Bulimia treated with imipramine: a placebo-controlled, double-blind study.

Bulimia, the syndrome of compulsive binge eating, is a common and often severe disorder frequently resistant to known therapies. Recent evidence suggesting a link between bulimia and affective disorder prompted the authors to perform a double-blind study of imipramine versus placebo with 22 chronically bulimic women. Imipramine was associated with a significantly reduced frequency of binge eating and with improvement on several other measures of eating behavior. On 1- to 8-month follow-up, 18 of the 20 treated subjects (90%) had responded to imipramine or a subsequent antidepressant. This finding augments the growing evidence that bulimia may be related to affective disorder.

[1]  D. Yurgelun-Todd,et al.  Family History Study of Anorexia Nervosa and Bulimia , 1983, British Journal of Psychiatry.

[2]  R. S. Stangler,et al.  DSM-III: psychiatric diagnosis in a university population. , 1980, The American journal of psychiatry.

[3]  G Russell,et al.  Bulimia nervosa: an ominous variant of anorexia nervosa , 1979, Psychological Medicine.

[4]  E. Eckert,et al.  Bulimia: a report of 34 cases. , 1981, The Journal of clinical psychiatry.

[5]  M. Hamilton.  A RATING SCALE FOR DEPRESSION , 1960, Journal of neurology, neurosurgery, and psychiatry.

[6]  C. Fairburn,et al.  A cognitive behavioural approach to the treatment of bulimia , 1981, Psychological Medicine.

[7]  H. Pope,et al.  Bulimia related to affective disorder by family history and response to the dexamethasone suppression test. , 1982, The American journal of psychiatry.

[8]  J. Shaffer,et al.  A controlled replication of the effectiveness of diphenylhydantoin in reducing irritability and anxiety in selected neurotic outpatients. , 1973, Journal of clinical pharmacology.

[9]  J. Stewart,et al.  Treatment of Bulimia with Monoamine Oxidase Inhibitors , 1982 .

[10]  Y. Nogami,et al.  On Kibarashi‐gui (Binge Eating) , 1977, Folia psychiatrica et neurologica japonica.

[11]  A. Stunkard.  The Pain of Obesity , 1976 .

[12]  H. Moldofsky,et al.  The heterogeneity of anorexia nervosa. Bulimia as a distinct subgroup. , 1980, Archives of general psychiatry.

[13]  K. Halmi,et al.  Binge-eating and vomiting: a survey of a college population , 1981, Psychological Medicine.

[14]  J. Davis,et al.  Bulimia. Its incidence and clinical importance in patients with anorexia nervosa. , 1980, Archives of general psychiatry.

[15]  L E Hollister,et al.  Phenytoin treatment of the binge-eating syndrome. , 1977, The American journal of psychiatry.

[16]  J. Rau,et al.  Treatment of compulsive eating disturbances with anticonvulsant medication. , 1974, The American journal of psychiatry.

[17]  D. Barlow,et al.  Effect of positive reinforcement, informational feedback, and contingency contracting on a bulimic anorexic female , 1977 .

[18]  G. C. George,et al.  ‘Dieters’ and ‘vomiters and purgers’ in anorexia nervosa , 1977, Psychological Medicine.