NRARP displays either pro- or anti-tumoral roles in T-cell acute lymphoblastic leukemia depending on Notch and Wnt signaling

[1]  A. Zelenetz,et al.  Acute lymphoblastic leukemia. , 2019, Journal of the National Comprehensive Cancer Network : JNCCN.

[2]  Barbara Squiban,et al.  Creation of a human T-ALL cell line online database , 2017, Leukemia & lymphoma.

[3]  Zhuo-wei Hu,et al.  The regulation of β-catenin activity and function in cancer: therapeutic opportunities , 2017, Oncotarget.

[4]  J. Barata,et al.  MiR-146b negatively regulates migration and delays progression of T-cell acute lymphoblastic leukemia , 2016, Scientific Reports.

[5]  P. Lemotte,et al.  Characterization of activating mutations of NOTCH3 in T cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies , 2016, Oncogene.

[6]  F. Kuo,et al.  A Phase 1 study of the novel gamma-secretase inhibitor PF-03084014 in patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma , 2015, Blood Cancer Journal.

[7]  Z. Ge,et al.  Characterization of LEF1 High Expression and Novel Mutations in Adult Acute Lymphoblastic Leukemia , 2015, PloS one.

[8]  D. Telesca,et al.  The CREB-Binding Protein Inhibitor ICG-001 Suppresses Pancreatic Cancer Growth , 2014, Molecular Cancer Therapeutics.

[9]  K. Stegmaier,et al.  New Approaches to Target T-ALL , 2014, Front. Oncol..

[10]  Emma R. Andersson,et al.  Therapeutic modulation of Notch signalling — are we there yet? , 2014, Nature Reviews Drug Discovery.

[11]  S. Schaffert,et al.  Modulating the Strength and Threshold of NOTCH Oncogenic Signals by mir-181a-1/b-1 , 2012, PLoS genetics.

[12]  A. Ferrando,et al.  Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia , 2011, Nature Genetics.

[13]  Chulan Kwon,et al.  Notch Post-Translationally Regulates β-Catenin Protein in Stem and Progenitor Cells , 2011, Nature Cell Biology.

[14]  Donna Neuberg,et al.  Inactivation of LEF1 in T-cell acute lymphoblastic leukemia. , 2010, Blood.

[15]  J. Barata,et al.  Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and γ-secretase inhibitors , 2010, Haematologica.

[16]  H. Kantarjian,et al.  Novel therapies for relapsed acute lymphoblastic leukemia , 2009, Current hematologic malignancy reports.

[17]  Malcolm A. Smith Update on developmental therapeutics for acute lymphoblastic leukemia , 2009, Current hematologic malignancy reports.

[18]  B. Vandekerckhove,et al.  An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells. , 2009, Blood.

[19]  Hee-Sae Park,et al.  Beta-catenin modulates the level and transcriptional activity of Notch1/NICD through its direct interaction. , 2009, Biochimica et biophysica acta.

[20]  Kwonseop Kim,et al.  Regulation of Notch1/NICD and Hes1 expressions by GSK-3α/β , 2009, Molecules and cells.

[21]  Holger Gerhardt,et al.  Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis. , 2009, Developmental cell.

[22]  Y. Yashiro‐Ohtani,et al.  Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas. , 2007, Blood.

[23]  Ajay B. Chitnis,et al.  Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability , 2005, Nature Cell Biology.

[24]  P. Ji,et al.  Alterations of lymphoid enhancer factor-1 isoform expression in solid tumors and acute leukemias. , 2005, Acta biochimica et biophysica Sinica.

[25]  Andrew P. Weng,et al.  Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia , 2004, Science.

[26]  Hong Ma,et al.  A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[27]  C. Nguyên,et al.  A small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcription , 2004 .

[28]  Michael J. Bevan,et al.  Notch-Regulated Ankyrin-Repeat Protein Inhibits Notch1 Signaling: Multiple Notch1 Signaling Pathways Involved In T Cell Development1 , 2003, The Journal of Immunology.

[29]  Hans Clevers,et al.  Notch1 functions as a tumor suppressor in mouse skin , 2003, Nature Genetics.

[30]  H. Clevers,et al.  TCF transcription factors, mediators of Wnt-signaling in development and cancer. , 2002, Developmental biology.

[31]  E. Bellefroid,et al.  XNAP, a conserved ankyrin repeat-containing protein with a role in the Notch pathway during Xenopus primary neurogenesis , 2002, Mechanisms of Development.

[32]  M. Bevan,et al.  The Nrarp gene encodes an ankyrin-repeat protein that is transcriptionally regulated by the notch signaling pathway. , 2001, Developmental biology.

[33]  C. Niehrs,et al.  Nrarp is a novel intracellular component of the Notch signaling pathway. , 2001, Genes & development.

[34]  Karine Hovanes,et al.  β-catenin–sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer , 2001, Nature Genetics.

[35]  A. Sparks,et al.  Identification of c-MYC as a target of the APC pathway. , 1998, Science.

[36]  C. Nguyên,et al.  A small molecule inhibitor of -cateninCREB-binding protein transcription , 2004 .

[37]  Ching-Hon Pui,et al.  Acute lymphoblastic leukemia. , 2004, The New England journal of medicine.

[38]  W. Trzeciak,et al.  A novel isoform of human lymphoid enhancer-binding factor-1 (LEF-1) gene transcript encodes a protein devoid of HMG domain and nuclear localization signal. , 2001, Acta biochimica Polonica.