Quaternary structure of proteins.

STOICHIOMETRY OF SUBUNITS. . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 DISSOCIATION METHODS . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 Denaturants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 Change of charge . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 Binding of metabolites or s mall ions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 Reaction with sulfhydryl groups .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 HyBRIDIZATION .... . . . . . . . . . . . . . . . . . . • . . . . . • • • . • . . . . . • . . . .. .... ... .. . 28 TABLE OF SUBUNITS . . . ' " . . . . . . . . . . . . . . . . . . . . . . . • • . . . . . . . ..... ... . .. . 29 GEOMETRIC ARRANGEMENTS OF SUBUNITS 29 CYCLIC SYMMETRY . . . . . . . . . • • . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 DIHEDRAL SYMMETRY . . . . . . . • . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . 36 CUBIC SYMMETRY • • . • . . . . . . • . • . . . . . . . . • . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . 38 GENERAL COMMENTS . . . . . • . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38 ENERGETICS OF INTERACTIONS 39 MOLECULAR STRUCTURE OF INTERFACE CONTACTS 52 FACTORS THAT MODIFY SUBUNIT INTERACTIONS S6 INTRINSIC FACTORS . . . . . . . . . . . . . . . . . . . . . . . • . . . . . . . . • . . . . . . . . . . . . . . . . . • 56 EXTRINSIC FACTORS . . . . . . • • . . . . . . • • . . • . . . • . . . . • . . . . . . . . . . . . . . . . . . . . . . . S7 CONCLUSION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . S9

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