B-cell acute lymphoblastic leukaemia: clinical and biological aspects.

Acute lymphoblastic leukaemia of B-cell phenotype (B-ALL) is uncommon. We studied eight cases of B-ALL, investigating the clinical characteristics as well as the biological features. Cytology revealed a typical L3 profile in most cases, but in one case the morphological diagnosis was L2 and morphometric analysis indicated that the blasts in B-ALL were larger than in other ALLs. Cytogenetic study detected the typical translocations (8; 14) and (8; 22) in most of the cases. Abnormalities of the long arm of the chromosome 1 were found in four cases and a major aneuploidy was observed in one case. Cell-cycle analysis showed a high degree of proliferation with, in all cases, a small fraction of cells in G1 with low protein content (corresponding to early G1). All these biological characteristics must be related to the poor prognosis of this disease.

[1]  P. Adeleine,et al.  Adult acute lymphoblastic leukaemia: is cell proliferation related to other clinical and biological features? , 1987, British journal of haematology.

[2]  G. Lenoir,et al.  B-cell maturation stages of Burkitt's lymphoma cell lines according to Epstein-Barr virus status and type of chromosome translocation. , 1987, Journal of the National Cancer Institute.

[3]  H. Drexler,et al.  Incidence of TdT positivity in cases of leukemia and lymphoma. , 1986, Acta haematologica.

[4]  A. Look,et al.  Chromosomal translocations play a unique role in influencing prognosis in childhood acute lymphoblastic leukemia. , 1986, Blood.

[5]  A. Levine,et al.  B cell acute lymphocytic leukemia in adults. Clinical, morphologic, and immunologic findings. , 1986, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[6]  A. Walle Identification of L3 leukemia and Burkitt's lymphoma cells by flow cytometric quantitation of nuclear and cellular RNA and DNA content. , 1986, Leukemia research.

[7]  R. Gallo,et al.  Rearrangement and enhanced expression of c-myc oncogene in fresh tumor cells obtained from a patient with acute lymphoblastic leukemia. , 1986, Leukemia research.

[8]  B. Coiffier,et al.  Burkitt's lymphoma. Distinction of subgroups by morphometric analysis of the characteristics of 55 cell lines. , 1985, Analytical and quantitative cytology and histology.

[9]  P. Adeleine,et al.  Cell-cycle, protein content, and nuclear size in acute myeloid leukemia. , 1985, Cytometry.

[10]  F. Sigaux,et al.  Malignant lymphomas with band 8q24 chromosome abnormality: a morphologic continuum extending from Burkitt's to immunoblastic lymphoma , 1984, British journal of haematology.

[11]  I. Nordenson,et al.  Patient with acute B-cell leukemia of Burkitt's type (L3) and marker chromosomes including an (8;14) translocation. , 1982, Leukemia research.

[12]  J. Ritz,et al.  Expression of common acute lymphoblastic leukemia antigen (CALLA) by lymphomas of B-cell and T-cell lineage. , 1981, Blood.

[13]  H. Gralnick,et al.  The Morphological Classification of Acute Lymphoblastic Leukaemia: Concordance among Observers and Clinical Correlations , 1981, British journal of haematology.

[14]  J. Whang‐Peng Clinical significance of chromosomal abnormalities in acute lymphoblastic leukemia , 1981 .

[15]  J. Ziegler,et al.  Bone marrow involvement in Burkitt's lymphoma and its relationship to acute B-cell leukemia. , 1980, Leukemia research.

[16]  J. Smith,et al.  B-cell acute lymphatic leukaemia: immunoglobulin synthesis, morphology and clinical features. , 2009, Scandinavian journal of haematology.

[17]  R. Berger,et al.  t(8;14) Translocation in a Burkitt's Type of Lymphoblastic Leukaemia (L3) , 1979, British journal of haematology.

[18]  G. Flandrin,et al.  Immunological Classification of Acute Lymphoblastic Leukaemias: Evaluation of its Clinical Significance in a Hundred Patients , 1976, British journal of haematology.

[19]  G. Flandrin,et al.  Acute leukemia with Burkitt's tumor cells: A study of six cases with special reference to lymphocyte surface markers. , 1975, Blood.

[20]  J. Steinkamp,et al.  RAPID, SIMULTANEOUS MEASUREMENT OF DNA, PROTEIN, AND CELL VOLUME IN SINGLE CELLS FROM LARGE MAMMALIAN CELL POPULATIONS , 1973, The Journal of cell biology.