A synthetic multifunctional mammalian pH sensor and CO2 transgene-control device.

[1]  M. Fussenegger,et al.  Inducible product gene expression technology tailored to bioprocess engineering. , 2007, Current opinion in biotechnology.

[2]  M. Fussenegger,et al.  A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice , 2011, Science.

[3]  J. Stelling,et al.  A tunable synthetic mammalian oscillator , 2009, Nature.

[4]  J. Larsen.  Pancreas transplantation: indications and consequences. , 2004, Endocrine reviews.

[5]  Jolanta Szulc,et al.  Tuning silence: conditional systems for RNA interference , 2006, Nature Methods.

[6]  Martin Fussenegger,et al.  Reward-based hypertension control by a synthetic brain–dopamine interface , 2013, Proceedings of the National Academy of Sciences.

[7]  M. Rewers,et al.  Clinical characteristics of children diagnosed with type 1 diabetes through intensive screening and follow-up. , 2004, Diabetes care.

[8]  Takao Shimizu,et al.  Identification of T Cell Death-associated Gene 8 (TDAG8) as a Novel Acid Sensing G-protein-coupled Receptor* , 2005, Journal of Biological Chemistry.

[9]  Martin Fussenegger,et al.  Gas-inducible transgene expression in mammalian cells and mice , 2004, Nature Biotechnology.

[10]  L. Nissim,et al.  A tunable dual-promoter integrator for targeting of cancer cells , 2010, Molecular systems biology.

[11]  W. Ward,et al.  Induction of type-1 diabetes mellitus in laboratory rats by use of alloxan: route of administration, pitfalls, and insulin treatment. , 2004, Comparative medicine.

[12]  M. Røder,et al.  Treatment of diabetic ketoacidosis in adults in Denmark: a national survey. , 2007, Diabetes research and clinical practice.

[13]  Roman Hovorka,et al.  Closed-loop insulin delivery: from bench to clinical practice , 2011, Nature Reviews Endocrinology.

[14]  Ahmad S. Khalil,et al.  Synthetic biology: applications come of age , 2010, Nature Reviews Genetics.

[15]  Christina D Smolke,et al.  Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems , 2010, Proceedings of the National Academy of Sciences.

[16]  Romain M. Wolf,et al.  Proton-sensing G-protein-coupled receptors , 2003, Nature.

[17]  J. N. Fisher,et al.  Hyperglycemic Crises in Adult Patients With Diabetes , 2009, Diabetes Care.

[18]  G. Umpierrez,et al.  Recurrent Diabetic Ketoacidosis in Inner-City Minority Patients , 2011, Diabetes Care.

[19]  Martin Fussenegger,et al.  Emerging biomedical applications of synthetic biology , 2011, Nature Reviews Genetics.

[20]  Martin Fussenegger,et al.  A closed-loop synthetic gene circuit for the treatment of diet-induced obesity in mice , 2013, Nature Communications.

[21]  M. Tresguerres,et al.  Physiological carbon dioxide, bicarbonate, and pH sensing , 2010, Pflügers Archiv - European Journal of Physiology.

[22]  M. Lazdunski,et al.  A proton-gated cation channel involved in acid-sensing , 1997, Nature.

[23]  D. Beebe,et al.  Fundamentals of microfluidic cell culture in controlled microenvironments. , 2010, Chemical Society reviews.

[24]  Martin Fussenegger,et al.  Self-sufficient control of urate homeostasis in mice by a synthetic circuit , 2010, Nature Biotechnology.

[25]  Jonathan S. Dordick,et al.  Radio-Wave Heating of Iron Oxide Nanoparticles Can Regulate Plasma Glucose in Mice , 2012, Science.

[26]  O. Ilkayeva,et al.  Leptin therapy in insulin-deficient type I diabetes , 2010, Proceedings of the National Academy of Sciences.

[27]  Melissa L. Langhan.  Acute alcohol intoxication in adolescents: frequency of respiratory depression. , 2013, The Journal of emergency medicine.

[28]  M. Fussenegger,et al.  A synthetic mammalian gene circuit reveals antituberculosis compounds , 2008, Proceedings of the National Academy of Sciences of the United States of America.

[29]  D. Pipeleers,et al.  Sustained function of alginate-encapsulated human islet cell implants in the peritoneal cavity of mice leading to a pilot study in a type 1 diabetic patient , 2013, Diabetologia.

[30]  J. Pickup.  Management of diabetes mellitus: is the pump mightier than the pen? , 2012, Nature Reviews Endocrinology.

[31]  A. Basbaum,et al.  The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli , 1998, Neuron.

[32]  I. Vanhorebeek,et al.  Glucose metabolism and insulin resistance in sepsis. , 2008, Current pharmaceutical design.

[33]  Frederick K. Balagaddé,et al.  Biology by design: reduction and synthesis of cellular components and behaviour , 2007, Journal of The Royal Society Interface.

[34]  Martin Fussenegger,et al.  Synthetic two-way communication between mammalian cells , 2012, Nature Biotechnology.

[35]  M. Fussenegger,et al.  Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin , 2009, Proceedings of the National Academy of Sciences.

[36]  Robert J Gillies,et al.  Renal and systemic pH imaging by contrast‐enhanced MRI , 2003, Magnetic resonance in medicine.

[37]  A. Kitabchi,et al.  Management of hyperglycemic crises in patients with diabetes. , 2001, Diabetes care.

[38]  Markus Wieland,et al.  Programmable single-cell mammalian biocomputers , 2012, Nature.

[39]  K. Wasserman,et al.  Ventilatory regulation of arterial H+ (pH) during exercise , 2014, Respiratory Physiology & Neurobiology.

[40]  K. Koshibu,et al.  Control of the establishment of aversive memory by calcineurin and Zif268 , 2008, Nature Neuroscience.

[41]  P. Pozzilli.  Type 1 diabetes mellitus in 2011: Heterogeneity of T1DM raises questions for therapy , 2012, Nature Reviews Endocrinology.

[42]  F. Wurm.  Production of recombinant protein therapeutics in cultivated mammalian cells , 2004, Nature Biotechnology.

[43]  L. Bouwens,et al.  The use of stem cells for pancreatic regeneration in diabetes mellitus , 2013, Nature Reviews Endocrinology.

[44]  K. Docherty,et al.  Enhanced expression of a furin-cleavable proinsulin. , 2003, Journal of molecular endocrinology.

[45]  Markus Wieland,et al.  Reprogrammed cell delivery for personalized medicine. , 2012, Advanced drug delivery reviews.

[46]  Sergio Grinstein,et al.  Sensors and regulators of intracellular pH , 2010, Nature Reviews Molecular Cell Biology.

[47]  B. Kłapcińska,et al.  Metabolic responses to a 48-h ultra-marathon run in middle-aged male amateur runners , 2013, European Journal of Applied Physiology.

[48]  T. Jensen,et al.  Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells , 2002, Nature Biotechnology.