1996, Journal of applied physiology.

[2]  R. Tompson,et al.  Computational flow and aerosol concentration profiles in lung bifurcations. , 1993, Health physics.

[3]  D E Olson,et al.  Models of the human bronchial tree. , 1971, Journal of applied physiology.

[4]  P. Worth Longest,et al.  Efficient computation of micro-particle dynamics including wall effects , 2004 .

[5]  R. Crystal,et al.  The Lung: Scientific Foundations , 1991 .

[6]  Charles Hirsch,et al.  Anatomically based three-dimensional model of airways to simulate flow and particle transport using computational fluid dynamics. , 2005, Journal of applied physiology.

[7]  Muir Dc,et al.  Inertial deposition of particles in human branching airways. , 1975, Inhaled particles.

[8]  R. Clift,et al.  Bubbles, Drops, and Particles , 1978 .

[9]  E. Weibel Morphometry of the Human Lung , 1965, Springer Berlin Heidelberg.

[10]  Yung-sung Cheng,et al.  Particle Deposition in a Cast of Human Tracheobronchial Airways , 2005 .

[11]  F. Haselton,et al.  Convective exchange in oscillatory flow through bronchial-tree models. , 1982, Journal of applied physiology: respiratory, environmental and exercise physiology.

[12]  Efstathios E. Michaelides,et al.  Review-The transient equation of motion for particles , 1997 .

[13]  Clement Kleinstreuer,et al.  Comparison of micro- and nano-size particle depositions in a human upper airway model , 2005 .

[14]  C. P. Yu,et al.  Inertial and interceptional deposition of spherical particles and fibers in a bifurcating airway , 1988 .

[15]  Joel Schwartz,et al.  REVIEW OF EPIDEMIOLOGICAL EVIDENCE OF HEALTH EFFECTS OF PARTICULATE AIR POLLUTION , 1995 .

[16]  C. N. Davies Inhaled Particles IV , 1972 .

[17]  C. S. Kim,et al.  Deposition of Inhaled Particles in Bifurcating Airway Models: I. Inspiratory Deposition , 1989 .

[18]  Clement Kleinstreuer,et al.  Aerosol Deposition Efficiencies and Upstream Release Positions for Different Inhalation Modes in an Upper Bronchial Airway Model , 2002 .

[19]  T. Heistracher,et al.  Flow and deposition patterns in successive airway bifurcations , 1997 .

[20]  Clement Kleinstreuer,et al.  Transient airflow structures and particle transport in a sequentially branching lung airway model , 2002 .

[21]  Michael J. Oldham,et al.  Computational Fluid Dynamic Predictions and Experimental Results for Particle Deposition in an Airway Model , 2000 .

[22]  B. Asgharian,et al.  Inertial Deposition of Particles in the Human Upper Airway Bifurcations , 1997 .

[23]  Clement Kleinstreuer,et al.  Flow structures and particle deposition patterns in double-bifurcation airway models. Part 2. Aerosol transport and deposition , 2001, Journal of Fluid Mechanics.

[24]  D. Fisher,et al.  Deposition Characteristics of Aerosol Particles in Sequentially Bifurcating Airway Models , 1999 .

[25]  Yu Zhang,et al.  Measurement of the Effect of Cartilaginous Rings on Particle Deposition in a Proximal Lung Bifurcation Model , 2005 .

[26]  D. Fisher,et al.  PARTICLE DEPOSITION IN BIFURCATING AIRWAY MODELS WITH VARYING AIRWAY GEOMETRY , 1994 .

[27]  Philip Worth Longest Computational Analyses of Transient Particle Hemodynamics with Applications to Femoral Bypass Graft Designs , 2003 .