FcγRs in health and disease.

[1]  M. Diamond,et al.  Lethal Antibody Enhancement of Dengue Disease in Mice Is Prevented by Fc Modification , 2010, PLoS pathogens.

[2]  A. Iwasaki,et al.  Regulation of Adaptive Immunity by the Innate Immune System , 2010, Science.

[3]  Maurice H J Selman,et al.  Immunoglobulin G galactosylation and sialylation are associated with pregnancy-induced improvement of rheumatoid arthritis and the postpartum flare: results from a large prospective cohort study , 2009, Arthritis research & therapy.

[4]  B. Nieswandt,et al.  Both FcγRIV and FcγRIII are essential receptors mediating type II and type III autoimmune responses via FcRγ‐LAT‐dependent generation of C5a , 2009, European journal of immunology.

[5]  A. Bergamaschi,et al.  The CDK Inhibitor p21Cip1/WAF1 Is Induced by FcγR Activation and Restricts the Replication of Human Immunodeficiency Virus Type 1 and Related Primate Lentiviruses in Human Macrophages , 2009, Journal of Virology.

[6]  D. Forthal,et al.  Fc receptor-mediated antiviral antibodies , 2009, Current opinion in HIV and AIDS.

[7]  Miriam M. Ngundi,et al.  Analysis of the Fc Gamma Receptor-Dependent Component of Neutralization Measured by Anthrax Toxin Neutralization Assays , 2009, Clinical and Vaccine Immunology.

[8]  Kenneth G. C. Smith,et al.  Low-affinity Fcγ receptors, autoimmunity and infection , 2009, Expert Reviews in Molecular Medicine.

[9]  P. Bruhns,et al.  Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses. , 2009, Blood.

[10]  W. Oertel,et al.  Impaired inhibitory Fcγ receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy , 2009, Proceedings of the National Academy of Sciences.

[11]  P. Wood,et al.  Primary antibody deficiency syndromes , 2009, Annals of clinical biochemistry.

[12]  Roy Jefferis,et al.  Glycosylation as a strategy to improve antibody-based therapeutics , 2009, Nature Reviews Drug Discovery.

[13]  L. Marnell,et al.  Macrophages Activated by C-Reactive Protein through FcγRI Transfer Suppression of Immune Thrombocytopenia1 , 2009, The Journal of Immunology.

[14]  W. Fridman,et al.  A novel subset of NK cells expressing high levels of inhibitory FcγRIIB modulating antibody‐dependent function , 2008, Journal of leukocyte biology.

[15]  S. Verbeek,et al.  Experimental Antibody Therapy of Liver Metastases Reveals Functional Redundancy between FcγRI and FcγRIV1 , 2008, The Journal of Immunology.

[16]  P. Bruhns,et al.  FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation. , 2008, The Journal of clinical investigation.

[17]  Jinghua Lu,et al.  Structural recognition and functional activation of FcγR by innate pentraxins , 2008, Nature.

[18]  J. Ravetch,et al.  In vivo enzymatic modulation of IgG glycosylation inhibits autoimmune disease in an IgG subclass-dependent manner , 2008, Proceedings of the National Academy of Sciences.

[19]  F. Nimmerjahn,et al.  Immune regulation: FcγRIIB—regulating the balance between protective and autoreactive immune responses , 2008, Immunology and cell biology.

[20]  Dennis R. Burton,et al.  Toward an AIDS Vaccine , 2008, Science.

[21]  Robert M. Anthony,et al.  Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc , 2008, Science.

[22]  Kutty Selva Nandakumar,et al.  Therapeutic cleavage of IgG: new avenues for treating inflammation. , 2008, Trends in immunology.

[23]  J. Ravetch,et al.  Anti-inflammatory actions of intravenous immunoglobulin. , 2008, Annual review of immunology.

[24]  L. Björck,et al.  IdeS: A Bacterial Proteolytic Enzyme with Therapeutic Potential , 2008, PloS one.

[25]  J. Ravetch,et al.  Differential Contribution of Three Activating IgG Fc Receptors (FcγRI, FcγRIII, and FcγRIV) to IgG2a- and IgG2b-Induced Autoimmune Hemolytic Anemia in Mice1 , 2008, The Journal of Immunology.

[26]  J. Sodroski,et al.  The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus , 2008, Nature Reviews Microbiology.

[27]  P. Bjorkman,et al.  The Human Cytomegalovirus Fc Receptor gp68 Binds the Fc CH2-CH3 Interface of Immunoglobulin G , 2008, Journal of Virology.

[28]  Maria Allhorn,et al.  Human IgG/FcγR Interactions Are Modulated by Streptococcal IgG Glycan Hydrolysis , 2008, PloS one.

[29]  Kutty Selva Nandakumar,et al.  Blocking of experimental arthritis by cleavage of IgG antibodies in vivo. , 2007, Arthritis and rheumatism.

[30]  A. Blom,et al.  Endoglycosidase treatment abrogates IgG arthritogenicity: Importance of IgG glycosylation in arthritis , 2007, European journal of immunology.

[31]  D. Burton,et al.  Fc receptor but not complement binding is important in antibody protection against HIV , 2007, Nature.

[32]  Shugo Nakamura,et al.  IgEb immune complexes activate macrophages through FcγRIV binding , 2007, Nature Immunology.

[33]  C. Snapper,et al.  C-Reactive Protein Enhances Immunity to Streptococcus pneumoniae by Targeting Uptake to FcγR on Dendritic Cells1 , 2007, The Journal of Immunology.

[34]  J. Ravetch,et al.  Agalactosylated IgG antibodies depend on cellular Fc receptors for in vivo activity , 2007, Proceedings of the National Academy of Sciences.

[35]  Kenneth G. C. Smith,et al.  Systemic lupus erythematosus-associated defects in the inhibitory receptor FcγRIIb reduce susceptibility to malaria , 2007, Proceedings of the National Academy of Sciences.

[36]  J. Ravetch,et al.  Antibodies, Fc receptors and cancer. , 2007, Current opinion in immunology.

[37]  Pauline M Rudd,et al.  The impact of glycosylation on the biological function and structure of human immunoglobulins. , 2007, Annual review of immunology.

[38]  B. Scallon,et al.  Higher levels of sialylated Fc glycans in immunoglobulin G molecules can adversely impact functionality. , 2007, Molecular immunology.

[39]  J. Ravetch,et al.  The antiinflammatory activity of IgG: the intravenous IgG paradox , 2007, The Journal of experimental medicine.

[40]  L. Marnell,et al.  C-Reactive Protein-Mediated Suppression of Nephrotoxic Nephritis: Role of Macrophages, Complement, and Fcγ Receptors1 , 2007, The Journal of Immunology.

[41]  J. Mouscadet,et al.  The Engagement of Activating FcγRs Inhibits Primate Lentivirus Replication in Human Macrophages1 , 2006, The Journal of Immunology.

[42]  N. Haigwood,et al.  Evaluation of Passively Transferred, Nonneutralizing Antibody-Dependent Cellular Cytotoxicity-Mediating IgG in Protection of Neonatal Rhesus Macaques against Oral SIVmac251 Challenge1 , 2006, The Journal of Immunology.

[43]  J. Ravetch,et al.  Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation , 2006, Science.

[44]  S. Zolla-Pazner,et al.  Nonneutralizing Antibodies Are Able To Inhibit Human Immunodeficiency Virus Type 1 Replication in Macrophages and Immature Dendritic Cells , 2006, Journal of Virology.

[45]  S. Zolla-Pazner,et al.  Efficient inhibition of HIV-1 replication in human immature monocyte-derived dendritic cells by purified anti-HIV-1 IgG without induction of maturation. , 2006, Blood.

[46]  T. Tedder,et al.  Antibody isotype-specific engagement of Fcγ receptors regulates B lymphocyte depletion during CD20 immunotherapy , 2006, The Journal of experimental medicine.

[47]  M. Madaio,et al.  Pathology and protection in nephrotoxic nephritis is determined by selective engagement of specific Fc receptors , 2006, The Journal of experimental medicine.

[48]  P. Umaña,et al.  The carbohydrate at FcgammaRIIIa Asn-162. An element required for high affinity binding to non-fucosylated IgG glycoforms. , 2006, The Journal of biological chemistry.

[49]  J. Leusen,et al.  The high-affinity IgG receptor, FcgammaRI, plays a central role in antibody therapy of experimental melanoma. , 2006, Cancer research.

[50]  J. Ravetch,et al.  Divergent Immunoglobulin G Subclass Activity Through Selective Fc Receptor Binding , 2005, Science.

[51]  L. Marnell,et al.  C-reactive protein: ligands, receptors and role in inflammation. , 2005, Clinical immunology.

[52]  J. Ravetch,et al.  Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions. , 2005, The Journal of clinical investigation.

[53]  R. Schmidt,et al.  Fc receptors and their interaction with complement in autoimmunity. , 2005, Immunology letters.

[54]  P. Bruhns,et al.  FcγRIV : A novel FcR with distinct IgG subclass specificity , 2005 .

[55]  J. Farrell,et al.  Control of Infection with Leishmania major in Susceptible BALB/c Mice Lacking the Common γ-Chain for FcR Is Associated with Reduced Production of IL-10 and TGF-β by Parasitized Cells 1 , 2005, The Journal of Immunology.

[56]  R. Steinman,et al.  Selective blockade of inhibitory Fcgamma receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[57]  D. Venzon,et al.  Vaccine-Elicited Antibodies Mediate Antibody-Dependent Cellular Cytotoxicity Correlated with Significantly Reduced Acute Viremia in Rhesus Macaques Challenged with SIVmac2511 , 2005, The Journal of Immunology.

[58]  R. Levy,et al.  Clinical outcome of lymphoma patients after idiotype vaccination is correlated with humoral immune response and immunoglobulin G Fc receptor genotype. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[59]  A. Bohbot,et al.  Involvement of FcγR I (CD64) in the Mechanism of HIV-1 Inhibition by Polyclonal IgG Purified from Infected Patients in Cultured Monocyte-Derived Macrophages1 , 2004, The Journal of Immunology.

[60]  M. Carroll,et al.  The complement system in regulation of adaptive immunity , 2004, Nature Immunology.

[61]  K. Haas,et al.  The Innate Mononuclear Phagocyte Network Depletes B Lymphocytes through Fc Receptor–dependent Mechanisms during Anti-CD20 Antibody Immunotherapy , 2004, The Journal of experimental medicine.

[62]  Kimberly C. Brouwer,et al.  Polymorphism of Fc receptor IIa for IgG in infants is associated with susceptibility to perinatal HIV-1 infection , 2004, AIDS.

[63]  Kenneth G. C. Smith,et al.  FcγRIIb Balances Efficient Pathogen Clearance and the Cytokine-mediated Consequences of Sepsis , 2004, The Journal of experimental medicine.

[64]  Dennis R. Burton,et al.  Human antibody–Fc receptor interactions illuminated by crystal structures , 2004, Nature Reviews Immunology.

[65]  C. Okada,et al.  TCR Vaccines against a Murine T Cell Lymphoma: A Primary Role for Antibodies of the IgG2c Class in Tumor Protection1 , 2004, The Journal of Immunology.

[66]  W. Weng,et al.  Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[67]  S. Faust,et al.  Ethics of antenatal screening for Down’s syndrome , 2003, Archives of disease in childhood.

[68]  M. Wong,et al.  FcγRIIA polymorphisms in Streptococcus pneumoniae infection , 2003 .

[69]  J. Pollard,et al.  Colony-stimulating factor-1-dependent macrophages are responsible for IVIG protection in antibody-induced autoimmune disease. , 2003, Immunity.

[70]  A. Halstensen,et al.  FcγRIIa and FcγRIIIb polymorphisms were not associated with meningococcal disease in Western Norway , 2003, Epidemiology and Infection.

[71]  F. Barré-Sinoussi,et al.  Fcγ Receptor-Mediated Suppression of Human Immunodeficiency Virus Type 1 Replication in Primary Human Macrophages , 2003, Journal of Virology.

[72]  K. Shitara,et al.  The Absence of Fucose but Not the Presence of Galactose or Bisecting N-Acetylglucosamine of Human IgG1 Complex-type Oligosaccharides Shows the Critical Role of Enhancing Antibody-dependent Cellular Cytotoxicity* , 2003, The Journal of Biological Chemistry.

[73]  P. Hogarth Fc receptors are major mediators of antibody based inflammation in autoimmunity. , 2002, Current opinion in immunology.

[74]  A. Tarkowski,et al.  The impact of Fcγ receptors on Staphylococcus aureus infection , 2002 .

[75]  M. Messerle,et al.  Identification and Expression of Human Cytomegalovirus Transcription Units Coding for Two Distinct Fcγ Receptor Homologs , 2002, Journal of Virology.

[76]  T. Takai Roles of Fc receptors in autoimmunity , 2002, Nature Reviews Immunology.

[77]  L. Presta,et al.  Lack of Fucose on Human IgG1 N-Linked Oligosaccharide Improves Binding to Human FcγRIII and Antibody-dependent Cellular Toxicity* , 2002, The Journal of Biological Chemistry.

[78]  N. White,et al.  Susceptibility to dengue hemorrhagic fever in vietnam: evidence of an association with variation in the vitamin d receptor and Fc gamma receptor IIa genes. , 2002, The American journal of tropical medicine and hygiene.

[79]  J. Ravetch,et al.  Inducing Tumor Immunity through the Selective Engagement of Activating Fcγ Receptors on Dendritic Cells , 2002, The Journal of experimental medicine.

[80]  R. Lawrence,et al.  A role for antibody and Fc receptor in the clearance of Brugia malayi microfilariae , 2002, European journal of immunology.

[81]  M. Ballow,et al.  Primary immunodeficiency disorders: antibody deficiency. , 2002, The Journal of allergy and clinical immunology.

[82]  M. Walport,et al.  Complement Activation Selectively Potentiates the Pathogenicity of the IgG2b and IgG3 Isotypes of a High Affinity Anti-Erythrocyte Autoantibody , 2002, The Journal of experimental medicine.

[83]  G. van Ommen,et al.  FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. , 2002, Immunity.

[84]  G. Salles,et al.  Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene. , 2002, Blood.

[85]  J. Coutelier,et al.  Increased Efficacy of the Immunoglobulin G2a Subclass in Antibody-Mediated Protection against Lactate Dehydrogenase-Elevating Virus-Induced Polioencephalomyelitis Revealed with Switch Mutants , 2002, Journal of Virology.

[86]  Stephen P. Young,et al.  Role of Oligosaccharide Residues of IgG1-Fc in FcγRIIb Binding* , 2001, The Journal of Biological Chemistry.

[87]  M. E. Rodriguez,et al.  Fc Receptor-Mediated Immunity Against Bordetella pertussis1 , 2001, The Journal of Immunology.

[88]  A. Olsén,et al.  Effect of SpeB and EndoS from Streptococcus pyogenes on Human Immunoglobulins , 2001, Infection and Immunity.

[89]  D. Metzger,et al.  Fc Receptor-Mediated Phagocytosis Makes a Significant Contribution to Clearance of Influenza Virus Infections1 , 2001, The Journal of Immunology.

[90]  C. Mold,et al.  Serum Amyloid P Component Binds to Fcγ Receptors and Opsonizes Particles for Phagocytosis1 , 2001, The Journal of Immunology.

[91]  Y. Iwakura,et al.  A Critical Role of Fc Receptor-Mediated Antibody-Dependent Phagocytosis in the Host Resistance to Blood-Stage Plasmodium berghei XAT Infection1 , 2001, The Journal of Immunology.

[92]  C. Sautès-Fridman,et al.  The Structure of a Human Type III Fcγ Receptor in Complex with Fc* , 2001, The Journal of Biological Chemistry.

[93]  F. Mooi,et al.  Targeting to Fcgamma receptors, but not CR3 (CD11b/CD18), increases clearance of Bordetella pertussis. , 2001, The Journal of infectious diseases.

[94]  Leonard G. Presta,et al.  High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR* , 2001, The Journal of Biological Chemistry.

[95]  J. Ravetch,et al.  Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor. , 2001, Science.

[96]  L. Lanier,et al.  Immune inhibitory receptors. , 2000, Science.

[97]  J. Ravetch,et al.  Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis. , 2000, Immunity.

[98]  Robert Huber,et al.  The 3.2-Å crystal structure of the human IgG1 Fc fragment–FcγRIII complex , 2000, Nature.

[99]  T. Out,et al.  The role of Fcγ receptor polymorphisms and C3 in the immune defence against Neisseria meningitidis in complement‐deficient individuals , 2000, Clinical and experimental immunology.

[100]  T. Honjo,et al.  Markedly Different Pathogenicity of Four Immunoglobulin G Isotype-Switch Variants of an Antierythrocyte Autoantibody Is Based on Their Capacity to Interact in Vivo with the Low-Affinity Fcγ Receptor III , 2000, The Journal of experimental medicine.

[101]  M. Shlomchik,et al.  Internalization of Leishmania mexicana Complex Amastigotes via the Fc Receptor Is Required to Sustain Infection in Murine Cutaneous Leishmaniasis , 2000, The Journal of experimental medicine.

[102]  D. Bharadwaj,et al.  The Major Receptor for C-Reactive Protein on Leukocytes Is Fcγ Receptor II , 1999 .

[103]  J. V. D. van de Winkel,et al.  Crucial role of FcgammaRIIa (CD32) in assessment of functional anti-Streptococcus pneumoniae antibody activity in human sera. , 1999, The Journal of infectious diseases.

[104]  R. Schmidt,et al.  FcγRIII (CD16)-Deficient Mice Show IgG Isotype-Dependent Protection to Experimental Autoimmune Hemolytic Anemia , 1998 .

[105]  P. Hogarth,et al.  Gain‐of‐function mutations in FcγRI of NOD mice: implications for the evolution of the Ig superfamily , 1998, The EMBO journal.

[106]  J. Ravetch,et al.  Immunoglobulin G–mediated Inflammatory Responses Develop Normally in Complement-deficient Mice , 1996, The Journal of experimental medicine.

[107]  R. Schmidt,et al.  Impaired IgG-Dependent Anaphylaxis and Arthus Reaction in FcγRIII (CD16) Deficient Mice , 1996 .

[108]  M. Ono,et al.  Augmented humoral and anaphylactic responses in FcγRII-deficient mice , 1996, Nature.

[109]  J. Ravetch,et al.  Cytotoxic antibodies trigger inflammation through Fc receptors. , 1995, Immunity.

[110]  R. Dwek,et al.  Glycosylation changes of IgG associated with rheumatooid arthritis can activate complement via the mannose-binding protein , 1995, Nature Medicine.

[111]  T. Out,et al.  Fcã Receptor Iia (Cd32) Polymorphism In Fulminant Meningococcal Septic , 1994 .

[112]  H. Friedman,et al.  Herpes simplex virus type 1 Fc receptor protects infected cells from antibody-dependent cellular cytotoxicity , 1991, Journal of virology.

[113]  R. Dwek,et al.  Changes in IgG glycoform levels are associated with remission of arthritis during pregnancy. , 1991, Journal of autoimmunity.

[114]  A. Cooke,et al.  Glycosylation of IgG, immune complexes and IgG subclasses in the MRL‐lpr/lpr mouse model of rheumatoid arthritis , 1990, European journal of immunology.

[115]  K. Titani,et al.  Structural changes in the oligosaccharide chains of IgG in autoimmune MRL/Mp-lpr/lpr mice. , 1990, Journal of immunology.

[116]  A. Schlageter,et al.  Opsonization of Cryptococcus neoformans by a family of isotype-switch variant antibodies specific for the capsular polysaccharide , 1990, Infection and immunity.

[117]  H. Friedman,et al.  A novel function of the herpes simplex virus type 1 Fc receptor: participation in bipolar bridging of antiviral immunoglobulin G , 1989, Journal of virology.

[118]  F. Ennis,et al.  Antibody-enhanced infection by HIV-1 via Fc receptor-mediated entry. , 1988, Science.

[119]  R. Levy,et al.  Importance of antibody isotype in monoclonal anti-idiotype therapy of a murine B cell lymphoma. A study of hybridoma class switch variants. , 1986, Journal of immunology.

[120]  T. Kipps,et al.  Importance of immunoglobulin isotype in human antibody-dependent, cell- mediated cytotoxicity directed by murine monoclonal antibodies , 1985, The Journal of experimental medicine.

[121]  W. Fridman,et al.  The role of the Fc receptor (FcR) of thymus‐derived lymphocytes I. Presence of FcR on cytotoxic lymphocytes and absence of direct role in cytotoxicity , 1977, European journal of immunology.

[122]  L. Herzenberg,et al.  The Fc receptor on thymus-derived lymphocytes. I. Detection of a subpopulation of murine T lymphocytes bearing the Fc receptor , 1975, The Journal of experimental medicine.

[123]  H. Grey,et al.  RECEPTORS FOR AGGREGATED IgG ON MOUSE LYMPHOCYTES , 1974, The Journal of experimental medicine.

[124]  J. Ravetch,et al.  Fc γ RIII and Fc γ RIV are indispensable for acute glomerular inflammation induced by switch variant monoclonal antibodies1 , 2012 .

[125]  C. Garlanda,et al.  Pattern recognition by pentraxins. , 2009, Advances in experimental medicine and biology.

[126]  Maria Allhorn,et al.  CONTEMPORARY CHALLENGES IN AUTOIMMUNITY Sugar-free Antibodies—The Bacterial Solution to Autoimmunity? , 2009 .

[127]  J. Ravetch,et al.  Fcγ receptors as regulators of immune responses , 2008, Nature Reviews Immunology.

[128]  J. Ravetch,et al.  Inaugural Article: Identification of a receptor required for the anti-inflammatory activity of IVIG , 2008 .

[129]  M. Daëron,et al.  Negative signaling in Fc receptor complexes. , 2006, Advances in immunology.

[130]  J. Ravetch,et al.  Fcgamma receptors: old friends and new family members. , 2006, Immunity.

[131]  A. Tarkowski,et al.  The impact of Fcg receptors on Staphylococcus Aureus infection , 2002 .

[132]  F. Ennis,et al.  HUMAN IgG FC RECEPTOR I 1 MEDIATES ANTIBODY-DEPENDENT ENHANCEMENT OF DENGUE VIRUS INFECTION ' , 2001 .

[133]  D. Musher,et al.  Association Between FcγRIIa-R131 Allotype and Bacteremic Pneumococcal Pneumonia , 2000 .

[134]  J. Ravetch,et al.  Inhibitory pathways triggered by ITIM-containing receptors. , 1999, Advances in immunology.

[135]  J. Ravetch,et al.  Divergent roles for Fc receptors and complement in vivo. , 1998, Annual review of immunology.

[136]  D. Briles,et al.  The effects of subclass on the ability of anti-phosphocholine antibodies to protect mice from fatal infection with Streptococcus pneumoniae. , 1984, The Journal of molecular and cellular immunology : JMCI.

[137]  D. Briles,et al.  The effects of idiotype on the ability of IgG1 antiphosphorylcholine antibodies to protect mice from fatal infection with Streptococcus pneumoniae , 1984, European journal of immunology.

[138]  Langone Jj Protein A of Staphylococcus aureus and related immunoglobulin receptors produced by streptococci and pneumonococci. , 1982 .