Association of PCB, PBDE and PCDD/F body burdens with hormone levels for children in an e-waste dismantling area of Zhejiang Province, China.

Increased electronic waste (e-waste) has raised public concerns regarding exposure to numerous toxic contaminants, particularly polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs) and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs). In China, the body burdens of PCBs, PBDEs and PCDD/Fs are associated with thyroid hormones in populations from e-waste dismantling sites; however, it is unclear whether this association occurs in children. In this study, we determined the serum levels of PCBs, PBDEs and PCDD/Fs and the endocrine hormones including free triiodothyronine (FT3), total triiodothyronine (TT3), free thyroxine (FT4), total thyroxine (TT4), thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), cortisol and growth hormone (GH) in 21 children from an e-waste dismantling area and 24 children from a control area. The results showed that the mean levels of ∑PCBs and ∑PBDEs in the exposure group were significantly higher than in the control group (40.56 and 32.09 ng g(-1) lipid vs. 20.69 and 8.43 ng g(-1) lipid, respectively, p<0.01 for each), and the mean level of ∑PCDD/Fs in the exposure group was higher than in the control group, but the difference was not significant (206.17 vs. 160.27 pg g(-1) lipid, p>0.05). For the endocrine hormones, we did not find significant differences between the exposed and control groups, although the mean levels of FT3, TT3, TT4, ACTH, cortisol and GH were higher, whereas the mean levels of FT4 and TSH were lower in the exposed group. The mean level of ∑PBDEs was positively correlated with the mean levels of ∑PCBs (r=0.60, p<0.05) and ∑PCDD/Fs (r=0.61, p<0.05). Furthermore, the mean level of ∑PBDEs was positively correlated with ACTH (r=0.61, p<0.05). In conclusion, our data suggested that exposure to e-waste dismantling environment increased the body burdens of PCBs and PBDEs in local children and that these contaminants released from the e-waste might contribute to abnormal changes in hormone levels.

[1]  Ming H Wong,et al.  Body burdens of polybrominated diphenyl ethers in childbearing-aged women at an intensive electronic-waste recycling site in China , 2010, Environmental science and pollution research international.

[2]  Timo Hamers,et al.  In vitro profiling of the endocrine-disrupting potency of brominated flame retardants. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[3]  Fiona Harden,et al.  Serum Polybrominated Diphenyl Ether (PBDE) Levels Are Higher in Children (2–5 Years of Age) than in Infants and Adults , 2009, Environmental health perspectives.

[4]  D. Barr,et al.  Associations between Prenatal Exposure to Polychlorinated Biphenyls and Neonatal Thyroid-Stimulating Hormone Levels in a Mexican-American Population, Salinas Valley, California , 2007, Environmental health perspectives.

[5]  Ming H Wong,et al.  Body loadings and health risk assessment of polychlorinated dibenzo-p-dioxins and dibenzofurans at an intensive electronic waste recycling site in China. , 2007, Environmental science & technology.

[6]  I. Olsaker,et al.  Fetal adrenal development: Comparing effects of combined exposures to PCB 118 and PCB 153 in a sheep model , 2013, Environmental toxicology.

[7]  L. Costa,et al.  Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants. , 2007, Neurotoxicology.

[8]  Xiaojun Luo,et al.  Dechlorane Plus in human hair from an e-waste recycling area in South China: comparison with dust. , 2010, Environmental science & technology.

[9]  R. Dietz,et al.  Associations between complex OHC mixtures and thyroid and cortisol hormone levels in East Greenland polar bears. , 2012, Environmental research.

[10]  Yang Song,et al.  Levels of PCDD/Fs and DL-PCBs in selected foods and estimated dietary intake for the local residents of Luqiao and Yuhang in Zhejiang, China. , 2011, Chemosphere.

[11]  S. Imaoka,et al.  Effects of polybrominated diphenyl ethers (PBDEs) and their derivatives on protein disulfide isomerase activity and growth hormone release of GH3 cells. , 2012, Chemical research in toxicology.

[12]  R. Norman,et al.  Health consequences of exposure to brominated flame retardants: a systematic review. , 2014, Chemosphere.

[13]  M. Wong,et al.  A review of environmental fate, body burdens, and human health risk assessment of PCDD/Fs at two typical electronic waste recycling sites in China. , 2013, The Science of the total environment.

[14]  Y. Zhang,et al.  Examining the relationship between brominated flame retardants (BFR) exposure and changes of thyroid hormone levels around e-waste dismantling sites. , 2010, International journal of hygiene and environmental health.

[15]  Tong Zhu,et al.  Exposure to typical persistent organic pollutants from an electronic waste recycling site in Northern China. , 2013, Chemosphere.

[16]  Jing Yuan,et al.  Elevated serum polybrominated diphenyl ethers and thyroid-stimulating hormone associated with lymphocytic micronuclei in Chinese workers from an E-waste dismantling site. , 2008, Environmental science & technology.

[17]  Yaxian Zhao,et al.  Polybrominated diphenyl ethers (PBDEs) in aborted human fetuses and placental transfer during the first trimester of pregnancy. , 2013, Environmental science & technology.

[18]  Janet Kit Yan Chan,et al.  Environmental impact and human exposure to PCBs in Guiyu, an electronic waste recycling site in China. , 2009, Environment international.

[19]  Bo Ling,et al.  PCB Levels in Humans in an Area of PCB Transformer Recycling , 2008, Annals of the New York Academy of Sciences.

[20]  L. Goldman,et al.  Birth Delivery Mode Modifies the Associations between Prenatal Polychlorinated Biphenyl (PCB) and Polybrominated Diphenyl Ether (PBDE) and Neonatal Thyroid Hormone Levels , 2008, Environmental health perspectives.

[21]  Wei Zhang,et al.  Polybrominated diphenyl ethers in water, sediment, soil, and biological samples from different industrial areas in Zhejiang, China. , 2011, Journal of hazardous materials.

[22]  Bin Liu,et al.  Elevated body burdens of PBDEs, dioxins, and PCBs on thyroid hormone homeostasis at an electronic waste recycling site in China. , 2010, Environmental science & technology.

[23]  Yong-Chuan Zhang,et al.  Dual body burdens of polychlorinated biphenyls and polybrominated diphenyl ethers among local residents in an e-waste recycling region in Southeast China. , 2010, Chemosphere.

[24]  I. Bryngelsson,et al.  Polybrominated diphenyl ethers—plasma levels and thyroid status of workers at an electronic recycling facility , 2005, International archives of occupational and environmental health.

[25]  H. Anderson,et al.  Relationships of Thyroid Hormones with Polychlorinated Biphenyls, Dioxins, Furans, and DDE in Adults , 2007, Environmental health perspectives.

[26]  Guoying Sheng,et al.  Pollution characterization and diurnal variation of PBDEs in the atmosphere of an E-waste dismantling region. , 2009, Environmental pollution.

[27]  Annamalai Subramanian,et al.  Environmental contamination and human exposure to dioxin-related compounds in e-waste recycling sites of developing countries. , 2013, Environmental science. Processes & impacts.

[28]  Guoying Sheng,et al.  Phase partitioning, concentration variation and risk assessment of polybrominated diphenyl ethers (PBDEs) in the atmosphere of an e-waste recycling site. , 2011, Chemosphere.

[29]  Olaf Päpke,et al.  In Utero Exposure to Dioxins and Polychlorinated Biphenyls and Its Relations to Thyroid Function and Growth Hormone in Newborns , 2005, Environmental health perspectives.

[30]  M. Wong,et al.  Chemical and ecotoxicological analyses of sediments and elutriates of contaminated rivers due to e-waste recycling activities using a diverse battery of bioassays. , 2009, Environmental pollution.

[31]  Xijin Xu,et al.  In utero exposure to polychlorinated biphenyls and reduced neonatal physiological development from Guiyu, China. , 2011, Ecotoxicology and environmental safety.

[32]  R. Ahmed,et al.  Early weaning PCB 95 exposure alters the neonatal endocrine system: thyroid adipokine dysfunction. , 2013, The Journal of endocrinology.

[33]  Sheng Wen,et al.  Elevated levels of urinary 8-hydroxy-2'-deoxyguanosine in male electrical and electronic equipment dismantling workers exposed to high concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans, polybrominated diphenyl ethers, and polychlorinated biphenyls. , 2008, Environmental science & technology.

[34]  Zhijian Chen,et al.  Health risk assessment of lead for children in tinfoil manufacturing and e-waste recycling areas of Zhejiang Province, China. , 2012, The Science of the total environment.

[35]  L. Knudsen,et al.  Placental transfer of the polybrominated diphenyl ethers BDE-47, BDE-99 and BDE-209 in a human placenta perfusion system: an experimental study , 2010, Environmental health : a global access science source.

[36]  Yan Li,et al.  Polybrominated diphenyl ether (PBDE) in blood from children (age 9-12) in Taizhou, China. , 2011, Journal of environmental sciences.

[37]  T. Kido,et al.  High cortisol and cortisone levels are associated with breast milk dioxin concentrations in Vietnamese women. , 2014, European journal of endocrinology.

[38]  Xijin Xu,et al.  Polybrominated diphenyl ethers in umbilical cord blood and relevant factors in neonates from Guiyu, China. , 2010, Environmental science & technology.