Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

[1]  S. Bandinelli,et al.  Plasma Klotho and Frailty in Older Adults: Findings From the InCHIANTI Study. , 2019, The journals of gerontology. Series A, Biological sciences and medical sciences.

[2]  R. McClelland,et al.  Relationship of fibroblast growth factor 21 with kidney function and albuminuria: multi-ethnic study of atherosclerosis. , 2019, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[3]  O. Tatli,et al.  Diagnostic Value of Plasma Pentraxin-3 in Acute Appendicitis , 2019, Journal of investigative surgery : the official journal of the Academy of Surgical Research.

[4]  A. Minelli,et al.  Insulin-like growth factor binding protein 2 in bipolar disorder: An expression study in peripheral tissues , 2018, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

[5]  M. Klintschar,et al.  Fibroblast growth factor 23 is induced by an activated renin–angiotensin–aldosterone system in cardiac myocytes and promotes the pro-fibrotic crosstalk between cardiac myocytes and fibroblasts , 2018, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[6]  S. Abdi,et al.  The Effects of Agrin Isoforms on Diabetic Neuropathic Pain in a Rat Streptozotocin Model , 2018, Anesthesia and analgesia.

[7]  Ryan L. Davis,et al.  Mitochondrial diseases. , 2018, Handbook of clinical neurology.

[8]  G. Matarese,et al.  Leptin and ghrelin: Sewing metabolism onto neurodegeneration , 2018, Neuropharmacology.

[9]  T. Strom,et al.  The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk. , 2018, Kidney international.

[10]  I. Gonçalves,et al.  Distinctive peri-luminal presence of agrin in murine and human carotid atherosclerotic plaques. , 2018, Histology and histopathology.

[11]  Y. Bao,et al.  The association of serum FGF23 and non‐alcoholic fatty liver disease is independent of vitamin D in type 2 diabetes patients , 2018, Clinical and experimental pharmacology & physiology.

[12]  L. Rodríguez-Mañas,et al.  Homocysteine levels are associated with bone resorption in pre-frail and frail Spanish women: The Toledo Study for Healthy Aging , 2018, Experimental Gerontology.

[13]  M. Akash,et al.  Leptin: A new therapeutic target for treatment of diabetes mellitus , 2018, Journal of cellular biochemistry.

[14]  H. Rakugi,et al.  High plasma adiponectin levels are associated with frailty in a general old‐old population: The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study , 2018, Geriatrics & gerontology international.

[15]  Jian Xiao,et al.  Cerebrospinal fluid FGF23 levels correlate with a measure of impulsivity , 2018, Psychiatry Research.

[16]  D. Karásek,et al.  Relationship of Selected Adipokines with Markers of Vascular Damage in Patients with Type 2 Diabetes. , 2018, Metabolic syndrome and related disorders.

[17]  Ting Zhou,et al.  Early increases in serum FGF21 levels predict mortality of septic patients , 2018, Cytokine.

[18]  T. Kraya,et al.  FGF-21 as a Potential Biomarker for Mitochondrial Diseases. , 2018, Current medicinal chemistry.

[19]  Xinyu Zhao,et al.  FGF23C-tail improves diabetic nephropathy by attenuating renal fibrosis and inflammation , 2018, BMC Biotechnology.

[20]  F. Lang,et al.  A high-fat diet stimulates fibroblast growth factor 23 formation in mice through TNFα upregulation , 2018, Nutrition & Diabetes.

[21]  F. Lang,et al.  Insulin suppresses the production of fibroblast growth factor 23 (FGF23) , 2018, Proceedings of the National Academy of Sciences.

[22]  M. de Antonio,et al.  Predictive biomarkers for death and rehospitalization in comorbid frail elderly heart failure patients , 2018, BMC Geriatrics.

[23]  M. Gillum.  Parsing the Potential Neuroendocrine Actions of FGF21 in Primates , 2018, Endocrinology.

[24]  B. Jacobsson,et al.  Amniotic fluid pentraxins: Potential early markers for identifying intra‐amniotic inflammatory complications in preterm pre‐labor rupture of membranes , 2018, American journal of reproductive immunology.

[25]  Lijun Xu,et al.  The participation of fibroblast growth factor 23 (FGF23) in the progression of osteoporosis via JAK/STAT pathway , 2018, Journal of cellular biochemistry.

[26]  B. Lanske,et al.  Biology of Fibroblast Growth Factor 23: From Physiology to Pathology. , 2018, Cold Spring Harbor perspectives in medicine.

[27]  S. Muley,et al.  Engineered agrin attenuates the severity of experimental autoimmune myasthenia gravis , 2018, Muscle & nerve.

[28]  J. Trebicka,et al.  Fibroblast growth factor 21 is an early predictor of acute‐on‐chronic liver failure in critically ill patients with cirrhosis , 2018, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[29]  Lihui Zhao,et al.  FGF23 (Fibroblast Growth Factor-23) and Incident Hypertension in Young and Middle-Aged Adults: The CARDIA Study , 2018, Hypertension.

[30]  S. Cha,et al.  Expression of Fibroblast Growth Factor 21 and β-Klotho Regulates Hepatic Fibrosis through the Nuclear Factor-κB and c-Jun N-Terminal Kinase Pathways , 2018, Gut and liver.

[31]  Yvette N. Lamb.  Burosumab: First Global Approval , 2018, Drugs.

[32]  D. Leaf,et al.  Fibroblast Growth Factor 23 Associates with Death in Critically Ill Patients. , 2018, Clinical journal of the American Society of Nephrology : CJASN.

[33]  Zhen Xiao,et al.  JQ1 is a potential therapeutic option for COPD patients with agrin overexpression. , 2018, American journal of physiology. Lung cellular and molecular physiology.

[34]  E. Kirk,et al.  Effect of very old age on anconeus motor unit loss and compensatory remodelling , 2018, Muscle & nerve.

[35]  Y. Toiyama,et al.  Prognostic impact of sarcopenia and its correlation with circulating miR-21 in colorectal cancer patients. , 2018, Oncology reports.

[36]  Qianzhou Lv,et al.  Plasma microRNAs reflecting cardiac and inflammatory injury in coronary artery bypass grafting surgery. , 2018, The Journal of surgical research.

[37]  P. Pinton,et al.  Calcium Dynamics as a Machine for Decoding Signals. , 2018, Trends in cell biology.

[38]  J. Manson,et al.  Markers of Inflammation and Incident Breast Cancer Risk in the Women’s Health Study , 2018, American journal of epidemiology.

[39]  K. Gomes,et al.  Circulating microparticles levels are increased in patients with diabetic kidney disease: A case-control research. , 2018, Clinica chimica acta; international journal of clinical chemistry.

[40]  P. Warde,et al.  MP37-08 SERUM MIRNA PREDICTS VIABLE DISEASE POST-CHEMOTHERAPY IN TESTICULAR NON-SEMINOMA GERM CELL TUMOR PATIENTS , 2018 .

[41]  J. Bacchetta,et al.  Hyperphosphatemic tumoral calcinosis caused by FGF23 compound heterozygous mutations: what are the therapeutic options for a better control of phosphatemia? , 2018, Pediatric Nephrology.

[42]  Christopher J. Cheng,et al.  Exercise and weight loss interventions and miRNA expression in women with breast cancer , 2018, Breast Cancer Research and Treatment.

[43]  Y. Qi,et al.  Protection Effect of Exogenous Fibroblast Growth Factor 21 on the Kidney Injury in Vascular Calcification Rats , 2018, Chinese medical journal.

[44]  N. Vorokhobina,et al.  [Fibroblast growth factor-21 as a marker of premature aging in young and middled-aged men with type 2 diabetes]. , 2018, Urologiia.

[45]  L. Mei,et al.  Induction of Anti-agrin Antibodies Causes Myasthenia Gravis in Mice , 2018, Neuroscience.

[46]  Bing Zhang,et al.  The ubiquitin ligase TRIM56 inhibits ovarian cancer progression by targeting vimentin , 2018, Journal of cellular physiology.

[47]  A. Rydzewska-Rosołowska,et al.  C‐terminal and intact FGF23 in critical illness and their associations with acute kidney injury and in‐hospital mortality , 2018, Cytokine.

[48]  H. Dellago,et al.  Cost-utility analysis of fracture risk assessment using microRNAs compared with standard tools and no monitoring in the Austrian female population. , 2018, Bone.

[49]  Lidian Chen,et al.  Inhibition of Complement Drives Increase in Early Growth Response Proteins and Neuroprotection Mediated by Salidroside After Cerebral Ischemia , 2018, Inflammation.

[50]  James D. Akula,et al.  Fibroblast Growth Factor 21 Protects Photoreceptor Function in Type 1 Diabetic Mice , 2018, Diabetes.

[51]  Gurinder K. Singh,et al.  Inhibition of fibroblast growth factor 23 (FGF23) signaling rescues renal anemia , 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[52]  S. Fukumoto.  Targeting Fibroblast Growth Factor 23 Signaling with Antibodies and Inhibitors, Is There a Rationale? , 2018, Front. Endocrinol..

[53]  J. Qiao,et al.  Elevated CD14++CD16+ Monocytes in Hyperhomocysteinemia-Associated Insulin Resistance in Polycystic Ovary Syndrome , 2018, Reproductive Sciences.

[54]  M. Gillum,et al.  FGF21, a liver hormone that inhibits alcohol intake in mice, increases in human circulation after acute alcohol ingestion and sustained binge drinking at Oktoberfest , 2018, bioRxiv.

[55]  L. Mei,et al.  Neuromuscular Junction Formation, Aging, and Disorders. , 2018, Annual review of physiology.

[56]  N. Chattipakorn,et al.  Increased plasma FGF21 level as an early biomarker for insulin resistance and metabolic disturbance in obese insulin-resistant rats , 2018, Diabetes & vascular disease research.

[57]  B. Souweine,et al.  Receptor for advanced glycation end-products and ARDS prediction: a multicentre observational study , 2018, Scientific Reports.

[58]  A. Budaj,et al.  Adiponectin gene variants and decreased adiponectin plasma levels are associated with the risk of myocardial infarction in young age. , 2018, Gene.

[59]  Jianhua Zhang,et al.  Leptin and chronic kidney diseases , 2018, Journal of receptor and signal transduction research.

[60]  Kenneth A. Philbrick,et al.  Effects of hypothalamic leptin gene therapy on osteopetrosis in leptin-deficient mice. , 2018, The Journal of endocrinology.

[61]  W. Hong,et al.  Linking Extracellular Matrix Agrin to the Hippo Pathway in Liver Cancer and Beyond , 2018, Cancers.

[62]  M. Pallàs,et al.  Resveratrol modulates response against acute inflammatory stimuli in aged mouse brain , 2018, Experimental Gerontology.

[63]  Jean Martínez,et al.  Heteromultivalent targeting of integrin αvβ3 and neuropilin 1 promotes cell survival via the activation of the IGF-1/insulin receptors. , 2018, Biomaterials.

[64]  M. Endres,et al.  Marathon running increases circulating endothelial- and thrombocyte-derived microparticles , 2018, European journal of preventive cardiology.

[65]  C. Buechler,et al.  Circulating fibroblast growth factor 21 in patients with liver cirrhosis , 2018, Clinical and Experimental Medicine.

[66]  L. Abenavoli,et al.  The Emerging Role of Complement C3 as A Biomarker of Insulin Resistance and Cardiometabolic Diseases: Preclinical and Clinical Evidence. , 2018, Reviews on recent clinical trials.

[67]  E. Kazemian,et al.  Association of circulating CTRP9 with soluble adhesion molecules and inflammatory markers in patients with type 2 diabetes mellitus and coronary artery disease , 2018, PloS one.

[68]  G. La Manna,et al.  Klotho-FGF23, Cardiovascular Disease, and Vascular Calcification: Black or White? , 2018, Current vascular pharmacology.

[69]  A. D. De Nicola,et al.  Potential Biomarkers with Plasma Cortisol, Brain-derived Neurotrophic Factor and Nitrites in Patients with Acute Ischemic Stroke. , 2018, Current neurovascular research.

[70]  Kevin K. W. Wang,et al.  Protein Biomarkers and Neuroproteomics Characterization of Microvesicles/Exosomes from Human Cerebrospinal Fluid Following Traumatic Brain Injury , 2018, Molecular Neurobiology.

[71]  A. Danser,et al.  Autoantibodies against angiotensin and adrenergic receptors: more than a biomarker? , 2018, Clinical science.

[72]  Li-Zhong Sun,et al.  Magnitude of Soluble ST2 as a Novel Biomarker for Acute Aortic Dissection , 2018, Circulation.

[73]  Zishan Wang,et al.  Long-term Changes in the Nigrostriatal Pathway in the MPTP Mouse Model of Parkinson’s Disease , 2018, Neuroscience.

[74]  M. Myers,et al.  Leptin and the maintenance of elevated body weight , 2018, Nature Reviews Neuroscience.

[75]  Ming Xu,et al.  Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy , 2018, Scientific Reports.

[76]  H. Loewen,et al.  Effect of an acute exercise bout on immediate post‐exercise irisin concentration in adults: A meta‐analysis , 2018, Scandinavian journal of medicine & science in sports.

[77]  L. Vécsei,et al.  Mitochondria, Oxidative Stress and the Kynurenine System, with a Focus on Ageing and Neuroprotection , 2018, Molecules.

[78]  A. C. Simões e Silva,et al.  Serum levels of angiotensin converting enzyme as a biomarker of liver fibrosis , 2017, World journal of gastroenterology.

[79]  H. Jeong,et al.  The involvement of serum exosomal miR-500-3p and miR-770-3p in aging: modulation by calorie restriction , 2017, Oncotarget.

[80]  Heng Du,et al.  Increased Serum Acylated Ghrelin Levels in Patients with Mild Cognitive Impairment. , 2017, Journal of Alzheimer's disease : JAD.

[81]  D. Beeson,et al.  Novel SEA and LG2 Agrin mutations causing congenital Myasthenic syndrome , 2017, Orphanet Journal of Rare Diseases.

[82]  K. Angelopoulou,et al.  Inflammation‐driven colon neoplasmatogenesis in uPA‐deficient mice is associated with an increased expression of Runx transcriptional regulators , 2017, Experimental cell research.

[83]  T. Yamashita,et al.  Extracellular Lactate Dehydrogenase A Release From Damaged Neurons Drives Central Nervous System Angiogenesis , 2017, EBioMedicine.

[84]  Dan Yang,et al.  GLP-1 and Ghrelin Attenuate High Glucose/High Lipid-Induced Apoptosis and Senescence of Human Microvascular Endothelial Cells , 2017, Cellular Physiology and Biochemistry.

[85]  M. Brizzi,et al.  Unacylated ghrelin prevents mitochondrial dysfunction in a model of ischemia/reperfusion liver injury , 2017, Cell Death Discovery.

[86]  M. Hedayati,et al.  Synergistic Effects of Resistin and Visfatin as Adipocyte Derived Hormones on Telomerase Gene Expression in AGS Gastric Cancer Cell Line. , 2017, Acta medica Iranica.

[87]  R. Kronmal,et al.  The relationship of circulating fibroblast growth factor 21 levels with incident atrial fibrillation: The Multi-Ethnic Study of Atherosclerosis. , 2017, Atherosclerosis.

[88]  Lingyun Wu,et al.  The interaction of IGF‐1/IGF‐1R and hydrogen sulfide on the proliferation of mouse primary vascular smooth muscle cells , 2017, Biochemical pharmacology.

[89]  H. Drissi,et al.  Calreticulin inhibits inflammation‐induced osteoclastogenesis and bone resorption , 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[90]  L. Porchia,et al.  Serum resistin levels inversely associated with cardiovascular risk indices in type 2 diabetics from central Mexico. , 2017, Diabetes & metabolic syndrome.

[91]  Huiying Zhao,et al.  Age‑related differences in serum MFG‑E8, TGF‑β1 and correlation to the severity of atherosclerosis determined by ultrasound. , 2017, Molecular medicine reports.

[92]  Y. Akasaka,et al.  Resistin upregulates chemokine production by fibroblast-like synoviocytes from patients with rheumatoid arthritis , 2017, Arthritis Research & Therapy.

[93]  R. Levy,et al.  CCL2, CXCL8, CXCL9 and CXCL10 serum levels increase with age but are not altered by treatment with hydroxychloroquine in patients with osteoarthritis of the knees , 2017, International journal of rheumatic diseases.

[94]  Jeffrey R. Chabot,et al.  Once‐weekly administration of a long‐acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people with hypertriglyceridaemia and in non‐human primates , 2017, Diabetes, obesity & metabolism.

[95]  N. Yano,et al.  Irisin plays a pivotal role to protect the heart against ischemia and reperfusion injury , 2017, Journal of cellular physiology.

[96]  A. Ray,et al.  The potential role of leptin in tumor invasion and metastasis. , 2017, Cytokine & growth factor reviews.

[97]  Andreas Radbruch,et al.  Monocyte alterations in rheumatoid arthritis are dominated by preterm release from bone marrow and prominent triggering in the joint , 2017, Annals of the rheumatic diseases.

[98]  A. Abbas,et al.  Long-lived weight-reduced αMUPA mice show higher and longer maternal-dependent postnatal leptin surge , 2017, PloS one.

[99]  N. Koulmann,et al.  Circulating myomiRs: a new class of biomarkers to monitor skeletal muscle in physiology and medicine , 2017, Journal of cachexia, sarcopenia and muscle.

[100]  J. Finlay,et al.  Blocking interleukin-6 signaling inhibits cell viability/proliferation, glycolysis, and colony forming activity of human medulloblastoma cells , 2017, International journal of oncology.

[101]  M. Pencina,et al.  Longitudinal FGF23 Trajectories and Mortality in Patients with CKD. , 2017, Journal of the American Society of Nephrology : JASN.

[102]  C. Luo,et al.  Lactoferrin Exerts Antitumor Effects by Inhibiting Angiogenesis in a HT29 Human Colon Tumor Model. , 2017, Journal of agricultural and food chemistry.

[103]  J. Tamaki,et al.  Changes in Serum Fibroblast Growth Factor 23 in Patients With Acute Myocardial Infarction. , 2017, Circulation journal : official journal of the Japanese Circulation Society.

[104]  Jianxia Fan,et al.  Correlation of Maternal Serum Homocysteine in the First Trimester with the Development of Gestational Hypertension and Preeclampsia , 2017, Medical science monitor : international medical journal of experimental and clinical research.

[105]  L. Gan,et al.  Reduced Endoplasmic Reticulum Stress-Mediated Autophagy Is Required for Leptin Alleviating Inflammation in Adipose Tissue , 2017, Front. Immunol..

[106]  M. Giacca,et al.  Acylated ghrelin treatment normalizes skeletal muscle mitochondrial oxidative capacity and AKT phosphorylation in rat chronic heart failure , 2017, Journal of cachexia, sarcopenia and muscle.

[107]  P. Gaussem,et al.  Endothelial Microparticles are Associated to Pathogenesis of Idiopathic Pulmonary Fibrosis , 2017, Stem Cell Reviews and Reports.

[108]  K. Rye,et al.  Fibroblast growth factor 21 in chronic kidney disease. , 2017, Clinica chimica acta; international journal of clinical chemistry.

[109]  Yong-Jie Lian,et al.  HMGB1 mediates depressive behavior induced by chronic stress through activating the kynurenine pathway , 2017, Brain, Behavior, and Immunity.

[110]  C. Prati,et al.  Brain-derived neurotrophic factor in adjuvant-induced arthritis in rats. Relationship with inflammation and endothelial dysfunction , 2017, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[111]  S. Trattnig,et al.  Gliptin therapy reduces hepatic and myocardial fat in type 2 diabetic patients , 2017, European journal of clinical investigation.

[112]  Shi-You Chen,et al.  S100B promotes injury-induced vascular remodeling through modulating smooth muscle phenotype. , 2017, Biochimica et biophysica acta. Molecular basis of disease.

[113]  A. Avogaro,et al.  Shift of monocyte subsets along their continuum predicts cardiovascular outcomes. , 2017, Atherosclerosis.

[114]  M. Bianchi,et al.  High‐mobility group box 1 protein orchestrates responses to tissue damage via inflammation, innate and adaptive immunity, and tissue repair , 2017, Immunological reviews.

[115]  Z. Li,et al.  Adiponectin attenuates endoplasmic reticulum stress and alveolar epithelial apoptosis in COPD rats. , 2017, European review for medical and pharmacological sciences.

[116]  Sanjiv J. Shah,et al.  A null mutation in SERPINE1 protects against biological aging in humans , 2017, Science Advances.

[117]  D. Bellar,et al.  Relationship between family history of type 2 diabetes and serum FGF21 , 2017, European journal of clinical investigation.

[118]  Kyu-Sang Park,et al.  Circulating irisin levels as a predictive biomarker for sarcopenia: A cross‐sectional community‐based study , 2017, Geriatrics & gerontology international.

[119]  Jie-ping Wang,et al.  Irisin protects against neuronal injury induced by oxygen‐glucose deprivation in part depends on the inhibition of ROS‐NLRP3 inflammatory signaling pathway , 2017, Molecular immunology.

[120]  P. Siegel,et al.  Targeting GPNMB with glembatumumab vedotin: Current developments and future opportunities for the treatment of cancer☆ , 2017, Pharmacology & therapeutics.

[121]  S. Haeberlein,et al.  BACE1 Inhibitor Lanabecestat (AZD3293) in a Phase 1 Study of Healthy Japanese Subjects: Pharmacokinetics and Effects on Plasma and Cerebrospinal Fluid Aβ Peptides , 2017, Journal of clinical pharmacology.

[122]  Chaoyi Qin,et al.  Mitochondrial DNA‑induced inflammatory damage contributes to myocardial ischemia reperfusion injury in rats: Cardioprotective role of epigallocatechin. , 2017, Molecular medicine reports.

[123]  R. Pratley,et al.  Circulating levels of miR-7, miR-152 and miR-192 respond to vitamin D supplementation in adults with prediabetes and correlate with improvements in glycemic control. , 2017, The Journal of nutritional biochemistry.

[124]  M. Mattson,et al.  Walking speed decline in older adults is associated with elevated pro-BDNF in plasma extracellular vesicles , 2017, Experimental Gerontology.

[125]  M. Domingo,et al.  Amiloide beta (1-40) en sangre, cognición y pronóstico en insuficiencia cardiaca , 2017 .

[126]  S. Hammes,et al.  Glycoprotein Non-Metastatic Melanoma Protein B (GPNMB) and Cancer: A Novel Potential Therapeutic Target , 2017, Steroids.

[127]  J. Chung,et al.  Lactoferrin Protects Human Mesenchymal Stem Cells from Oxidative Stress-Induced Senescence and Apoptosis. , 2017, Journal of microbiology and biotechnology.

[128]  G. Calin,et al.  Cell‐to‐cell communication: microRNAs as hormones , 2017, Molecular oncology.

[129]  S. Titze,et al.  Change in inflammatory parameters in prefrail and frail persons obtaining physical training and nutritional support provided by lay volunteers: A randomized controlled trial , 2017, PloS one.

[130]  N. Rajab,et al.  Identification of Neuroprotective Factors Associated with Successful Ageing and Risk of Cognitive Impairment among Malaysia Older Adults , 2017, Current gerontology and geriatrics research.

[131]  J. Harvey,et al.  Food for thought: Leptin regulation of hippocampal function and its role in Alzheimer's disease , 2017, Neuropharmacology.

[132]  A. Vezzani,et al.  High Mobility Group Box 1 is a novel pathogenic factor and a mechanistic biomarker for epilepsy , 2017, Brain, Behavior, and Immunity.

[133]  K. Iczkowski,et al.  Tissue-Specific MicroRNA Expression Patterns in Four Types of Kidney Disease. , 2017, Journal of the American Society of Nephrology : JASN.

[134]  Li-Li Zou,et al.  Calreticulin is an effective immunologic adjuvant to tumor-associated antigens. , 2017, Experimental and therapeutic medicine.

[135]  Y-H Li,et al.  Diagnostic value of joint detection of homocysteine and RDW CV on acute myocardial infarction. , 2017, European review for medical and pharmacological sciences.

[136]  V. Tancredi,et al.  Impairment of PTX3 expression in osteoblasts: a key element for osteoporosis , 2017, Cell Death & Disease.

[137]  J. Tsai.  The association of serum leptin levels with metabolic diseases , 2017, Ci ji yi xue za zhi = Tzu-chi medical journal.

[138]  R. Erben.  Pleiotropic Actions of FGF23 , 2017, Toxicologic pathology.

[139]  Xingshun Xu,et al.  Erratum to: Exogenous Adipokine Peptide Resistin Protects Against Focal Cerebral Ischemia/Reperfusion Injury in Mice , 2017, Neurochemical Research.

[140]  K. Huber,et al.  Predictive value of low interleukin‐33 in critically ill patients , 2017, Cytokine.

[141]  Yufei Yan,et al.  Diagnostic accuracy of alpha-defensin in periprosthetic joint infection: a systematic review and meta-analysis , 2017, International Orthopaedics.

[142]  Jason G. Smith,et al.  Defensins in Viral Infection and Pathogenesis. , 2017, Annual review of virology.

[143]  M. Sabbatini,et al.  Diagnostic, Predictive, Prognostic, and Therapeutic Molecular Biomarkers in Third Millennium: A Breakthrough in Gastric Cancer , 2017, BioMed research international.

[144]  H. Yoshiji,et al.  Serum angiotensin-converting enzyme level for evaluating significant fibrosis in chronic hepatitis B , 2017, World journal of gastroenterology.

[145]  H. Hara,et al.  GPNMB Induces BiP Expression by Enhancing Splicing of BiP Pre-mRNA during the Endoplasmic Reticulum Stress Response , 2017, Scientific Reports.

[146]  Zhimin Chen,et al.  Serum Matrix Metalloproteinase-7 Level is Associated with Fibrosis and Renal Survival in Patients with IgA Nephropathy , 2017, Kidney and Blood Pressure Research.

[147]  Jian-dong Wang,et al.  Effect of TALEN-mediated IL-6 knockout on cell proliferation, apoptosis, invasion and anti-cancer therapy in hepatocellular carcinoma (HCC-LM3) cells , 2017, Oncotarget.

[148]  P. Challande,et al.  Vimentin knockout results in increased expression of sub-endothelial basement membrane components and carotid stiffness in mice , 2017, Scientific Reports.

[149]  Dianjun Sun,et al.  Sodium Arsenite-Induced Learning and Memory Impairment Is Associated with Endoplasmic Reticulum Stress-Mediated Apoptosis in Rat Hippocampus , 2017, Front. Mol. Neurosci..

[150]  H. Chung,et al.  Growth differentiation factor 15 as a predictor of adverse renal outcomes in patients with immunoglobulin A nephropathy , 2017, Internal medicine journal.

[151]  Z. Modrušan,et al.  Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation , 2017, The Journal of experimental medicine.

[152]  D. Dingli,et al.  Elevation of serum lactate dehydrogenase in AL amyloidosis reflects tissue damage and is an adverse prognostic marker in patients not eligible for stem cell transplantation , 2017, British journal of haematology.

[153]  D. Krasowska,et al.  Resistin: a possible biomarker of organ involvement in systemic sclerosis patients? , 2017, Clinical and experimental rheumatology.

[154]  K. White,et al.  Heritable and acquired disorders of phosphate metabolism: Etiologies involving FGF23 and current therapeutics. , 2017, Bone.

[155]  T. Tammela,et al.  Resistin and interleukin 6 as predictive factors for recurrence and long-term prognosis in renal cell cancer. , 2017, Urologic oncology.

[156]  M. Nishihara,et al.  Involvement of progranulin in modulating neuroinflammatory responses but not neurogenesis in the hippocampus of aged mice , 2017, Experimental Gerontology.

[157]  Yidong Bai,et al.  Aging-associated mitochondrial DNA mutations alter oxidative phosphorylation machinery and cause mitochondrial dysfunctions. , 2017, Biochimica et biophysica acta. Molecular basis of disease.

[158]  C. Schernthaner,et al.  Multibiomarker analysis in patients with acute myocardial infarction , 2017, European journal of clinical investigation.

[159]  C. Pepine,et al.  Intestinal Permeability Biomarker Zonulin is Elevated in Healthy Aging. , 2017, Journal of the American Medical Directors Association.

[160]  M. Bazzo,et al.  Circulating levels of pentraxin-3 (PTX3) in patients with liver cirrhosis. , 2017, Annals of hepatology.

[161]  Y. Chen,et al.  Gemcitabine treatment induces endoplasmic reticular (ER) stress and subsequently upregulates urokinase plasminogen activator (uPA) to block mitochondrial-dependent apoptosis in Panc-1 cancer stem-like cells (CSCs) , 2017, PloS one.

[162]  F. Safadi,et al.  Glycoprotein NMB: an Emerging Role in Neurodegenerative Disease , 2017, Molecular Neurobiology.

[163]  H. D. den Ruijter,et al.  Growth Differentiation Factor 15 Is Associated With Major Amputation and Mortality in Patients With Peripheral Artery Disease , 2017, Journal of the American Heart Association.

[164]  S. Fumagalli,et al.  C-Reactive Protein Binds to Cholesterol Crystals and Co-Localizes with the Terminal Complement Complex in Human Atherosclerotic Plaques , 2017, Front. Immunol..

[165]  T. Davis,et al.  Identification of Novel Circulating Biomarkers Predicting Rapid Decline in Renal Function in Type 2 Diabetes: The Fremantle Diabetes Study Phase II , 2017, Diabetes Care.

[166]  I. Korponay-Szabó,et al.  Transglutaminase 2 in human diseases , 2017, BioMedicine.

[167]  Dong Hyun Kim,et al.  Effects of subconjunctival administration of anti-high mobility group box 1 on dry eye in a mouse model of Sjӧgren’s syndrome , 2017, PloS one.

[168]  Gang Li,et al.  Plasma Growth Differentiation Factor-15 is a Potential Biomarker for Pediatric Pulmonary Arterial Hypertension Associated with Congenital Heart Disease , 2017, Pediatric Cardiology.

[169]  Beata Franczyk,et al.  Biomarkers of Cardiovascular Risk in Haemodialysis Patients. , 2017, Current pharmaceutical design.

[170]  H. D. den Ruijter,et al.  Circulating GDF-15 levels predict future secondary manifestations of cardiovascular disease explicitly in women but not men with atherosclerosis. , 2017, International journal of cardiology.

[171]  Lingling Wu,et al.  Knockdown of Cxcl10 Inhibits Mesangial Cell Proliferation in Murine Habu Nephritis Via ERK Signaling , 2017, Cellular Physiology and Biochemistry.

[172]  Guoliang Meng,et al.  Raf-1/CK2 and RhoA/ROCK signaling promote TNF-α-mediated endothelial apoptosis via regulating vimentin cytoskeleton. , 2017, Toxicology.

[173]  Chiu-fen Yang,et al.  Serum resistin as an independent marker of aortic stiffness in patients with coronary artery disease , 2017, PloS one.

[174]  I. Castilla-Cortázar,et al.  Partial IGF-1 deficiency is sufficient to reduce heart contractibility, angiotensin II sensibility, and alter gene expression of structural and functional cardiac proteins , 2017, PloS one.

[175]  C. Östenson,et al.  Plasma GDF15 level is elevated in psychosis and inversely correlated with severity , 2017, Scientific Reports.

[176]  Zhenxiang Zhao,et al.  Serum Growth Differentiation Factor 15 in Parkinson Disease , 2017, Neurodegenerative Diseases.

[177]  Hachidai Takahashi,et al.  Impact of CD14++CD16+ monocytes on plaque vulnerability in diabetic and non-diabetic patients with asymptomatic coronary artery disease: a cross-sectional study , 2017, Cardiovascular Diabetology.

[178]  W. März,et al.  Soluble Urokinase Plasminogen Activator Receptor and Outcomes in Patients with Diabetes on Hemodialysis. , 2017, Clinical journal of the American Society of Nephrology : CJASN.

[179]  S. Blankenberg,et al.  GDF-15 predicts cardiovascular events in acute chest pain patients , 2017, PloS one.

[180]  Jian-zhi Zhou,et al.  Prenatal Exposure to Lipopolysaccharide Induces PTX3 Expression and Results in Obesity in Mouse Offspring , 2017, Inflammation.

[181]  Daniel W Trott,et al.  Selected life‐extending interventions reduce arterial CXCL10 and macrophage colony‐stimulating factor in aged mouse arteries , 2017, Cytokine.

[182]  I. Castilla-Cortázar,et al.  The single IGF-1 partial deficiency is responsible for mitochondrial dysfunction and is restored by IGF-1 replacement therapy. , 2017, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[183]  G. Svegliati-Baroni,et al.  Fibronectin Type III Domain–Containing Protein 5 rs3480 A>G Polymorphism, Irisin, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease , 2017, The Journal of clinical endocrinology and metabolism.

[184]  W. Ollier,et al.  Heightened autoantibody immune response to citrullinated calreticulin in bronchiectasis: Implications for rheumatoid arthritis. , 2017, The international journal of biochemistry & cell biology.

[185]  F. Gao,et al.  Therapeutic potential of an anti-high mobility group box-1 monoclonal antibody in epilepsy , 2017, Brain, Behavior, and Immunity.

[186]  F. Santolaria,et al.  Prognostic value of acute delirium recovery in older adults , 2017, Geriatrics & gerontology international.

[187]  J. Poulton,et al.  Use of FGF-21 as a Biomarker of Mitochondrial Disease in Clinical Practice , 2017, Journal of clinical medicine.

[188]  H. Jang,et al.  Association of circulating irisin levels with metabolic and metabolite profiles of Korean adolescents. , 2017, Metabolism: clinical and experimental.

[189]  Q. Ye,et al.  miR-30a-5p suppresses breast tumor growth and metastasis through inhibition of LDHA-mediated Warburg effect. , 2017, Cancer letters.

[190]  M. Gekle,et al.  Calcineurin inhibitors regulate fibroblast growth factor 23 (FGF23) synthesis , 2017, Naunyn-Schmiedeberg's Archives of Pharmacology.

[191]  S. Kjellqvist,et al.  Altered Protein Composition of Subcutaneous Adipose Tissue in Chronic Kidney Disease , 2017, Kidney international reports.

[192]  P. Ryan,et al.  CXCL9-11 polymorphisms are associated with liver fibrosis in patients with chronic hepatitis C: a cross-sectional study , 2017, Clinical and Translational Medicine.

[193]  P. Gresele,et al.  Platelet amyloid precursor protein is a modulator of venous thromboembolism in mice. , 2017, Blood.

[194]  P. Tam,et al.  Fibroblast Growth Factor 23 Predicts Mortality and End-Stage Renal Disease in a Canadian Asian Population with Chronic Kidney Disease , 2017, Nephron.

[195]  M. Chapman,et al.  Therapeutic targeting of HMGB1 during experimental sepsis modulates the inflammatory cytokine profile to one associated with improved clinical outcomes , 2017, Scientific Reports.

[196]  M. Bugliani,et al.  The Myokine Irisin Is Released in Response to Saturated Fatty Acids and Promotes Pancreatic β-Cell Survival and Insulin Secretion , 2017, Diabetes.

[197]  L. Hsu,et al.  Growth Differentiation Factor 15 May Predict Mortality of Peripheral and Coronary Artery Diseases and Correlate with Their Risk Factors , 2017, Mediators of inflammation.

[198]  T. Walther,et al.  Angiotensin-(1-7) counteracts the transforming effects triggered by angiotensin II in breast cancer cells , 2017, Oncotarget.

[199]  M. Recanatini,et al.  LDH inhibition impacts on heat shock response and induces senescence of hepatocellular carcinoma cells , 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[200]  S. Rehman,et al.  AGEs, RAGEs and s-RAGE; friend or foe for cancer. , 2017, Seminars in cancer biology.

[201]  Y. Bao,et al.  Complementary Role of Fibroblast Growth Factor 21 and Cytokeratin 18 in Monitoring the Different Stages of Nonalcoholic Fatty Liver Disease , 2017, Scientific Reports.

[202]  A. Trifunovic,et al.  Origins of mtDNA mutations in ageing. , 2017, Essays in biochemistry.

[203]  F. Lang,et al.  The production of fibroblast growth factor 23 is controlled by TGF-β2 , 2017, Scientific Reports.

[204]  H. Chung,et al.  High‐mobility group box‐1 contributes tumor angiogenesis under interleukin‐8 mediation during gastric cancer progression , 2017, Cancer science.

[205]  J. Broderick,et al.  Soluble ST2 predicts outcome and hemorrhagic transformation after acute stroke , 2017, Annals of clinical and translational neurology.

[206]  Nektarios Tavernarakis,et al.  Modulation of Autophagy by BDNF Underlies Synaptic Plasticity. , 2017, Cell metabolism.

[207]  B. Viollet,et al.  AMPKα1‐LDH pathway regulates muscle stem cell self‐renewal by controlling metabolic homeostasis , 2017, The EMBO journal.

[208]  B. Kestenbaum,et al.  Growth Differentiation Factor-15 and Risk of CKD Progression. , 2017, Journal of the American Society of Nephrology : JASN.

[209]  M. Wolf,et al.  Klotho, an antiaging molecule, attenuates oxidant-induced alveolar epithelial cell mtDNA damage and apoptosis. , 2017, American journal of physiology. Lung cellular and molecular physiology.

[210]  G. Castellani,et al.  Inflammaging and human longevity in the omics era , 2017, Mechanisms of Ageing and Development.

[211]  C. Faul.  Cardiac actions of fibroblast growth factor 23. , 2017, Bone.

[212]  Hyun Kim,et al.  Serum tumour necrosis factor‐α and interleukin‐6 levels in Alzheimer's disease and mild cognitive impairment , 2017, Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society.

[213]  M. Econs.  Genetic diseases resulting from disordered FGF23/klotho biology. , 2017, Bone.

[214]  L. Brodin,et al.  Exercise and BDNF reduce Aβ production by enhancing α‐secretase processing of APP , 2017, Journal of neurochemistry.

[215]  Y. Hsieh,et al.  Everolimus suppresses invasion and migration of renal cell carcinoma by inhibiting FAK activity and reversing epithelial to mesenchymal transition in vitro and in vivo , 2017, Environmental toxicology.

[216]  R. Erben,et al.  FGF23-Klotho signaling axis in the kidney. , 2017, Bone.

[217]  Ruoyu Li,et al.  Serum Human Beta-Defensin-2 Is a Possible Biomarker for Monitoring Response to JAK Inhibitor in Psoriasis Patients , 2017, Dermatology.

[218]  Min Wu,et al.  Leptin/OB-R pathway promotes IL-4 secretion from B lymphocytes and induces salivary gland epithelial cell apoptosis in Sjögren's syndrome , 2017, Oncotarget.

[219]  D. Tziakas,et al.  C-terminal fragment of agrin (CAF) levels predict acute kidney injury after acute myocardial infarction , 2017, BMC Nephrology.

[220]  Ja-june Jang,et al.  The correlation between poor prognosis and increased yes-associated protein 1 expression in keratin 19 expressing hepatocellular carcinomas and cholangiocarcinomas , 2017, BMC Cancer.

[221]  K. Huber,et al.  Urokinase plasminogen activator protects cardiac myocytes from oxidative damage and apoptosis via hOGG1 induction , 2017, Apoptosis.

[222]  Maojun Liu,et al.  Hydrogen sulfide reduced renal tissue fibrosis by regulating autophagy in diabetic rats , 2017, Molecular medicine reports.

[223]  Lin Liu,et al.  Ghrelin improves vascular autophagy in rats with vascular calcification , 2017, Life sciences.

[224]  W. Yao,et al.  Serum Irisin Predicts Mortality Risk in Acute Heart Failure Patients , 2017, Cellular Physiology and Biochemistry.

[225]  J. Martínez,et al.  Plasma FGF21 levels in obese patients undergoing energy-restricted diets or bariatric surgery: a marker of metabolic stress? , 2017, International Journal of Obesity.

[226]  Jose M Garcia,et al.  Deletion of ghrelin prevents aging‐associated obesity and muscle dysfunction without affecting longevity , 2017, Aging cell.

[227]  Y. Asano,et al.  Association between circulating fibroblast growth factor 21 and mortality in end-stage renal disease , 2017, PloS one.

[228]  Guowei Huang,et al.  Folic acid attenuates homocysteine and enhances antioxidative capacity in atherosclerotic rats. , 2017, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[229]  Amany M El-Saeed,et al.  Circulating Fibroblast Growth Factors 21 and 23 as Biomarkers of Progression in Diabetic Nephropathy in Type 2 Diabetes with Normoalbuminuria. , 2017, The Egyptian journal of immunology.

[230]  Lin Sun,et al.  Glycoprotein non-metastatic melanoma protein b (Gpnmb) is highly expressed in macrophages of acute injured kidney and promotes M2 macrophages polarization. , 2017, Cellular immunology.

[231]  A. Ray,et al.  The influence of different calorie restriction protocols on serum pro-inflammatory cytokines, adipokines and IGF-I levels in female C57BL6 mice: short term and long term diet effects. , 2017, Meta gene.

[232]  K. Docherty,et al.  Increased vimentin in human α- and β-cells in type 2 diabetes. , 2017, The Journal of endocrinology.

[233]  Yanyan Tang,et al.  Increased circulating leukocyte-derived microparticles in ischemic cerebrovascular disease. , 2017, Thrombosis research.

[234]  Yaoh-Shiang Lin,et al.  Vimentin is a potential prognostic factor for tongue squamous cell carcinoma among five epithelial–mesenchymal transition-related proteins , 2017, PloS one.

[235]  Beth Stevens,et al.  Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice , 2017, Science Translational Medicine.

[236]  Zude Liu,et al.  Leptin differentially regulates chondrogenesis in mouse vertebral and tibial growth plates , 2017, BMC Musculoskeletal Disorders.

[237]  D. Tang,et al.  Irisin-mediated protective effect on LPS-induced acute lung injury via suppressing inflammation and apoptosis of alveolar epithelial cells. , 2017, Biochemical and biophysical research communications.

[238]  J. Molina,et al.  Early diagnosis of mild cognitive impairment and Alzheimer's disease based on salivary lactoferrin , 2017, Alzheimer's & dementia.

[239]  J. Donato,et al.  The role of leptin in health and disease , 2017, Temperature.

[240]  A. Gómez-Tato,et al.  Improving circulating tumor cells enumeration and characterization to predict outcome in first line chemotherapy mCRPC patients. , 2017, Oncotarget.

[241]  M. Świderska,et al.  Serum irisin levels in patients with psoriasis , 2017, The Journal of dermatological treatment.

[242]  Natasha T. Snider,et al.  Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications. , 2017, Journal of visualized experiments : JoVE.

[243]  Q. Dai,et al.  Exogenous BDNF Increases Mitochondrial pCREB and Alleviates Neuronal Metabolic Defects Following Mechanical Injury in a MPTP-Dependent Way , 2017, Molecular Neurobiology.

[244]  P. Boschetto,et al.  Inflammatory Long Pentraxin 3 is Associated with Leukocyte Telomere Length in Night-Shift Workers , 2017, Front. Immunol..

[245]  R. Leak,et al.  ST2/IL-33-Dependent Microglial Response Limits Acute Ischemic Brain Injury , 2017, The Journal of Neuroscience.

[246]  T. Goiran,et al.  β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog–Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models , 2017, Biological Psychiatry.

[247]  Yuan-Fang Li,et al.  The Reference Intervals for Serum C‐Terminal Agrin Fragment in Healthy Individuals and as a Biomarker for Renal Function in Kidney Transplant Recipients , 2017, Journal of clinical laboratory analysis.

[248]  Guo-Jun Chen,et al.  Plasma levels of soluble receptor for advanced glycation end products in Alzheimer's disease , 2017, The International journal of neuroscience.

[249]  M. Bhat,et al.  Resistin causes G1 arrest in colon cancer cells through upregulation of SOCS3 , 2017, FEBS letters.

[250]  Y. Bek,et al.  Saliva/serum ghrelin, obestatin and homocysteine levels in patients with ischaemic heart disease , 2017, Cardiovascular journal of Africa.

[251]  Yichao Wang,et al.  Association of calreticulin expression with disease activity and organ damage in systemic lupus erythematosus patients. , 2017, Experimental and therapeutic medicine.

[252]  T. Imai,et al.  Fractalkine/CX3CL1 in rheumatoid arthritis , 2017, Modern rheumatology.

[253]  A. Mazur-Bialy,et al.  Irisin acts as a regulator of macrophages host defense , 2017, Life sciences.

[254]  D. Haffner,et al.  Extrarenal effects of FGF23 , 2017, Pediatric Nephrology.

[255]  A. Slusher,et al.  Exercise reduced pentraxin 3 levels produced by endotoxin-stimulated human peripheral blood mononuclear cells in obese individuals , 2017, Experimental biology and medicine.

[256]  S. Paczesny,et al.  The ST2/IL-33 Axis in Immune Cells during Inflammatory Diseases , 2017, Front. Immunol..

[257]  F. Pontén,et al.  Affinity Proteomics Exploration of Melanoma Identifies Proteins in Serum with Associations to T-Stage and Recurrence , 2017, Translational oncology.

[258]  Surachet Benjathummarak,et al.  PPBP and DEFA1/DEFA3 genes in hyperlipidaemia as feasible synergistic inflammatory biomarkers for coronary heart disease , 2017, Lipids in Health and Disease.

[259]  X. Lu,et al.  GDF-15 gene expression alterations in human lymphoblastoid cells and peripheral blood lymphocytes following exposure to ionizing radiation , 2017, Molecular medicine reports.

[260]  Yaru Wu,et al.  Effects and underlying mechanisms of irisin on the proliferation and apoptosis of pancreatic β cells , 2017, PloS one.

[261]  Patrick A. Lewis,et al.  Increased brain expression of GPNMB is associated with genome wide significant risk for Parkinson’s disease on chromosome 7p15.3 , 2017, neurogenetics.

[262]  Y. Kuo,et al.  Neuroprotection against apoptosis of SK-N-MC cells using RMP-7- and lactoferrin-grafted liposomes carrying quercetin , 2017, International journal of nanomedicine.

[263]  R. Chien,et al.  Analysis of the associations among Helicobacter pylori infection, adiponectin, leptin, and 10-year fracture risk using the fracture risk assessment tool: A cross-sectional community-based study , 2017, PloS one.

[264]  Judith Campisi,et al.  Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells , 2017, GeroScience.

[265]  M. Nishibori,et al.  Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity , 2017, The Journal of Biological Chemistry.

[266]  F. Rodríguez‐Artalejo,et al.  Serum Leptin Concentration is Associated with Incident Frailty in Older Adults , 2017, Aging and disease.

[267]  Dan Yu,et al.  Pharmacological efficacy of FGF21 analogue, liraglutide and insulin glargine in treatment of type 2 diabetes. , 2017, Journal of diabetes and its complications.

[268]  M. C. Zuniga,et al.  PKC-epsilon and TLR4 synergistically regulate resistin-mediated inflammation in human macrophages. , 2017, Atherosclerosis.

[269]  S. Komoly,et al.  Elevated FGF 21 in myotonic dystrophy type 1 and mitochondrial diseases , 2017, Muscle & nerve.

[270]  K. Miura,et al.  Macrophage-derived exosomes induce inflammatory factors in endothelial cells under hypertensive conditions , 2017, Hypertension Research.

[271]  P. Aukrust,et al.  Complement activation by cholesterol crystals triggers a subsequent cytokine response , 2017, Molecular immunology.

[272]  Carlos Cruchaga,et al.  CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN , 2017, Experimental Gerontology.

[273]  Ming-feng Yang,et al.  Serum Resistin Levels May Contribute to an Increased Risk of Acute Cerebral Infarction , 2017, Molecular Neurobiology.

[274]  Zhen Chen,et al.  Serum lactate dehydrogenase predicts prognosis and correlates with systemic inflammatory response in patients with advanced pancreatic cancer after gemcitabine-based chemotherapy , 2017, Scientific Reports.

[275]  E. Pocheć,et al.  Anti-Inflammatory Properties of Irisin, Mediator of Physical Activity, Are Connected with TLR4/MyD88 Signaling Pathway Activation , 2017, International journal of molecular sciences.

[276]  R. Henning,et al.  Predictive Properties of Biomarkers GDF-15, NTproBNP, and hs-TnT for Morbidity and Mortality in Patients With Type 2 Diabetes With Nephropathy , 2017, Diabetes Care.

[277]  Michael Merz,et al.  Drug-induced liver injury: recent advances in diagnosis and risk assessment , 2017, Gut.

[278]  F. Lammert,et al.  Panel of three novel serum markers predicts liver stiffness and fibrosis stages in patients with chronic liver disease , 2017, PloS one.

[279]  Chiu-fen Yang,et al.  High serum resistin levels are associated with peripheral artery disease in the hypertensive patients , 2017, BMC Cardiovascular Disorders.

[280]  S. Allan,et al.  Enhanced susceptibility of triple transgenic Alzheimer’s disease (3xTg-AD) mice to acute infection , 2017, Journal of Neuroinflammation.

[281]  M. Jensen,et al.  Amyloid precursor protein modulates macrophage phenotype and diet-dependent weight gain , 2017, Scientific Reports.

[282]  Yuan Zhang,et al.  Quantitative proteomic analysis of gastric cancer tissue reveals novel proteins in platelet-derived growth factor B signaling pathway , 2017, Oncotarget.

[283]  H. Jaeschke,et al.  Caspase inhibitors for the treatment of liver disease: friend or foe? , 2017, Expert review of gastroenterology & hepatology.

[284]  K. Hirata,et al.  Decreased levels of irisin, a skeletal muscle cell-derived myokine, are related to emphysema associated with chronic obstructive pulmonary disease , 2017, International journal of chronic obstructive pulmonary disease.

[285]  Tiancheng Xie,et al.  Downregulation of pigment epithelium-derived factor is associated with increased epithelial-mesenchymal transition in bladder cancer. , 2017, Panminerva medica.

[286]  Pei Wang,et al.  The novel exercise-induced hormone irisin protects against neuronal injury via activation of the Akt and ERK1/2 signaling pathways and contributes to the neuroprotection of physical exercise in cerebral ischemia. , 2017, Metabolism: clinical and experimental.

[287]  Ru-yuan Zhang,et al.  Endothelial microparticles activate endothelial cells to facilitate the inflammatory response. , 2017, Molecular medicine reports.

[288]  R. Kučera,et al.  MIC1/GDF15 as a Bone Metastatic Disease Biomarker. , 2017, Anticancer research.

[289]  D. Agrawal,et al.  Clinical use of high mobility group box 1 and the receptor for advanced glycation end products in the prognosis and risk stratification of heart failure: a literature review. , 2017, Canadian journal of physiology and pharmacology.

[290]  Shang-Der Chen,et al.  Roles of p62 in BDNF‐dependent autophagy suppression and neuroprotection against mitochondrial dysfunction in rat cortical neurons , 2017, Journal of neurochemistry.

[291]  H. Zhang,et al.  Prognostic Value of C-Reactive Protein and Homocysteine in Large-Artery Atherosclerotic Stroke: a Prospective Observational Study. , 2017, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

[292]  O. Ceyhan-Birsoy,et al.  A Novel Missense Variant in the AGRN Gene; Congenital Myasthenic Syndrome Presenting With Head Drop , 2017, Journal of clinical neuromuscular disease.

[293]  R. Muniyappa,et al.  Metreleptin therapy lowers plasma angiopoietin-like protein 3 in patients with generalized lipodystrophy. , 2017, Journal of clinical lipidology.

[294]  H. Flores-Rozas,et al.  Stable shRNA Silencing of Lactate Dehydrogenase A (LDHA) in Human MDA-MB-231 Breast Cancer Cells Fails to Alter Lactic Acid Production, Glycolytic Activity, ATP or Survival. , 2017, Anticancer research.

[295]  T. Pieber,et al.  &bgr;‐Defensin 2 is a responsive biomarker of IL‐17A–driven skin pathology in patients with psoriasis , 2017, The Journal of allergy and clinical immunology.

[296]  Marita Hernández,et al.  A dangerous liaison: Leptin and sPLA2-IIA join forces to induce proliferation and migration of astrocytoma cells , 2017, PloS one.

[297]  C. Bondor,et al.  The metabolic hormone FGF21 is associated with endothelial dysfunction in hemodialysis patients , 2017, International Urology and Nephrology.

[298]  M. Kuro-o.  The FGF23 and Klotho system beyond mineral metabolism , 2017, Clinical and Experimental Nephrology.

[299]  L. Tan,et al.  PGRN Is Associated with Late-Onset Alzheimer’s Disease: a Case–Control Replication Study and Meta-analysis , 2017, Molecular Neurobiology.

[300]  J. Lekakis,et al.  The interplay between renin-angiotensin system activation, abnormal myocardial deformation and neurohumoral activation in hypertensive heart disease: a speckle tracking echocardiography study , 2017, The International Journal of Cardiovascular Imaging.

[301]  Min-Seok Kim,et al.  Angiotensin II Causes Apoptosis of Adult Hippocampal Neural Stem Cells and Memory Impairment Through the Action on AMPK‐PGC1α Signaling in Heart Failure , 2017, Stem cells translational medicine.

[302]  J. Bełtowski,et al.  Progranulin, a New Adipokine at the Crossroads of Metabolic Syndrome, Diabetes, Dyslipidemia and Hypertension. , 2017, Current pharmaceutical design.

[303]  B. Usluogulları,et al.  Role of serum levels of irisin and oxidative stress markers in pregnant women with and without gestational diabetes , 2017, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.

[304]  Yanjie Zhang,et al.  Emerging Role of MicroRNAs in mTOR Signaling , 2017, Cellular and Molecular Life Sciences.

[305]  Wenjian Song,et al.  Diagnostic Value of CK-18, FGF-21, and Related Biomarker Panel in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis , 2017, BioMed research international.

[306]  M. Vaidya,et al.  Vimentin regulates differentiation switch via modulation of keratin 14 levels and their expression together correlates with poor prognosis in oral cancer patients , 2017, PloS one.

[307]  C. Mantzoros,et al.  Physiology and role of irisin in glucose homeostasis , 2017, Nature Reviews Endocrinology.

[308]  J. Guiot,et al.  Sputum biomarkers in IPF: Evidence for raised gene expression and protein level of IGFBP-2, IL-8 and MMP-7 , 2017, PloS one.

[309]  M. Afarideh,et al.  Circulating levels of fibroblast growth factor 21 in early-stage diabetic kidney disease , 2017, Irish Journal of Medical Science (1971 -).

[310]  M. Lindstrom,et al.  Aging and caloric restriction impact adipose tissue, adiponectin, and circulating lipids , 2017, Aging cell.

[311]  E. Theander,et al.  Blood chemokine profile in untreated early rheumatoid arthritis: CXCL10 as a disease activity marker , 2017, Arthritis Research & Therapy.

[312]  O. Djurdjev,et al.  The Association between Biomarker Profiles, Etiology of Chronic Kidney Disease, and Mortality , 2017, American Journal of Nephrology.

[313]  Connie M. Rhee,et al.  Association of Growth Differentiation Factor 15 with Mortality in a Prospective Hemodialysis Cohort , 2017, Cardiorenal Medicine.

[314]  S. Socorro,et al.  Regucalcin counteracts tert‐butyl hydroperoxide and cadmium‐induced oxidative stress in rat testis , 2017, Journal of applied toxicology : JAT.

[315]  M. Bianchi,et al.  The shedding-derived soluble receptor for advanced glycation endproducts sustains inflammation during acute Pseudomonas aeruginosa lung infection. , 2017, Biochimica et biophysica acta. General subjects.

[316]  A. Bartke,et al.  GH and ageing: Pitfalls and new insights. , 2017, Best practice & research. Clinical endocrinology & metabolism.

[317]  K. Rye,et al.  The role of fibroblast growth factor 21 in atherosclerosis. , 2017, Atherosclerosis.

[318]  Lin Zhu,et al.  Salidroside protects against homocysteine‐induced injury in human umbilical vein endothelial cells via the regulation of endoplasmic reticulum stress , 2017, Cardiovascular therapeutics.

[319]  K. Demi̇rci̇,et al.  The Serum Levels of Resistin and Its Relationship with Other Proinflammatory Cytokines in Patients with Alzheimer’s Disease , 2017, Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology.

[320]  Jiali Liu,et al.  Progranulin causes adipose insulin resistance via increased autophagy resulting from activated oxidative stress and endoplasmic reticulum stress , 2017, Lipids in Health and Disease.

[321]  I. Castilla-Cortázar,et al.  IGF-1 modulates gene expression of proteins involved in inflammation, cytoskeleton, and liver architecture , 2017, Journal of Physiology and Biochemistry.

[322]  Yudong Qiu,et al.  Ellagic acid inhibits the proliferation of human pancreatic carcinoma PANC-1 cells in vitro and in vivo , 2017, Oncotarget.

[323]  T. Edvardsen,et al.  Soluble ST2 is associated with disease severity in arrhythmogenic right ventricular cardiomyopathy , 2017, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

[324]  Guo-Jun Chen,et al.  Overexpression of MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10. , 2017, Biochemical and biophysical research communications.

[325]  U. Bhadra,et al.  Insulin/insulin-like growth factor-1 signalling (IIS) based regulation of lifespan across species , 2017, Biogerontology.

[326]  Hyeon-Woo Lee,et al.  Progranulin Inhibits Human T Lymphocyte Proliferation by Inducing the Formation of Regulatory T Lymphocytes , 2017, Mediators of inflammation.

[327]  M. Hecker,et al.  Endothelial Microparticles From Acute Coronary Syndrome Patients Induce Premature Coronary Artery Endothelial Cell Aging and Thrombogenicity: Role of the Ang II/AT1 Receptor/NADPH Oxidase-Mediated Activation of MAPKs and PI3-Kinase Pathways , 2017, Circulation.

[328]  T. Yamashita,et al.  Leptin sustains spontaneous remyelination in the adult central nervous system , 2017, Scientific Reports.

[329]  Jianwen Liu,et al.  MiR‐212–3p inhibits LPS‐induced inflammatory response through targeting HMGB1 in murine macrophages , 2017, Experimental cell research.

[330]  Qian Cai,et al.  Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons , 2017, eLife.

[331]  Yue Chen,et al.  High serum resistin associates with intrahepatic inflammation and necrosis: an index of disease severity for patients with chronic HBV infection , 2017, BMC Gastroenterology.

[332]  G. Lip,et al.  Novel Risk Markers and Risk Assessments for Cardiovascular Disease , 2017, Circulation research.

[333]  Usama A A Sharaf El Din,et al.  FGF23 and inflammation , 2017, World journal of nephrology.

[334]  T. Funahashi,et al.  Adiponectin association with T‐cadherin protects against neointima proliferation and atherosclerosis , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[335]  Kenneth A. Philbrick,et al.  Leptin stimulates bone formation in ob/ob mice at doses having minimal impact on energy metabolism. , 2017, The Journal of endocrinology.

[336]  B. Cheung,et al.  Serum fibroblast growth factor 21 is a superior biomarker to other adipokines in predicting incident diabetes , 2017, Clinical endocrinology.

[337]  A. Chella,et al.  Serum Mesothelin, Osteopontin and Vimentin: Useful Markers for Clinical Monitoring of Malignant Pleural Mesothelioma , 2017, The International journal of biological markers.

[338]  E. White,et al.  MMP-7 is a predictive biomarker of disease progression in patients with idiopathic pulmonary fibrosis , 2017, ERJ Open Research.

[339]  D. Fraser,et al.  Complement Protein C1q Enhances Macrophage Foam Cell Survival and Efferocytosis , 2017, The Journal of Immunology.

[340]  A. Scaloni,et al.  Differential representation of liver proteins in obese human subjects suggests novel biomarkers and promising targets for drug development in obesity , 2017, Journal of enzyme inhibition and medicinal chemistry.

[341]  H. Gerstein,et al.  Growth Differentiation Factor 15 as a Novel Biomarker for Metformin , 2016, Diabetes Care.

[342]  M. Mayr,et al.  MicroRNAs in Cardiovascular Disease. , 2016, Journal of the American College of Cardiology.

[343]  A. Sugiyama,et al.  Lactoferrin ameliorates corticosterone-related acute stress and hyperglycemia in rats , 2016, The Journal of veterinary medical science.

[344]  M. Frosch,et al.  Aβ Amyloid Pathology Affects the Hearts of Patients With Alzheimer's Disease: Mind the Heart. , 2016, Journal of the American College of Cardiology.

[345]  D. D. de Luis,et al.  rs1501299 Polymorphism in the Adiponectin Gene and Their Association with Total Adiponectin Levels, Insulin Resistance and Metabolic Syndrome in Obese Subjects , 2016, Annals of Nutrition and Metabolism.

[346]  Min‐Young Kwon,et al.  Tunicamycin-induced Endoplasmic Reticulum Stress Upregulates the Expression of Pentraxin 3 in Human Retinal Pigment Epithelial Cells , 2016, Korean journal of ophthalmology : KJO.

[347]  T. Zglinicki,et al.  Frailty in mouse ageing: A conceptual approach , 2016, Mechanisms of Ageing and Development.

[348]  M. Zeviani,et al.  FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders , 2016, Neurology.

[349]  Xiaoqiang Ding,et al.  Increased Soluble Suppression of Tumorigenicity 2 Level Predicts All-Cause and Cardiovascular Mortality in Maintenance Hemodialysis Patients: A Prospective Cohort Study , 2016, Blood Purification.

[350]  M. Hu,et al.  Klotho/FGF23 Axis in Chronic Kidney Disease and Cardiovascular Disease , 2016, Kidney Diseases.

[351]  H. Chung,et al.  An engineered FGF21 variant, LY2405319, can prevent non-alcoholic steatohepatitis by enhancing hepatic mitochondrial function. , 2016, American journal of translational research.

[352]  M. Vervloet,et al.  Novel Faces of Fibroblast Growth Factor 23 (FGF23): Iron Deficiency, Inflammation, Insulin Resistance, Left Ventricular Hypertrophy, Proteinuria and Acute Kidney Injury , 2016, Calcified Tissue International.

[353]  D. Kwon,et al.  Tongqiaohuoxue decoction ameliorates obesity-induced inflammation and the prothrombotic state by regulating adiponectin and plasminogen activator inhibitor-1. , 2016, Journal of ethnopharmacology.

[354]  Richard Nicoletti,et al.  Growth differentiating factor-15 (GDF-15): A potential biomarker and therapeutic target for cancer-associated weight loss. , 2016, Oncology letters.

[355]  L. Gan,et al.  Adiponectin reduces ER stress-induced apoptosis through PPARα transcriptional regulation of ATF2 in mouse adipose , 2016, Cell Death and Disease.

[356]  Barbara Malicka,et al.  Salivary lactate dehydrogenase and aminotransferases in diabetic patients , 2016, Medicine.

[357]  G. Sergi,et al.  Inflammation and frailty in the elderly: A systematic review and meta-analysis , 2016, Ageing Research Reviews.

[358]  H. Jüppner,et al.  Fibroblast growth factor 23: fueling the fire. , 2016, Kidney international.

[359]  A. Blom,et al.  Complement in removal of the dead – balancing inflammation , 2016, Immunological reviews.

[360]  Biao Xu,et al.  High Mobility Group Box-1: A Missing Link between Diabetes and Its Complications , 2016, Mediators of inflammation.

[361]  Leslie A. Blair,et al.  Circulating microparticles in severe pulmonary arterial hypertension increase intercellular adhesion molecule-1 expression selectively in pulmonary artery endothelium , 2016, Respiratory Research.

[362]  C. Burant,et al.  Frailty has a stronger association with inflammation than age in older veterans , 2016, Immunity & Ageing.

[363]  M. Hammami,et al.  Plasma Levels of Pentosidine, Carboxymethyl-Lysine, Soluble Receptor for Advanced Glycation End Products, and Metabolic Syndrome: The Metformin Effect , 2016, Disease markers.

[364]  H. Ohta,et al.  Roles of FGF Signals in Heart Development, Health, and Disease , 2016, Front. Cell Dev. Biol..

[365]  Rick B. Vega,et al.  Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle* , 2016, The Journal of Biological Chemistry.

[366]  P. Donnan,et al.  Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension , 2016, Aging Clinical and Experimental Research.

[367]  B. Fontaine,et al.  Distinct inflammatory phenotypes of microglia and monocyte‐derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology , 2016, Aging cell.

[368]  Astrid E. Berggreen,et al.  Preoperative plasma growth-differentiation factor-15 for prediction of acute kidney injury in patients undergoing cardiac surgery , 2016, Critical Care.

[369]  A. Ghosh,et al.  A small molecule inhibitor of PAI-1 protects against doxorubicin-induced cellular senescence , 2016, Oncotarget.

[370]  J. H. Kim,et al.  Doxorubicin Regulates Autophagy Signals via Accumulation of Cytosolic Ca2+ in Human Cardiac Progenitor Cells , 2016, International journal of molecular sciences.

[371]  Jun Zhang,et al.  High Prevalence of Hyperhomocysteinemia and Its Association with Target Organ Damage in Chinese Patients with Chronic Kidney Disease , 2016, Nutrients.

[372]  G. Georgiou,et al.  Serum resistin is inversely related to breast cancer risk in premenopausal women. , 2016, Breast.

[373]  S. Kihara,et al.  Marked elevation of serum M2BP-adiponectin complex in men with coronary artery disease. , 2016, Atherosclerosis.

[374]  M. Bacci,et al.  Association between irisin and major chronic diseases: a review. , 2016, European review for medical and pharmacological sciences.

[375]  M. Duffy,et al.  Validated biomarkers: The key to precision treatment in patients with breast cancer. , 2016, Breast.

[376]  Zhao Zhong （兆忠） Chong （种）.  S100B raises the alert in subarachnoid hemorrhage , 2016, Reviews in the neurosciences.

[377]  X. Lou,et al.  Ghrelin protects small intestinal epithelium against sepsis-induced injury by enhancing the autophagy of intestinal epithelial cells. , 2016, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[378]  M. Unruh,et al.  Fibroblast growth factor 23 actions in inflammation: a key factor in CKD outcomes. , 2016, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[379]  Rui-wei Gao,et al.  The ROS derived mitochondrial respirstion not from NADPH oxidase plays key role in Celastrol against angiotensin II-mediated HepG2 cell proliferation , 2016, Apoptosis.

[380]  Jinsong Zhang,et al.  Growth factor progranulin blocks tumor necrosis factor-α-mediated inhibition of osteoblast differentiation. , 2016, Genetics and molecular research : GMR.

[381]  M. Romano,et al.  Circulating Calreticulin Is Increased in Myelofibrosis: Correlation with Interleukin-6 Plasma Levels, Bone Marrow Fibrosis, and Splenomegaly , 2016, Mediators of inflammation.

[382]  J. Grillari,et al.  Circulating microRNAs as novel biomarkers for bone diseases – Complex signatures for multifactorial diseases? , 2016, Molecular and Cellular Endocrinology.

[383]  Jian Zhou,et al.  Soluble Receptor for Advanced Glycation End Product Ameliorates Chronic Intermittent Hypoxia Induced Renal Injury, Inflammation, and Apoptosis via P38/JNK Signaling Pathways , 2016, Oxidative medicine and cellular longevity.

[384]  R. Erben.  Update on FGF23 and Klotho signaling , 2016, Molecular and Cellular Endocrinology.

[385]  H. Chu,et al.  Cigarette Smoke Induces Human Airway Epithelial Senescence via Growth Differentiation Factor 15 Production. , 2016, American journal of respiratory cell and molecular biology.

[386]  G. Duque,et al.  Association Between Circulating Osteogenic Progenitor Cells and Disability and Frailty in Older Persons: The Nepean Osteoporosis and Frailty Study. , 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

[387]  N. Okudan,et al.  Association of Circulating Irisin with Insulin Resistance and Oxidative Stress in Obese Women , 2016, Hormone and Metabolic Research.

[388]  E. Hoffman,et al.  Identification of Pathway-Specific Serum Biomarkers of Response to Glucocorticoid and Infliximab Treatment in Children with Inflammatory Bowel Disease , 2016, Clinical and Translational Gastroenterology.

[389]  L. Ding,et al.  Possible Involvement of Serum and Synovial Fluid Resistin in Knee Osteoarthritis: Cartilage Damage, Clinical, and Radiological Links , 2016, Journal of clinical laboratory analysis.

[390]  M. Omary,et al.  Keratins: Biomarkers and modulators of apoptotic and necrotic cell death in the liver , 2016, Hepatology.

[391]  T. Hamaoka,et al.  Elevated pentraxin 3 level at the early stage of exercise training is associated with reduction of arterial stiffness in middle-aged and older adults , 2016, Journal of Human Hypertension.

[392]  K. Mehta,et al.  Transglutaminase-2: evolution from pedestrian protein to a promising therapeutic target , 2016, Amino Acids.

[393]  J. Bijlsma,et al.  Can baseline serum microRNAs predict response to TNF-alpha inhibitors in rheumatoid arthritis? , 2016, Arthritis Research & Therapy.

[394]  R. Sacco,et al.  Fibroblast Growth Factor 23 and Cause-Specific Mortality in the General Population: The Northern Manhattan Study. , 2016, The Journal of clinical endocrinology and metabolism.

[395]  D. Sandesc,et al.  Using Circulating miRNAs as Biomarkers for the Evaluation and Monitoring of the Mitochondrial Damage in the Critically Ill Polytrauma Patients. , 2016, Clinical laboratory.

[396]  Bin Zhu,et al.  Is FGF23 or FGF21 a Promising Biomarker to Indicate the Aging Process in COPD? , 2016, Chest.

[397]  Yonghong Tang,et al.  Formaldehyde accelerates cellular senescence in HT22 cells: possible involvement of the leptin pathway. , 2016, Acta biochimica et biophysica Sinica.

[398]  T. Murata,et al.  Increased regucalcin gene expression extends survival in breast cancer patients: Overexpression of regucalcin suppresses the proliferation and metastatic bone activity in MDA-MB-231 human breast cancer cells in vitro. , 2016, International journal of oncology.

[399]  Shang-Der Chen,et al.  Nuclear Factor-kappaB-Dependent Sestrin2 Induction Mediates the Antioxidant Effects of BDNF Against Mitochondrial Inhibition in Rat Cortical Neurons , 2016, Molecular Neurobiology.

[400]  J. Dyck,et al.  Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis , 2016, PloS one.

[401]  T. Mayadas,et al.  Lactoferrin Suppresses Neutrophil Extracellular Traps Release in Inflammation , 2016, EBioMedicine.

[402]  S. Shohaimi,et al.  Calreticulin mediates an invasive breast cancer phenotype through the transcriptional dysregulation of p53 and MAPK pathways , 2016, Cancer Cell International.

[403]  D. Pisano,et al.  Deep sequencing reveals microRNAs predictive of antiangiogenic drug response. , 2016, JCI insight.

[404]  N. Schwarz,et al.  Intermediate Filaments as Organizers of Cellular Space: How They Affect Mitochondrial Structure and Function , 2016, Cells.

[405]  C. Wagner,et al.  The C-Terminal Fragment of Agrin (CAF), a Novel Marker of Renal Function, Is Filtered by the Kidney and Reabsorbed by the Proximal Tubule , 2016, PloS one.

[406]  D. Chung,et al.  In vitro and in vivo downregulation of C3 by lipoteichoic acid isolated from Lactobacillus plantarum K8 suppressed cytokine-mediated complement system activation. , 2016, FEMS microbiology letters.

[407]  Jinsong Gao,et al.  Serum levels of leptin, adiponectin and resistin in relation to clinical characteristics in normal pregnancy and preeclampsia. , 2016, Clinica chimica acta; international journal of clinical chemistry.

[408]  G. Kitas,et al.  Associations between asymmetric dimethylarginine, homocysteine, and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism (rs1801133) in rheumatoid arthritis , 2016, Scandinavian journal of rheumatology.

[409]  M. Pallàs,et al.  Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence , 2016, Experimental Gerontology.

[410]  V. David,et al.  Inflammation regulates fibroblast growth factor 23 production , 2016, Current opinion in nephrology and hypertension.

[411]  P. Nilsson,et al.  High serum CXCL10 in Rickettsia conorii infection is endothelial cell mediated subsequent to whole blood activation. , 2016, Cytokine.

[412]  R. Hui,et al.  Plasma growth differentiation factor 15 predicts first-ever stroke in hypertensive patients , 2016, Medicine.

[413]  Carmen Sánchez González,et al.  Bone mineral disorder in chronic kidney disease: Klotho and FGF23; cardiovascular implications. , 2016, Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.

[414]  Chadwick M. Hales,et al.  Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia , 2016, Molecular Neurodegeneration.

[415]  Stephen L. Johnson,et al.  Lactate Metabolism is Associated with Mammalian Mitochondria , 2016, Nature chemical biology.

[416]  Kaixian Yu,et al.  Elevated Resistin Gene Expression in African American Estrogen and Progesterone Receptor Negative Breast Cancer , 2016, PloS one.

[417]  L. Peng,et al.  Soluble ICAM-1, Independent of IL-6, Is Associated with Prevalent Frailty in Community-Dwelling Elderly Taiwanese People , 2016, PloS one.

[418]  N. Perrimon,et al.  Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila , 2016, Genes & development.

[419]  X-L Du,et al.  Lower Circulating Irisin Level in Patients with Diabetes Mellitus: A Systematic Review and Meta-Analysis , 2016, Hormone and Metabolic Research.

[420]  Shun-Fa Yang,et al.  Inhibition of pentraxin 3 in glioma cells impairs proliferation and invasion in vitro and in vivo , 2016, Journal of Neuro-Oncology.

[421]  C. Indolfi,et al.  Modulation of Circulating MicroRNAs Levels during the Switch from Clopidogrel to Ticagrelor , 2016, BioMed research international.

[422]  A. Papavassiliou,et al.  Pivotal role of high-mobility group box 1 (HMGB1) signaling pathways in glioma development and progression , 2016, Journal of Molecular Medicine.

[423]  Zhongjie Sun,et al.  The Antiaging Gene Klotho Regulates Proliferation and Differentiation of Adipose‐Derived Stem Cells , 2016, Stem cells.

[424]  S. Kojima,et al.  Transglutaminase 2 has opposing roles in the regulation of cellular functions as well as cell growth and death , 2016, Cell Death and Disease.

[425]  M. Sperling.  Traditional and novel aspects of the metabolic actions of growth hormone. , 2016, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[426]  S. Koh,et al.  High Serum Irisin Level as an Independent Predictor of Diabetes Mellitus , 2016, Medicine.

[427]  C. Kovesdy,et al.  FGF23 from bench to bedside. , 2016, American journal of physiology. Renal physiology.

[428]  P. Claus,et al.  Fibroblast growth factor 23 signaling in hippocampal cells: impact on neuronal morphology and synaptic density , 2016, Journal of neurochemistry.

[429]  Ryan L. Davis,et al.  A comparison of current serum biomarkers as diagnostic indicators of mitochondrial diseases , 2016, Neurology.

[430]  L. Puricelli,et al.  Circulating Fibroblast Growth Factor 21 (Fgf21) as Diagnostic and Prognostic Biomarker in Renal Cancer , 2016, Journal of molecular biomarkers & diagnosis.

[431]  D. Fine,et al.  Correlates and Longitudinal Renal and Cardiovascular Implications of FGF23 Levels in HIV-Positive Individuals , 2016, PloS one.

[432]  F. Glorieux,et al.  Effect of four monthly doses of a human monoclonal anti-FGF23 antibody (KRN23) on quality of life in X-linked hypophosphatemia , 2016, Bone reports.

[433]  MayeurSylvain,et al.  Lactoferrin, a Pleiotropic Protein in Health and Disease , 2016 .

[434]  Nathan D. Kingery,et al.  Megf10 Is a Receptor for C1Q That Mediates Clearance of Apoptotic Cells by Astrocytes , 2016, The Journal of Neuroscience.

[435]  A. Lenzi,et al.  Phosphodiesterase Type 5 Inhibitor Sildenafil Decreases the Proinflammatory Chemokine CXCL10 in Human Cardiomyocytes and in Subjects with Diabetic Cardiomyopathy , 2016, Inflammation.

[436]  A. Schmidt,et al.  Soluble RAGE Treatment Delays Progression of Amyotrophic Lateral Sclerosis in SOD1 Mice , 2016, Front. Cell. Neurosci..

[437]  D. Selkoe,et al.  Complement and microglia mediate early synapse loss in Alzheimer mouse models , 2016, Science.

[438]  Michelle K. Cahill,et al.  Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation , 2016, Cell.

[439]  F. Shen,et al.  Exercise-stimulated FGF23 promotes exercise performance via controlling the excess reactive oxygen species production and enhancing mitochondrial function in skeletal muscle. , 2016, Metabolism: clinical and experimental.

[440]  Zhao Zhong （兆忠） Chong （种）,et al.  Identifying S100B as a Biomarker and a Therapeutic Target For Brain Injury and Multiple Diseases. , 2016, Current medicinal chemistry.

[441]  W. März,et al.  GDF-15, soluble ST2 and Troponin-I: Biomarkers of Subclinical Vascular Disease? , 2016, Atherosclerosis.

[442]  Danielle M. Enserro,et al.  Relations of circulating GDF-15, soluble ST2, and troponin-I concentrations with vascular function in the community: The Framingham Heart Study. , 2016, Atherosclerosis.

[443]  M. Löhning,et al.  IL-33 in T Cell Differentiation, Function, and Immune Homeostasis. , 2016, Trends in immunology.

[444]  Huijun Sun,et al.  Alpha-lipoic acid defends homocysteine-induced endoplasmic reticulum and oxidative stress in HAECs. , 2016, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[445]  Hong-Xia Wang,et al.  Soluble receptor for advanced glycation end-products protects against ischemia/reperfusion-induced myocardial apoptosis via regulating the ubiquitin proteasome system. , 2016, Free radical biology & medicine.

[446]  D. Alexander,et al.  NFκB-sensitive Orai1 expression in the regulation of FGF23 release , 2016, Journal of Molecular Medicine.

[447]  A. Larbi,et al.  Inflammatory and immune markers associated with physical frailty syndrome: findings from Singapore longitudinal aging studies , 2016, Oncotarget.

[448]  Tom H. Cheung,et al.  IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline , 2016, Proceedings of the National Academy of Sciences.

[449]  T. Beißbarth,et al.  Social defeat leads to changes in the endocannabinoid system: An overexpression of calreticulin and motor impairment in mice , 2016, Behavioural Brain Research.

[450]  E. Masliah,et al.  Synergistic Increase of Serum BDNF in Alzheimer Patients Treated with Cerebrolysin and Donepezil: Association with Cognitive Improvement in ApoE4 Cases , 2016, The international journal of neuropsychopharmacology.

[451]  M. Hill,et al.  Regulation of Coronary Endothelial Function by Interactions between TNF-α, LOX-1 and Adiponectin in Apolipoprotein E Knockout Mice , 2016, Journal of Vascular Research.

[452]  B. Amuzescu,et al.  Electrophysiology, immunophenotype, and gene expression characterization of senescent and cryopreserved human amniotic fluid stem cells , 2016, The Journal of Physiological Sciences.

[453]  C. Dubois,et al.  Microparticles and cancer thrombosis in animal models. , 2016, Thrombosis research.

[454]  Z. Tabka,et al.  Role of eNOS‐ and NOX‐containing microparticles in endothelial dysfunction in patients with obesity , 2016, Obesity.

[455]  K. Arai,et al.  Astrocyte-Derived Pentraxin 3 Supports Blood–Brain Barrier Integrity Under Acute Phase of Stroke , 2016, Stroke.

[456]  G. Forloni,et al.  Loss of exosomes in progranulin-associated frontotemporal dementia , 2016, Neurobiology of Aging.

[457]  A. Alghasham,et al.  Lactoferrin from Camelus dromedarius Inhibits Nuclear Transcription Factor-kappa B Activation, Cyclooxygenase-2 Expression and Prostaglandin E2 Production in Stimulated Human Chondrocytes , 2016, Pharmacognosy research.

[458]  C. Mantzoros,et al.  Diet quality and diet patterns in relation to circulating cardiometabolic biomarkers. , 2016, Clinical nutrition.

[459]  O. Topolcan,et al.  Soluble receptor for advanced glycation end products and increased aortic stiffness in the general population , 2016, Hypertension Research.

[460]  Alex F. Chen,et al.  Decreased serum level of HMGB1 and MyD88 during human aging progress in healthy individuals , 2016, Aging Clinical and Experimental Research.

[461]  M. Álvarez,et al.  Effects of CX3CR1 and Fractalkine Chemokines in Amyloid Beta Clearance and p-Tau Accumulation in Alzheimer's Disease (AD) Rodent Models: Is Fractalkine a Systemic Biomarker for AD? , 2016, Current Alzheimer research.

[462]  A. Izzotti,et al.  Preface: MicroRNA as Disease Biomarkers. , 2016, MicroRNA.

[463]  S. John,et al.  C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury , 2016, Molecular Neurodegeneration.

[464]  R. Powers,et al.  Redox Imbalance Underlies the Fitness Defect Associated with Inactivation of the Pta-AckA Pathway in Staphylococcus aureus. , 2016, Journal of proteome research.

[465]  Jeffrey S. Buguliskis,et al.  Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes , 2016, Acta Neuropathologica Communications.

[466]  E. Puffenberger,et al.  Abnormal Hypermethylation at Imprinting Control Regions in Patients with S-Adenosylhomocysteine Hydrolase (AHCY) Deficiency , 2016, PloS one.

[467]  Shih-Chien Huang,et al.  Vitamin B-6 Supplementation Could Mediate Antioxidant Capacity by Reducing Plasma Homocysteine Concentration in Patients with Hepatocellular Carcinoma after Tumor Resection , 2016, BioMed research international.

[468]  Jeffrey R. Chabot,et al.  A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects. , 2016, Cell metabolism.

[469]  Xiao-cong Zuo,et al.  The role of high mobility group box 1 (HMGB1) in the pathogenesis of kidney diseases , 2016, Acta pharmaceutica Sinica. B.

[470]  Weihui Zhou,et al.  Regulation of global gene expression and cell proliferation by APP , 2016, Scientific Reports.

[471]  D. Berg,et al.  GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson’s Disease and Lewy Body Dementia , 2016, PloS one.

[472]  W. Pang,et al.  B vitamin supplementation improves cognitive function in the middle aged and elderly with hyperhomocysteinemia , 2016, Nutritional neuroscience.

[473]  P. Sachdev,et al.  Macrophage inhibitory cytokine-1/growth differentiation factor 15 as a marker of cognitive ageing and dementia , 2016, Current opinion in psychiatry.

[474]  S. Shinkai,et al.  Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age‐related disorders , 2016, Geriatrics & gerontology international.

[475]  Ş. Arslan,et al.  Novel myokine: irisin may be an independent predictor for subclinic atherosclerosis in Behçet's disease , 2016, Journal of Investigative Medicine.

[476]  L. Renders,et al.  Comparison of Peritoneal Low-Molecular-Weight-Protein-Removal in CCPD and CAPD Patients Based on C-Terminal Agrin Fragment Clearance , 2016, Kidney and Blood Pressure Research.

[477]  R. Kraemer,et al.  Effects of partial vascular occlusion on irisin responses to loaded muscle contractions. , 2016, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[478]  M. Gandhe,et al.  Preliminary Study on Serum Lactate Dehydrogenase (LDH)-Prognostic Biomarker in Carcinoma Breast. , 2016, Journal of clinical and diagnostic research : JCDR.

[479]  M. J. Kim,et al.  Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse. , 2016, Brain : a journal of neurology.

[480]  S. Rose-John,et al.  Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation. , 2016, Cancer research.

[481]  M. Alique,et al.  Aging-associated oxidized albumin promotes cellular senescence and endothelial damage , 2016, Clinical interventions in aging.

[482]  A. Keller,et al.  Distribution of miRNA expression across human tissues , 2016, Nucleic acids research.

[483]  A. Bartke.  Healthspan and longevity can be extended by suppression of growth hormone signaling , 2016, Mammalian Genome.

[484]  R. Hogg,et al.  Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration , 2016, Immunity & Ageing.

[485]  J. Pérez-Gracia,et al.  Circulating melanoma exosomes as diagnostic and prognosis biomarkers. , 2016, Clinica chimica acta; international journal of clinical chemistry.

[486]  Sajjad Karim,et al.  Metformin improves the angiogenic potential of human CD34+ cells co-incident with downregulating CXCL10 and TIMP1 gene expression and increasing VEGFA under hyperglycemia and hypoxia within a therapeutic window for myocardial infarction , 2016, Cardiovascular Diabetology.

[487]  M. González-Gay,et al.  The novel adipokine progranulin counteracts IL-1 and TLR4-driven inflammatory response in human and murine chondrocytes via TNFR1 , 2016, Scientific Reports.

[488]  D. Sharma,et al.  In Vitro Effects of Pioglitazone on the Expression of Components of Wnt Signaling Pathway and Markers of Bone Mineralization , 2016, Hormone and Metabolic Research.

[489]  X. Xiang,et al.  Correlation between adiponectin and hemorrhagic shock in mice. , 2016, Genetics and molecular research : GMR.

[490]  I. Sakata,et al.  Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1 , 2016, Molecular Psychiatry.

[491]  E. Vittinghoff,et al.  Association between resistin levels and cardiovascular disease events in older adults: The health, aging and body composition study. , 2016, Atherosclerosis.

[492]  V. W. Tsai,et al.  Anorexia–cachexia and obesity treatment may be two sides of the same coin: role of the TGF-b superfamily cytokine MIC-1/GDF15 , 2016, International Journal of Obesity.

[493]  H. Kato,et al.  Enteric lactoferrin attenuates the development of high-fat and high-cholesterol diet-induced hypercholesterolemia and atherosclerosis in Microminipigs , 2016, Bioscience, biotechnology, and biochemistry.

[494]  J. Shapiro,et al.  Role of Serum Biomarkers in Early Detection of Non-Alcoholic Steatohepatitis and Fibrosis in West Virginian Children , 2016, Journal of clinical & cellular immunology.

[495]  S. Vanni,et al.  Plasma Lactate Dehydrogenase Levels Predict Mortality in Acute Aortic Syndromes , 2016, Medicine.

[496]  M. Copetti,et al.  Evidence of a causal relationship between high serum adiponectin levels and increased cardiovascular mortality rate in patients with type 2 diabetes , 2016, Cardiovascular Diabetology.

[497]  W. Jia,et al.  Circulating Fibroblast Growth Factor 21 Is A Sensitive Biomarker for Severe Ischemia/reperfusion Injury in Patients with Liver Transplantation , 2016, Scientific Reports.

[498]  Q. Ye,et al.  Osteopontin promotes epithelial-mesenchymal transition of hepatocellular carcinoma through regulating vimentin , 2016, Oncotarget.

[499]  N. Chang,et al.  Sitagliptin decreases ventricular arrhythmias by attenuated glucose-dependent insulinotropic polypeptide (GIP)-dependent resistin signalling in infarcted rats , 2016, Bioscience reports.

[500]  J. Larkin,et al.  Serum lactate dehydrogenase as an early marker for outcome in patients treated with anti-PD-1 therapy in metastatic melanoma , 2016, British Journal of Cancer.

[501]  Y. Hwang,et al.  The ratio of skeletal muscle mass to visceral fat area is a main determinant linking circulating irisin to metabolic phenotype , 2016, Cardiovascular Diabetology.

[502]  M. Cho,et al.  Metformin Prevents Fatty Liver and Improves Balance of White/Brown Adipose in an Obesity Mouse Model by Inducing FGF21 , 2016, Mediators of inflammation.

[503]  M. Makishima,et al.  Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging mice. , 2016, Biochemical and biophysical research communications.

[504]  Q. Qian,et al.  Acute Kidney Injury: Tubular Markers and Risk for Chronic Kidney Disease and End-Stage Kidney Failure , 2016, Blood Purification.

[505]  Ke-Qin Zhang,et al.  Proteomic characteristics of circulating microparticles in patients with newly-diagnosed type 2 diabetes. , 2016, American journal of translational research.

[506]  D. Murray,et al.  Discontinuation of dialysis with eculizumab therapy in a pediatric patient with dense deposit disease , 2016, Pediatric Nephrology.

[507]  L. Pan,et al.  Baicalin exerts protective effects against lipopolysaccharide-induced acute lung injury by regulating the crosstalk between the CX3CL1-CX3CR1 axis and NF-κB pathway in CX3CL1-knockout mice , 2016, International journal of molecular medicine.

[508]  Juan Li,et al.  Suppression of lactate dehydrogenase A compromises tumor progression by downregulation of the Warburg effect in glioblastoma , 2016, Neuroreport.

[509]  D. Candinas,et al.  Endothelial- and Platelet-Derived Microparticles Are Generated During Liver Resection in Humans , 2016, Journal of investigative surgery : the official journal of the Academy of Surgical Research.

[510]  I. Castilla-Cortázar,et al.  Partial IGF-1 deficiency induces brain oxidative damage and edema, which are ameliorated by replacement therapy. , 2016, BioFactors.

[511]  Rui Wang,et al.  Association of irisin concentrations with the presence of diabetic nephropathy and retinopathy , 2016, Annals of clinical biochemistry.

[512]  J. Shapiro,et al.  Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population , 2016, International journal of medical sciences.

[513]  K. Mishima,et al.  Overexpression of Swedish mutant APP in aged astrocytes attenuates excitatory synaptic transmission , 2016, Physiological reports.

[514]  S. Sen,et al.  MicroRNA as Biomarkers and Diagnostics , 2016, Journal of cellular physiology.

[515]  Mariano Rodríguez,et al.  FGF23 as a calciotropic hormone , 2015, F1000Research.

[516]  A. Lasek-Bal,et al.  Low Concentration of BDNF in the Acute Phase of Ischemic Stroke as a Factor in Poor Prognosis in Terms of Functional Status of Patients , 2015, Medical science monitor : international medical journal of experimental and clinical research.

[517]  K. Peter,et al.  Staphylococcal SSL5-induced platelet microparticles provoke proinflammatory responses via the CD40/TRAF6/NFKB signalling pathway in monocytes , 2015, Thrombosis and Haemostasis.

[518]  P. Sachdev,et al.  An inverse relationship between serum macrophage inhibitory cytokine-1 levels and brain white matter integrity in community-dwelling older individuals , 2015, Psychoneuroendocrinology.

[519]  Á. Valverde,et al.  Inhibition of Protein Tyrosine Phosphatase 1B Improves IGF-I Receptor Signaling and Protects Against Inflammation-Induced Gliosis in the Retina. , 2015, Investigative ophthalmology & visual science.

[520]  M. Omary,et al.  Absence of keratin 8 or 18 promotes antimitochondrial autoantibody formation in aging male mice , 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[521]  A. Feldstein,et al.  Serum cytokeratin‐18 fragment levels predict development of type 2 diabetes mellitus in adult patients with NAFLD , 2015, Liver international : official journal of the International Association for the Study of the Liver.

[522]  Wang Wang,et al.  Leptin knockout attenuates hypoxia-induced pulmonary arterial hypertension by inhibiting proliferation of pulmonary arterial smooth muscle cells. , 2015, Translational research : the journal of laboratory and clinical medicine.

[523]  S. Anker,et al.  Detection of muscle wasting in patients with chronic heart failure using C‐terminal agrin fragment: results from the Studies Investigating Co‐morbidities Aggravating Heart Failure (SICA‐HF) , 2015, European journal of heart failure.

[524]  L. Andersen,et al.  Effects of a multi-component camp-based intervention on inflammatory markers and adipokines in children: A randomized controlled trial. , 2015, Preventive medicine.

[525]  S. Volpato,et al.  Klotho, a new marker for osteoporosis and muscle strength in β-thalassemia major. , 2015, Blood cells, molecules & diseases.

[526]  Jiali Liu,et al.  Progranulin induces adipose insulin resistance and autophagic imbalance via TNFR1 in mice. , 2015, Journal of molecular endocrinology.

[527]  R. Kavalar,et al.  Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1) in breast cancer - correlation with traditional prognostic factors , 2015, Radiology and oncology.

[528]  V. Kolek,et al.  Matrix Metalloproteinases and Their Inhibitors in Chronic Obstructive Pulmonary Disease , 2015, Archivum Immunologiae et Therapiae Experimentalis.

[529]  A. Ido,et al.  Glycoprotein Nonmetastatic Melanoma B (Gpnmb)-Positive Macrophages Contribute to the Balance between Fibrosis and Fibrolysis during the Repair of Acute Liver Injury in Mice , 2015, PloS one.

[530]  H. Kiyonari,et al.  Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis , 2015, Scientific Reports.

[531]  Ming Liu,et al.  Blockade of high mobility group box-1 signaling via the receptor for advanced glycation end-products ameliorates inflammatory damage after acute intracerebral hemorrhage , 2015, Neuroscience Letters.

[532]  X. Yi,et al.  Growth differentiation factor-15 (GDF-15), novel biomarker for assessing atrial fibrosis in patients with atrial fibrillation and rheumatic heart disease. , 2015, International journal of clinical and experimental medicine.

[533]  Yuhchyau Chen,et al.  IL-6 signaling promotes DNA repair and prevents apoptosis in CD133+ stem-like cells of lung cancer after radiation , 2015, Radiation Oncology.

[534]  Anett Benedek,et al.  Growth Differentiation Factor-15 (GDF-15) is a potential marker of radiation response and radiation sensitivity. , 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

[535]  Yali Liang,et al.  Pharmacokinetics and pharmacodynamics of PF-05231023, a novel long-acting FGF21 mimetic, in a first-in-human study. , 2015, British journal of clinical pharmacology.

[536]  Y. Liu,et al.  Association of homocysteine with immunological-inflammatory and metabolic laboratory markers and factors in relation to hyperhomocysteinaemia in rheumatoid arthritis. , 2015, Clinical and experimental rheumatology.

[537]  A. Ortiz,et al.  Kidney tissue proteomics reveals regucalcin downregulation in response to diabetic nephropathy with reflection in urinary exosomes. , 2015, Translational research : the journal of laboratory and clinical medicine.

[538]  J. Muñóz-Valle,et al.  Comparative analysis of autoantibodies targeting peptidylarginine deiminase type 4, mutated citrullinated vimentin and cyclic citrullinated peptides in rheumatoid arthritis: associations with cytokine profiles, clinical and genetic features , 2015, Clinical and experimental immunology.

[539]  S. Miura,et al.  Is pentraxin 3 a biomarker, a player, or both in the context of coronary atherosclerosis and metabolic factors? , 2015, Heart and Vessels.

[540]  C. Pepine,et al.  Angiotensin-converting enzyme 2 inhibits high-mobility group box 1 and attenuates cardiac dysfunction post-myocardial ischemia , 2015, Journal of Molecular Medicine.

[541]  Z. Kamenov,et al.  Irisin in the Glucose Continuum. , 2015, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

[542]  L. Wood,et al.  Airway β-Defensin-1 Protein Is Elevated in COPD and Severe Asthma , 2015, Mediators of inflammation.

[543]  Jing Zhang,et al.  [Statins decreases expression of five inflammation-associated microRNAs in the plasma of patients with unstable angina]. , 2015, Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences.

[544]  C. Hölscher,et al.  Prophylactic liraglutide treatment prevents amyloid plaque deposition, chronic inflammation and memory impairment in APP/PS1 mice , 2015, Behavioural Brain Research.

[545]  C. Hsieh,et al.  IGF-1 mediated phosphorylation of specific IRS-1 serines in Ames dwarf fibroblasts is associated with longevity , 2015, Oncotarget.

[546]  T. Strom,et al.  Development of A Cell-Based Assay to Identify Small Molecule Inhibitors of FGF23 Signaling. , 2015, Assay and drug development technologies.

[547]  S. Antonov,et al.  Homocysteine-induced membrane currents, calcium responses and changes in mitochondrial potential in rat cortical neurons , 2015, Journal of Evolutionary Biochemistry and Physiology.

[548]  B. Spiegelman,et al.  Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry. , 2015, Cell metabolism.

[549]  Haichang Wang,et al.  Irisin improves endothelial function in type 2 diabetes through reducing oxidative/nitrative stresses. , 2015, Journal of molecular and cellular cardiology.

[550]  M. Montero‐Odasso,et al.  Motor unit loss is accompanied by decreased peak muscle power in the lower limb of older adults , 2015, Experimental Gerontology.

[551]  Hao Wang,et al.  Effects of bone marrow MSCs transfected with sRAGE on the intervention of HMGB1 induced immuno-inflammatory reaction. , 2015, International journal of clinical and experimental pathology.

[552]  S. Socorro,et al.  Effect of extracellular calcium on regucalcin expression and cell viability in neoplastic and non-neoplastic human prostate cells. , 2015, Biochimica et biophysica acta.

[553]  L. Otvos,et al.  The adipokine leptin mediates muscle- and liver-derived IGF-1 in aged mice , 2015, Experimental Gerontology.

[554]  A. Ortiz,et al.  Klotho Prevents NFκB Translocation and Protects Endothelial Cell From Senescence Induced by Uremia. , 2015, The journals of gerontology. Series A, Biological sciences and medical sciences.

[555]  Yanyu Xiao,et al.  A novel LDL-mimic nanocarrier for the targeted delivery of curcumin into the brain to treat Alzheimer's disease. , 2015, Colloids and surfaces. B, Biointerfaces.

[556]  Sungha Park,et al.  Irisin, a novel myokine is an independent predictor for sarcopenia and carotid atherosclerosis in dialysis patients. , 2015, Atherosclerosis.

[557]  Shaomin Li,et al.  Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline , 2015, The Journal of Neuroscience.

[558]  F. Wen,et al.  MiR-34a is Involved in the Decrease of ATP Contents Induced by Resistin Through Target on ATP5S in HepG2 Cells , 2015, Biochemical Genetics.

[559]  P. Nunn,et al.  The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor , 2015, Brain pathology.

[560]  Michail I. Papafaklis,et al.  Fibroblast growth factors in cardiovascular disease: The emerging role of FGF21. , 2015, American journal of physiology. Heart and circulatory physiology.

[561]  L. Lv,et al.  Urinary vimentin mRNA as a potential novel biomarker of renal fibrosis. , 2015, American journal of physiology. Renal physiology.

[562]  M. Staufenbiel,et al.  A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice , 2015, Molecular Neurodegeneration.

[563]  Zhongjie Sun,et al.  Antiaging Gene Klotho Attenuates Pancreatic β-Cell Apoptosis in Type 1 Diabetes , 2015, Diabetes.

[564]  C. DeCarli,et al.  Associations of Circulating Growth Differentiation Factor-15 and ST2 Concentrations With Subclinical Vascular Brain Injury and Incident Stroke , 2015, Stroke.

[565]  C. Limatola,et al.  Fractalkine in the nervous system: neuroprotective or neurotoxic molecule? , 2015, Annals of the New York Academy of Sciences.

[566]  A. Schmidt.  Soluble RAGEs - Prospects for treating & tracking metabolic and inflammatory disease. , 2015, Vascular pharmacology.

[567]  Biao Xu,et al.  A New Role for an Old Drug: Metformin Targets MicroRNAs in Treating Diabetes and Cancer , 2015, Drug development research.

[568]  R. McLeod,et al.  Fatty acids increase adiponectin secretion through both classical and exosome pathways. , 2015, Biochimica et biophysica acta.

[569]  Jesper Tegnér,et al.  Laboratory biomarkers and frailty: presentation of the FRAILOMIC initiative , 2015, Clinical chemistry and laboratory medicine.

[570]  Y. Qi,et al.  Possible role of fibroblast growth factor 21 on atherosclerosis via amelioration of endoplasmic reticulum stress-mediated apoptosis in apoE−/− mice , 2015, Heart and Vessels.

[571]  R. Galal,et al.  Advanced glycation end products and soluble receptor as markers of oxidative stress in children on hemodialysis , 2015, Renal failure.

[572]  L. Ferder,et al.  Inflammation, oxidative stress and renin angiotensin system in atherosclerosis. , 2015, World journal of biological chemistry.

[573]  Yuan Zhang,et al.  Irisin Controls Growth, Intracellular Ca2+ Signals, and Mitochondrial Thermogenesis in Cardiomyoblasts , 2015, PloS one.

[574]  Yong Ji,et al.  Elevated Total Homocysteine Levels in Acute Ischemic Stroke Are Associated With Long-Term Mortality , 2015, Stroke.

[575]  F. Dell’Accio,et al.  Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo , 2015, Annals of the rheumatic diseases.

[576]  Bin Zhao,et al.  Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex , 2015, Neuropsychiatric disease and treatment.

[577]  I. Rektor,et al.  Interleukin-6 May Contribute to Mortality in Parkinson's Disease Patients: A 4-Year Prospective Study , 2015, Parkinson's disease.

[578]  G. Van den Berghe,et al.  FGF21 Response to Critical Illness: Effect of Blood Glucose Control and Relation With Cellular Stress and Survival. , 2015, The Journal of clinical endocrinology and metabolism.

[579]  M. Kassem,et al.  Telomerase activity promotes osteoblast differentiation by modulating IGF-signaling pathway , 2015, Biogerontology.

[580]  Javier A. Neyra,et al.  Klotho, stem cells, and aging , 2015, Clinical interventions in aging.

[581]  Jeffrey N. Martin,et al.  Novel Biomarkers of Cardiac Stress, Cardiovascular Dysfunction, and Outcomes in HIV-Infected Individuals. , 2015, JACC. Heart failure.

[582]  Farzaneh A. Sorond,et al.  Circulating Vascular Cell Adhesion Molecule-1 Is Associated With Cerebral Blood Flow Dysregulation, Mobility Impairment, and Falls in Older Adults , 2015, Hypertension.

[583]  R. Silber,et al.  Protein glycation — Between tissue aging and protection , 2015, Experimental Gerontology.

[584]  Gregory J. Matthews,et al.  Serum Fractalkine (CX3CL1) and Cardiovascular Outcomes and Diabetes: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study. , 2015, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[585]  R. Cuomo,et al.  S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer's Disease , 2015, BioMed research international.

[586]  Hugues Berry,et al.  Suppression of IGF-I signals in neural stem cells enhances neurogenesis and olfactory function during aging , 2015, Aging cell.

[587]  A. Heguy,et al.  Calorie Restriction Suppresses Age-Dependent Hippocampal Transcriptional Signatures , 2015, PloS one.

[588]  A. Sinclair,et al.  In Search of ‘Omics'-Based Biomarkers to Predict Risk of Frailty and Its Consequences in Older Individuals: The FRAILOMIC Initiative , 2015, Gerontology.

[589]  K. Behbehani,et al.  Obesity Is a Positive Modulator of IL-6R and IL-6 Expression in the Subcutaneous Adipose Tissue: Significance for Metabolic Inflammation , 2015, PLoS ONE.

[590]  Kenneth Rockwood,et al.  Age-related frailty and its association with biological markers of ageing , 2015, BMC Medicine.

[591]  Shruti V. Kabadi,et al.  S100B Inhibition Reduces Behavioral and Pathologic Changes in Experimental Traumatic Brain Injury , 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[592]  R. Ge,et al.  Energy Metabolism Disorder as a Contributing Factor of Rheumatoid Arthritis: A Comparative Proteomic and Metabolomic Study , 2015, PloS one.

[593]  Shuiping Yang,et al.  Acetyl-l-carnitine prevents homocysteine-induced suppression of Nrf2/Keap1 mediated antioxidation in human lens epithelial cells. , 2015, Molecular medicine reports.

[594]  A. Kalinkovich,et al.  Sarcopenia – The search for emerging biomarkers , 2015, Ageing Research Reviews.

[595]  F. Wang,et al.  Serum Level of Fibroblast Growth Factor 21 Is Independently Associated with Acute Myocardial Infarction , 2015, PloS one.

[596]  F. Al Hannan,et al.  Human resistin and the RELM of Inflammation in diabesity , 2015, Diabetology & Metabolic Syndrome.

[597]  Jong Hoon Park,et al.  Inhibition of S-adenosylhomocysteine hydrolase decreases cell mobility and cell proliferation through cell cycle arrest. , 2015, American journal of cancer research.

[598]  Y. Lo,et al.  Targeting chemotherapy-induced PTX3 in tumor stroma to prevent the progression of drug-resistant cancers , 2015, Oncotarget.

[599]  S. Barni,et al.  Prognostic role of lactate dehydrogenase in solid tumors: A systematic review and meta-analysis of 76 studies , 2015, Acta oncologica.

[600]  R. Weichselbaum,et al.  Oncogenic CXCL10 signalling drives metastasis development and poor clinical outcome , 2015, British Journal of Cancer.

[601]  Ahmed M. Mehdi,et al.  Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients , 2015, Science Translational Medicine.

[602]  C. Postic,et al.  Hepatokines: unlocking the multi-organ network in metabolic diseases , 2015, Diabetologia.

[603]  Chengjie Xiong,et al.  Age and amyloid effects on human central nervous system amyloid‐beta kinetics , 2015, Annals of neurology.

[604]  M. Bocchetta,et al.  ­­Depletion of Amyloid Precursor Protein (APP) Causes G0 Arrest in Non‐Small Cell Lung Cancer (NSCLC) Cells , 2015, Journal of cellular physiology.

[605]  T. Murata,et al.  Suppressive effects of exogenous regucalcin on the proliferation of human pancreatic cancer MIA PaCa-2 cells in vitro. , 2015, International journal of molecular medicine.

[606]  Xin Wang,et al.  Klotho: a novel biomarker for cancer , 2015, Journal of Cancer Research and Clinical Oncology.

[607]  E. Palomera,et al.  Relationship between plasma ghrelin levels and sarcopenia in elderly subjects: A cross-sectional study , 2015, The journal of nutrition, health & aging.

[608]  N. Kobyliak,et al.  Diagnostic accuracy of acyl-ghrelin and it association with non-alcoholic fatty liver disease in type 2 diabetic patients , 2015, Journal of Diabetes & Metabolic Disorders.

[609]  Zaiqing Yang,et al.  Resistin Increases Ectopic Deposition of Lipids Through miR-696 in C2C12 Cells , 2015, Biochemical Genetics.

[610]  Qingbo Xu,et al.  Resveratrol-Induced Vascular Progenitor Differentiation towards Endothelial Lineage via MiR-21/Akt/β-Catenin Is Protective in Vessel Graft Models , 2015, PloS one.

[611]  A. Stopeck,et al.  EMERGE: A Randomized Phase II Study of the Antibody-Drug Conjugate Glembatumumab Vedotin in Advanced Glycoprotein NMB-Expressing Breast Cancer. , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[612]  D. Zwolińska,et al.  Urine matrix metalloproteinases and their extracellular inducer EMMPRIN in children with chronic kidney disease , 2015, Renal failure.

[613]  Wei-guo Li,et al.  Serum Levels of High-sensitivity C-Reactive Protein at Admission Are More Strongly Associated with Poststroke Depression in Acute Ischemic Stroke than Homocysteine Levels , 2015, Molecular Neurobiology.

[614]  G. Ricevuti,et al.  A preliminary candidate approach identifies the combination of chemerin, fetuin-A, and fibroblast growth factors 19 and 21 as a potential biomarker panel of successful aging , 2015, AGE.

[615]  J. She,et al.  Inflammatory Serum Proteins Are Severely Altered in Metastatic Gastric Adenocarcinoma Patients from the Chinese Population , 2015, PloS one.

[616]  Hui-Hua Li,et al.  A soluble receptor for advanced glycation end-products inhibits myocardial apoptosis induced by ischemia/reperfusion via the JAK2/STAT3 pathway , 2015, Apoptosis.

[617]  Quanfang Huang,et al.  Pratensein ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels , 2015, Neuroscience Letters.

[618]  A. Enomoto,et al.  Cytokinetic Failure-induced Tetraploidy Develops into Aneuploidy, Triggering Skin Aging in Phosphovimentin-deficient Mice* , 2015, The Journal of Biological Chemistry.

[619]  H. Tschan,et al.  Serum concentrations of insulin-like growth factor-1, members of the TGF-beta superfamily and follistatin do not reflect different stages of dynapenia and sarcopenia in elderly women , 2015, Experimental Gerontology.

[620]  G. López-Lluch,et al.  Anti-inflammatory effect of resveratrol in old mice liver , 2015, Experimental Gerontology.

[621]  N. Mermod,et al.  Nuclear Factor I‐C acts as a regulator of hepatocyte proliferation at the onset of liver regeneration , 2015, Liver international : official journal of the International Association for the Study of the Liver.

[622]  L. Huo,et al.  Fractalkine (CX3CL1) , 2015, Journal of Investigative Medicine.

[623]  Lina Ma,et al.  The β-amyloid precursor protein analog P165 improves impaired insulin signal transduction in type 2 diabetic rats , 2015, Neurological Sciences.

[624]  M. Konishi,et al.  Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress , 2015, Diabetologia.

[625]  J. Solé-Violán,et al.  Serum Levels of Caspase-Cleaved Cytokeratin-18 in Patients with Severe Traumatic Brain Injury Are Associated with Mortality: A Pilot Study , 2015, PloS one.

[626]  Takashi Katsu,et al.  Targeting LDH enzymes with a stiripentol analog to treat epilepsy , 2015, Science.

[627]  R. Erben.  α-Klotho's effects on mineral homeostasis are fibroblast growth factor-23 dependent , 2015, Current opinion in nephrology and hypertension.

[628]  H. Kuo,et al.  Fulvic acid attenuates homocysteine-induced cyclooxygenase-2 expression in human monocytes , 2015, BMC Complementary and Alternative Medicine.

[629]  B. Allinquant,et al.  PAT1 inversely regulates the surface Amyloid Precursor Protein level in mouse primary neurons , 2015, BMC Neuroscience.

[630]  S. Cha,et al.  Biological Role of Anti-aging Protein Klotho , 2015, Journal of lifestyle medicine.

[631]  R. J. McDonald,et al.  Co-morbid beta-amyloid toxicity and stroke produce impairments in an ambiguous context task in rats without any impairment in spatial working memory , 2015, Neurobiology of Learning and Memory.

[632]  T. Hansen,et al.  Soluble urokinase plasminogen activator receptor levels are elevated and associated with complications in patients with type 1 diabetes , 2015, Journal of internal medicine.

[633]  A. L. Munain,et al.  Increasing progranulin levels and blockade of the ERK1/2 pathway: Upstream and downstream strategies for the treatment of progranulin deficient frontotemporal dementia , 2015, European Neuropsychopharmacology.

[634]  Randolph P. Martin,et al.  Longitudinal Changes in Multiple Biomarkers Are Associated with Cardiotoxicity in Breast Cancer Patients Treated with Doxorubicin, Taxanes, and Trastuzumab. , 2015, Clinical chemistry.

[635]  M. Mayr,et al.  Signature of circulating microRNAs in osteoarthritis. , 2015, Annals of the rheumatic diseases.

[636]  T. Kurihara,et al.  Serum C1q as a novel biomarker of sarcopenia in older adults , 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[637]  G. Schuler,et al.  Fibronectin type III domain containing 5 expression in skeletal muscle in chronic heart failure—relevance of inflammatory cytokines , 2015, Journal of cachexia, sarcopenia and muscle.

[638]  P. Scheltens,et al.  Can agrin cerebrospinal fluid concentration be used as an early biomarker for Alzheimer's disease? , 2015, Alzheimer's & dementia.

[639]  H. Chung,et al.  Anti-inflammatory activity of SMP30 modulates NF-κB through protein tyrosine kinase/phosphatase balance , 2015, Journal of Molecular Medicine.

[640]  F. Tsai,et al.  CXCL10/IP-10 is a biomarker and mediator for Kawasaki disease. , 2015, Circulation research.

[641]  Zhongjie Sun,et al.  Molecular basis of Klotho: from gene to function in aging. , 2015, Endocrine reviews.

[642]  Zhanchun Li,et al.  Fibroblast growth factor-21 concentration in serum and synovial fluid is associated with radiographic bone loss of knee osteoarthritis , 2015, Scandinavian journal of clinical and laboratory investigation.

[643]  Gangyi Yang,et al.  Elevated circulating levels of irisin and the effect of metformin treatment in women with polycystic ovary syndrome. , 2015, The Journal of clinical endocrinology and metabolism.

[644]  A. Ghaemmaghami,et al.  Nuclear trafficking, histone cleavage and induction of apoptosis by the meningococcal App and MspA autotransporters , 2015, Cellular microbiology.

[645]  Wei Zhang,et al.  Calreticulin as Cancer Treatment Adjuvant: Combination with Photodynamic Therapy and Photodynamic Therapy-Generated Vaccines , 2015, Front. Oncol..

[646]  S. Bakker,et al.  Advanced glycation end products (AGEs) and the soluble receptor for AGE (sRAGE) in patients with type 1 diabetes and coeliac disease. , 2015, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[647]  I. Sora,et al.  Therapeutic concentration of lithium stimulates complement C3 production in dendritic cells and microglia via GSK‐3 inhibition , 2015, Glia.

[648]  Y. Chang,et al.  Angiotensin II in inflammation, immunity and rheumatoid arthritis , 2015, Clinical and experimental immunology.

[649]  Q. Lu,et al.  Metabolic consequences of LDHA inhibition by epigallocatechin gallate and oxamate in MIA PaCa-2 pancreatic cancer cells , 2015, Metabolomics.

[650]  V. Thannickal,et al.  Plasminogen activator inhibitor 1, fibroblast apoptosis resistance, and aging-related susceptibility to lung fibrosis , 2015, Experimental Gerontology.

[651]  B. Pettmann,et al.  Calreticulin levels determine onset of early muscle denervation by fast motoneurons of ALS model mice , 2015, Neurobiology of Disease.

[652]  A. Xu,et al.  Circulating fibroblast growth factor 21 levels predict progressive kidney disease in subjects with type 2 diabetes and normoalbuminuria. , 2015, The Journal of clinical endocrinology and metabolism.

[653]  C. Garlanda,et al.  Pentraxin 3 mediates neurogenesis and angiogenesis after cerebral ischaemia , 2015, Journal of Neuroinflammation.

[654]  Huadong Zhou,et al.  Serum Aβ is Predictive for Short-Term Neurological Deficits After Acute Ischemic Stroke , 2015, Neurotoxicity Research.

[655]  Diego Diez,et al.  Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia , 2015, Scientific Reports.

[656]  Jiaqi Chen,et al.  Irisin: a new molecular marker and target in metabolic disorder , 2015, Lipids in Health and Disease.

[657]  Jeremy R. Townsend,et al.  C‐terminal agrin fragment is inversely related to neuromuscular fatigue in older men , 2015, Muscle & nerve.

[658]  Yi Zhu,et al.  Homocysteine Accelerates Senescence of Endothelial Cells via DNA Hypomethylation of Human Telomerase Reverse Transcriptase , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[659]  O. Muzik,et al.  Plasma irisin in runners and nonrunners: no favorable metabolic associations in humans , 2015, Physiological reports.

[660]  S. Guzel,et al.  Relationship between Levels of Brain-Derived Neurotrophic Factor and Metabolic Parameters in Patients with Type 2 Diabetes Mellitus , 2014, Journal of diabetes research.

[661]  Paul Martin,et al.  Wound repair and regeneration: Mechanisms, signaling, and translation , 2014, Science Translational Medicine.

[662]  K. Hur.  Is GDF15 a Novel Biomarker to Predict the Development of Prediabetes or Diabetes? , 2014, Diabetes & metabolism journal.

[663]  Jun Yu,et al.  CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis. , 2014, Journal of hepatology.

[664]  D. Gustafson,et al.  Obesity and dementia: Adipokines interact with the brain , 2014, European Neuropsychopharmacology.

[665]  F. Marini,et al.  Serum levels of C-terminal agrin fragment (CAF) are associated with sarcopenia in older hip fractured patients , 2014, Experimental Gerontology.

[666]  H. Chung,et al.  GDF15 Is a Novel Biomarker for Impaired Fasting Glucose , 2014, Diabetes & metabolism journal.

[667]  Q. Lin,et al.  Serum Calreticulin Is a Negative Biomarker in Patients with Alzheimer’s Disease , 2014, International journal of molecular sciences.

[668]  M. Ankarcrona,et al.  Amyloid-β peptides are generated in mitochondria-associated endoplasmic reticulum membranes. , 2014, Journal of Alzheimer's disease : JAD.

[669]  B. Vaes,et al.  Interleukin-6 predicts short-term global functional decline in the oldest old: results from the BELFRAIL study , 2014, AGE.

[670]  R. Froemke,et al.  Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4 , 2014, eLife.

[671]  V. Fuentes-Santamaría,et al.  IGF-1 deficiency causes atrophic changes associated with upregulation of VGluT1 and downregulation of MEF2 transcription factors in the mouse cochlear nuclei , 2014, Brain Structure and Function.

[672]  Feng Liu,et al.  Pentraxin 3 as a Prognostic Biomarker in Patients with Systemic Inflammation or Infection , 2014, Mediators of inflammation.

[673]  R. Zechner,et al.  Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis , 2014, Journal of Lipid Research.

[674]  Shinn-Jang Hwang,et al.  Association between inflammatory markers and frailty in institutionalized older men. , 2014, Maturitas.

[675]  J. Cui,et al.  Agrin requires specific proteins to selectively activate γ-aminobutyric acid neurons for pain suppression , 2014, Experimental Neurology.

[676]  A. Hartemann,et al.  Association of peripheral neuropathy with circulating advanced glycation end products, soluble receptor for advanced glycation end products and other risk factors in patients with type 2 diabetes , 2014, Diabetes/metabolism research and reviews.

[677]  A. Chalaris,et al.  Senescence‐associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[678]  H. Jaeschke,et al.  Biomarkers distinguish apoptotic and necrotic cell death during hepatic ischemia/reperfusion injury in mice , 2014, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[679]  C. Shen,et al.  Calreticulin promotes angiogenesis via activating nitric oxide signalling pathway in rheumatoid arthritis , 2014, Clinical and experimental immunology.

[680]  M. Cheng,et al.  [Gene expression changes of regucalcin and prohibitin in cirrhotic rat liver and the related effects of compound glutathione inosine injection intervention]. , 2014, Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.

[681]  K. Cross,et al.  Predicting carotid artery disease and plaque instability from cell-derived microparticles. , 2014, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[682]  M. Rothermundt,et al.  Normal Cerebellar Development in S100B-Deficient Mice , 2014, The Cerebellum.

[683]  H. Wildiers,et al.  Circulating MicroRNAs as Easy-to-Measure Aging Biomarkers in Older Breast Cancer Patients: Correlation with Chronological Age but Not with Fitness/Frailty Status , 2014, PloS one.

[684]  M. Braddock,et al.  The role of fibroblast growth factor 21 in the pathogenesis of liver disease: a novel predictor and therapeutic target , 2014, Expert opinion on therapeutic targets.

[685]  P. Almgren,et al.  Fasting Levels of High-Sensitivity Growth Hormone Predict Cardiovascular Morbidity and Mortality , 2014, Journal of the American College of Cardiology.

[686]  J. Viña,et al.  Growth hormone replacement therapy prevents sarcopenia by a dual mechanism: improvement of protein balance and of antioxidant defenses. , 2014, The journals of gerontology. Series A, Biological sciences and medical sciences.

[687]  P. Barker,et al.  S100B protein activates a RAGE‐dependent autocrine loop in astrocytes: implications for its role in the propagation of reactive gliosis , 2014, Journal of neurochemistry.

[688]  Y. Izumiya,et al.  High serum levels of thrombospondin-2 correlate with poor prognosis of patients with heart failure with preserved ejection fraction , 2014, Heart and Vessels.

[689]  F. Hu,et al.  Knockdown of the inflammatory factor pentraxin-3 suppresses growth and invasion of lung adenocarcinoma through the AKT and NF-kappa B pathways. , 2014, Journal of biological regulators and homeostatic agents.

[690]  Toshio Tanaka,et al.  IL-6 in inflammation, immunity, and disease. , 2014, Cold Spring Harbor perspectives in biology.

[691]  C. Bole-Feysot,et al.  Hyperhomocysteinemia-induced oxidative stress differentially alters proteasome composition and activities in heart and aorta. , 2014, Biochemical and biophysical research communications.

[692]  T. Numakawa,et al.  The Role of Brain-Derived Neurotrophic Factor in Comorbid Depression: Possible Linkage with Steroid Hormones, Cytokines, and Nutrition , 2014, Front. Psychiatry.

[693]  Craig E. Higgins,et al.  Chemical Antagonists of Plasminogen Activator Inhibitor-1: Mechanisms of Action and Therapeutic Potential in Vascular Disease , 2014, Journal of molecular and genetic medicine : an international journal of biomedical research.

[694]  J. Fallowfield,et al.  Non‐invasive hepatic biomarkers (ELF and CK18) in people with type 2 diabetes: the Edinburgh type 2 diabetes study , 2014, Liver international : official journal of the International Association for the Study of the Liver.

[695]  J. Carson,et al.  Lactate dehydrogenase regulation in aged skeletal muscle: Regulation by anabolic steroids and functional overload , 2014, Experimental Gerontology.

[696]  E. Blaber,et al.  Mechanical unloading of bone in microgravity reduces mesenchymal and hematopoietic stem cell-mediated tissue regeneration. , 2014, Stem cell research.

[697]  H. Azhdari-Zarmehri,et al.  Evaluation of the association between blood homocysteine concentration and the degree of behavioral symptoms in the 6-hydroxydopamine-induced Parkinsonism in rat , 2014, Pharmacology Biochemistry and Behavior.

[698]  R. Kalluri,et al.  Increased concentration of circulating angiogenesis and nitric oxide inhibitors induces endothelial to mesenchymal transition and myocardial fibrosis in patients with chronic kidney disease. , 2014, International journal of cardiology.

[699]  A. Lucia,et al.  Serum irisin levels, precocious myocardial infarction, and healthy exceptional longevity. , 2014, The American journal of medicine.

[700]  Woo Jin Park,et al.  Intracellular amyloid beta alters the tight junction of retinal pigment epithelium in 5XFAD mice , 2014, Neurobiology of Aging.

[701]  W. Jia,et al.  Fibroblast growth factor 21 protects against acetaminophen‐induced hepatotoxicity by potentiating peroxisome proliferator‐activated receptor coactivator protein‐1α‐mediated antioxidant capacity in mice , 2014, Hepatology.

[702]  G. Gilkeson,et al.  Are Microparticles the Missing Link between Thrombosis and Autoimmune Diseases? Involvement in Selected Rheumatologic Diseases , 2014, Seminars in Thrombosis & Hemostasis.

[703]  Chuan-ju Liu,et al.  Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling , 2014, Annals of the rheumatic diseases.

[704]  E. Ranieri,et al.  Pentraxin 3: a novel biomarker for predicting progression from prostatic inflammation to prostate cancer. , 2014, Cancer research.

[705]  Koji Yamamoto,et al.  Plasminogen Activator Inhibitor-1 in Aging , 2014, Seminars in Thrombosis & Hemostasis.

[706]  C. Verschoor,et al.  Alterations to the Frequency and Function of Peripheral Blood Monocytes and Associations with Chronic Disease in the Advanced-Age, Frail Elderly , 2014, PloS one.

[707]  R. Yan,et al.  Calreticulin is localized at mitochondria of rat cardiomyocytes and affected by furazolidone , 2014, Molecular and Cellular Biochemistry.

[708]  J. Seoane,et al.  Active CREB1 promotes a malignant TGFβ2 autocrine loop in glioblastoma. , 2014, Cancer discovery.

[709]  K. Boini,et al.  Inhibition of Hyperhomocysteinemia-Induced Inflammasome Activation and Glomerular Sclerosis by NLRP3 Gene Deletion , 2014, Cellular Physiology and Biochemistry.

[710]  J. Vissing,et al.  Insulin resistance and increased muscle cytokine levels in patients with mitochondrial myopathy. , 2014, The Journal of clinical endocrinology and metabolism.

[711]  N. Samaras,et al.  Off-label use of hormones as an antiaging strategy: a review , 2014, Clinical interventions in aging.

[712]  N. Itoh.  FGF21 as a Hepatokine, Adipokine, and Myokine in Metabolism and Diseases , 2014, Front. Endocrinol..

[713]  L. Aguirre,et al.  Testosterone and Adipokines are Determinants of Physical Performance, Strength, and Aerobic Fitness in Frail, Obese, Older Adults , 2014, International journal of endocrinology.

[714]  Subrata K. Das,et al.  Vimentin knockdown decreases corneal opacity. , 2014, Investigative ophthalmology & visual science.

[715]  M. Dong,et al.  Overexpression of Calreticulin Contributes to the Development and Progression of Pancreatic Cancer , 2014, Journal of cellular physiology.

[716]  C. López-Larrea,et al.  Immunosenescence and inflammation characterize chronic heart failure patients with more advanced disease. , 2014, International journal of cardiology.

[717]  W. Oh,et al.  Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Prostate Cancer Progression , 2014, Cancers.

[718]  S. Tyagi,et al.  Curcumin-primed exosomes mitigate endothelial cell dysfunction during hyperhomocysteinemia. , 2014, Life sciences.

[719]  Je-Jung Lee,et al.  Serum Lactate Dehydrogenase with a Systemic Inflammation Score Is Useful for Predicting Response and Survival in Patients with Newly Diagnosed Diffuse Large B-Cell Lymphoma , 2014, Acta Haematologica.

[720]  S. Tyagi,et al.  Mitochondrial epigenetics in bone remodeling during hyperhomocysteinemia , 2014, Molecular and Cellular Biochemistry.

[721]  H. Kuo,et al.  Resistin-induced stromal cell-derived factor-1 expression through Toll-like receptor 4 and activation of p38 MAPK/ NFκB signaling pathway in gastric cancer cells , 2014, Journal of Biomedical Science.

[722]  S. Çelik,et al.  Associations between serum hepcidin level, FGF-21 level and oxidative stress with arterial stiffness in CAPD patients , 2014, International Urology and Nephrology.

[723]  K. Sonoyama,et al.  Adiponectin is partially associated with exosomes in mouse serum. , 2014, Biochemical and biophysical research communications.

[724]  T. Dorff,et al.  Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. , 2014, Cell stem cell.

[725]  Jianbo Li,et al.  Homocysteine is Linked to Macular Edema in Type 2 Diabetes , 2014, Current eye research.

[726]  S. Aydin,et al.  Decreased saliva/serum irisin concentrations in the acute myocardial infarction promising for being a new candidate biomarker for diagnosis of this pathology , 2014, Peptides.

[727]  M. Teixeira,et al.  Effect of exercise on the plasma BDNF levels in elderly women with knee osteoarthritis , 2014, Rheumatology International.

[728]  R. Petersen,et al.  Progranulin protein levels are differently regulated in plasma and CSF , 2014, Neurology.

[729]  Qingxian Zhang,et al.  Pentraxin 3 Inhibits Acute Renal Injury-Induced Interstitial Fibrosis Through Suppression of IL-6/Stat3 Pathway , 2014, Inflammation.

[730]  Rüdiger Rudolf,et al.  Degeneration of Neuromuscular Junction in Age and Dystrophy , 2014, Front. Aging Neurosci..

[731]  Z. Pei,et al.  Exogenous fractalkine enhances proliferation of endothelial cells, promotes migration of endothelial progenitor cells and improves neurological deficits in a rat model of ischemic stroke , 2014, Neuroscience Letters.

[732]  Xu,et al.  Prognostic value of pretreatment serum levels of lactate dehydrogenase in nonmetastatic nasopharyngeal carcinoma: single-site analysis of 601 patients in a highly endemic area , 2014, OncoTargets and therapy.

[733]  J. Hayashi,et al.  Increased Serum GP88 (Progranulin) Concentrations in Rheumatoid Arthritis , 2014, Inflammation.

[734]  A. Báez-ruiz,et al.  Daily Patterns and Adaptation of the Ghrelin, Growth Hormone and Insulin‐Like Growth Factor‐1 System Under Daytime Food Synchronisation in Rats , 2014, Journal of neuroendocrinology.

[735]  J. Milner,et al.  Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways , 2014, Oncogenesis.

[736]  G. Sypniewska,et al.  Secreted frizzled-related protein 4 (SFRP4) and fractalkine (CX3CL1) - Potential new biomarkers for β-cell dysfunction and diabetes. , 2014, Clinical biochemistry.

[737]  G. Mutlu,et al.  PAI-1–regulated extracellular proteolysis governs senescence and survival in Klotho mice , 2014, Proceedings of the National Academy of Sciences.

[738]  H. Makizako,et al.  A Large, Cross-Sectional Observational Study of Serum BDNF, Cognitive Function, and Mild Cognitive Impairment in the Elderly , 2014, Front. Aging Neurosci..

[739]  J. Little,et al.  Microparticles: A New Perspective in Central Nervous System Disorders , 2014, BioMed research international.

[740]  K. Ellacott,et al.  Regulation of S100B in white adipose tissue by obesity in mice , 2014, Adipocyte.

[741]  Xiaomin Sun,et al.  Common single nucleotide polymorphisms in the FNDC5 gene are associated with glucose metabolism but do not affect serum irisin levels in Japanese men with low fitness levels. , 2014, Metabolism: clinical and experimental.

[742]  S. Rho,et al.  High-mobility group box 1 (HMGB1) protein regulates tumor-associated cell migration through the interaction with BTB domain. , 2014, Cellular signalling.

[743]  Thomas H Thatcher,et al.  Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules. , 2014, American journal of respiratory cell and molecular biology.

[744]  S. Yamagishi,et al.  Role of AGEs-RAGE system in cardiovascular disease. , 2014, Current pharmaceutical design.

[745]  J. Elmquist,et al.  Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice , 2014, Diabetologia.

[746]  Zaiqing Yang,et al.  MiRNA-145 is involved in the development of resistin-induced insulin resistance in HepG2 cells. , 2014, Biochemical and biophysical research communications.

[747]  C. Mantzoros,et al.  Circulating irisin is associated with osteoporotic fractures in postmenopausal women with low bone mass but is not affected by either teriparatide or denosumab treatment for 3 months , 2014, Osteoporosis International.

[748]  M. Yamaguchi.  Regucalcin as a potential biomarker for metabolic and neuronal diseases , 2014, Molecular and Cellular Biochemistry.

[749]  M. Yamaguchi.  Regulatory role of regucalcin in heart calcium signaling: Insight into cardiac failure (Review) , 2014, Biomedical reports.

[750]  J. Martínez,et al.  Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women , 2014, American journal of human biology : the official journal of the Human Biology Council.

[751]  Craig E. Higgins,et al.  SERPINE1: A Molecular Switch in the Proliferation-Migration Dichotomy in Wound-"Activated" Keratinocytes. , 2014, Advances in wound care.

[752]  J. Keijer,et al.  Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine. , 2014, American journal of physiology. Endocrinology and metabolism.

[753]  N. Afzal,et al.  Negative association of serum IL-6 and IL-17 with type-II diabetes retinopathy. , 2014, Iranian journal of immunology : IJI.

[754]  P. Watkins,et al.  Keratin‐18 and microRNA‐122 complement alanine aminotransferase as novel safety biomarkers for drug‐induced liver injury in two human cohorts , 2014, Liver international : official journal of the International Association for the Study of the Liver.

[755]  L. Azzalis,et al.  Systemic Chemotherapy Interferes in Homocysteine Metabolism in Breast Cancer Patients , 2014, Journal of clinical laboratory analysis.

[756]  Masayoshi Yamaguchi,et al.  The role of regucalcin in bone homeostasis: involvement as a novel cytokine. , 2014, Integrative biology : quantitative biosciences from nano to macro.

[757]  Li Zhang,et al.  The relationship between hepatic resistin overexpression and inflammation in patients with nonalcoholic steatohepatitis , 2014, BMC Gastroenterology.

[758]  Shuo Lin,et al.  Injection of a Soluble Fragment of Neural Agrin (NT-1654) Considerably Improves the Muscle Pathology Caused by the Disassembly of the Neuromuscular Junction , 2014, PloS one.

[759]  C. Mantzoros,et al.  Irisin in patients with nonalcoholic fatty liver disease. , 2014, Metabolism: clinical and experimental.

[760]  S. Espinoza,et al.  Plasma protein biomarkers of the geriatric syndrome of frailty. , 2014, The journals of gerontology. Series A, Biological sciences and medical sciences.

[761]  Jinhua Wang,et al.  A novel tumor-promoting role for nuclear factor IA in glioblastomas is mediated through negative regulation of p53, p21, and PAI1. , 2014, Neuro-oncology.

[762]  H. Randeva,et al.  Plasma irisin levels predict telomere length in healthy adults , 2014, AGE.

[763]  Joon Young Choi,et al.  Synergistic Anti-Cancer Effect of Phenformin and Oxamate , 2014, PloS one.

[764]  G. Melino,et al.  ITCH Deficiency Protects From Diet-Induced Obesity , 2014, Diabetes.

[765]  Yuan Zhang,et al.  Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling , 2014, Diabetes.

[766]  M. Ruseva,et al.  C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens , 2014, Proceedings of the National Academy of Sciences.

[767]  N. Tanık,et al.  S100B as a glial cell marker in diabetic peripheral neuropathy , 2014, Neuroscience Letters.

[768]  C. Coimbra,et al.  Involvement of BDNF in knee osteoarthritis: the relationship with inflammation and clinical parameters , 2014, Rheumatology International.

[769]  Xiao-Min Wang,et al.  Sleep Disorders in Parkinson’s Disease: Clinical Features, Iron Metabolism and Related Mechanism , 2013, PloS one.

[770]  W. Bains.  Transglutaminse 2 and EGGL, the protein cross-link formed by transglutaminse 2, as therapeutic targets for disabilities of old age. , 2013, Rejuvenation research.

[771]  P. Dahinden,et al.  C-Terminal Agrin Fragment - A New Fast Biomarker for Kidney Function in Renal Transplant Recipients , 2013, American Journal of Nephrology.

[772]  S. Pirkmajer,et al.  Non-Synaptic Roles of Acetylcholinesterase and Agrin , 2013, Journal of Molecular Neuroscience.

[773]  Caiyan Zhao,et al.  Cytokeratin 18, Alanine Aminotransferase, Platelets and Triglycerides Predict the Presence of Nonalcoholic Steatohepatitis , 2013, PloS one.

[774]  J. Morley.  Cognition and nutrition , 2013, Current opinion in clinical nutrition and metabolic care.

[775]  C. Cavada,et al.  Loss of serum IGF-I input to the brain as an early biomarker of disease onset in Alzheimer mice , 2013, Translational Psychiatry.

[776]  E. Hirsch,et al.  The Iron-Binding Protein Lactoferrin Protects Vulnerable Dopamine Neurons from Degeneration by Preserving Mitochondrial Calcium Homeostasis , 2013, Molecular Pharmacology.

[777]  E. Razvi.  Epigenetic and circulating biomarkers: future analytes for liquid biopsies. , 2013, Epigenomics.

[778]  Ryan L. Davis,et al.  Fibroblast growth factor 21 is a sensitive biomarker of mitochondrial disease , 2013, Neurology.

[779]  A. Fabio,et al.  Soluble receptor for advanced glycation end products predicts 28-day mortality in critically ill patients with sepsis , 2013, Scandinavian journal of clinical and laboratory investigation.

[780]  Jeremy R. Townsend,et al.  Biomarkers of muscle quality: N-terminal propeptide of type III procollagen and C-terminal agrin fragment responses to resistance exercise training in older adults , 2013, Journal of cachexia, sarcopenia and muscle.

[781]  Jiandie D. Lin,et al.  Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. , 2013, Cell metabolism.

[782]  P. Bourin,et al.  Concise Review: Growth Differentiation Factor 15 in Pathology: A Clinical Role? , 2013, Stem cells translational medicine.

[783]  M. Michalak,et al.  Epithelial calreticulin up-regulation promotes profibrotic responses and tubulointerstitial fibrosis development. , 2013, The American journal of pathology.

[784]  R. Henning,et al.  Genetic deletion of growth differentiation factor 15 augments renal damage in both type 1 and type 2 models of diabetes. , 2013, American journal of physiology. Renal physiology.

[785]  A. Simm.  Protein glycation during aging and in cardiovascular disease. , 2013, Journal of proteomics.

[786]  Yimin Fang,et al.  Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice , 2013, eLife.

[787]  F. Atyabi,et al.  Enhanced brain delivery of deferasirox-lactoferrin conjugates for iron chelation therapy in neurodegenerative disorders: in vitro and in vivo studies. , 2013, Molecular pharmaceutics.

[788]  T. Saido,et al.  Aβ secretion and plaque formation depend on autophagy. , 2013, Cell reports.

[789]  A. Stavreus-Evers,et al.  Prostasomes from four different species are able to produce extracellular adenosine triphosphate (ATP). , 2013, Biochimica et biophysica acta.

[790]  B. Cheung,et al.  Serum Fibroblast Growth Factor-21 Levels Are Associated With Carotid Atherosclerosis Independent of Established Cardiovascular Risk Factors , 2013, Arteriosclerosis, thrombosis, and vascular biology.

[791]  S. Yamashita,et al.  Deletion of progranulin exacerbates atherosclerosis in ApoE knockout mice. , 2013, Cardiovascular research.

[792]  J. Foster,et al.  The Serum Concentration of the Calcium Binding Protein S100B is Positively Associated with Cognitive Performance in Older Adults , 2013, Front. Aging Neurosci..

[793]  R. Cumming,et al.  Attenuation of LDHA expression in cancer cells leads to redox-dependent alterations in cytoskeletal structure and cell migration. , 2013, Cancer letters.

[794]  Robert A. Rose,et al.  A Clinical Frailty Index in Aging Mice: Comparisons With Frailty Index Data in Humans , 2013, The journals of gerontology. Series A, Biological sciences and medical sciences.

[795]  Sivakumar Gowrisankar,et al.  Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration , 2013, Nature Genetics.

[796]  Ju-kyung Lee,et al.  DZNep, inhibitor of S-adenosylhomocysteine hydrolase, down-regulates expression of SETDB1 H3K9me3 HMTase in human lung cancer cells. , 2013, Biochemical and biophysical research communications.

[797]  A. Garufi,et al.  Zinc supplementation is required for the cytotoxic and immunogenic effects of chemotherapy in chemoresistant p53-functionally deficient cells , 2013, Oncoimmunology.

[798]  G. Harry.  Microglia during development and aging. , 2013, Pharmacology & therapeutics.

[799]  M. Gawne-Cain,et al.  IL-6 is a predictive biomarker for stroke associated infection and future mortality in the elderly after an ischemic stroke , 2013, Experimental Gerontology.

[800]  D. Spandidos,et al.  Chemokines and atherosclerosis: focus on the CX3CL1/CX3CR1 pathway , 2013, Acta Pharmacologica Sinica.

[801]  E. Huang,et al.  A Dramatic Increase of C1q Protein in the CNS during Normal Aging , 2013, The Journal of Neuroscience.

[802]  E. Vara,et al.  Growth hormone and melatonin prevent age-related alteration in apoptosis processes in the dentate gyrus of male rats , 2013, Biogerontology.

[803]  P. Siegel,et al.  Glycoprotein non-metastatic b (GPNMB): A metastatic mediator and emerging therapeutic target in cancer , 2013, OncoTargets and therapy.

[804]  Mark R. Wilson,et al.  Acute phase proteins are major clients for the chaperone action of α2-macroglobulin in human plasma , 2013, Cell Stress and Chaperones.

[805]  H. Redl,et al.  Secretion of microvesicular miRNAs in cellular and organismal aging , 2013, Experimental Gerontology.

[806]  A. Procopio,et al.  Circulating inflamma-miRs in aging and age-related diseases , 2013, Front. Genet..

[807]  R. Yan,et al.  Calreticulin-STAT3 Signaling Pathway Modulates Mitochondrial Function in a Rat Model of Furazolidone-Induced Dilated Cardiomyopathy , 2013, PloS one.

[808]  F. Villarroya,et al.  Fibroblast growth factor 21 protects against cardiac hypertrophy in mice , 2013, Nature Communications.

[809]  L. Partridge,et al.  The Hallmarks of Aging , 2013, Cell.

[810]  S. Goriely,et al.  Frailty in Old Age Is Associated with Decreased Interleukin-12/23 Production in Response to Toll-Like Receptor Ligation , 2013, PloS one.

[811]  A. Fontana,et al.  Serum Resistin, Cardiovascular Disease and All-Cause Mortality in Patients with Type 2 Diabetes , 2013, PloS one.

[812]  M. Riddle,et al.  Influence of glucocorticoids and growth hormone on insulin sensitivity in humans , 2013, Diabetic medicine : a journal of the British Diabetic Association.

[813]  M. Yamaguchi.  Suppressive role of regucalcin in liver cell proliferation: involvement in carcinogenesis , 2013, Cell proliferation.

[814]  R. Nass.  Growth hormone axis and aging. , 2013, Endocrinology and metabolism clinics of North America.

[815]  H. Vargas-Robles,et al.  Correlation between Levels of Circulating Adipokines and Adiponectin/Resistin Index with Carotid Intima-Media Thickness in Hypertensive Type 2 Diabetic Patients , 2013, Cardiology.

[816]  D. Bennett,et al.  Association of brain pathology with the progression of frailty in older adults , 2013, Neurology.

[817]  T. McCaffrey,et al.  Aspirin insensitive thrombophilia: transcript profiling of blood identifies platelet abnormalities and HLA restriction. , 2013, Gene.

[818]  M. Yamaguchi.  The anti-apoptotic effect of regucalcin is mediated through multisignaling pathways , 2013, Apoptosis.

[819]  Chao-Yung Wang,et al.  Decrease in Irisin in Patients with Chronic Kidney Disease , 2013, PloS one.

[820]  Yung-Hyun Choi,et al.  Comparative proteome analysis of Tumor necrosis factor α-stimulated human Vascular Smooth Muscle Cells in response to melittin , 2013, Proteome Science.

[821]  S. Yoshida,et al.  Bovine Milk–derived Lactoferrin Exerts Proangiogenic Effects in an Src-Akt-eNOS–dependent Manner in Response to Ischemia , 2013, Journal of cardiovascular pharmacology.

[822]  G. Hankey,et al.  Associations of insulin‐like growth factor‐I and its binding proteins and testosterone with frailty in older men , 2013, Clinical endocrinology.

[823]  Seamus J. Martin,et al.  Autophagy in multiple myeloma: what makes you stronger can also kill you. , 2013, Cancer cell.

[824]  M. Schachner,et al.  Generation of Amyloid-β Is Reduced by the Interaction of Calreticulin with Amyloid Precursor Protein, Presenilin and Nicastrin , 2013, PloS one.

[825]  D. Volkert,et al.  Dietary quality is related to frailty in community-dwelling older adults. , 2013, The journals of gerontology. Series A, Biological sciences and medical sciences.

[826]  A. Xu,et al.  Fibroblast Growth Factor 21 as an emerging metabolic regulator: clinical perspectives , 2013, Clinical endocrinology.

[827]  T. Zhu,et al.  Comparison of anti‐mutated citrullinated vimentin, anti‐cyclic citrullinated peptides, anti‐glucose‐6‐phosphate isomerase and anti‐keratin antibodies and rheumatoid factor in the diagnosis of rheumatoid arthritis in Chinese patients , 2013, International journal of rheumatic diseases.

[828]  J. Eckel,et al.  Resistin reduces mitochondria and induces hepatic steatosis in mice by the protein kinase C/protein kinase G/p65/PPAR gamma coactivator 1 alpha pathway , 2013, Hepatology.

[829]  P. Latham,et al.  Resistin expression correlates with steatohepatitis in morbidly obese patients , 2013, Surgical Endoscopy.

[830]  Yichao Wang,et al.  Serum Levels of Calreticulin in Correlation with Disease Activity in Patients with Rheumatoid Arthritis , 2013, Journal of Clinical Immunology.

[831]  S. Socorro,et al.  The diverse roles of calcium-binding protein regucalcin in cell biology: from tissue expression and signalling to disease , 2013, Cellular and Molecular Life Sciences.

[832]  Leway Chen,et al.  Elevated levels of interleukin 6 and C-reactive protein associated with cognitive impairment in heart failure. , 2013, Congestive heart failure.

[833]  Chih-Yang Huang,et al.  Resistin protects against 6‐hydroxydopamine‐induced cell death in dopaminergic‐like MES23.5 cells , 2013, Journal of cellular physiology.

[834]  J. Stoker,et al.  Accuracy of prediction scores and novel biomarkers for predicting nonalcoholic fatty liver disease in obese children , 2013, Obesity.

[835]  Wenjuan Yao,et al.  Proteomic analysis for anti-atherosclerotic effect of tetrahydroxystilbene glucoside in rats. , 2013, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[836]  Li-jun Guo,et al.  Association between serum resistin level and cardiovascular events in postmenopausal women with acute coronary syndrome undergoing percutaneous coronary intervention. , 2013, Chinese medical journal.

[837]  R. Donato,et al.  S100B protein in tissue development, repair and regeneration. , 2013, World journal of biological chemistry.

[838]  E. Kardami,et al.  Calreticulin Induces Dilated Cardiomyopathy , 2013, PloS one.

[839]  H. J. Yoo,et al.  Implication of Progranulin and C1q/TNF-Related Protein-3 (CTRP3) on Inflammation and Atherosclerosis in Subjects with or without Metabolic Syndrome , 2013, PloS one.

[840]  R. Kalluri,et al.  Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis. , 2013, American journal of physiology. Cell physiology.

[841]  Satish K. Nair,et al.  The Crystal Structure of Human Soluble CD14 Reveals a Bent Solenoid with a Hydrophobic Amino-Terminal Pocket , 2013, The Journal of Immunology.

[842]  Ju-Hee Lee,et al.  Lactoferrin protects against prion protein-induced cell death in neuronal cells by preventing mitochondrial dysfunction. , 2013, International journal of molecular medicine.

[843]  P. Dahinden,et al.  Elevated levels of a C-terminal agrin fragment identifies a new subset of sarcopenia patients , 2013, Experimental Gerontology.

[844]  W. Uter,et al.  C-terminal Agrin Fragment as a potential marker for sarcopenia caused by degeneration of the neuromuscular junction , 2013, Experimental Gerontology.

[845]  R. T. Pickering,et al.  Altered Hepatic Lipid Metabolism Contributes to Nonalcoholic Fatty Liver Disease in Leptin-Deficient Ob/Ob Mice , 2013, Journal of obesity.

[846]  A. Mantovani,et al.  Inflammation, wound repair, and fibrosis: reassessing the spectrum of tissue injury and resolution , 2013, The Journal of pathology.

[847]  Kira S. Sheinerman,et al.  Early detection of neurodegenerative diseases , 2013, Cell cycle.

[848]  R. Donato,et al.  Functions of S100 proteins. , 2012, Current molecular medicine.

[849]  Yi-Chung Lee,et al.  FGF21 in ataxia patients with spinocerebellar atrophy and mitochondrial disease. , 2012, Clinica chimica acta; international journal of clinical chemistry.

[850]  R. Cuomo,et al.  The antiprotozoal drug pentamidine ameliorates experimentally induced acute colitis in mice , 2012, Journal of Neuroinflammation.

[851]  R. Donato,et al.  Causes of elevated serum levels of S100B protein in athletes , 2012, European Journal of Applied Physiology.

[852]  G. Sypniewska,et al.  Diabetes as a complication of adipose tissue dysfunction. Is there a role for potential new biomarkers? , 2012, Clinical chemistry and laboratory medicine.

[853]  A. Pfeiffer,et al.  Fibroblast Growth Factor 21 Predicts the Metabolic Syndrome and Type 2 Diabetes in Caucasians , 2012, Diabetes Care.

[854]  J. Grillari,et al.  From cellular senescence to age-associated diseases: the miRNA connection , 2012, Longevity & healthspan.

[855]  G. Ferraccioli,et al.  Rheumatoid arthritis and Alzheimer's disease: genetic and epigenetic links in inflammatory regulation. , 2012, Discovery medicine.

[856]  H. Haller,et al.  Urokinase Receptor Mediates Doxorubicin-Induced Vascular Smooth Muscle Cell Senescence via Proteasomal Degradation of TRF2 , 2012, Journal of Vascular Research.

[857]  N. Munshi,et al.  Biomarkers of Bone Remodeling in Multiple Myeloma Patients to Tailor Bisphosphonate Therapy , 2012, Clinical Cancer Research.

[858]  A. Keech,et al.  Long-term fenofibrate therapy increases fibroblast growth factor 21 and retinol-binding protein 4 in subjects with type 2 diabetes. , 2012, The Journal of clinical endocrinology and metabolism.

[859]  R. Goldschmeding,et al.  Circulating growth differentiation factor‐15 correlates with myocardial fibrosis in patients with non‐ischaemic dilated cardiomyopathy and decreases rapidly after left ventricular assist device support , 2012, European journal of heart failure.

[860]  K. Wollert,et al.  Growth differentiation factor 15 predicts future insulin resistance and impaired glucose control in obese nondiabetic individuals: results from the XENDOS trial. , 2012, European journal of endocrinology.

[861]  J. Jia,et al.  Genetic association of urokinase-type plasminogen activator gene rs2227564 site polymorphism with sporadic Alzheimer's disease in the Han Chinese population , 2012, Neural regeneration research.

[862]  N. Sattar,et al.  Soluble ST2 Associates with Diabetes but Not Established Cardiovascular Risk Factors: A New Inflammatory Pathway of Relevance to Diabetes? , 2012, PloS one.

[863]  S. Kliewer,et al.  The starvation hormone, fibroblast growth factor-21, extends lifespan in mice , 2012, eLife.

[864]  R. Lee,et al.  A meta-analysis of cognitive deficits in first-episode Major Depressive Disorder. , 2012, Journal of affective disorders.

[865]  A. Maisa,et al.  Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function , 2012, Aging cell.

[866]  T. Pabst,et al.  The angiogenesis inhibitor vasostatin is regulated by neutrophil elastase-dependent cleavage of calreticulin in AML patients. , 2012, Blood.

[867]  Xiangjun Zeng,et al.  A Soluble Receptor for Advanced Glycation End-Products Inhibits Hypoxia/Reoxygenation-Induced Apoptosis in Rat Cardiomyocytes via the Mitochondrial Pathway , 2012, International journal of molecular sciences.

[868]  J. Lee,et al.  High expression of CX3CL1 by tumor cells correlates with a good prognosis and increased tumor‐infiltrating CD8+ T cells, natural killer cells, and dendritic cells in breast carcinoma , 2012, Journal of surgical oncology.

[869]  Trushar R. Patel,et al.  Site Specific Cleavage Mediated by MMPs Regulates Function of Agrin , 2012, PloS one.

[870]  Tim Rappon,et al.  Overexpression of Pyruvate Dehydrogenase Kinase 1 and Lactate Dehydrogenase A in Nerve Cells Confers Resistance to Amyloid β and Other Toxins by Decreasing Mitochondrial Respiration and Reactive Oxygen Species Production* , 2012, The Journal of Biological Chemistry.

[871]  K. Lapane,et al.  Depression and frailty in later life: a synthetic review , 2012, International journal of geriatric psychiatry.

[872]  H. Amièva,et al.  Is Frailty a Prodromal Stage of Vascular Dementia? Results From the Three‐City Study , 2012, Journal of the American Geriatrics Society.

[873]  G. Iguchi,et al.  IGF-I enhances cellular senescence via the reactive oxygen species-p53 pathway. , 2012, Biochemical and biophysical research communications.

[874]  J. Bauersachs,et al.  Fractalkine Is Expressed in Early and Advanced Atherosclerotic Lesions and Supports Monocyte Recruitment via CX3CR1 , 2012, PloS one.

[875]  M. Charbonneau,et al.  Transglutaminase 2 cross-linking activity is linked to invadopodia formation and cartilage breakdown in arthritis , 2012, Arthritis Research & Therapy.

[876]  H. Groenewegen,et al.  The Proteome of the Locus Ceruleus in Parkinson's Disease: Relevance to Pathogenesis , 2012, Brain pathology.

[877]  Seung Hwan An,et al.  S-Adenosylhomocysteine hydrolase of the protozoan parasite Trichomonas vaginalis: potent inhibitory activity of 9-(2-deoxy-2-fluoro-β,D-arabinofuranosyl)adenine. , 2012, Bioorganic & medicinal chemistry letters.

[878]  I. Komuro,et al.  Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes , 2012, Cell.

[879]  Michael Loran Dustin,et al.  Agrin is required for survival and function of monocytic cells. , 2012, Blood.

[880]  M. Catt,et al.  Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study , 2012, Mechanisms of Ageing and Development.

[881]  R. Touyz,et al.  Microparticles Induce Cell Cycle Arrest Through Redox-Sensitive Processes in Endothelial Cells: Implications in Vascular Senescence , 2012, Journal of the American Heart Association.

[882]  V. Wong,et al.  Non-invasive diagnosis of non-alcoholic steatohepatitis by combined serum biomarkers. , 2012, Journal of hepatology.

[883]  Nam-Hee Kim,et al.  Proteomic analysis of plasma from a Tau transgenic mouse , 2012, International Journal of Developmental Neuroscience.

[884]  M. Oladnabi,et al.  Novel evidence of the involvement of calreticulin in major psychiatric disorders , 2012, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[885]  F. Deák,et al.  Aging, synaptic dysfunction, and insulin-like growth factor (IGF)-1. , 2012, The journals of gerontology. Series A, Biological sciences and medical sciences.

[886]  S. Paek,et al.  Induction of Neuronal Death by Microglial AGE-Albumin: Implications for Alzheimer’s Disease , 2012, PloS one.

[887]  V. Videm,et al.  Functional polymorphisms in the LTF gene and risk of coronary artery stenosis. , 2012, Human immunology.

[888]  Ding-Yah Yang,et al.  c-Jun-dependent sulfiredoxin induction mediates BDNF protection against mitochondrial inhibition in rat cortical neurons , 2012, Neurobiology of Disease.

[889]  Simon C Watkins,et al.  p53/HMGB1 complexes regulate autophagy and apoptosis. , 2012, Cancer research.

[890]  M. Sheffield-Moore,et al.  The role of androgens and estrogens on healthy aging and longevity. , 2012, The journals of gerontology. Series A, Biological sciences and medical sciences.

[891]  A. Segura‐Carretero,et al.  Metformin lowers the threshold for stress-induced senescence: A role for the microRNA-200 family and miR-205 , 2012, Cell cycle.

[892]  S. Maxwell,et al.  Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation , 2012, Angiogenesis.

[893]  H. Syddall,et al.  Immune-endocrine biomarkers as predictors of frailty and mortality: a 10-year longitudinal study in community-dwelling older people , 2012, AGE.

[894]  K. Rockwood,et al.  A procedure for creating a frailty index based on deficit accumulation in aging mice. , 2012, The journals of gerontology. Series A, Biological sciences and medical sciences.

[895]  F. Marín,et al.  Growth differentiation factor-15, a novel biomarker related with disease severity in patients with hypertrophic cardiomyopathy. , 2012, European journal of internal medicine.

[896]  J. Merrick,et al.  Inflammation and oxidative stress as biomarkers of premature aging in persons with intellectual disability. , 2012, Research in developmental disabilities.

[897]  N. Stergiopulos,et al.  Role of renin-angiotensin system in inflammation, immunity and aging. , 2012, Current pharmaceutical design.

[898]  R. Bosotti,et al.  Transcriptional analysis of the Aurora inhibitor Danusertib leading to biomarker identification in TP53 wild type cells. , 2012, Gene.

[899]  G. Johnson,et al.  Transglutaminase 2: a molecular Swiss army knife. , 2012, Biochimica et biophysica acta.

[900]  J. Langhorst,et al.  Fecal lactoferrin as a noninvasive biomarker in inflammatory bowel diseases. , 2012, Drugs of today.

[901]  M. Fujimoto,et al.  Increased accumulation of extracellular thrombospondin-2 due to low degradation activity stimulates type I collagen expression in scleroderma fibroblasts. , 2012, The American journal of pathology.

[902]  P. Caffarra,et al.  The hormonal pathway to cognitive impairment in older men , 2012, The journal of nutrition, health & aging.

[903]  L. Lind,et al.  Relations of growth-differentiation factor-15 to biomarkers reflecting vascular pathologies in a population-based sample of elderly subjects , 2012, Scandinavian journal of clinical and laboratory investigation.

[904]  B. Spiegelman,et al.  A PGC1α-dependent myokine that drives browning of white fat and thermogenesis , 2012, Nature.

[905]  Jianhua Zhang,et al.  Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling , 2011, The Biochemical journal.

[906]  N. LeBrasseur,et al.  Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders , 2011, Nature.

[907]  P. Bickford,et al.  CX3CR1 Deficiency Leads to Impairment of Hippocampal Cognitive Function and Synaptic Plasticity , 2011, The Journal of Neuroscience.

[908]  C. McClain,et al.  Keratin 18, Apoptosis, and Liver Disease in Children. , 2011, Current pediatric reviews.

[909]  S. Terai,et al.  Senescence marker protein 30 (SMP30)/regucalcin (RGN) expression decreases with aging, acute liver injuries and tumors in zebrafish. , 2011, Biochemical and biophysical research communications.

[910]  R. Mutani,et al.  Progranulin expression in brain tissue and cerebrospinal fluid levels in multiple sclerosis , 2011, Multiple sclerosis.

[911]  Yeon-Ah Lee,et al.  Increased levels of thymosin β4 in synovial fluid of patients with rheumatoid arthritis: association of thymosin β4 with other factors that are involved in inflammation and bone erosion in joints , 2011, International journal of rheumatic diseases.

[912]  J. Bond,et al.  Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study , 2011, Mechanisms of Ageing and Development.

[913]  W. Jia,et al.  Circulating Fibroblast Growth Factor 21 Levels Are Closely Associated with Hepatic Fat Content: A Cross-Sectional Study , 2011, PloS one.

[914]  N. Schaum,et al.  p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes , 2011, The Journal of cell biology.

[915]  J. Hamilton,et al.  The TGF-β superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism , 2011, Growth factors.

[916]  Wei Zhang,et al.  Age as a Modulator of Inflammatory Cardiovascular Risk Factors , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[917]  S. Moon,et al.  Measurement of Interleukin-33 (IL-33) and IL-33 Receptors (sST2 and ST2L) in Patients with Rheumatoid Arthritis , 2011, Journal of Korean medical science.

[918]  A. Paetau,et al.  FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study , 2011, The Lancet Neurology.

[919]  D. Papanicolaou,et al.  MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb study. , 2011, Archives of gerontology and geriatrics.

[920]  A. Castiglioni,et al.  High-mobility group box 1 release and redox regulation accompany regeneration and remodeling of skeletal muscle. , 2011, Antioxidants & redox signaling.

[921]  D. Yoo,et al.  Reduced Cell Proliferation and Neuroblast Differentiation in the Dentate Gyrus of High Fat Diet-Fed Mice are Ameliorated by Metformin and Glimepiride Treatment , 2011, Neurochemical Research.

[922]  Gry H. Dihazi,et al.  Calreticulin is crucial for calcium homeostasis mediated adaptation and survival of thick ascending limb of Henle's loop cells under osmotic stress. , 2011, The international journal of biochemistry & cell biology.

[923]  T. Koh,et al.  Macrophage-Specific Expression of Urokinase-Type Plasminogen Activator Promotes Skeletal Muscle Regeneration , 2011, The Journal of Immunology.

[924]  K. Kang,et al.  Daidzein supplementation prevents non-alcoholic fatty liver disease through alternation of hepatic gene expression profiles and adipocyte metabolism , 2011, International Journal of Obesity.

[925]  S. Liebner,et al.  Current concepts of blood-brain barrier development. , 2011, The International journal of developmental biology.

[926]  A. Baranova,et al.  Association of Obestatin, Ghrelin, and Inflammatory Cytokines in Obese Patients with Non-alcoholic Fatty Liver Disease , 2011, Obesity surgery.

[927]  M. Sudol,et al.  From Rous sarcoma virus to plasminogen activator, src oncogene and cancer management , 2011, Oncogene.

[928]  S. Jiang,et al.  Gene expression profiling suggests a pathological role of human bone marrow-derived mesenchymal stem cells in aging-related skeletal diseases , 2011, Aging.

[929]  Douglas Galasko,et al.  PF-04494700, an Oral Inhibitor of Receptor for Advanced Glycation End Products (RAGE), in Alzheimer Disease , 2011, Alzheimer disease and associated disorders.

[930]  G. Kroemer,et al.  High-mobility group box 1 is essential for mitochondrial quality control. , 2011, Cell metabolism.

[931]  C. Garlanda,et al.  Pathogen Recognition by the Long Pentraxin PTX3 , 2011, Journal of biomedicine & biotechnology.

[932]  F. Baas,et al.  Innate and adaptive immunity in amyotrophic lateral sclerosis: Evidence of complement activation , 2011, Neurobiology of Disease.

[933]  Shuxia Liu,et al.  High mobility group box 1 induces synoviocyte proliferation in rheumatoid arthritis by activating the signal transducer and activator transcription signal pathway , 2011, Clinical and Experimental Medicine.

[934]  E. Barrett-Connor,et al.  Growth-Differentiation Factor-15 Is a Robust, Independent Predictor of 11-Year Mortality Risk in Community-Dwelling Older Adults: The Rancho Bernardo Study , 2011, Circulation.

[935]  R. Hass,et al.  Extracellular signals in young and aging breast epithelial cells and possible connections to age-associated breast cancer development , 2011, Mechanisms of Ageing and Development.

[936]  Mingyao Li,et al.  Fractalkine Is a Novel Human Adipochemokine Associated With Type 2 Diabetes , 2011, Diabetes.

[937]  Scott D Covey,et al.  Leptin Therapy Reverses Hyperglycemia in Mice With Streptozotocin-Induced Diabetes, Independent of Hepatic Leptin Signaling , 2011, Diabetes.

[938]  J. Wilkins,et al.  Requirement of Podocalyxin in TGF-Beta Induced Epithelial Mesenchymal Transition , 2011, PloS one.

[939]  S. Akira,et al.  Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway. , 2011, Cell metabolism.

[940]  J. Grande,et al.  Effects of Intermittent and Chronic Calorie Restriction on Mammalian Target of Rapamycin (mTOR) and IGF-I Signaling Pathways in Mammary Fat Pad Tissues and Mammary Tumors , 2011, Nutrition and cancer.

[941]  R. Cuomo,et al.  S100B protein in the gut: the evidence for enteroglial-sustained intestinal inflammation. , 2011, World journal of gastroenterology.

[942]  Gregory C Kujoth,et al.  Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice , 2011, Proceedings of the National Academy of Sciences.

[943]  M. Konishi,et al.  FGF21 as an Endocrine Regulator in Lipid Metabolism: From Molecular Evolution to Physiology and Pathophysiology , 2011, Journal of nutrition and metabolism.

[944]  A. Pfeiffer,et al.  Relation between fibroblast growth factor-21, adiposity, metabolism, and weight reduction. , 2011, Metabolism: clinical and experimental.

[945]  R. Takahashi,et al.  Involvement of CX3CL1/CX3CR1 axis in etanercept therapy for patients with active rheumatoid arthritis , 2011, Open access rheumatology : research and reviews.

[946]  R. Donato,et al.  S100B Protein Stimulates Microglia Migration via RAGE-dependent Up-regulation of Chemokine Expression and Release* , 2011, The Journal of Biological Chemistry.

[947]  D. D’Lima,et al.  Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis , 2011, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[948]  A. Blom,et al.  Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis. , 2010, Arthritis and rheumatism.

[949]  H. Grönberg,et al.  Macrophage inhibitory cytokine‐1 (MIC‐1/GDF15): a new marker of all‐cause mortality , 2010, Aging cell.

[950]  M. Francolini,et al.  Specific proteolytic cleavage of agrin regulates maturation of the neuromuscular junction , 2010, Journal of Cell Science.

[951]  N. Herrmann,et al.  A Meta-Analysis of Cytokines in Alzheimer's Disease , 2010, Biological Psychiatry.

[952]  J. Cui,et al.  Agrin Downregulation Induced by Nerve Injury Contributes to Neuropathic Pain , 2010, The Journal of Neuroscience.

[953]  K. Park,et al.  Serum fibroblast growth factor-21 concentration is associated with residual renal function and insulin resistance in end-stage renal disease patients receiving long-term peritoneal dialysis. , 2010, Metabolism: clinical and experimental.

[954]  K. Xiang,et al.  Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride. , 2010, Journal of hepatology.

[955]  N. Glaichenhaus,et al.  CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung , 2010, Nature Medicine.

[956]  D. Blacker,et al.  Systemic markers of inflammation are independently associated with S100B concentration: results of an observational study in subjects with acute ischaemic stroke , 2010, Journal of Neuroinflammation.

[957]  Guo-Hai Zhang,et al.  Resistin is associated with mortality in patients with traumatic brain injury , 2010, Critical care.

[958]  M. Beamer,et al.  Fractalkine/CX3CL1: a potential new target for inflammatory diseases. , 2010, Molecular interventions.

[959]  G. Zhu,et al.  Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro. , 2010, Experimental parasitology.

[960]  K. Midthjell,et al.  Lactoferrin is a novel predictor of fatal ischemic heart disease in diabetes mellitus type 2: long-term follow-up of the HUNT 1 study. , 2010, Atherosclerosis.

[961]  I. Tooyama,et al.  Deposition of lactoferrin in fibrillar-type senile plaques in the brains of transgenic mouse models of Alzheimer's disease , 2010, Neuroscience Letters.

[962]  T. Town,et al.  Targeting S100B in Cerebral Ischemia and in Alzheimer's Disease , 2010, Cardiovascular psychiatry and neurology.

[963]  S. Leppla,et al.  Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation. , 2010, Blood.

[964]  V. Leblanc,et al.  XIAP gene expression and function is regulated by autocrine and paracrine TGF-β signaling , 2010, Molecular Cancer.

[965]  M. Martínez-Chantar,et al.  Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. , 2010, Gastroenterology.

[966]  M. van Meurs,et al.  Leptin Exacerbates Sepsis-Mediated Morbidity and Mortality , 2010, The Journal of Immunology.

[967]  G. Remuzzi,et al.  Angiotensin II revisited: new roles in inflammation, immunology and aging , 2010, EMBO molecular medicine.

[968]  David J Weber,et al.  The Calcium-binding Protein S100B Down-regulates p53 and Apoptosis in Malignant Melanoma* , 2010, The Journal of Biological Chemistry.

[969]  A. Reinisch,et al.  Replicative senescence-associated gene expression changes in mesenchymal stromal cells are similar under different culture conditions , 2010, Haematologica.

[970]  P. Sonderegger,et al.  Agrin Binds BMP2, BMP4 and TGFβ1 , 2010, PloS one.

[971]  E. Jury,et al.  New role for Agrin in T cells and its potential importance in immune system regulation , 2010, Arthritis research & therapy.

[972]  Y. Hayashi,et al.  Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1 , 2010, Nature.

[973]  S. Park,et al.  The integrated stress response-associated signals modulates intestinal tumor cell growth by NSAID-activated gene 1 (NAG-1/MIC-1/PTGF-beta). , 2010, Carcinogenesis.

[974]  M. Yamaguchi.  Regucalcin and metabolic disorders: osteoporosis and hyperlipidemia are induced in regucalcin transgenic rats , 2010, Molecular and Cellular Biochemistry.

[975]  L. Ferrucci,et al.  The concept of multiple hormonal dysregulation. , 2010, Acta bio-medica : Atenei Parmensis.

[976]  H. Nagawa,et al.  Adiponectin suppresses tumorigenesis in Apc(Min)(/+) mice. , 2010, Cancer letters.

[977]  P. Allavena,et al.  Human glioma tumors express high levels of the chemokine receptor CX3CR1. , 2010, European cytokine network.

[978]  Louise A Knight,et al.  The effect of pentamidine on melanoma ex vivo , 2010, Anti-cancer drugs.

[979]  K. Kłosowska,et al.  Fractalkine-Induced Endothelial Cell Migration Requires MAP Kinase Signaling , 2010, Pathobiology (Basel).

[980]  S. Arora,et al.  Potential role of CXCL10 in the induction of cell injury and mitochondrial dysfunction , 2009, International journal of experimental pathology.

[981]  H. Bülow,et al.  The PAPS transporter PST-1 is required for heparan sulfation and is essential for viability and neural development in C. elegans , 2009, Journal of Cell Science.

[982]  R. Youle,et al.  The role of mitochondria in apoptosis*. , 2009, Annual review of genetics.

[983]  J. Flier,et al.  Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis. , 2009, Endocrinology.

[984]  C. Daniel,et al.  Thrombospondin-2 therapy ameliorates experimental glomerulonephritis via inhibition of cell proliferation, inflammation, and TGF-beta activation. , 2009, American journal of physiology. Renal physiology.

[985]  Yuquan Wei,et al.  Keratins modulate the shape and function of hepatocyte mitochondria: a mechanism for protection from apoptosis , 2009, Journal of Cell Science.

[986]  P. Carmeliet,et al.  Absence of Thrombospondin-2 Causes Age-Related Dilated Cardiomyopathy , 2009, Circulation.

[987]  M. Puig-Domingo,et al.  Long‐term effect of ghrelin on nutritional status and functional capacity in the elderly: a population‐based cohort study , 2009, Clinical endocrinology.

[988]  Z. Pan,et al.  MMP7 expression regulated by endocrine therapy in ERβ-positive colon cancer cells , 2009, Journal of experimental & clinical cancer research : CR.

[989]  J. Kanellopoulos,et al.  IL-33 Enhances Lipopolysaccharide-Induced Inflammatory Cytokine Production from Mouse Macrophages by Regulating Lipopolysaccharide Receptor Complex1 , 2009, The Journal of Immunology.

[990]  R. Vasan,et al.  Serum Resistin Concentrations and Risk of New Onset Heart Failure in Older Persons: The Health, Aging, and Body Composition (Health ABC) Study , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[991]  S. Leng,et al.  Upregulated monocytic expression of CXC chemokine ligand 10 (CXCL-10) and its relationship with serum interleukin-6 levels in the syndrome of frailty. , 2009, Cytokine.

[992]  F. Brozzi,et al.  S100B's double life: intracellular regulator and extracellular signal. , 2009, Biochimica et biophysica acta.

[993]  V. Perry,et al.  Microglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation , 2009, Glia.

[994]  A. Hoffman,et al.  Effects of an oral growth hormone secretagogue in older adults. , 2009, The Journal of clinical endocrinology and metabolism.

[995]  L. Kuller,et al.  Associations of Pentraxin 3 With Cardiovascular Disease and All-Cause Death: The Cardiovascular Health Study , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[996]  A. Waxman,et al.  IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins. , 2009, American journal of respiratory cell and molecular biology.

[997]  M. Fasshauer,et al.  Serum Levels of the Adipokine FGF21 Depend on Renal Function , 2009, Diabetes Care.

[998]  B. Yeganeh,et al.  Calreticulin regulates insulin receptor expression and its downstream PI3 Kinase/Akt signalling pathway. , 2008, Biochimica et biophysica acta.

[999]  T. Magin,et al.  A dominant vimentin mutant upregulates Hsp70 and the activity of the ubiquitin-proteasome system, and causes posterior cataracts in transgenic mice , 2008, Journal of Cell Science.

[1000]  Lianbo Yu,et al.  Detection of microRNA Expression in Human Peripheral Blood Microvesicles , 2008, PloS one.

[1001]  L. Mei,et al.  LRP4 Serves as a Coreceptor of Agrin , 2008, Neuron.

[1002]  S. Hubbard,et al.  Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK , 2008, Cell.

[1003]  A. Xu,et al.  Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury , 2008, Hepatology.

[1004]  T. M. Reeves,et al.  Agrin expression during synaptogenesis induced by traumatic brain injury. , 2008, Journal of neurotrauma.

[1005]  P. Sonderegger,et al.  Neurotrypsin cleaves agrin locally at the synapse , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[1006]  R. Hubbard,et al.  Plasma esterases and inflammation in ageing and frailty , 2008, European Journal of Clinical Pharmacology.

[1007]  J. Lee,et al.  Changes in the levels of plasma soluble fractalkine in patients with mild cognitive impairment and Alzheimer's disease , 2008, Neuroscience Letters.

[1008]  C. Jacobson,et al.  Agrin and neuregulin, expanding roles and implications for therapeutics. , 2008, Biotechnology advances.

[1009]  F. Schmitt,et al.  Regucalcin is expressed in rat mammary gland and prostate and down-regulated by 17β-estradiol , 2008, Molecular and Cellular Biochemistry.

[1010]  S. Uchiyama,et al.  Effect of zinc on gene expression in osteoblastic MC3T3-E1 cells: enhancement of Runx2, OPG, and regucalcin mRNA expressions , 2008, Molecular and Cellular Biochemistry.

[1011]  N. Gilhus,et al.  Serum matrix metalloproteinase-3 levels are elevated in myasthenia gravis , 2008, Journal of Neuroimmunology.

[1012]  T. Kawaguchi,et al.  Mutation in keratin 18 induces mitochondrial fragmentation in liver-derived epithelial cells. , 2008, Biochemical and biophysical research communications.

[1013]  R. Hubbard,et al.  Nutrition, Inflammation, and Leptin Levels in Aging and Frailty , 2008, Journal of the American Geriatrics Society.

[1014]  J. Moreno-Navarrete,et al.  Association of circulating lactoferrin concentration and 2 nonsynonymous LTF gene polymorphisms with dyslipidemia in men depends on glucose-tolerance status. , 2008, Clinical chemistry.

[1015]  H. Allgayer,et al.  The urokinase-system--role of cell proliferation and apoptosis. , 2008, Histology and histopathology.

[1016]  T. Wynn,et al.  Cellular and molecular mechanisms of fibrosis , 2008, The Journal of pathology.

[1017]  D. Kaplan,et al.  Trk signaling regulates neural precursor cell proliferation and differentiation during cortical development , 2007, Development.

[1018]  D. Isenberg,et al.  Agrin Signalling Contributes to Cell Activation and Is Overexpressed in T Lymphocytes from Lupus Patients1 , 2007, The Journal of Immunology.

[1019]  W. Pan,et al.  The fasting polypeptide FGF21 can enter brain from blood , 2007, Peptides.

[1020]  P. Sonderegger,et al.  Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[1021]  T. Koh,et al.  Urokinase-type plasminogen activator and macrophages are required for skeletal muscle hypertrophy in mice. , 2007, American journal of physiology. Cell physiology.

[1022]  J. Lawler,et al.  Thrombospondin-based antiangiogenic therapy. , 2007, Microvascular research.

[1023]  Baofeng Yang,et al.  Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95 2. , 2007, Endocrine-related cancer.

[1024]  A. Lokshin,et al.  Dynamic alteration of soluble serum biomarkers in healthy aging. , 2007, Cytokine.

[1025]  T. Yoo,et al.  Podocyte biology in diabetic nephropathy. , 2007, Kidney international. Supplement.

[1026]  J. Sanes,et al.  Synapse Loss in Cortex of Agrin-Deficient Mice after Genetic Rescue of Perinatal Death , 2007, The Journal of Neuroscience.

[1027]  A. Bilici,et al.  Tissue levels of adiponectin in breast cancer patients , 2007, Medical oncology.

[1028]  A. Körner,et al.  New Predictors of the Metabolic Syndrome in Children—Role of Adipocytokines , 2007, Pediatric Research.

[1029]  F. L. D. Silva,et al.  Complement activation in experimental and human temporal lobe epilepsy , 2007, Neurobiology of Disease.

[1030]  D. Cleveland,et al.  Inaugural Article: Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons , 2007 .

[1031]  A. Foussat,et al.  Interactions between CD47 and Thrombospondin Reduce Inflammation1 , 2007, The Journal of Immunology.

[1032]  Marinos C. Dalakas,et al.  β‐Amyloid is a substrate of autophagy in sporadic inclusion body myositis , 2007 .

[1033]  P. Carmeliet,et al.  Plasminogen activator inhibitor-1 production is pathogenetic in experimental murine diabetic renal disease , 2007, Diabetologia.

[1034]  E. Cooper,et al.  Synaptic transmission is impaired at neuronal autonomic synapses in agrin‐null mice , 2007, Developmental neurobiology.

[1035]  M. Yamaguchi,et al.  Suppression of regucalcin mRNA expression in the hearts of rats administered with free radical compound: the administration-induced death is accelerated in regucalcin transgenic rats. , 2007, International journal of molecular medicine.

[1036]  M. Ruegg,et al.  Agrin is highly expressed by chondrocytes and is required for normal growth , 2007, Histochemistry and Cell Biology.

[1037]  P. Fuerst,et al.  Defects in eye development in transgenic mice overexpressing the heparan sulfate proteoglycan agrin. , 2007, Developmental biology.

[1038]  P. Tak,et al.  Serum macrophage inhibitory cytokine 1 in rheumatoid arthritis: a potential marker of erosive joint destruction. , 2007, Arthritis and rheumatism.

[1039]  P. Bornstein,et al.  Thrombospondin 2 functions as an endogenous regulator of angiogenesis and inflammation in experimental glomerulonephritis in mice. , 2007, Journal of the American Society of Nephrology : JASN.

[1040]  N. Secher,et al.  Brain-derived neurotrophic factor (BDNF) and type 2 diabetes , 2007, Diabetologia.

[1041]  H. Satoh,et al.  Tetrahydrobiopterin prevents endothelial dysfunction and restores adiponectin levels in rats. , 2007, European journal of pharmacology.

[1042]  R. Bernards,et al.  Senescence, Wound Healing, and Cancer: the PAI-1 Connection , 2006, Cell cycle.

[1043]  T. Funahashi,et al.  [Mutations and polymorphisms in adiponectin gene]. , 2006, Nihon rinsho. Japanese journal of clinical medicine.

[1044]  I. Kovalszky,et al.  Agrin, a novel basement membrane component in human and rat liver, accumulates in cirrhosis and hepatocellular carcinoma , 2006, Laboratory Investigation.

[1045]  J. Danesh,et al.  Adiponectin and Coronary Heart Disease: A Prospective Study and Meta-Analysis , 2006, Circulation.

[1046]  S. Tang,et al.  Protective effects of EUK4010 on β‐amyloid(1–42) induced degeneration of neuronal cells , 2006, The European journal of neuroscience.

[1047]  H. Weiler,et al.  Plasma Adipokines and Body Composition in Response to Modest Dietary Manipulations in the Mouse , 2006, Obesity.

[1048]  M. Yamaguchi,et al.  Regucalcin increases Ca2+-ATPase activity in the heart mitochondria of normal and regucalcin transgenic rats. , 2006, International journal of molecular medicine.

[1049]  M. Suwa,et al.  Serum brain-derived neurotrophic factor level is increased and associated with obesity in newly diagnosed female patients with type 2 diabetes mellitus. , 2006, Metabolism: clinical and experimental.

[1050]  M. Dieudonné,et al.  Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells. , 2006, Biochemical and biophysical research communications.

[1051]  C. Bucana,et al.  Expression of chemokine receptors predicts the site of metastatic relapse in patients with axillary node positive primary breast cancer. , 2006, Annals of oncology : official journal of the European Society for Medical Oncology.

[1052]  J. Constans,et al.  Circulating markers of endothelial function in cardiovascular disease. , 2006, Clinica chimica acta; international journal of clinical chemistry.

[1053]  J. Schneider,et al.  Serum adiponectin levels are an independent predictor of the extent of coronary artery disease in men. , 2006, Journal of the American College of Cardiology.

[1054]  H. Brenner,et al.  Relationship of adiponectin with markers of systemic inflammation, atherogenic dyslipidemia, and heart failure in patients with coronary heart disease. , 2006, Clinical chemistry.

[1055]  Alessandro Antonelli,et al.  Increase of CXC chemokine CXCL10 and CC chemokine CCL2 serum levels in normal ageing. , 2006, Cytokine.

[1056]  C. Mantzoros,et al.  Adiponectin and cancer: a systematic review , 2006, British Journal of Cancer.

[1057]  S. Ye.  Influence of matrix metalloproteinase genotype on cardiovascular disease susceptibility and outcome. , 2006, Cardiovascular research.

[1058]  N. Ruderman,et al.  Mice Lacking Adiponectin Show Decreased Hepatic Insulin Sensitivity and Reduced Responsiveness to Peroxisome Proliferator-activated Receptor γ Agonists* , 2006, Journal of Biological Chemistry.

[1059]  David Pinson,et al.  CXCL10‐induced cell death in neurons: role of calcium dysregulation , 2006, The European journal of neuroscience.

[1060]  Z. Canturk,et al.  Serum levels of hepatoprotective peptide adiponectin in non-alcoholic fatty liver disease , 2006, European journal of gastroenterology & hepatology.

[1061]  M. Kowalski,et al.  RANTES and Chemotactic Activity in Synovial Fluids From Patients With Rheumatoid Arthritis and Osteoarthritis , 2005, Mediators of inflammation.

[1062]  S. Kihara,et al.  Adiponectin Inhibits Endothelial Synthesis of Interleukin-8 , 2005, Circulation research.

[1063]  I. Pogribny,et al.  S-Adenosylhomocysteine hydrolase deficiency: A second patient, the younger brother of the index patient, and outcomes during therapy , 2005, Journal of Inherited Metabolic Disease.

[1064]  O. Quehenberger,et al.  Expression of Fractalkine (CX3CL1) and its Receptor, CX3CR1, Is Elevated in Coronary Artery Disease and Is Reduced During Statin Therapy , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[1065]  B. Yu,et al.  Adiponectin induces growth arrest and apoptosis of MDA-MB-231 breast cancer cell , 2005, Archives of pharmacal research.

[1066]  Y. Abe,et al.  Plasma concentrations and importance of high mobility group box protein in the prognosis of organ failure in patients with disseminated intravascular coagulation , 2005, Thrombosis and Haemostasis.

[1067]  S. Müller,et al.  Exogenous High-Mobility Group Box 1 Protein Induces Myocardial Regeneration After Infarction via Enhanced Cardiac C-Kit+ Cell Proliferation and Differentiation , 2005, Circulation research.

[1068]  M. Visser,et al.  Endocrine and inflammatory markers as predictors of frailty , 2005, Clinical endocrinology.

[1069]  P. Muñoz-Cánoves,et al.  The plasminogen activation system in skeletal muscle regeneration: antagonistic roles of urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1). , 2005, Frontiers in bioscience : a journal and virtual library.

[1070]  I. McDowell,et al.  A global clinical measure of fitness and frailty in elderly people , 2005, Canadian Medical Association Journal.

[1071]  A. Ishigami,et al.  [Molecular abnormality in aging: its contribution to clinical pathology]. , 2005, Rinsho byori. The Japanese journal of clinical pathology.

[1072]  T. Koh,et al.  Mice deficient in plasminogen activator inhibitor-1 have improved skeletal muscle regeneration. , 2005, American journal of physiology. Cell physiology.

[1073]  P. Barzaghi,et al.  Overexpression of mini‐agrin in skeletal muscle increases muscle integrity and regenerative capacity in laminin‐α2‐deficient mice , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[1074]  D. Souza,et al.  Ontogenetic changes in serum S100B in Down syndrome patients. , 2005, Clinical biochemistry.

[1075]  N. Kieffer,et al.  The intermediate filament protein vimentin binds specifically to a recombinant integrin α2/β1 cytoplasmic tail complex and co-localizes with native α2/β1 in endothelial cell focal adhesions , 2005 .

[1076]  Daniel W Stashuk,et al.  Motor unit number estimates in the tibialis anterior muscle of young, old, and very old men , 2005, Muscle & nerve.

[1077]  C. Gladson,et al.  Endogenous inhibitors of angiogenesis in malignant gliomas: nature's antiangiogenic therapy. , 2005, Neuro-oncology.

[1078]  M. Freeman,et al.  Distinct Roles of Pattern Recognition Receptors CD14 and Toll-Like Receptor 4 in Acute Lung Injury , 2005, Infection and Immunity.

[1079]  S. Baek,et al.  The conventional nonsteroidal anti-inflammatory drug sulindac sulfide arrests ovarian cancer cell growth via the expression of NAG-1/MIC-1/GDF-15 , 2005, Molecular Cancer Therapeutics.

[1080]  N. Chalasani,et al.  Is Adiponectin Involved in the Pathogenesis of Nonalcoholic Steatohepatitis?: A Preliminary Human Study , 2005, Journal of clinical gastroenterology.

[1081]  O. Tirosh,et al.  αMUPA mice: a transgenic model for longevity induced by caloric restriction , 2005, Mechanisms of Ageing and Development.

[1082]  K. Eriksson,et al.  Complement C3 is a risk factor for the development of diabetes: a population-based cohort study. , 2005, Diabetes.

[1083]  L. Feuk,et al.  Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene. , 2005, Human molecular genetics.

[1084]  W. Shimizu,et al.  Effects of Ghrelin Administration on Left Ventricular Function, Exercise Capacity, and Muscle Wasting in Patients With Chronic Heart Failure , 2004, Circulation.

[1085]  M. Detmar,et al.  Thrombospondin 2 functions as an endogenous regulator of angiogenesis and inflammation in rheumatoid arthritis. , 2004, The American journal of pathology.

[1086]  Youngho Kim,et al.  Neutrophil lactoferrin upregulates the human p53 gene through induction of NF-κB activation cascade , 2004, Oncogene.

[1087]  S. Kihara,et al.  Adiponectin as a biomarker of the metabolic syndrome. , 2004, Circulation journal : official journal of the Japanese Circulation Society.

[1088]  C. Fuhrer,et al.  A Single Pulse of Agrin Triggers a Pathway That Acts To Cluster Acetylcholine Receptors , 2004, Molecular and Cellular Biology.

[1089]  S. Rosenkranz.  TGF-β1 and angiotensin networking in cardiac remodeling , 2004 .

[1090]  K. Behar,et al.  Comparing adiposity profiles in three mouse models with altered GH signaling. , 2004, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[1091]  B. Riggs,et al.  A genetic basis for the “Adonis” phenotype of low adiposity and strong bones , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[1092]  M. Yamaguchi,et al.  Role of regucalcin in liver nuclear function: binding of regucalcin to nuclear protein or DNA and modulation of tumor-related gene expression. , 2004, International journal of molecular medicine.

[1093]  E. Lane,et al.  Keratin 8/18 breakdown and reorganization during apoptosis. , 2004, Experimental cell research.

[1094]  D. Taub,et al.  Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. , 2004, The Journal of clinical investigation.

[1095]  A. Ishigami,et al.  Senescence Marker Protein‐30 Knockout Mouse as an Aging Model , 2004, Annals of the New York Academy of Sciences.

[1096]  Cynthia J. Girman,et al.  Plasma adiponectin levels and risk of myocardial infarction in men. , 2004, JAMA.

[1097]  Á. Chamorro,et al.  Activation of Matrix Metalloproteinase‐3 and Agrin Cleavage in Cerebral Ischemia/Reperfusion , 2004, Journal of neuropathology and experimental neurology.

[1098]  S. Kihara,et al.  Selective Suppression of Endothelial Cell Apoptosis by the High Molecular Weight Form of Adiponectin , 2004, Circulation research.

[1099]  S. Müller,et al.  Regulated expression and subcellular localization of HMGB1, a chromatin protein with a cytokine function , 2004, Journal of internal medicine.

[1100]  R. Kammerer,et al.  Modulation of agrin function by alternative splicing and Ca2+ binding. , 2004, Structure.

[1101]  C. Mantzoros,et al.  Adiponectin and breast cancer risk. , 2004, The Journal of clinical endocrinology and metabolism.

[1102]  S. Kihara,et al.  Obesity, adiponectin and vascular inflammatory disease , 2003, Current opinion in lipidology.

[1103]  S. Kihara,et al.  Association of serum adiponectin levels with breast cancer risk. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[1104]  M. Werle,et al.  Structural alterations at the neuromuscular junctions of matrix metalloproteinase 3 null mutant mice , 2003, Journal of neurocytology.

[1105]  S. Blankenberg,et al.  Adhesion molecules and atherosclerosis. , 2003, Atherosclerosis.

[1106]  M. Yamaguchi,et al.  Decrease in regucalcin level and enhancement of protein tyrosine phosphatase activity in rat brain microsomes with increasing age. , 2003, International journal of molecular medicine.

[1107]  L. Vassilev,et al.  Macrophage inhibitory cytokine-1: a novel biomarker for p53 pathway activation. , 2003, Molecular cancer therapeutics.

[1108]  E. Sadoun,et al.  Impaired Angiogenesis in Aging Is Associated with Alterations in Vessel Density, Matrix Composition, Inflammatory Response, and Growth Factor Expression , 2003, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[1109]  B. Nicklas,et al.  Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesity. , 2003, Diabetes care.

[1110]  R. Nitsch,et al.  Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22.2 , 2003, Neurogenetics.

[1111]  Yu Wang,et al.  The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. , 2003, The Journal of clinical investigation.

[1112]  G. Bezakova,et al.  New insights into the roles of agrin , 2003, Nature Reviews Molecular Cell Biology.

[1113]  M. Crow,et al.  Caspase‐dependent cleavage of myosin light chain kinase (MLCK) is involved in TNF‐α‐mediated bovine pulmonary endothelial cell apoptosis , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[1114]  P. Kubes,et al.  Human fractalkine mediates leukocyte adhesion but not capture under physiological shear conditions; a mechanism for selective monocyte recruitment , 2003, European journal of immunology.

[1115]  S. Kihara,et al.  Association of Hypoadiponectinemia With Coronary Artery Disease in Men , 2003, Arteriosclerosis, thrombosis, and vascular biology.

[1116]  Yong Y. He,et al.  Differential Regulation of Thrombospondin-1 and Thrombospondin-2 After Focal Cerebral Ischemia/Reperfusion , 2003, Stroke.

[1117]  E. Olson,et al.  Cardiac-specific Expression of Calcineurin Reverses Embryonic Lethality in Calreticulin-deficient Mouse* , 2002, The Journal of Biological Chemistry.

[1118]  B. Vellas,et al.  Is There a Relationship Between Fat‐Free Soft Tissue Mass and Low Cognitive Function? Results From a Study of 7,105 Women , 2002, Journal of the American Geriatrics Society.

[1119]  P. Crean,et al.  Prediction of cardiovascular risk using soluble cell adhesion molecules. , 2002, European heart journal.

[1120]  P. Saha,et al.  Increased β-Oxidation but No Insulin Resistance or Glucose Intolerance in Mice Lacking Adiponectin* , 2002, The Journal of Biological Chemistry.

[1121]  E. Cooper,et al.  Agrin plays an organizing role in the formation of sympathetic synapses , 2002, The Journal of cell biology.

[1122]  Philippe Froguel,et al.  Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation* , 2002, The Journal of Biological Chemistry.

[1123]  Kathleen Koenig,et al.  Serum Interleukin‐6 and Hemoglobin as Physiological Correlates in the Geriatric Syndrome of Frailty: A Pilot Study , 2002, Journal of the American Geriatrics Society.

[1124]  M. Matsuda,et al.  Diet-induced insulin resistance in mice lacking adiponectin/ACRP30 , 2002, Nature Medicine.

[1125]  O. Yoshie,et al.  Dual Functions of Fractalkine/CX3C Ligand 1 in Trafficking of Perforin+/Granzyme B+ Cytotoxic Effector Lymphocytes That Are Defined by CX3CR1 Expression , 2002, The Journal of Immunology.

[1126]  I. Rebelo,et al.  Erythrocyte damage and leukocyte activation in ischemic stroke. , 2002, Clinica chimica acta; international journal of clinical chemistry.

[1127]  P. D. de Tombe,et al.  Functional consequences of caspase activation in cardiac myocytes , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[1128]  J. Bixby,et al.  A neuronal inhibitory domain in the N-terminal half of agrin. , 2002, Journal of neurobiology.

[1129]  G. Cao,et al.  Schwann Cells Express Active Agrin and Enhance Aggregation of Acetylcholine Receptors on Muscle Fibers , 2001, The Journal of Neuroscience.

[1130]  C. Leeuwenburgh,et al.  Apoptosis and aging: role of the mitochondria. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[1131]  J. Sanes,et al.  Induction, assembly, maturation and maintenance of a postsynaptic apparatus , 2001, Nature reviews. Neuroscience.

[1132]  D. C. Woodruff,et al.  Fractalkine, a novel chemokine in rheumatoid arthritis and in rat adjuvant-induced arthritis. , 2001, Arthritis and rheumatism.

[1133]  V. Henderson,et al.  Clock Drawing: Analysis in a Retirement Community , 2001, Journal of the American Geriatrics Society.

[1134]  T. Lømo,et al.  Effects of Purified Recombinant Neural and Muscle Agrin on Skeletal Muscle Fibers in Vivo , 2001, The Journal of cell biology.

[1135]  J. Fallon,et al.  Shaping Membrane Architecture , 2001, The Journal of cell biology.

[1136]  Eric Vivier,et al.  Agrin--A Bridge Between the Nervous and Immune Systems , 2001, Science.

[1137]  M. Soloski,et al.  Physiological Regulation of the Immunological Synapse by Agrin , 2001, Science.

[1138]  J. Sanes,et al.  Motoneuron Survival Is Enhanced in the Absence of Neuromuscular Junction Formation in Embryos , 2001, The Journal of Neuroscience.

[1139]  F. Chen,et al.  Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis , 2001, Cell Death and Differentiation.

[1140]  A. Groffen,et al.  Decreased Glomerular Expression of Agrin in Diabetic Nephropathy and Podocytes, Cultured in High Glucose Medium , 2001, Nephron Experimental Nephrology.

[1141]  L. Fried,et al.  Associations of subclinical cardiovascular disease with frailty. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[1142]  L. Fried,et al.  Frailty in older adults: evidence for a phenotype. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[1143]  M. Ruegg,et al.  An Alternative Amino-Terminus Expressed in the Central Nervous System Converts Agrin to a Type II Transmembrane Protein , 2001, Molecular and Cellular Neuroscience.

[1144]  A. Villa,et al.  Agrin Controls Synaptic Differentiation in Hippocampal Neurons , 2000, The Journal of Neuroscience.

[1145]  J. Sanes,et al.  Agrin isoforms with distinct amino termini: differential expression, localization, and function. , 2000 .

[1146]  NoriyukiOuchi,et al.  Adiponectin, an Adipocyte-Derived Plasma Protein, Inhibits Endothelial NF-&kgr;B Signaling Through a cAMP-Dependent Pathway , 2000, Circulation.

[1147]  Michael J. Werle,et al.  Matrix metalloproteinase-3 removes agrin from synaptic basal lamina. , 2000, Journal of neurobiology.

[1148]  C. Tanikawa,et al.  Identification of fractalkine, a CX3C-type chemokine, as a direct target of p53. , 2000, Cancer research.

[1149]  Paul Martin,et al.  Impaired wound healing in embryonic and adult mice lacking vimentin. , 2000, Journal of cell science.

[1150]  M. Yamaguchi,et al.  Stimulatory effect of regucalcin on ATP‐dependent Ca2+ uptake activity in rat liver mitochondria , 2000, Journal of cellular biochemistry.

[1151]  T Nakamura,et al.  Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[1152]  C. Franceschi,et al.  Inflamm‐aging: An Evolutionary Perspective on Immunosenescence , 2000 .

[1153]  J. Fahey,et al.  Distinct categories of immunologic changes in frail elderly , 2000, Mechanisms of Ageing and Development.

[1154]  H. van Essen,et al.  Altered flow-induced arterial remodeling in vimentin-deficient mice. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[1155]  M. Rafii,et al.  Agrin and microvascular damage in Alzheimer’s disease , 2000, Neurobiology of Aging.

[1156]  W. Halfter,et al.  Agrin Binds to β-Amyloid (Aβ), Accelerates Aβ Fibril Formation, and Is Localized to Aβ Deposits in Alzheimer's Disease Brain , 2000, Molecular and Cellular Neuroscience.

[1157]  M. Detmar,et al.  Thrombospondin-2: a potent endogenous inhibitor of tumor growth and angiogenesis. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[1158]  P. Wesseling,et al.  Agrin is a major heparan sulfate proteoglycan accumulating in Alzheimer's disease brain. , 1999, The American journal of pathology.

[1159]  Werner Hoch,et al.  Formation of the neuromuscular junction , 1999 .

[1160]  H. Gordon,et al.  Agrin-independent activation of the agrin signal transduction pathway. , 1999, Journal of neurobiology.

[1161]  Martin A. Smith,et al.  Evidence of an Agrin Receptor in Cortical Neurons , 1999, The Journal of Neuroscience.

[1162]  D. O'Dowd,et al.  Formation of functional synaptic connections between cultured cortical neurons from agrin-deficient mice. , 1999, Journal of neurobiology.

[1163]  M. Rafii,et al.  Agrin in Alzheimer's Disease: Altered Solubility and Abnormal Distribution within Microvasculature and Brain Parenchyma , 1999 .

[1164]  G. Yancopoulos,et al.  Distinct phenotypes of mutant mice lacking agrin, MuSK, or rapsyn. , 1999, Brain research. Developmental brain research.

[1165]  J. Sanes,et al.  Alternatively Spliced Isoforms of Nerve- and Muscle-Derived Agrin Their Roles at the Neuromuscular Junction , 1999, Neuron.

[1166]  J. Fallon,et al.  The role of alternative splicing in regulating agrin binding to muscle cells. , 1998, Brain research. Developmental brain research.

[1167]  R. Nagai,et al.  Klotho protein protects against endothelial dysfunction. , 1998, Biochemical and biophysical research communications.

[1168]  Jeff W. Lichtman,et al.  Development of the neuromuscular junction: Genetic analysis in mice , 1998, Journal of Physiology-Paris.

[1169]  A. Groffen,et al.  Primary structure and high expression of human agrin in basement membranes of adult lung and kidney. , 1998, European journal of biochemistry.

[1170]  J. Sanes,et al.  Agrin Receptors at the Skeletal Neuromuscular Junction , 1998, Annals of the New York Academy of Sciences.

[1171]  M. Rimer.  Agrin‐induced Aggregation of Acetylcholine Receptors in Muscles of Rats with Experimental Autoimmune Myasthenia Gravis a , 1998, Annals of the New York Academy of Sciences.

[1172]  Steven Finkbeiner,et al.  Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism , 1998, Neuron.

[1173]  S. Burden.  The formation of neuromuscular synapses. , 1998, Genes & development.

[1174]  J. Bixby,et al.  Agrin orchestrates synaptic differentiation at the vertebrate neuromuscular junction , 1998, Trends in Neurosciences.

[1175]  K. Tsim,et al.  Antisense Agrin cDNA Transfection Blocks Neuroblastoma Cell-Induced Acetylcholine Receptor Aggregation When Co-cultured with Myotubes , 1997, Molecular and Cellular Neuroscience.

[1176]  M. Omary,et al.  Apoptosis Generates Stable Fragments of Human Type I Keratins* , 1997, The Journal of Biological Chemistry.

[1177]  Tadashi Kaname,et al.  Mutation of the mouse klotho gene leads to a syndrome resembling ageing , 1997, Nature.

[1178]  D. Black,et al.  A unique intronic splicing enhancer controls the inclusion of the agrin Y exon. , 1997, RNA.

[1179]  J. Bixby,et al.  Evidence That Agrin directly Influences Presynaptic Differentiation at Neuromuscular Junctions In Vitro , 1997, The European journal of neuroscience.

[1180]  M. Ruegg,et al.  Neural Agrin Induces Ectopic Postsynaptic Specializations in Innervated Muscle Fibers , 1997, The Journal of Neuroscience.

[1181]  R. Miskin,et al.  Transgenic mice overexpressing urokinase-type plasminogen activator in the brain exhibit reduced food consumption, body weight and size, and increased longevity. , 1997, The journals of gerontology. Series A, Biological sciences and medical sciences.

[1182]  A. Barber,et al.  Agrin accumulates in the brain microvascular basal lamina during development of the blood‐brain barrier , 1997 .

[1183]  S. Mann,et al.  Agrin Is Synthesized by Retinal Cells and Colocalizes with Gephyrin [corrected title] , 1996, Molecular and Cellular Neuroscience.

[1184]  K. Freedland,et al.  Iatrogenic Congestive Heart Failure in Older Adults: Clinical Course and Prognosis , 1996, Journal of the American Geriatrics Society.

[1185]  P. Distefano,et al.  The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo , 1996, Cell.

[1186]  P. Distefano,et al.  Agrin Acts via a MuSK Receptor Complex , 1996, Cell.

[1187]  J. Sanes,et al.  Defective Neuromuscular Synaptogenesis in Agrin-Deficient Mutant Mice , 1996, Cell.

[1188]  J. Silver,et al.  Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. , 1996, Immunity.

[1189]  M. Yamaguchi,et al.  Expression of hepatic calcium-binding protein regucalcin mRNA is decreased by phenobarbital administration in rats , 1994, Molecular and Cellular Biochemistry.

[1190]  R. Hodes.  Frailty and Disability: Can Growth Hormone Or Other Trophic Agents Make a Difference? , 1994, Journal of the American Geriatrics Society.

[1191]  J. Morley,et al.  Trophic Factors in Aging , 1994 .

[1192]  P. Carmeliet,et al.  Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization. , 1993, The Journal of clinical investigation.

[1193]  M. Sporn,et al.  Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[1194]  D. Blake,et al.  Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C1q. The complete derived amino acid sequence of human C1q. , 1991, The Biochemical journal.

[1195]  H. Cohen,et al.  The role of the cytoskeleton in aging , 1990, Experimental Gerontology.

[1196]  R. Ulevitch,et al.  CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. , 1990, Science.

[1197]  D. White,et al.  Characterization of Bacteria That Suppress Rhizoctonia Damping-Off in Bark Compost Media by Analysis of Fatty Acid Biomarkers , 1989, Applied and environmental microbiology.

[1198]  Andrew D. Luster,et al.  γ-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins , 1985, Nature.

[1199]  H. Hays.  Home care of the frail elderly and the terminally ill. , 1984, Canadian family physician Medecin de famille canadien.

[1200]  J. Friend.  Alas for Human Frailties! , 1954, Science.

[1201]  Dimitris Tousoulis,et al.  Biomarkers in Aortic Valve Stenosis and their Clinical Significance in Transcatheter Aortic Valve Implantation. , 2019, Current medicinal chemistry.

[1202]  M. Kuro-o.  Klotho and endocrine fibroblast growth factors: markers of chronic kidney disease progression and cardiovascular complications? , 2019, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[1203]  H. Kim,et al.  High fibroblast growth factor 23 is associated with coronary calcification in patients with high adiponectin: analysis from the KoreaN cohort study for Outcome in patients With Chronic Kidney Disease (KNOW-CKD) study , 2019, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[1204]  S. Wong,et al.  Pentraxin-3 as a marker of sepsis severity and predictor of mortality outcomes: A systematic review and meta-analysis. , 2018, The Journal of infection.

[1205]  M. Presta,et al.  Long pentraxin 3: A novel multifaceted player in cancer. , 2018, Biochimica et biophysica acta. Reviews on cancer.

[1206]  R. Seeley,et al.  Dietary Manipulations That Induce Ketosis Activate the HPA Axis in Male Rats and Mice: A Potential Role for Fibroblast Growth Factor-21 , 2018, Endocrinology.

[1207]  G. Binetti,et al.  Serum C-Peptide, Visfatin, Resistin, and Ghrelin are Altered in Sporadic and GRN-Associated Frontotemporal Lobar Degeneration. , 2018, Journal of Alzheimer's disease : JAD.

[1208]  F. Safadi,et al.  Glycoprotein Nonmelanoma Clone B Regulates the Crosstalk between Macrophages and Mesenchymal Stem Cells toward Wound Repair. , 2018, The Journal of investigative dermatology.

[1209]  J. Xu,et al.  MiR-34a regulates mitochondrial content and fat ectopic deposition induced by resistin through the AMPK/PPARα pathway in HepG2 cells. , 2018, The international journal of biochemistry & cell biology.

[1210]  Hua Wang,et al.  Prognostic value of growth differentiation factor-15 in Chinese patients with heart failure: A prospective observational study. , 2018, Cardiology journal.

[1211]  Yue Guo,et al.  Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-κB-mediated inflammation both in vitro and in vivo. , 2018, Biochimica et biophysica acta. Molecular basis of disease.

[1212]  Ryo Ueta,et al.  [Homeostasis and Disorder of Musculoskeletal System.Molecular signaling and its pathogenic alterations in neuromuscular junction formation.] , 2018, Clinical calcium.

[1213]  Lan Xiang,et al.  Leptin Gene Transfer Improves Symptoms of Type 2 Diabetic Mice by Regulating Leptin Signaling Pathway and Insulin Resistance of Peripheral Tissues. , 2018, Human gene therapy.

[1214]  S. Ferguson,et al.  Neurodegenerative Markers are Increased in Postmortem BA21 Tissue from African Americans with Alzheimer's Disease. , 2017, Journal of Alzheimer's disease : JAD.

[1215]  G. Pawelec,et al.  Polymorphonuclear Neutrophil Functions are Differentially Altered in Amnestic Mild Cognitive Impairment and Mild Alzheimer's Disease Patients. , 2017, Journal of Alzheimer's disease : JAD.

[1216]  R. Savino,et al.  C3f is a potential tool for the staging of osteoarthritis. , 2017, Journal of biological regulators and homeostatic agents.

[1217]  Š. Kutílek.  Burosumab: A new drug to treat hypophosphatemic rickets. , 2017, Sudanese journal of paediatrics.

[1218]  D. Agrawal,et al.  Clinical Implications of High-mobility Group Box-1 (HMGB1) and the Receptor for Advanced Glycation End-products (RAGE) in Cutaneous Malignancy: A Systematic Review. , 2017, Anticancer research.

[1219]  Xingshun Xu,et al.  Exogenous Adipokine Peptide Resistin Protects Against Focal Cerebral Ischemia/Reperfusion Injury in Mice , 2017, Neurochemical Research.

[1220]  M. Targosz-Gajniak,et al.  Cognitive impairment and BDNF serum levels. , 2017, Neurologia i neurochirurgia polska.

[1221]  Jing Liu,et al.  Therapeutic Use of Tumor Cell-Derived Extracellular Vesicles. , 2017, Methods in molecular biology.

[1222]  P. Fissler,et al.  Novel Blood-Based Biomarkers of Cognition, Stress, and Physical or Cognitive Training in Older Adults at Risk of Dementia: Preliminary Evidence for a Role of BDNF, Irisin, and the Kynurenine Pathway. , 2017, Journal of Alzheimer's disease : JAD.

[1223]  J. López,et al.  New insights into adipokines as potential biomarkers for type-2 diabetes mellitus. , 2017, Current medicinal chemistry.

[1224]  Zhihong Li,et al.  Adiponectin: A biomarker for chronic hepatitis C? , 2017, Cytokine.

[1225]  H. Ji,et al.  Inflammation in lung after acute myocardial infarction is induced by dendritic cell-mediated immune response. , 2017, Journal of biological regulators and homeostatic agents.

[1226]  A. Suleyman,et al.  The effect of iloprost and sildenafil, alone and in combination, on myocardial ischaemia and nitric oxide and irisin levels , 2017, Cardiovascular Journal of Africa.

[1227]  H. Ishikawa,et al.  Serum Fibroblast Growth Factor 23 (FGF23) in Patients with Rheumatoid Arthritis. , 2016, Internal medicine.

[1228]  J. Brieger,et al.  Growth differentiation factor 15 as a radiation-induced marker in oral carcinoma increasing radiation resistance. , 2016, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[1229]  M. Kawai,et al.  The FGF23/KLOTHO Regulatory Network and Its Roles in Human Disorders. , 2016, Vitamins and hormones.

[1230]  E. Zeldich,et al.  Klotho Is a Neuroprotective and Cognition-Enhancing Protein. , 2016, Vitamins and hormones.

[1231]  K. Panati,et al.  Irisin/FNDC5--An updated review. , 2016, European review for medical and pharmacological sciences.

[1232]  S. Mayeur,et al.  Lactoferrin, a Pleiotropic Protein in Health and Disease. , 2016, Antioxidants & redox signaling.

[1233]  S. Ohlmeier,et al.  Biomarkers in Lung Diseases : from Pathogenesis to Prediction to New Therapies Lung tissue proteomics identifies elevated transglutaminase 2 levels in stable chronic obstructive pulmonary disease , 2016 .

[1234]  Kenneth W Witwer,et al.  Circulating microRNA biomarker studies: pitfalls and potential solutions. , 2015, Clinical chemistry.

[1235]  M. Sopjani,et al.  Intracellular signaling of the aging suppressor protein Klotho. , 2015, Current molecular medicine.

[1236]  T. Kojima,et al.  GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases. , 2015, Mitochondrion.

[1237]  D. Vriens,et al.  Serum GDF15 Levels Correlate to Mitochondrial Disease Severity and Myocardial Strain, but Not to Disease Progression in Adult m.3243A>G Carriers. , 2015, JIMD reports.

[1238]  Jose M Garcia,et al.  Anamorelin for patients with cancer cachexia: an integrated analysis of two phase 2, randomised, placebo-controlled, double-blind trials. , 2015, The Lancet. Oncology.

[1239]  M. Çakmak,et al.  The Effects of Valsartan and Amlodipine on the Levels of Irisin, Adropin, and Perilipin. , 2015, Clinical laboratory.

[1240]  M. Drey,et al.  C-terminal agrin fragment (CAF) reflects renal function in patients suffering from severe sepsis or septic shock. , 2015, Clinical laboratory.

[1241]  P. Codoñer-Franch,et al.  Plasma resistin levels are associated with homocysteine, endothelial activation, and nitrosative stress in obese youths. , 2014, Clinical biochemistry.

[1242]  M. Ratajczak,et al.  Links between growth hormone and aging. , 2013, Endokrynologia Polska.

[1243]  B. Bartali,et al.  Klotho, FGF21 and FGF23: Novel Pathways to Musculoskeletal Health? , 2013, The Journal of frailty & aging.

[1244]  David J Weber,et al.  The evolution of S100B inhibitors for the treatment of malignant melanoma. , 2013, Future medicinal chemistry.

[1245]  T. Funahashi,et al.  Three-month treatment with pioglitazone reduces circulating C1q-binding adiponectin complex to total-adiponectin ratio, without changes in body mass index, in people with type 2 diabetes. , 2013, Diabetes research and clinical practice.

[1246]  H. Gürvit,et al.  BDNF, TNFα, HSP90, CFH, and IL-10 serum levels in patients with early or late onset Alzheimer's disease or mild cognitive impairment. , 2013, Journal of Alzheimer's disease : JAD.

[1247]  D. Amberg,et al.  Cellular ageing and the actin cytoskeleton. , 2012, Sub-cellular biochemistry.

[1248]  J. Vencovský,et al.  Novel adipokine fibroblast growth factor 21 is increased in rheumatoid arthritis. , 2012, Physiological research.

[1249]  M. Waters,et al.  Growth hormone and cell growth. , 2012, Endocrine development.

[1250]  A. Xu,et al.  Distinct changes in serum fibroblast growth factor 21 levels in different subtypes of diabetes. , 2012, The Journal of clinical endocrinology and metabolism.

[1251]  M. Brandi,et al.  Phosphatonins: physiological role and pathological changes. , 2012, Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases.

[1252]  M. Kuro-o,et al.  Klotho deficiency causes vascular calcification in chronic kidney disease. , 2011, Journal of the American Society of Nephrology : JASN.

[1253]  K. Miyazono,et al.  TGF-β in aging and disease , 2011, Cell and Tissue Research.

[1254]  J. Grande,et al.  Effects of chronic vs. intermittent calorie restriction on mammary tumor incidence and serum adiponectin and leptin levels in MMTV-TGF-α mice at different ages. , 2010, Oncology letters.

[1255]  I. Kaupe,et al.  Signal transduction and metabolism in chondrocytes is modulated by lactoferrin. , 2010, Osteoarthritis and cartilage.

[1256]  M. Fasshauer,et al.  Serum fibroblast growth factor 21 levels in gestational diabetes mellitus in relation to insulin resistance and dyslipidemia. , 2010, Metabolism: clinical and experimental.

[1257]  C. Marshall,et al.  Regulation of cell signalling by uPAR , 2010, Nature Reviews Molecular Cell Biology.

[1258]  Wen-chao Song,et al.  Complement and its role in innate and adaptive immune responses , 2010, Cell Research.

[1259]  A. Nowakowski,et al.  Evaluation of concentrations of FGF-21 - a new adipocytokine in type 2 diabetes. , 2010, Endokrynologia Polska.

[1260]  A. Ishigami.  [Anti-aging research using SMP30/GNL knockout mice]. , 2010, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[1261]  Christian Gieger,et al.  Six new loci associated with body mass index highlight a neuronal influence on body weight regulation , 2009, Nature Genetics.

[1262]  A. Kunamneni,et al.  Urokinase-a very popular cardiovascular agent. , 2008, Recent patents on cardiovascular drug discovery.

[1263]  L. Zitvogel,et al.  Calreticulin exposure dictates the immunogenicity of cancer cell death , 2007, Nature Medicine.

[1264]  D. Tang,et al.  Dissociation of Crk-associated substrate from the vimentin network is regulated by p21-activated kinase on ACh activation of airway smooth muscle. , 2007, American journal of physiology. Lung cellular and molecular physiology.

[1265]  G. Johnson,et al.  Transglutaminase 2 in neurodegenerative disorders. , 2007, Frontiers in bioscience : a journal and virtual library.

[1266]  Y. Deshaies,et al.  A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. , 2004, Endocrinology.

[1267]  H. Rus,et al.  The role of complement activation in atherosclerosis , 2004, Immunologic research.

[1268]  S. Papa,et al.  Reactive oxygen species, mitochondria, apoptosis and aging , 2004, Molecular and Cellular Biochemistry.

[1269]  S. Bandinelli,et al.  Biomarkers of frailty in older persons. , 2002, Journal of endocrinological investigation.

[1270]  E. Huang,et al.  Neurotrophins: roles in neuronal development and function. , 2001, Annual review of neuroscience.

[1271]  N. Daigle,et al.  Keratin-mediated resistance to stress and apoptosis in simple epithelial cells in relation to health and disease. , 2001, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[1272]  G. Feng,et al.  Synapse formation by hippocampal neurons from agrin-deficient mice. , 1999, Developmental biology.

[1273]  J. Broeck,et al.  Hormones and the cytoskeleton of animals and plants. , 1996, International review of cytology.

[1274]  M. Brownlee,et al.  Advanced protein glycosylation in diabetes and aging. , 1995, Annual review of medicine.

[1275]  E. Gallagher,et al.  Effects of complex waste mixtures on hepatic monooxygenase activities in brown bullheads (Ictalurus nebulosus). , 1989, Environmental pollution.

[1276]  E. Masoro.  Food restriction research: Its significance for human aging , 1989, American journal of human biology : the official journal of the Human Biology Council.

[1277]  Colin L. Mastersa,et al.  Peripheral (cid:1) -Defensins 1 and 2 are Elevated in Alzheimer’s Disease , 2022 .

[1278]  Xiaokun Li,et al.  O R I G I N a L I N V E S T I G a T I O N Open Access Fibroblast Growth Factor 21 Deletion Aggravates Diabetes-induced Pathogenic Changes in the Aorta in Type 1 Diabetic Mice , 2022 .