Overall obesity had similar ability to identify the insulin resistance and pancreatic β-cell function compared with abdominal obesity in Chinese community-dwelling population without type 2 diabetes

Background: Just as the prevalence of obesity is increasing, so is the prevalence of type 2 diabetes (T2DM). Obesity is considered to be a factor that drives insulin resistance (IR), and IR is the underlying mechanism through which persons develop T2DM. This analysis was to test the hypothesis that body mass index (BMI, and overall obesity) had similar ability to identify the IR and pancreatic β-cell function compared with waist circumference (WC, and abdominal obesity) in Chinese community-dwelling population without T2DM. Methods: This analysis consisted of 1330 participants without T2DM, who received the homeostasis model assessment of IR (HOMA-IR) and HOMA-β determination. Results: Age ranged from 18 to 80 years, with a median of 38 years. Logistic regression analyses indicated that gender, BMI (and overall obesity), WC (and abdominal obesity), FBG and TG levels were independently associated with IR status and pancreatic β-cell function expressed as HOMA-IR and HOMA-β. C-statistic of BMI to identify the IR status and pancreatic β-cell function had no statistically significant difference with that of WC. Conclusions: Both BMI (and overall obesity) and WC (and abdominal obesity) could be used to identify the IR status and pancreatic β-cell function in Chinese community-dwelling population without T2DM. BMI (and overall obesity) had similar ability to identify the IR status and pancreatic β-cell function compared with WC (and abdominal obesity). BMI (and overall obesity) and WC (and abdominal obesity) provided similar guidance for clinical doctors to determine the risk of T2DM and the need for further medical check-up before the onset of T2DM.

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