Instructional Course Lectures, The American Academy of Orthopaedic Surgeons - Common Complications of Total Knee Arthroplasty*†

The success of a total joint arthroplasty is contingent on a clear understanding of the potential complications of the procedure. This Instructional Course Lecture presents a review of specific problems related to wound-healing, neurovascular injuries, infections, thromboembolic disease, the extensor mechanism, stiffness, and periprosthetic fractures to provide the reader with a clear understanding of ways to avoid and treat these common complications. Primary wound-healing is critical for the success of any total knee arthroplasty. Any delay in wound-healing increases the risk of infection and failure of the arthroplasty214,216. The prevention of soft-tissue problems through the selection of the proper skin incision, an understanding of the vascular anatomy and patient-related risk factors, and prompt treatment of wound problems (should they arise) are imperative if a good result is to be achieved. ### Vascular Anatomy The blood supply to the soft tissues of the anterior aspect of the knee is completely random, with contributions from multiple vessels2,23,43,161,203,258,295. This blood supply arises predominantly from the terminal branches of the peripatellar anastomotic arterial ring, which has numerous contributing arterial branches, including the medial and lateral superior genicular arteries, the medial and lateral inferior genicular arteries, the supreme genicular artery, the anterior tibial recurrent artery, and a branch of the profunda femoris artery. In contrast to the skin circulation of the thigh proximal to the knee, there is no underlying muscle or intermuscular septum directly anterior to the knee to provide a direct pathway for arterial perforators43,161. Skin circulation in this area is dependent on the dermal plexus, which originates directly from arterioles traveling within the subcutaneous fascia. Any operative dissection performed superficial to this subcutaneous fascia disrupts the arterial supply to the skin and increases …

[1]  J. P. Green,et al.  Steroid therapy and wound healing in surgical patients , 1965, The British journal of surgery.

[2]  C. Ranawat,et al.  A comparison of four models of total knee-replacement prostheses. , 1976, The Journal of bone and joint surgery. American volume.

[3]  W. Hozack,et al.  The treatment of patellar fractures after total knee arthroplasty. , 1988, Clinical orthopaedics and related research.

[4]  J. Insall,et al.  Technical considerations of total knee arthroplasty after proximal tibial osteotomy. , 1988, The Journal of bone and joint surgery. American volume.

[5]  J. Rand,et al.  Intramedullary arthrodesis of the knee after failed total knee arthroplasty. , 1994, The Journal of bone and joint surgery. American volume.

[6]  R. Scapinelli Studies on the vasculature of the human knee joint. , 1968, Acta anatomica.

[7]  W P Graham,et al.  Soft-tissue expansion in the lower extremities. , 1988, Plastic and reconstructive surgery.

[8]  J. Clough,et al.  Local infectious complications following large joint replacement in rheumatoid arthritis patients treated with methotrexate versus those not treated with methotrexate. , 1991, Arthritis and rheumatism.

[9]  W. F. Conway,et al.  Breakage of the patellar component of a kinematic total knee arthroplasty. A case report. , 1986, Orthopedics.

[10]  D. Hungerford,et al.  The Operative Treatment of Peroneal Nerve Palsy* , 1996, The Journal of bone and joint surgery. American volume.

[11]  K. Black,et al.  Transcutaneous PO2 in Flaps: A New Method of Survival Prediction , 1980, Plastic and reconstructive surgery.

[12]  M Roffman,et al.  Supracondylar fracture of the femur following total knee replacement. Report of four cases. , 1981, The Journal of bone and joint surgery. American volume.

[13]  Thomas G. Ryan,et al.  Treatment of supracondylar fractures of the femur proximal to a total knee arthroplasty. A report of four cases. , 1995, The Journal of bone and joint surgery. American volume.

[14]  C. Ranawat,et al.  Indications for total hip and total knee arthroplasties. Results of orthopaedic surveys. , 1996, The Journal of arthroplasty.

[15]  T S Thornhill,et al.  Infection as a complication of total knee-replacement arthroplasty. Risk factors and treatment in sixty-seven cases. , 1990, The Journal of bone and joint surgery. American volume.

[16]  G. Scuderi**,et al.  Results after knee replacement with a posterior cruciate-substituting prosthesis. , 1988, The Journal of bone and joint surgery. American volume.

[17]  V. Goldberg,et al.  Distal femoral replacement with allograft/prosthetic reconstruction for treatment of supracondylar fractures in patients with total knee arthroplasty. , 1992, The Journal of arthroplasty.

[18]  Peter J. E. Cruse,et al.  A five-year prospective study of 23,649 surgical wounds. , 1973, Archives of surgery.

[19]  S. H. Anzel,et al.  Salvage of an infected total knee prosthesis with medial and lateral gastrocnemius muscle flaps. A case report. , 1983, Journal of Bone and Joint Surgery. American volume.

[20]  J. Hirsh Oral anticoagulant drugs. , 1991, The New England journal of medicine.

[21]  M. Crawford,et al.  Retrograde intramedullary nailing of supracondylar femur fractures above total knee arthroplasty. A preliminary report of four cases. , 1995, The Journal of arthroplasty.

[22]  R. Balderston,et al.  The patellar clunk syndrome. A complication of posterior stabilized total knee arthroplasty. , 1989, Clinical orthopaedics and related research.

[23]  A. M. Ahmed,et al.  Force analysis of the patellar mechanism , 1987, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[24]  H. Berkowitz,et al.  Indications for the treatment of deep venous thrombosis following total knee replacement. , 1984, The Journal of bone and joint surgery. American volume.

[25]  R. Cawson,et al.  Antibiotic prophylaxis for dental treatment. , 1992, BMJ.

[26]  A. Tria,et al.  Resurfacing of the patella. , 1980, The Journal of bone and joint surgery. American volume.

[27]  L. Argenta,et al.  Controlled tissue expansion in reconstructive surgery. , 1984, British journal of plastic surgery.

[28]  D. P. Johnson The effect of continuous passive motion on wound-healing and joint mobility after knee arthroplasty. , 1990, The Journal of bone and joint surgery. American volume.

[29]  G. Stiris,et al.  The risk of deep-vein thrombosis after operations on a bloodless lower limb. A venographic study. , 1976, Injury.

[30]  Nf Sprangue Arthroscopic treatment of postoperative knee arthrofibrosis , 1982 .

[31]  L. S. Matthews,et al.  Spherocentric arthroplasty of the knee. Clinical experience with an average four-year follow-up. , 1981, The Journal of bone and joint surgery. American volume.

[32]  D. Dennis Removal of well-fixed cementless metal-backed patellar components. , 1992, The Journal of arthroplasty.

[33]  Mazas Fb Guepar total knee prosthesis. , 1973 .

[34]  D. A. Webster,et al.  The variable-axis knee prosthesis. Two-year follow-up study. , 1981, The Journal of bone and joint surgery. American volume.

[35]  C. Francis,et al.  Prevention of venous thrombosis after total hip arthroplasty. Antithrombin III and low-dose heparin compared with dextran 40. , 1989, The Journal of bone and joint surgery. American volume.

[36]  V. Goldberg,et al.  The effect of alignment of the implant on fractures of the patella after condylar total knee arthroplasty. , 1989, The Journal of bone and joint surgery. American volume.

[37]  Yohu Watanabe,et al.  Evaluation of Claudicatory Extremities by Ankle Blood Pressure and Muscle Blood Flow in Exercise Testing Before and After Operations , 1991 .

[38]  M. Ritter,et al.  Effect of range of motion on the success of a total knee arthroplasty. , 1987, The Journal of arthroplasty.

[39]  R. H. Fitzgerald Total hip arthroplasty sepsis. Prevention and diagnosis. , 1992, The Orthopedic clinics of North America.

[40]  P. Jalovaara,et al.  Arthrodesis of the knee with intramedullary nail fixation. , 1990, The Journal of bone and joint surgery. American volume.

[41]  L. S. Matthews,et al.  Load bearing characteristics of the patello-femoral joint. , 1977, Acta orthopaedica Scandinavica.

[42]  J. Galante,et al.  Prevention of venous thromboembolism after total knee replacement by high-dose aspirin or intermittent calf and thigh compression. , 1980, British medical journal.

[43]  T P Andriacchi,et al.  Patellar component failure in cementless total knee arthroplasty. , 1988, Clinical orthopaedics and related research.

[44]  P. D. Wilson,et al.  Infection rates after 3175 total hip and total knee replacements performed with and without a horizontal unidirectional filtered air-flow system. , 1982, The Journal of bone and joint surgery. American volume.

[45]  O M Lidwell,et al.  Effect of ultraclean air in operating rooms on deep sepsis in the joint after total hip or knee replacement: a randomised study. , 1982, British medical journal.

[46]  Z. Werb Biochemical actions of glucocorticoids on macrophages in culture. Specific inhibition of elastase, collagenase, and plasminogen activator secretion and effects on other metabolic functions , 1978, The Journal of experimental medicine.

[47]  N. Eftekhar Total knee-replacement arthroplasty. Results with the intramedullary adjustable total knee prosthesis. , 1983, The Journal of bone and joint surgery. American volume.

[48]  Turner Rh,et al.  Patellofemoral problems following total knee arthroplasty. , 1988 .

[49]  E. Manders,et al.  Soft-Tissue Expansion: Concepts and Complications , 1984, Plastic and reconstructive surgery.

[50]  R. Bryan,et al.  Reimplantation for the salvage of an infected total knee arthroplasty. , 1983, The Journal of bone and joint surgery. American volume.

[51]  R. J. Booth The results of spacer block technique in revision of total knee arthroplasty , 1989 .

[52]  M. Ecker,et al.  Postoperative care of the total knee patient. , 1989, The Orthopedic clinics of North America.

[53]  A. Weiss,et al.  Persistent wound drainage after primary total knee arthroplasty. , 1993, The Journal of arthroplasty.

[54]  T. Imperiale,et al.  Does prophylaxis prevent postdental infective endocarditis? A controlled evaluation of protective efficacy. , 1990, The American journal of medicine.

[55]  C. Colwell,et al.  The clinical course of distal deep venous thrombosis after total hip and total knee arthroplasty, as determined with duplex ultrasonography. , 1994, The Journal of bone and joint surgery. American volume.

[56]  J. Thorburn,et al.  Spinal and general anaesthesia in total hip replacement: frequency of deep vein thrombosis. , 1980, British journal of anaesthesia.

[57]  L. S. Matthews,et al.  Resection arthroplasty as a salvage procedure for a knee with infection after a total arthroplasty. , 1987, The Journal of bone and joint surgery. American volume.

[58]  L. Latta,et al.  Comparison of patellar resurfacing versus nonresurfacing in bilateral total knee arthroplasty. , 1990, Clinical orthopaedics and related research.

[59]  R Poss,et al.  The role of manipulation following total knee replacement. , 1981, The Journal of bone and joint surgery. American volume.

[60]  L. Lidgren,et al.  Treatment of the exposed knee prosthesis. , 1987, Acta orthopaedica Scandinavica.

[61]  A. McLaren,et al.  Open reduction internal fixation of supracondylar fractures above total knee arthroplasties using the intramedullary supracondylar rod. , 1994, Clinical orthopaedics and related research.

[62]  Sprague Nf rd,et al.  Arthroscopic treatment of postoperative knee fibroarthrosis. , 1982 .

[63]  R. Scott,et al.  Failure of the metal-backed patellar component after total knee replacement. , 1988, The Journal of bone and joint surgery. American volume.

[64]  T. Loughran,et al.  Supracondylar fracture of the femur following total knee arthroplasty. , 1989, The Journal of arthroplasty.

[65]  J. Loehr,et al.  The Gschwend-Scheier-Bähler (GSB) replacement of the rheumatoid knee joint. , 1981, Reconstruction surgery and traumatology.

[66]  C. Colwell,et al.  Use of enoxaparin, a low-molecular-weight heparin, and unfractionated heparin for the prevention of deep venous thrombosis after elective hip replacement. A clinical trial comparing efficacy and safety. Enoxaparin Clinical Trial Group. , 1994, The Journal of bone and joint surgery. American volume.

[67]  H. Kaufer Mechanical function of the patella. , 1971, The Journal of bone and joint surgery. American volume.

[68]  J. Hirsh,et al.  The optimal intensity of oral anticoagulant therapy. , 1987, JAMA.

[69]  M. McGrath The effect of prostaglandin inhibitors on wound contraction and the myofibroblast. , 1982, Plastic and reconstructive surgery.

[70]  G. Scuderi**,et al.  Patellar fractures in total knee arthroplasty. , 1989, The Journal of arthroplasty.

[71]  Extensor mechanism complications following total knee arthroplasty. , 1987, The Journal of arthroplasty.

[72]  Scott Rd Prosthetic replacement of the patellofemoral joint. , 1979 .

[73]  J. Reuben,et al.  Effect of patella thickness on patella strain following total knee arthroplasty. , 1991, The Journal of arthroplasty.

[74]  B. Ghelman,et al.  Deep-vein thrombosis following total knee replacement. An analysis of six hundred and thirty-eight arthroplasties. , 1984, The Journal of bone and joint surgery. American volume.

[75]  L. Jørgensen,et al.  Lower thrombosis risk with epidural blockade in knee arthroplasty. , 1990, Acta orthopaedica Scandinavica.

[76]  L. Jm Patellar complications in total knee arthroplasty. A literature review. , 1989 .

[77]  J. Evrard,et al.  PROPHYLACTIC CEFAZOLIN VERSUS PLACEBO IN TOTAL HIP REPLACEMENT Report of a Multicentre Double-blind Randomised Trial , 1981, The Lancet.

[78]  F. Burny,et al.  Extraosseous variations of temperature during polymerization of acrylic cement in hip arthroplasties. , 1976, Acta orthopaedica Scandinavica.

[79]  R. Balderston,et al.  Arthroscopic management of the patellar clunk syndrome following posterior stabilized total knee arthroplasty. , 1989, The Journal of arthroplasty.

[80]  R. D'ambrosia,et al.  Secondarily infected total joint replacements by hematogenous spread. , 1976, The Journal of bone and joint surgery. American volume.

[81]  I. Goldie,et al.  A study of the arterial supply of the patella in the normal state, in chondromalacia patellae and in osteoarthrosis. , 1980, Acta orthopaedica Scandinavica.

[82]  D. Larossa,et al.  Salvage of Jeopardized Total‐Knee Prosthesis: The Role of the Gastrocnemius Muscle Flap , 1989, Plastic and reconstructive surgery.

[83]  B. Morrey,et al.  Treatment of infection after total knee arthroplasty by débridement with retention of the components. , 1990, The Journal of bone and joint surgery. American volume.

[84]  M. Semlitsch,et al.  Reaction of bone to methacrylate after hip arthroplasty: a long-term gross, light microscopic, and scanning electron microscopic study. , 1974, The Journal of bone and joint surgery. American volume.

[85]  D. Patel,et al.  Hemostatic changes and postoperative deep-vein thrombosis associated with use of a pneumatic tourniquet. , 1981, The Journal of bone and joint surgery. American volume.

[86]  J. Rand,et al.  The value of indium 111 leukocyte scanning in the evaluation of painful or infected total knee arthroplasties. , 1990, Clinical orthopaedics and related research.

[87]  G. Scuderi**,et al.  The relationship of lateral releases to patella viability in total knee arthroplasty. , 1987, The Journal of arthroplasty.

[88]  L. S. Matthews,et al.  Patellar surface strain , 1986, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[89]  M. Martens,et al.  Experimental analysis of the quadriceps muscle force and patello-femoral joint reaction force for various activities. , 1972, Acta orthopaedica Scandinavica.

[90]  M. Clayton,et al.  Patellar complications after total condylar arthroplasty. , 1982, Clinical orthopaedics and related research.

[91]  R. Gustilo,et al.  Technique of patellar resurfacing in total knee arthroplasty , 1988 .

[92]  V. Pellegrini,et al.  Natural History of Thromboembolic Disease After Total Hip Arthroplasty , 1996 .

[93]  C. Francis,et al.  Comparison of Two Warfarin Regimens in the Prevention of Venous Thrombosis following Total Knee Replacement , 1996, Thrombosis and Haemostasis.

[94]  S. C. Dickhaut,et al.  Nutritional status: importance in predicting wound-healing after amputation. , 1984, The Journal of bone and joint surgery. American volume.

[95]  G. Raskob,et al.  Effectiveness of intermittent pneumatic leg compression for preventing deep vein thrombosis after total hip replacement. , 1990, JAMA.

[96]  T. D. Rees,et al.  The effects of smoking on experimental skin flaps in hamsters. , 1985, Plastic and reconstructive surgery.

[97]  P. Lotke,et al.  Influence of positioning of prosthesis in total knee replacement. , 1977, The Journal of bone and joint surgery. American volume.

[98]  R. Laskin Flexion space configuration in total knee arthroplasty. , 1995, The Journal of arthroplasty.

[99]  J. McMurry,et al.  Wound healing with diabetes mellitus. Better glucose control for better wound healing in diabetes. , 1984, The Surgical clinics of North America.

[100]  M A Mont,et al.  Surgical decompression for peroneal nerve palsy after total knee arthroplasty. , 1993, Clinical orthopaedics and related research.

[101]  D. Berry,et al.  Isolated patellar component revision of total knee arthroplasty. , 1993, Clinical orthopaedics and related research.

[102]  R. Scott,et al.  Stress fracture of the patella following duopatellar total knee arthroplasty with patellar resurfacing. , 1982, Clinical orthopaedics and related research.

[103]  S. Incavo,et al.  Operative treatment of distal femoral fractures proximal to total knee replacements. , 1993, The Journal of bone and joint surgery. American volume.

[104]  J. Charnley,et al.  Postoperative infection in total prosthetic replacement arthroplasty of the hip‐joint with special reference to the bacterial content of the air of the operating room , 1969, The British journal of surgery.

[105]  Giles R. Scuderi,et al.  Patellofemoral Pain After Total Knee Arthroplasty , 1994, The Journal of the American Academy of Orthopaedic Surgeons.

[106]  G. Picetti,et al.  The patellofemoral joint after total knee arthroplasty without patellar resurfacing. , 1990, The Journal of bone and joint surgery. American volume.

[107]  T. D. Rees,et al.  The effect of cigarette smoking on skin-flap survival in the face lift patient. , 1984, Plastic and reconstructive surgery.

[108]  R. Bourne,et al.  Management of recurrent dislocation of the patella following total knee arthroplasty. , 1992, The Journal of arthroplasty.

[109]  T. Sculco,et al.  Prophylaxis against Deep Venous Thrombosis after Total Knee Arthroplasty. Pneumatic Plantar Compression and Aspirin Compared with Aspirin Alone* , 1996, The Journal of bone and joint surgery. American volume.

[110]  M. Klain,et al.  Tobacco Smoking: Impairment of Experimental Flap Survival , 1984, Annals of plastic surgery.

[111]  L. Jørgensen,et al.  Antithrombotic efficacy of continuous extradural analgesia after knee replacement. , 1991, British journal of anaesthesia.

[112]  A. Cracchiolo,et al.  Treatment of major wound necrosis following total knee arthroplasty. , 1989, The Journal of arthroplasty.

[113]  S. Henry,et al.  Management of Supracondylar Fractures Above Total Knee Prostheses , 1994 .

[114]  J. Insall,et al.  A five to seven-year follow-up of unicondylar arthroplasty. , 1980, The Journal of bone and joint surgery. American volume.

[115]  J. Insall,et al.  Patellar dislocation following total knee replacement. , 1985, The Journal of bone and joint surgery. American volume.

[116]  C. Ranawat,et al.  The total condylar knee prosthesis. A report of two hundred and twenty cases. , 1979, The Journal of bone and joint surgery. American volume.

[117]  C. Sledge,et al.  Total knee arthroplasty experience at the Robert Breck Brigham Hospital. , 1979, Clinical Orthopaedics and Related Research.

[118]  M. Kasdan,et al.  Postoperative results of rheumatoid arthritis patients on methotrexate at the time of reconstructive surgery of the hand. , 1993, Orthopedics.

[119]  W. Goodson,et al.  Studies of wound healing in experimental diabetes mellitus. , 1977, The Journal of surgical research.

[120]  C. Ranawat,et al.  GUEPAR knee arthroplasty results and late complications. , 1979, Clinical orthopaedics and related research.

[121]  C. Colwell,et al.  Postoperative surveillance for deep venous thrombosis with duplex ultrasonography after total knee arthroplasty. , 1994, The Journal of bone and joint surgery. American volume.

[122]  U Persson,et al.  Ultraviolet radiation and ultra-clean air enclosures in operating rooms. UV-protection, economy, and comfort. , 1992, The Journal of arthroplasty.

[123]  J. Hodgkinson,et al.  Patellar resurfacing in total condylar knee arthroplasty , 1990 .

[124]  F. Ebert,et al.  The medial gastrocnemius muscle flap in the treatment of wound complications following total knee arthroplasty. , 1992, Orthopedics.

[125]  J. Insall,et al.  Two-stage reimplantation for the salvage of total knee arthroplasty complicated by infection. Further follow-up and refinement of indications. , 1990, The Journal of bone and joint surgery. American volume.

[126]  C. Francis,et al.  Comparison of warfarin and external pneumatic compression in prevention of venous thrombosis after total hip replacement. , 1992, JAMA.

[127]  G. Raskob,et al.  Different intensities of oral anticoagulant therapy in the treatment of proximal-vein thrombosis. , 1982, The New England journal of medicine.

[128]  K. Merkel,et al.  Supracondylar fracture of the femur after total knee arthroplasty. , 1986, The Journal of bone and joint surgery. American volume.

[129]  G. Scuderi**,et al.  Pneumatic sequential-compression boots compared with aspirin prophylaxis of deep-vein thrombosis after total knee arthroplasty. , 1990, The Journal of bone and joint surgery. American volume.

[130]  W C Hayes,et al.  Patellofemoral contact pressures. The influence of q-angle and tendofemoral contact. , 1984, The Journal of bone and joint surgery. American volume.

[131]  L. Wahl Hormonal regulation of macrophage collagenase activity. , 1977, Biochemical and biophysical research communications.

[132]  I. Gradisar,et al.  The Use of Postoperative Suction Drainage in Total Knee Arthroplasty , 1986, Clinical orthopaedics and related research.

[133]  V. Goldberg,et al.  Technical considerations in total knee surgery. Management of patella problems. , 1989, The Orthopedic clinics of North America.

[134]  T. Slama,et al.  Prophylaxis against infection in total joint arthroplasty. One day of cefuroxime compared with three days of cefazolin. , 1994, The Journal of bone and joint surgery. American volume.

[135]  J. Esterhai,et al.  Supracondylar fracture of the femur following prosthetic knee arthroplasty. , 1987, Clinical orthopaedics and related research.

[136]  B. Bierbaum,et al.  Bone scanning in the assessment of patellar viability following knee replacement. , 1985, Clinical orthopaedics and related research.

[137]  J. Hirsh,et al.  Accuracy of Ultrasound for the Diagnosis of Deep Venous Thrombosis in Asymptomatic Patients after Orthopedic Surgery , 1995, Annals of Internal Medicine.

[138]  F. J. Ensell,et al.  ATMOSPHERIC OZONE AND FEMORAL FRACTURES , 1975, The Lancet.

[139]  R. N. Stauffer,et al.  Kinematic rotating-hinge total knee arthroplasty. , 1987, The Journal of bone and joint surgery. American volume.

[140]  G. Hallock Salvage of total knee arthroplasty with local fasciocutaneous flaps. , 1990, The Journal of bone and joint surgery. American volume.

[141]  L. S. M. Gomes,et al.  Patellar prosthesis positioning in total knee arthroplasty , 1988 .

[142]  C. Ranawat,et al.  Peroneal-nerve palsy following total knee arthroplasty. A review of The Hospital for Special Surgery experience. , 1982, The Journal of bone and joint surgery. American volume.

[143]  R E Booth,et al.  The patellar "clunk" syndrome after posterior stabilized total knee arthroplasty. , 1994, Clinical orthopaedics and related research.

[144]  J. Mcnamara,et al.  Effect of short-term pharmacologic doses of adrenocorticosteroid therapy on wound healing. , 1969 .

[145]  C. Ranawat,et al.  The patellofemoral joint in total condylar knee arthroplasty. Pros and cons based on five- to ten-year follow-up observations. , 1986, Clinical orthopaedics and related research.

[146]  B. Risberg,et al.  Fibrinolytic activity in human legs in tourniquet ischemia. , 1977, Thrombosis research.

[147]  M. Marks,et al.  Advances in tissue expansion. , 1985, Clinics in plastic surgery.

[148]  J. Heit,et al.  RD heparin compared with warfarin for prevention of venous thromboembolic disease following total hip or knee arthroplasty. RD Heparin Arthroplasty Group. , 1994, The Journal of bone and joint surgery. American volume.

[149]  L. Abbott,et al.  SURGICAL APPROACHES TO THE KNEE JOINT , 1945 .

[150]  D. Schurman,et al.  Total condylar knee replacement. A study of factors influencing range of motion as late as two years after arthroplasty. , 1985, The Journal of bone and joint surgery. American volume.

[151]  Mayor Mb,et al.  The painful total knee replacement and the influence of component design. , 1994 .

[152]  J. Bono,et al.  Infected Total Knee Replacements , 1994, The Journal of the American Academy of Orthopaedic Surgeons.

[153]  M. Ritter,et al.  Anterior femoral notching and ipsilateral supracondylar femur fracture in total knee arthroplasty. , 1988, The Journal of arthroplasty.

[154]  W. Geerts,et al.  Prevention of Deep Vein Thrombosis after Major Knee Surgery - A Randomized, Double-Blind Trial Comparing a Low Molecular Weight Heparin Fragment (Enoxaparin) to Placebo , 1992, Thrombosis and Haemostasis.

[155]  E. Chao,et al.  Failed total knee arthroplasty treated by arthrodesis of the knee using the Ace-Fischer apparatus. , 1987, The Journal of bone and joint surgery. American volume.

[156]  S. Totterman,et al.  Deep venous thrombosis following total hip arthroplasty. Effects of prolonged postoperative epidural anesthesia. , 1994, The Journal of arthroplasty.

[157]  K. Rabinov,et al.  Roentgen diagnosis of venous thrombosis in the leg. , 1972, Archives of surgery.

[158]  D. Murray,et al.  Thromboprophylaxis and death after total hip replacement. , 1996, The Journal of bone and joint surgery. British volume.

[159]  D. Raoult,et al.  Oral rifampin plus ofloxacin for treatment of Staphylococcus-infected orthopedic implants , 1993, Antimicrobial Agents and Chemotherapy.

[160]  U. Frankl,et al.  Fracture of polyethylene of patellar component in total knee arthroplasty, diagnosed by arthroscopy. , 1989, The Journal of arthroplasty.

[161]  F. Dorey,et al.  Deep sepsis following total knee arthroplasty. Ten-year experience at the University of California at Los Angeles Medical Center. , 1986, The Journal of bone and joint surgery. American volume.

[162]  C. Francis,et al.  Two-step warfarin therapy. Prevention of postoperative venous thrombosis without excessive bleeding. , 1983, JAMA.

[163]  J. Insall,et al.  Gastrocnemius muscle flap coverage of exposed or infected knee prostheses. , 1993, Clinical orthopaedics and related research.

[164]  D. Schurman,et al.  Patellar complications following total knee arthroplasty. , 1979, The Journal of bone and joint surgery. American volume.

[165]  C. Francis,et al.  Antithrombin III prophylaxis of venous thromboembolic disease after total hip or total knee replacement. , 1989, American Journal of Medicine.

[166]  A H Burstein,et al.  The posterior stabilized condylar prosthesis: a modification of the total condylar design. Two to four-year clinical experience. , 1982, The Journal of bone and joint surgery. American volume.

[167]  F. Finseth,et al.  NICOTINE AND ITS EFFECT ON WOUND HEALING , 1978, Plastic and reconstructive surgery.

[168]  R Poss,et al.  Long-term complications after total knee arthroplasty with or without resurfacing of the patella. , 1993, The Journal of bone and joint surgery. American volume.

[169]  K. H. Chan,et al.  The effect of postoperative collateral ligament laxity in total knee arthroplasty. , 1988, Clinical orthopaedics and related research.

[170]  Chedomir Radovan,et al.  Tissue expansion in soft-tissue reconstruction. , 1984 .

[171]  D. Eastwood,et al.  Lateral patellar release in knee arthroplasty. Effect on wound healing. , 1992, The Journal of arthroplasty.

[172]  L. S. Matthews,et al.  Arthrodesis of the knee with an intramedullary nail. , 1991, The Journal of bone and joint surgery. American volume.

[173]  B. K. Vaughn,et al.  The efficacy of suction drains after routine total joint arthroplasty. , 1991, The Journal of bone and joint surgery. American volume.

[174]  T. Sculco,et al.  Complications in primary total knee arthroplasty. , 1990, Orthopaedic review.

[175]  C. Francis,et al.  Embolic complications of calf thrombosis following total hip arthroplasty. , 1993, The Journal of arthroplasty.

[176]  R. Bourne,et al.  Deep-vein thrombosis and continuous passive motion after total knee arthroplasty. , 1988, The Journal of bone and joint surgery. American volume.

[177]  R. Bryan,et al.  Infection after total knee arthroplasty. , 1975, The Orthopedic clinics of North America.

[178]  V. Kakkar,et al.  Prevention of venous thrombosis and pulmonary embolism. , 1990, The American journal of cardiology.

[179]  K. Knutson,et al.  The infected knee arthroplasty. A 6-year follow-up of 357 cases. , 1991, Acta orthopaedica Scandinavica.

[180]  D. Lyttle,et al.  Surgical interruption of patellar blood supply by total knee arthroplasty. , 1988, Clinical orthopaedics and related research.

[181]  H. Tullos,et al.  Intra-articular fibrous bands. Patellar complications after total knee replacement. , 1990, The Journal of bone and joint surgery. American volume.

[182]  V. Goldberg,et al.  The results of treatment of supracondylar fracture above total knee arthroplasty. , 1990, The Journal of arthroplasty.

[183]  N. Benowitz,et al.  Influence of nicotine on cardiovascular and hormonal effects of cigarette smoking , 1984, Clinical pharmacology and therapeutics.

[184]  G. Scuderi**,et al.  Scintigraphic determination of patellar viability after excision of infrapatellar fat pad and/or lateral retinacular release in total knee arthroplasty. , 1990, Clinical orthopaedics and related research.