Smad3 Mutant Mice Develop Metastatic Colorectal Cancer
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J. Graff | J. Richardson | L. Parada | James A Richardson | Yuan Zhu | Luis F Parada | Yuan Zhu | Jonathan M Graff
[1] K. Kinzler,et al. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. , 1995, Science.
[2] Y. Yuasa,et al. Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers. , 1998, Cancer letters.
[3] M. Taketo,et al. TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis. , 1996, Developmental biology.
[4] Bert Vogelstein,et al. Hypermutability and mismatch repair deficiency in RER+ tumor cells , 1993, Cell.
[5] K. Polyak. Negative regulation of cell growth by TGF beta. , 1996, Biochimica et biophysica acta.
[6] K. Kinzler,et al. Erratum: Multiple Intestinal Neoplasia Caused By a Mutation in the Murine Homolog of the APC Gene , 1992, Science.
[7] R. Weinberg,et al. Tumor spectrum analysis in p53-mutant mice , 1994, Current Biology.
[8] R. Derynck,et al. Intracellular signalling: The Mad way to do it , 1996, Current Biology.
[9] R. Derynck,et al. Receptor-associated Mad homologues synergize as effectors of the TGF-β response , 1996, Nature.
[10] Margaret Robertson,et al. Identification and characterization of the familial adenomatous polyposis coli gene , 1991, Cell.
[11] C. Deng,et al. The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[12] V. Kaartinen,et al. Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction , 1995, Nature Genetics.
[13] C. Heldin,et al. Identification of Smad2, a Human Mad-related Protein in the Transforming Growth Factor β Signaling Pathway* , 1997, The Journal of Biological Chemistry.
[14] Kathleen R. Cho,et al. DPC4 gene in various tumor types. , 1996, Cancer research.
[15] J. Rossant,et al. The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. , 1998, Genes & development.
[16] M. Taketo,et al. Morphological and molecular processes of polyp formation in Apc(delta716) knockout mice. , 1997, Cancer research.
[17] G. Boivin,et al. TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. , 1997, Development.
[18] R. Weinberg,et al. Effects of an Rb mutation in the mouse , 1992, Nature.
[19] D. Ward,et al. Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer , 1994, Nature.
[20] M. Sporn,et al. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[21] J. Massagué,et al. A human Mad protein acting as a BMP-regulated transcriptional activator , 1996, Nature.
[22] L. Donehower,et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours , 1992, Nature.
[23] J. Graff,et al. Embryonic Patterning: To BMP or Not to BMP, That Is the Question , 1997, Cell.
[24] A. Kulkarni,et al. Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice. , 1995, Development.
[25] Takeshi Imamura,et al. TGF‐β receptor‐mediated signalling through Smad2, Smad3 and Smad4 , 1997 .
[26] J. Jiricny. Colon cancer and DNA repair: have mismatches met their match? , 1994, Trends in genetics : TIG.
[27] K. Miyazono,et al. HNPCC associated with germline mutation in the TGF-β type II receptor gene , 1998, Nature Genetics.
[28] K. Kinzler,et al. Corrections and Clarifications: Multiple Intestinal Neoplasia Caused By a Mutation in the Murine Homolog of the APC Gene , 1992, Science.
[29] I. Petersen,et al. Evidence for a novel tumor suppressor gene on chromosome 15 associated with progression to a metastatic stage in breast cancer. , 1996, Oncogene.
[30] D. Melton,et al. The mRNA encoding elongation factor 1-α (EF-1α) is a major transcript at the midblastula transition in Xenopus , 1989 .
[31] R. Weinberg,et al. Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[32] N. Copeland,et al. Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. , 1994, Genes & development.
[33] K. Kinzler,et al. Frequency of Smad gene mutations in human cancers. , 1997, Cancer research.
[34] J. Baker,et al. A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway. , 1996, Genes & development.
[35] Kohei Miyazono,et al. TGF-β signalling from cell membrane to nucleus through SMAD proteins , 1997, Nature.
[36] J DeMiguel,et al. Cancer of the colon , 1973 .
[37] K. Kinzler,et al. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. , 1991, Science.
[38] J. Uitto,et al. Revertant Mosaicism in Epidermolysis Bullosa Caused by Mitotic Gene Conversion , 1997, Cell.
[39] J. Massagué. TGFβ Signaling: Receptors, Transducers, and Mad Proteins , 1996, Cell.
[40] G. Boivin,et al. TGF β 2 knockout mice have multiple developmental defects that are non-overlapping with other TGF β knockout phenotypes , 1997 .
[41] J. Wrana,et al. MAD-related proteins in TGF-β signalling , 1996 .
[42] Darryl Shibata,et al. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis , 1993, Nature.
[43] Robert A. Weinberg,et al. Tumour predisposition in mice heterozygous for a targeted mutation in Nf1 , 1994, Nature Genetics.
[44] Robin J. Leach,et al. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer , 1993, Cell.
[45] R. White,et al. Tumor Suppressing Pathways , 1998, Cell.
[46] Ken W. Y. Cho,et al. Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. , 1997, Development.
[47] E. Lander,et al. Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse , 1993, Cell.
[48] K. Kinzler,et al. Lessons from Hereditary Colorectal Cancer , 1996, Cell.
[49] S. Astrin,et al. The molecular genetics of colon cancer. , 1989, Seminars in Oncology.
[50] A. Bradley,et al. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis , 1992, Nature.
[51] Irene L Andrulis,et al. MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma , 1996, Cell.
[52] J. Graff,et al. Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily , 1996, Cell.
[53] A. Berns,et al. Requirement for a functional Rb-1 gene in murine development , 1992, Nature.
[54] G. Proetzel,et al. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease , 1992, Nature.
[55] V. Devita,et al. Cancer : Principles and Practice of Oncology , 1982 .
[56] Luzhe Sun,et al. Demonstration That Mutation of the Type II Transforming Growth Factor β Receptor Inactivates Its Tumor Suppressor Activity in Replication Error-positive Colon Carcinoma Cells (*) , 1995, The Journal of Biological Chemistry.
[57] R. Derynck. TGF-β-receptor-mediated signaling , 1994 .
[58] X. F. Wang,et al. Smad5 induces ventral fates in Xenopus embryo. , 1997, Developmental biology.
[59] R. Fleischmann,et al. Mutation of a mutL homolog in hereditary colon cancer. , 1994, Science.
[60] Hiroyuki Miyoshi,et al. Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes , 1998, Cell.
[61] David J. Anderson,et al. Eph Family Transmembrane Ligands Can Mediate Repulsive Guidance of Trunk Neural Crest Migration and Motor Axon Outgrowth , 1997, Neuron.
[62] P. Hoodless,et al. Smad2 Signaling in Extraembryonic Tissues Determines Anterior-Posterior Polarity of the Early Mouse Embryo , 1998, Cell.
[63] K. Polyak. Negative regulation of cell growth by TGFβ , 1996 .
[64] Scott E. Kern,et al. Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers , 1996, Nature Genetics.
[65] S. Fraser,et al. Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration , 1997, Current Biology.