The antiviral activity of isoprinosine.
暂无分享,去创建一个
A hypothesis predicting that increase in the rate of synthesis of host messenger RNA would be associated with antiviral activity was examined. Biochemically, Isoprinosine or NPT-10381 (methisoprinol) increased the rate of rapid labeling of polyribosomal RNA and protein in uninfected monkey kidney cells in tissue culture. In tissue-culture systems, Isoprinosine exerted antiviral effects against influenza virus, PR-8 and A2 strains; herpes virus, LU strain; polio virus 3; and adenovirus 10. In in vivo mortality studies, Isoprinosine was observed to exert therapeutic antiviral effects against the A2 strain of influenza and, as well, against a herpes infection of newborn mice. Experiments were carried out which demonstrated a correlation between the in vivo anti-influenza (PR-8) effects of Isoprinosine and reduction in the virus titer in lungs of infected mice.
[1] P. Gordon. Molecular approaches to the drug enhancement of deteriorated functioning in the aged. , 1971, Advances in gerontological research.
[2] F. Rapp,et al. VIRUSES AND MAMMALIAN CHROMOSOMES. IV. REPLICATION OF HERPES SIMPLEX VIRUS IN DIPLOID CHINESE HAMSTER CELLS. , 1965, Virology.
[3] W. H. Murphy,et al. Handbook of cell and organ culture , 1964 .