Protein hot spots: the islands of stability.

[1]  A. Levine,et al.  Mapping of the p53 and mdm-2 interaction domains. , 1993, Molecular and cellular biology.

[2]  D. Covell,et al.  A role for surface hydrophobicity in protein‐protein recognition , 1994, Protein science : a publication of the Protein Society.

[3]  A. Levine,et al.  Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain , 1996, Science.

[4]  K Schulten,et al.  VMD: visual molecular dynamics. , 1996, Journal of molecular graphics.

[5]  John Kuriyan,et al.  Structure of the C-Terminal Region of p21WAF1/CIP1 Complexed with Human PCNA , 1996, Cell.

[6]  Alexander D. MacKerell,et al.  All-atom empirical potential for molecular modeling and dynamics studies of proteins. , 1998, The journal of physical chemistry. B.

[7]  W. Delano,et al.  Convergent solutions to binding at a protein-protein interface. , 2000, Science.

[8]  R. Norel,et al.  Electrostatic aspects of protein-protein interactions. , 2000, Current opinion in structural biology.

[9]  E. Warbrick.  The puzzle of PCNA's many partners , 2000 .

[10]  Kurt S. Thorn,et al.  ASEdb: a database of alanine mutations and their effects on the free energy of binding in protein interactions , 2001, Bioinform..

[11]  H. Wolfson,et al.  Access the most recent version at doi: 10.1110/ps.21302 References , 2001 .

[12]  Michelle R. Arkin,et al.  Binding of small molecules to an adaptive protein–protein interface , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[13]  M. Randal,et al.  Potent small-molecule binding to a dynamic hot spot on IL-2. , 2003, Journal of the American Chemical Society.

[14]  Michelle R Arkin,et al.  Discovery of a potent small molecule IL-2 inhibitor through fragment assembly. , 2003, Journal of the American Chemical Society.

[15]  G. Maga,et al.  Proliferating cell nuclear antigen (PCNA): a dancer with many partners , 2003, Journal of Cell Science.

[16]  Jie Liang,et al.  Protein-protein interactions: hot spots and structurally conserved residues often locate in complemented pockets that pre-organized in the unbound states: implications for docking. , 2004, Journal of molecular biology.

[17]  Y. Shamoo,et al.  Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-delta p66 subunit and flap endonuclease-1. , 2004, Structure.

[18]  Laxmikant V. Kalé,et al.  Scalable molecular dynamics with NAMD , 2005, J. Comput. Chem..

[19]  Su-Ying Wu,et al.  Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[20]  A. Hamilton,et al.  Strategies for targeting protein-protein interactions with synthetic agents. , 2005, Angewandte Chemie.

[21]  Paul N Barlow,et al.  Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding. , 2005, Journal of molecular biology.

[22]  Ian A Wilson,et al.  Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[23]  Scott P. Brown,et al.  Effects of Conformational Dynamics on Predicted Protein Druggability , 2006, ChemMedChem.

[24]  Pedro A Fernandes,et al.  Hot spots—A review of the protein–protein interface determinant amino‐acid residues , 2007, Proteins.

[25]  Christopher L. McClendon,et al.  Reaching for high-hanging fruit in drug discovery at protein–protein interfaces , 2007, Nature.

[26]  V. Helms,et al.  Transient pockets on protein surfaces involved in protein-protein interaction. , 2007, Journal of medicinal chemistry.

[27]  Lisa Yan,et al.  LOOPER: a molecular mechanics-based algorithm for protein loop prediction. , 2008, Protein engineering, design & selection : PEDS.

[28]  Julie C. Mitchell,et al.  KFC Server: interactive forecasting of protein interaction hot spots , 2008, Nucleic Acids Res..

[29]  Huan‐Xiang Zhou,et al.  Fundamental aspects of protein-protein association kinetics. , 2009, Chemical reviews.

[30]  Jonathan C. Fuller,et al.  Predicting druggable binding sites at the protein-protein interface. , 2009, Drug discovery today.

[31]  Xin Huang,et al.  Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction. , 2009, Journal of medicinal chemistry.