Inlet boundary conditions for blood flow simulations in truncated arterial networks.

In the context of patient-specific cardiovascular applications, hemodynamics models (going from 3D to 0D) are often limited to a part of the arterial tree. This restriction implies the set up of artificial interfaces with the remaining parts of the cardiovascular system. In particular, the inlet boundary condition is crucial: it supplies the impulsion to the system and receives the reflected backward waves created by the distal network. Some aspects of this boundary condition need to be properly defined such as the treatment of backward waves (reflected or absorbed) and the value of the imposed hemodynamic wave (total or forward component). Most authors prescribe as inlet boundary condition (BC) the total measured variable (pressure, velocity or flow rate) in a reflective way. We show that with this type of inlet boundary condition, the model does not produce physiological waveforms. We suggest instead to prescribe only the forward component of the prescribed variable in an absorbing way. In this way, the computed reflected waves superpose with the prescribed forward waves to produce the total wave at the inlet. In this work, different inlet boundary conditions are implemented and compared for a 1D blood flow model. We test our boundary conditions on a truncated arterial model presented in the literature as well as on a patient-specific lower-limb model of a femoral bypass. We show that with this new boundary condition, a much better fitting is observed on the shape and intensity of the simulated pressure and velocity waves.

[1]  Spencer J. Sherwin,et al.  Computational modelling of 1D blood flow with variable mechanical properties and its application to the simulation of wave propagation in the human arterial system , 2003 .

[2]  G. W. Hedstrom,et al.  Nonreflecting Boundary Conditions for Nonlinear Hyperbolic Systems , 1979 .

[3]  M. Davidson,et al.  A numerical model of neonatal pulmonary atresia with intact ventricular septum and RV‐dependent coronary flow , 2010 .

[4]  P. Blanco,et al.  On the potentialities of 3D-1D coupled models in hemodynamics simulations. , 2009, Journal of biomechanics.

[5]  K. Parker,et al.  Determination of wave speed and wave separation in the arteries. , 2001, Journal of biomechanics.

[6]  E. N. Marieb,et al.  Anatomie et physiologie humaines , 1999 .

[7]  J AlastrueyArimon Numerical modelling of pulse wave propagation in the cardiovascular system : development, validation and clinical applications. , 2006 .

[8]  Emilie Marchandise,et al.  A numerical hemodynamic tool for predictive vascular surgery. , 2009, Medical engineering & physics.

[9]  C Bertolotti,et al.  Three-dimensional numerical simulations of flow through a stenosed coronary bypass. , 2000, Journal of biomechanics.

[10]  N. Stergiopulos,et al.  Validation of a one-dimensional model of the systemic arterial tree. , 2009, American journal of physiology. Heart and circulatory physiology.

[11]  K. Parker,et al.  Forward and backward running waves in the arteries: analysis using the method of characteristics. , 1990, Journal of biomechanical engineering.

[12]  G. De Backer,et al.  Determining carotid artery pressure from scaled diameter waveforms: comparison and validation of calibration techniques in 2026 subjects , 2008, Physiological measurement.

[13]  F N van de Vosse,et al.  Estimation of distributed arterial mechanical properties using a wave propagation model in a reverse way. , 2010, Medical engineering & physics.

[14]  Alfio Quarteroni,et al.  A One Dimensional Model for Blood Flow: Application to Vascular Prosthesis , 2002 .

[15]  D. F. Young,et al.  Computer simulation of blood flow in the human arm. , 1989, Journal of biomechanics.

[16]  M. Olufsen,et al.  Numerical Simulation and Experimental Validation of Blood Flow in Arteries with Structured-Tree Outflow Conditions , 2000, Annals of Biomedical Engineering.

[17]  E. Marchandise,et al.  Accurate modelling of unsteady flows in collapsible tubes , 2010, Computer methods in biomechanics and biomedical engineering.

[18]  S. Sherwin,et al.  Pulse wave propagation in a model human arterial network: Assessment of 1-D visco-elastic simulations against in vitro measurements , 2011, Journal of biomechanics.

[19]  Jean-François Remacle,et al.  A quadrature-free discontinuous Galerkin method for the level set equation , 2006, J. Comput. Phys..

[20]  A W Khir,et al.  Arterial waves in humans during peripheral vascular surgery. , 2001, Clinical science.

[21]  S. Sherwin,et al.  Modelling the circle of Willis to assess the effects of anatomical variations and occlusions on cerebral flows. , 2007, Journal of biomechanics.

[22]  S. Sherwin,et al.  Can the modified Allen's test always detect sufficient collateral flow in the hand? A computational study , 2006, Computer methods in biomechanics and biomedical engineering.

[23]  P. Nithiarasu,et al.  A 1D arterial blood flow model incorporating ventricular pressure, aortic valve and regional coronary flow using the locally conservative Galerkin (LCG) method , 2008 .

[24]  Mette S Olufsen,et al.  Structured tree outflow condition for blood flow in larger systemic arteries. , 1999, American journal of physiology. Heart and circulatory physiology.

[25]  Alfio Quarteroni,et al.  Multiscale modelling of the circulatory system: a preliminary analysis , 1999 .

[26]  S. Sherwin,et al.  Lumped parameter outflow models for 1-D blood flow simulations: Effect on pulse waves and parameter estimation , 2008 .

[27]  Pablo J. Blanco,et al.  Multidimensional modelling for the carotid artery blood flow , 2006 .

[28]  J K Raines,et al.  A computer simulation of arterial dynamics in the human leg. , 1974, Journal of biomechanics.

[29]  L. Formaggia,et al.  Numerical modeling of 1D arterial networks coupled with a lumped parameters description of the heart , 2006, Computer methods in biomechanics and biomedical engineering.

[30]  D. F. Young,et al.  Computer simulation of arterial flow with applications to arterial and aortic stenoses. , 1992, Journal of biomechanics.

[31]  A D Hughes,et al.  Blood flow and vessel mechanics in a physiologically realistic model of a human carotid arterial bifurcation. , 2000, Journal of biomechanics.

[32]  S. Sherwin,et al.  One-dimensional modelling of a vascular network in space-time variables , 2003 .