Thiorphan-induced neprilysin inhibition raises amyloid β levels in rabbit cortex and cerebrospinal fluid

[1]  G. Wenk,et al.  Beta-amyloid deposition in the brains of rats chronically infused with thiorphan or lipopolysaccharide: the role of ascorbic acid in the vehicle , 2002, Neuroscience Letters.

[2]  P. Mcgeer,et al.  Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain , 2001, Brain Research.

[3]  T. Iwatsubo,et al.  Neprilysin Degrades Both Amyloid β Peptides 1–40 and 1–42 Most Rapidly and Efficiently among Thiorphan- and Phosphoramidon-sensitive Endopeptidases* , 2001, The Journal of Biological Chemistry.

[4]  T. Saido,et al.  Metabolic Regulation of Brain Aβ by Neprilysin , 2001, Science.

[5]  P. Mcgeer,et al.  Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of β-amyloid peptide , 2001, Neuroscience Letters.

[6]  T. Saido,et al.  Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain. , 2000, Journal of biochemistry.

[7]  T. Saido,et al.  Reply to: 'Clearance of amyloid β-peptide from brain: transport or metabolism?' , 2000, Nature Medicine.

[8]  T. Saido,et al.  Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition , 2000, Nature Medicine.

[9]  B. Greenberg,et al.  Turnover of Amyloid β-Protein in Mouse Brain and Acute Reduction of Its Level by Phorbol Ester , 1998, The Journal of Neuroscience.

[10]  T. Saido.  Alzheimer’s Disease as Proteolytic Disorders: Anabolism and Catabolism of β-Amyloid , 1998, Neurobiology of Aging.

[11]  B. Greenberg,et al.  Enhanced Amyloidogenic Processing of the β-Amyloid Precursor Protein in Gene-targeted Mice Bearing the Swedish Familial Alzheimer's Disease Mutations and a “Humanized” Aβ Sequence* , 1996, The Journal of Biological Chemistry.

[12]  B. de Strooper,et al.  Production of intracellular amyloid‐containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence. , 1995, The EMBO journal.

[13]  P. Kotikalapudi,et al.  Sequence and nethylation in the βA4 region of the rabbit anyloid precursor protein gene , 1992 .

[14]  J. Hardy,et al.  The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics , 2009 .

[15]  H. Mantsch,et al.  Human and rodent Alzheimer beta-amyloid peptides acquire distinct conformations in membrane-mimicking solvents. , 1993, European journal of biochemistry.