Chronic dietary intake of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at 5 or 25 parts per trillion in the monkey: TCDD kinetics and dose-effect estimate of reproductive toxicity

Abstract TCDD half-life in seven adult female rhesus monkeys was 391 + 88 (S.E.) days. During four months of nursing, three mothers shed 22% of triglycerides and 21% of TCDD. Offspring accumulated in fat about 4.3 times the TCDD/fat of their mothers. A dose-effect estimate of reproductive toxicity is presented.

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